{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:32:35Z","timestamp":1787502755119,"version":"build-2736575974"},"reference-count":93,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Severe Combined Immunodeficiency (SCID) is a widely underdiagnosed congenital disease that is fatal by 2-years old if left untreated. Most cases of SCID are diagnosed from the prompting of family history while other cases are sporadic and have no indicators for diagnosis besides the onset of debilitating infections. T-cell Receptor Excision Circle Newborn Screening (TREC NBS) offers an accessible way of flagging for SCID and other T-cell lymphopenia; however, the test implementation rate is low, particularly in Asian countries. This review of the literature will explore the significance of TREC NBS for diagnosing SCID with a focus on the potential impact of widespread implementation on infant healthcare in Southeast and East Asian countries including South Korea, Japan, China, Mongolia, Taiwan, Malaysia, Singapore, and Thailand.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1549768","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T01:16:04Z","timestamp":1747617364000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The clinical and socioeconomic aspects of t-cell receptor excision circle based newborn screening for severe combined immunodeficiency in Southeast and East Asia"],"prefix":"10.3389","volume":"16","author":[{"given":"Noelle","family":"Yoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongjin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Gyun","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insoo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junghee J.","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1159\/000357710","article-title":"Consanguinity and primary immunodeficiencies","volume":"77","author":"Al-Herz","year":"2014","journal-title":"Hum Hered"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e13130","DOI":"10.1111\/sji.13130","article-title":"and B Cell development by TREC\/KREC analysis in primary immunodeficiency patients and healthy controls","volume":"95","author":"Senturk","year":"2022","journal-title":"Scand J Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/ijns3020014","article-title":"Newborn screening for severe combined immunodeficiency-A history of the TREC assay","volume":"3","author":"Bausch-Jurken","year":"2017","journal-title":"Int J Neonatal Screen"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.5045\/br.2019.54.4.274","article-title":"Clinical significance of T cell receptor excision circle (TREC) quantitation after allogenic HSCT","volume":"54","author":"Mikhael","year":"2019","journal-title":"Blood Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/s41398-022-02159-7","article-title":"Blood levels of T-Cell Receptor Excision Circles (TRECs) provide an index of exposure to traumatic stress in mice and humans","volume":"12","author":"McCullough","year":"2022","journal-title":"Transl Psychiatry"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01470","article-title":"A practical approach to newborn screening for severe combined immunodeficiency using the T cell receptor excision circle assay","volume":"8","author":"Thakar","year":"2017","journal-title":"Front Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.10.020","article-title":"J","volume":"147","author":"Currier","year":"2021","journal-title":"M. 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