{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:16:54Z","timestamp":1794273414399,"version":"4.9.0"},"reference-count":163,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Epigenetic regulation of placental development and pregnancy-related disease processes has recently been a hot research topic. Implantation and subsequent placental development depend on carefully orchestrated interactions between fetal and maternal tissues, involving a delicate balance of immune factors. Epigenetic regulation, which refers to altering gene expression and function without changing the DNA sequence, is an essential regulatory process in cell biology. Several epigenetic modifications are known, such as DNA methylation, histone modifications, non-coding RNA regulation, and RNA methylation. Recently, there has been increasing evidence that epigenetic modifications are critical for the immune microenvironment at the maternal-fetal interface. In this review, we highlight recent advances in the role of epigenetics in the immune microenvironment at the maternal-fetal interface and in epigenetic regulation and placenta-associated pregnancy complications.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1549839","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T05:14:02Z","timestamp":1743657242000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Epigenetics of maternal-fetal interface immune microenvironment and placental related pregnancy complications"],"prefix":"10.3389","volume":"16","author":[{"given":"Xueqin","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3131","article-title":"Immune mechanisms at the maternal-fetal interface: perspectives and challenges","volume":"16","author":"PrabhuDas","year":"2015","journal-title":"Nat Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.biopha.2017.01.016","article-title":"Immune regulatory network in successful pregnancy and reproductive failures","volume":"88","author":"Ghaebi","year":"2017","journal-title":"Biomed pharmacother = Biomed pharmacotherapie"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.64","article-title":"The unique immunological and microbial aspects of pregnancy","volume":"17","author":"Mor","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00599-y","article-title":"The role of immune cells in recurrent spontaneous abortion","volume":"28","author":"Li","year":"2021","journal-title":"Reprod Sci (Thousand Oaks Calif.)"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2012.02.023","article-title":"Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis","volume":"62","author":"Robinson","year":"2012","journal-title":"Hormones Behav"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100142R","article-title":"Tim-3\/CTLA-4 pathways regulate decidual immune cells-extravillous trophoblasts interaction by IL-4 and IL-10","volume":"35","author":"Li","year":"2021","journal-title":"FASEB J"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.11.1345","article-title":"Epigenetics at the epicenter of modern medicine","volume":"299","author":"Feinberg","year":"2008","journal-title":"JAMA"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1411-0","article-title":"Advances in epigenetics link genetics to the environment and disease","volume":"571","author":"Cavalli","year":"2019","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.molcel.2017.10.030","article-title":"Protein-based inheritance: epigenetics beyond the chromosome","volume":"69","author":"Harvey","year":"2018","journal-title":"Mol Cell"},{"key":"B10","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.shpsc.2017.10.002","article-title":"Epigenetics: A way to bridge the gap between biological fields","volume":"66","author":"Nicoglou","year":"2017","journal-title":"Stud history philosophy Biol Biomed Sci"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.01.117","article-title":"Basic concepts of epigenetics","volume":"99","author":"Inbar-Feigenberg","year":"2013","journal-title":"Fertility sterility"},{"key":"B12","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.pharmthera.2017.11.002","article-title":"Readers of DNA methylation, the MBD family as potential therapeutic targets","volume":"184","author":"Ginder","year":"2018","journal-title":"Pharmacol Ther"},{"key":"B13","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/s41580-019-0159-6","article-title":"The diverse roles of DNA methylation in mammalian development and disease","volume":"20","author":"Greenberg","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-103019-102815","article-title":"Role of mammalian DNA methyltransferases in development","volume":"89","author":"Chen","year":"2020","journal-title":"Annu Rev Biochem"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nature14192","article-title":"Function and information content of DNA methylation","volume":"517","author":"Sch\u00fcbeler","year":"2015","journal-title":"Nature"},{"key":"B16","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1600-0897.2012.01108.x","article-title":"Methylome of fetal and maternal monocytes and macrophages at the feto-maternal interface","volume":"68","author":"Kim","year":"2012","journal-title":"Am J Reprod Immunol (New York N.Y.: 1989)"},{"key":"B17","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.preghy.2012.04.176","article-title":"PP065. dNK and dNK-CM mediated alterations of DNA methylation in extravillous cytotrophoblasts (EVTS)","volume":"2","author":"Hu","year":"2012","journal-title":"Pregnancy hypertension"},{"key":"B18","doi-asserted-by":"publisher","first-page":"66","DOI":"10.4161\/epi.23115","article-title":"DNA demethylation and histone H3K9 acetylation determine the active transcription of the NKG2D gene in human CD8+ T and NK cells","volume":"8","author":"Fern\u00e1ndez-S\u00e1nchez","year":"2013","journal-title":"Epigenetics"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1159\/000366386","article-title":"Distinct DNA methylomes of human placentas between pre-eclampsia and gestational diabetes mellitus","volume":"34","author":"Liu","year":"2014","journal-title":"Cell Physiol Biochem"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118766265","article-title":"Placental defects: an epigenetic perspective","volume":"25","author":"Deshpande","year":"2018","journal-title":"Reprod Sci (Thousand Oaks Calif.)"},{"key":"B21","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13223-018-0259-4","article-title":"Histone modifications and their role in epigenetics of atopy and allergic diseases","volume":"14","author":"Alaskhar Alhamwe","year":"2018","journal-title":"Allergy asthma Clin Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.865975","article-title":"Lysine acetylation\/deacetylation modification of immune-related molecules in cancer immunotherapy","volume":"13","author":"Ding","year":"2022","journal-title":"Front Immunol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063127","article-title":"Translating the histone code","volume":"293","author":"Jenuwein","year":"2001","journal-title":"Sci (New York N.Y.)"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4286","article-title":"Targeting bromodomains: epigenetic readers of lysine acetylation","volume":"13","author":"Filippakopoulos","year":"2014","journal-title":"Nat Rev Drug Discovery"},{"key":"B25","doi-asserted-by":"publisher","first-page":"F842","DOI":"10.1152\/ajprenal.00313.2017","article-title":"Dynamic regulation of lysine acetylation: the balance between acetyltransferase and deacetylase activities","volume":"313","author":"Hyndman","year":"2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaaa035","article-title":"Downregulation of HDAC8 expression decreases CD163 levels and promotes the apoptosis of macrophages by activating the ERK signaling pathway in recurrent spontaneous miscarriage","volume":"26","author":"Yao","year":"2020","journal-title":"Mol Hum Reprod"},{"key":"B27","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/s41419-020-2500-6","article-title":"Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts","volume":"11","author":"Jaju Bhattad","year":"2020","journal-title":"Cell Death Dis"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1761","article-title":"The diverse functions of histone lysine methylation","volume":"6","author":"Martin","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nature04048","article-title":"Reversing histone methylation","volume":"436","author":"Bannister","year":"2005","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/nu6104273","article-title":"The role of dietary histone deacetylases (HDACs) inhibitors in health and disease","volume":"6","author":"Bassett","year":"2014","journal-title":"Nutrients"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05343.x","article-title":"The epigenetic magic of histone lysine methylation","volume":"273","author":"Jenuwein","year":"2006","journal-title":"FEBS J"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/nature05915","article-title":"The complex language of chromatin regulation during transcription","volume":"447","author":"Berger","year":"2007","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/procel\/pwac032","article-title":"The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications","volume":"14","author":"Li","year":"2023","journal-title":"Protein Cell"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.4161\/epi.21975","article-title":"Histone phosphorylation: a chromatin modification involved in diverse nuclear events","volume":"7","author":"Rossetto","year":"2012","journal-title":"Epigenetics"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1139\/o06-072","article-title":"GammaH2AX and its role in DNA double-strand break repair","volume":"84","author":"Fillingham","year":"2006","journal-title":"Biochem Cell Biol = Biochimie biologie cellulaire"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.05631-11","article-title":"A peek into the complex realm of histone phosphorylation","volume":"31","author":"Banerjee","year":"2011","journal-title":"Mol Cell Biol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.molimm.2019.04.011","article-title":"Classification, biogenesis and functions in blood cells","volume":"112","author":"Dahariya","year":"2019","journal-title":"Mol Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1053\/j.gastro.2017.04.046","article-title":"Long noncoding RNAs in the pathogenesis of Barrett\u2019s esophagus and esophageal carcinoma","volume":"153","author":"Abraham","year":"2017","journal-title":"Gastroenterology"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.812008","article-title":"Non-coding RNA in penile cancer","volume":"12","author":"Pinho","year":"2022","journal-title":"Front Oncol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"153959","DOI":"10.1016\/j.prp.2022.153959","article-title":"Mechanisms and functions of long noncoding RNAs in intervertebral disc degeneration","volume":"235","author":"Ran","year":"2022","journal-title":"Pathology Res Pract"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.782938","article-title":"The emerging roles of circ-ABCB10 in cancer","volume":"10","author":"Huang","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa654","article-title":"Predictions and analyses of RNA nearest neighbor parameters for modified nucleotides","volume":"48","author":"Hopfinger","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal transduction targeted Ther"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.19.5735","article-title":"Sequence specificity of the human mRNA N6-adenosine methylase in vitro","volume":"18","author":"Harper","year":"1990","journal-title":"Nucleic Acids Res"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab378","article-title":"A comprehensive review of m6A\/m6Am RNA methyltransferase structures","volume":"49","author":"Oerum","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2214684120","article-title":"METTL3 is essential for normal progesterone signaling during embryo implantation via m(6)A-mediated translation control of progesterone receptor","volume":"120","author":"Zheng","year":"2023","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2750-y","article-title":"Post-translational regulation of the maternal-to-zygotic transition","volume":"75","author":"Liu","year":"2018","journal-title":"Cell Mol Life sciences: CMLS"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6153","article-title":"The effects of sex, menstrual cycle, and oral contraceptives on the number and activity of natural killer cells","volume":"81","author":"Yovel","year":"2001","journal-title":"Gynecologic Oncol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/nri886","article-title":"Natural killer cells and pregnancy","volume":"2","author":"Moffett-King","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00467","article-title":"Uterine natural killer cells: functional distinctions and influence on pregnancy in humans and mice","volume":"8","author":"Gaynor","year":"2017","journal-title":"Front Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal-fetal interface in humans","volume":"563","author":"Vento-Tormo","year":"2018","journal-title":"Nature"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.immuni.2017.11.018","article-title":"Natural killer cells promote fetal development through the secretion of growth-promoting factors","volume":"47","author":"Fu","year":"2017","journal-title":"Immunity"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.12.009","article-title":"Maternal uterine natural killer cells nurture fetal growth: in medio stat virtus","volume":"21","author":"Colucci","year":"2015","journal-title":"Trends Mol Med"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.883636","article-title":"The regulatory roles of chemerin-chemokine-like receptor 1 axis in placental development and vascular remodeling during early pregnancy","volume":"10","author":"Zhang","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2016.1163454","article-title":"The DNA methylation profile of activated human natural killer cells","volume":"11","author":"Wiencke","year":"2016","journal-title":"Epigenetics"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202582","article-title":"Conversion of peripheral blood NK cells to a decidual NK-like phenotype by a cocktail of defined factors","volume":"190","author":"Cerdeira","year":"2013","journal-title":"J Immunol (Baltimore Md.: 1950)"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308888110","article-title":"Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1","volume":"110","author":"Nandakumar","year":"2013","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B58","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.immuni.2020.09.008","article-title":"Rapid enhancer remodeling and transcription factor repurposing enable high magnitude gene induction upon acute activation of NK cells","volume":"53","author":"Scium\u00e8","year":"2020","journal-title":"Immunity"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00909-1","article-title":"Deconvoluting global cytokine signaling networks in natural killer cells","volume":"22","author":"Wiedemann","year":"2021","journal-title":"Nat Immunol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioaa208","article-title":"Uterine decidual niche modulates the progressive dedifferentiation of spiral artery vascular smooth muscle cells during human pregnancy\u2020","volume":"104","author":"Ma","year":"2021","journal-title":"Biol Reprod"},{"key":"B61","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1186\/s12967-024-05253-0","article-title":"Deficiency of UCHL1 results in insufficient decidualization accompanied by impaired dNK modulation and eventually miscarriage","volume":"22","author":"Zhang","year":"2024","journal-title":"J Trans Med"},{"key":"B62","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.immuni.2018.03.030","article-title":"Trained memory of human uterine NK cells enhances their function in subsequent pregnancies","volume":"48","author":"Gamliel","year":"2018","journal-title":"Immunity"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey323","article-title":"Differential microRNA expression between decidual and peripheral blood natural killer cells in early pregnancy","volume":"33","author":"Carlino","year":"2018","journal-title":"Hum Reprod (Oxford England)"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1111\/aji.2018.80.issue-5","article-title":"Genome-wide identification of microRNAs in decidual natural killer cells from patients with unexplained recurrent spontaneous abortion","volume":"80","author":"Li","year":"2018","journal-title":"Am J Reprod Immunol (New York N.Y.: 1989)"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.172","article-title":"Effect of miR-30e regulating NK cell activities on immune tolerance of maternal-fetal interface by targeting PRF1","volume":"109","author":"Huang","year":"2019","journal-title":"Biomed pharmacother = Biomed pharmacotherapie"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-023-02733-y","article-title":"Maternal circulating exosomal miR-185-5p levels as a predictive biomarker in patients with recurrent pregnancy loss","volume":"40","author":"Xiong","year":"2023","journal-title":"J assisted Reprod Genet"},{"key":"B67","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/s12964-024-01610-0","article-title":"Increased levels of villus-derived exosomal miR-29a-3p in normal pregnancy than uRPL patients suppresses decidual NK cell production of interferon-\u03b3 and exerts a therapeutic effect in abortion-prone mice","volume":"22","author":"Fang","year":"2024","journal-title":"Cell communication signaling: CCS"},{"key":"B68","doi-asserted-by":"publisher","first-page":"5522","DOI":"10.1038\/s41467-021-25803-0","article-title":"METTL3-mediated m(6)A RNA methylation promotes the anti-tumour immunity of natural killer cells","volume":"12","author":"Song","year":"2021","journal-title":"Nat Commun"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/aji.2018.79.issue-6","article-title":"IL-33\/ST2 axis affects the polarization and efferocytosis of decidual macrophages in early pregnancy","volume":"79","author":"Sheng","year":"2018","journal-title":"Am J Reprod Immunol (New York N.Y.: 1989)"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.505","article-title":"RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization","volume":"8","author":"Meng","year":"2017","journal-title":"Cell Death Dis"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05938.x","article-title":"Inflammation and pregnancy: the role of the immune system at the implantation site","volume":"1221","author":"Mor","year":"2011","journal-title":"Ann New York Acad Sci"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2017.03.011","article-title":"M1 macrophages decrease in the deciduae from normal pregnancies but not from spontaneous abortions or unexplained recurrent spontaneous abortions","volume":"117","author":"Tsao","year":"2018","journal-title":"J Formosan Med Assoc = Taiwan yi zhi"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.10.011","article-title":"Differential distribution and phenotype of decidual macrophages in preeclamptic versus control pregnancies","volume":"178","author":"Schonkeren","year":"2011","journal-title":"Am J Pathol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12881-019-0835-6","article-title":"Effect of prematurity on genome wide methylation in the placenta","volume":"20","author":"Schuster","year":"2019","journal-title":"BMC Med Genet"},{"key":"B76","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jri.2017.05.003","article-title":"Increased expression of toll-like receptors 2 and 9 is associated with reduced DNA methylation in spontaneous preterm labor","volume":"121","author":"Walsh","year":"2017","journal-title":"J Reprod Immunol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.v25.16","article-title":"Histone deacetylase 9 deficiency exaggerates uterine M2 macrophage polarization","volume":"25","author":"Liu","year":"2021","journal-title":"J Cell Mol Med"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.46144","article-title":"MiR-103 protects from recurrent spontaneous abortion via inhibiting STAT1 mediated M1 macrophage polarization","volume":"16","author":"Zhu","year":"2020","journal-title":"Int J Biol Sci"},{"key":"B79","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12967-023-04831-y","article-title":"Trophoblast-derived miR-410-5p induces M2 macrophage polarization and mediates immunotolerance at the fetal-maternal interface by targeting the STAT1 signaling pathway","volume":"22","author":"Yang","year":"2024","journal-title":"J Trans Med"},{"key":"B80","doi-asserted-by":"publisher","first-page":"6696636","DOI":"10.1155\/2021\/6696636","article-title":"MiR-6869-5p induces M2 polarization by regulating PTPRO in gestational diabetes mellitus","volume":"2021","author":"Wang","year":"2021","journal-title":"Mediators Inflammation"},{"key":"B81","doi-asserted-by":"publisher","first-page":"4851214","DOI":"10.1155\/2019\/4851214","article-title":"miR-657 promotes macrophage polarization toward M1 by targeting FAM46C in gestational diabetes mellitus","volume":"2019","author":"Wang","year":"2019","journal-title":"Mediators Inflammation"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiad022","article-title":"Placenta exosomal miRNA-30d-5p facilitates decidual macrophage polarization by targeting HDAC9","volume":"113","author":"Bai","year":"2023","journal-title":"J leukocyte Biol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"113510","DOI":"10.1016\/j.yexcr.2023.113510","article-title":"Downregulation of miR-455-3p in decidual cells promotes macrophage polarization and suppresses trophoblasts invasion","volume":"425","author":"Ma","year":"2023","journal-title":"Exp Cell Res"},{"key":"B84","doi-asserted-by":"publisher","first-page":"108930","DOI":"10.1016\/j.intimp.2022.108930","article-title":"miR-146a-5p enhances embryo survival in unexplained recurrent spontaneous abortion by promoting M2 polarization of decidual macrophages","volume":"110","author":"Ye","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1333549","article-title":"Macrophage plasticity and function in cancer and pregnancy","volume":"14","author":"Yin","year":"2023","journal-title":"Front Immunol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"111201","DOI":"10.1016\/j.intimp.2023.111201","article-title":"LncRNA AOC4P recruits TRAF6 to regulate EZH2 ubiquitination and participates in trophoblast glycolysis and M2 macrophage polarization which is associated with recurrent spontaneous abortion","volume":"125","author":"Wu","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.v118.9","article-title":"Long non-coding RNA MALAT1 promotes proliferation, angiogenesis, and immunosuppressive properties of mesenchymal stem cells by inducing VEGF and IDO","volume":"118","author":"Li","year":"2017","journal-title":"J Cell Biochem"},{"key":"B88","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s10020-022-00531-3","article-title":"LINC00240\/miR-155 axis regulates function of trophoblasts and M2 macrophage polarization via modulating oxidative stress-induced pyroptosis in preeclampsia","volume":"28","author":"Wu","year":"2022","journal-title":"Mol Med (Cambridge Mass.)"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-022-02593-y","article-title":"Downregulation of LINC00221 promotes angiopoiesis in HUVEC and inhibits recruitment of macrophages by augmenting miR-542-3p in trophoblast cells","volume":"39","author":"Zhao","year":"2022","journal-title":"J assisted Reprod Genet"},{"key":"B90","doi-asserted-by":"publisher","first-page":"110283","DOI":"10.1016\/j.cellsig.2022.110283","article-title":"METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway","volume":"93","author":"Cai","year":"2022","journal-title":"Cell signalling"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24019","article-title":"Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling","volume":"36","author":"Li","year":"2022","journal-title":"J Clin Lab Anal"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415819","article-title":"The N6-methyladenosine regulator ALKBH5 mediated stromal cell-macrophage interaction via VEGF signaling to promote recurrent spontaneous abortion: A bioinformatic and in vitro study","volume":"23","author":"Zhao","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191040","article-title":"VEGF may contribute to macrophage recruitment and M2 polarization in the decidua","volume":"13","author":"Wheeler","year":"2018","journal-title":"PloS One"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-024-10725-5","article-title":"Bioinformatic analysis of m6A regulator-mediated RNA methylation modification patterns and immune microenvironment characterization in endometriosis","volume":"63","author":"Zheng","year":"2025","journal-title":"Biochem Genet"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.68335","article-title":"Insight of autophagy in spontaneous miscarriage","volume":"18","author":"Qin","year":"2022","journal-title":"Int J Biol Sci"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2021.02.003","article-title":"T cell metabolism in homeostasis and cancer immunity","volume":"68","author":"Wei","year":"2021","journal-title":"Curr Opin Biotechnol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.717014","article-title":"Metabolic reprogramming of immune cells at the maternal-fetal interface and the development of techniques for immunometabolism","volume":"12","author":"Wei","year":"2021","journal-title":"Front Immunol"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0220-6","article-title":"Helper T cell differentiation","volume":"16","author":"Saravia","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"104437","DOI":"10.1016\/j.cellimm.2021.104437","article-title":"Th1 polarization in the tumor microenvironment upregulates the myeloid-derived suppressor-like function of macrophages","volume":"369","author":"Nonaka","year":"2021","journal-title":"Cell Immunol"},{"key":"B100","doi-asserted-by":"publisher","first-page":"2814510","DOI":"10.1155\/2022\/2814510","article-title":"Bach2: A key regulator in Th2-related immune cells and Th2 immune response","volume":"2022","author":"Liu","year":"2022","journal-title":"J Immunol Res"},{"key":"B101","doi-asserted-by":"publisher","first-page":"8782672","DOI":"10.1155\/2021\/8782672","article-title":"The role and function of regulatory T cells in toxoplasma Gondii-induced adverse pregnancy outcomes","volume":"2021","author":"Gao","year":"2021","journal-title":"J Immunol Res"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094926","article-title":"At embryo implantation site IL-35 secreted by trophoblast, polarizing T cells towards IL-35+ IL-10+ IL-4+ Th2-type cells, could favour fetal allograft tolerance and pregnancy success","volume":"23","author":"Lombardelli","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.03.004","article-title":"Differences in regulatory T-cell and dendritic cell pattern in decidual tissue of placenta accreta\/increta cases","volume":"35","author":"Schwede","year":"2014","journal-title":"Placenta"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02025","article-title":"T helper (Th) cell profiles in pregnancy and recurrent pregnancy losses: Th1\/Th2\/Th9\/Th17\/Th22\/Tfh cells","volume":"11","author":"Wang","year":"2020","journal-title":"Front Immunol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020477","article-title":"Changes in DNA methylation from age 18 to pregnancy in type 1, 2, and 17 T helper and regulatory T-cells pathway genes","volume":"19","author":"Iqbal","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.738962","article-title":"DNA methylation and recurrent pregnancy loss: A mysterious compass","volume":"12","author":"Zhou","year":"2021","journal-title":"Front Immunol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1111\/jog.2016.42.issue-11","article-title":"Correlation between protein expression of FOXP3 and level of FOXP3 promoter methylation in recurrent spontaneous abortion","volume":"42","author":"Hou","year":"2016","journal-title":"J obstetrics gynaecology Res"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00849-2","article-title":"Histone methyltransferase Nsd2 ensures maternal-fetal immune tolerance by promoting regulatory T-cell recruitment","volume":"19","author":"Zhang","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-020-0255-0","article-title":"MicroRNA miR-155 is required for expansion of regulatory T cells to mediate robust pregnancy tolerance in mice","volume":"13","author":"Schjenken","year":"2020","journal-title":"Mucosal Immunol"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2022.03.011","article-title":"Downregulation of miR-33a\/b and miR-181a contributes to recurrent pregnancy loss by upregulating S1PR1 and repressing regulatory T cell differentiation","volume":"121","author":"Geng","year":"2022","journal-title":"Placenta"},{"key":"B111","doi-asserted-by":"publisher","first-page":"e13475","DOI":"10.1111\/aji.13475","article-title":"T lymphocytes and preeclampsia: The potential role of T-cell subsets and related MicroRNAs in the pathogenesis of preeclampsia","volume":"86","author":"Zolfaghari","year":"2021","journal-title":"Am J Reprod Immunol (New York N.Y.: 1989)"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.720635","article-title":"Prenatal cadmium exposure alters proliferation in mouse CD4(+) T cells via lncRNA Snhg7","volume":"12","author":"McCall","year":"2021","journal-title":"Front Immunol"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1038\/nature23450","article-title":"m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7\/STAT5\/SOCS pathways","volume":"548","author":"Li","year":"2017","journal-title":"Nature"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2018.7","article-title":"m(6)A mRNA methylation sustains Treg suppressive functions","volume":"28","author":"Tong","year":"2018","journal-title":"Cell Res"},{"key":"B115","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/s41467-021-21594-6","article-title":"METTL3-dependent m(6)A modification programs T follicular helper cell differentiation","volume":"12","author":"Yao","year":"2021","journal-title":"Nat Commun"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00128","article-title":"HLA-G orchestrates the early interaction of human trophoblasts with the maternal niche","volume":"6","author":"Gregori","year":"2015","journal-title":"Front Immunol"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1038\/nri1897","article-title":"Immunology of placentation in eutherian mammals","volume":"6","author":"Moffett","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008236","article-title":"Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome","volume":"15","author":"Vlahos","year":"2019","journal-title":"PloS Genet"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.2019655","article-title":"ZBTB24 (Zinc Finger and BTB Domain Containing 24) prevents recurrent spontaneous abortion by promoting trophoblast proliferation, differentiation and migration","volume":"13","author":"Ruan","year":"2022","journal-title":"Bioengineered"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gav007","article-title":"Genome-wide DNA methylation identifies trophoblast invasion-related genes: Claudin-4 and Fucosyltransferase IV control mobility via altering matrix metalloproteinase activity","volume":"21","author":"Hu","year":"2015","journal-title":"Mol Hum Reprod"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.10.010","article-title":"Transcriptomic and epigenomic landscapes during cell fusion in BeWo trophoblast cells","volume":"36","author":"Shankar","year":"2015","journal-title":"Placenta"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1210\/en.2019-00144","article-title":"Human trophoblast differentiation is associated with profound gene regulatory and epigenetic changes","volume":"160","author":"Kwak","year":"2019","journal-title":"Endocrinology"},{"key":"B123","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1016\/j.stem.2024.07.003","article-title":"Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells","volume":"31","author":"Yu","year":"2024","journal-title":"Cell Stem Cell"},{"key":"B124","doi-asserted-by":"publisher","first-page":"5216786","DOI":"10.1155\/2022\/5216786","article-title":"Deletion of ACLY disrupts histone acetylation and IL-10 secretion in trophoblasts, which inhibits M2 polarization of macrophages: A possible role in recurrent spontaneous abortion","volume":"2022","author":"Chen","year":"2022","journal-title":"Oxid Med Cell Longevity"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030728","article-title":"SIRT1 alleviates LPS-induced IL-1\u03b2 Production by suppressing NLRP3 inflammasome activation and ROS production in trophoblasts","volume":"9","author":"Park","year":"2020","journal-title":"Cells"},{"key":"B126","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s10815-022-02677-9","article-title":"MicroRNAs: key regulators of the trophoblast function in pregnancy disorders","volume":"40","author":"Liang","year":"2023","journal-title":"J assisted Reprod Genet"},{"key":"B127","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s00018-024-05385-y","article-title":"Overexpression of long noncoding RNA DUXAP8 inhibits ER-phagy through activating AKT\/mTOR signaling and contributes to preeclampsia","volume":"81","author":"Wei","year":"2024","journal-title":"Cell Mol Life sciences: CMLS"},{"key":"B128","doi-asserted-by":"publisher","first-page":"145950","DOI":"10.1016\/j.scitotenv.2021.145950","article-title":"Lnc-HZ01 with m6A RNA methylation inhibits human trophoblast cell proliferation and induces miscarriage by up-regulating BPDE-activated lnc-HZ01\/MXD1 positive feedback loop","volume":"776","author":"Xu","year":"2021","journal-title":"Sci total Environ"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-024-05011-4","article-title":"Circ_0003314 combines with the miR-26b-5p\/IL1RAP axis to inhibit HTR-8\/SVneo cell proliferation, migration, invasion and tube formation and promote apoptosis","volume":"197","author":"Li","year":"2024","journal-title":"Appl Biochem Biotechnol"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-024-01685-7","article-title":"Circ_0015382 regulates the miR-942-5p\/NDRG1 axis to suppress trophoblast cell functions","author":"Wu","year":"2024","journal-title":"Reprod Sci (Thousand Oaks Calif.)"},{"key":"B131","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41419-020-2679-6","article-title":"Circular RNA circ_0111277 attenuates human trophoblast cell invasion and migration by regulating miR-494\/HTRA1\/Notch-1 signal pathway in pre-eclampsia","volume":"11","author":"Ou","year":"2020","journal-title":"Cell Death Dis"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.7150\/thno.31868","article-title":"The m6A demethylase ALKBH5 controls trophoblast invasion at the maternal-fetal interface by regulating the stability of CYR61 mRNA","volume":"9","author":"Li","year":"2019","journal-title":"Theranostics"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.18227","article-title":"ALKBH5 modulation of ferroptosis in recurrent miscarriage: implications in cytotrophoblast dysfunction","volume":"12","author":"Qin","year":"2024","journal-title":"PeerJ"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1111\/febs.v291.7","article-title":"FTO protein regulates the TGF-\u03b2 signalling pathway through RNA N6-methyladenosine modification to induce unexplained recurrent spontaneous abortion","volume":"291","author":"Zhang","year":"2024","journal-title":"FEBS J"},{"key":"B135","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1095\/biolreprod.113.113142","article-title":"Generalized disturbance of DNA methylation in the uterine decidua in the CBA\/J x DBA\/2 mouse model of pregnancy failure","volume":"89","author":"Brown","year":"2013","journal-title":"Biol Reprod"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.686676","article-title":"Pregnancy induces an immunological memory characterized by maternal immune alterations through specific genes methylation","volume":"12","author":"Huang","year":"2021","journal-title":"Front Immunol"},{"key":"B137","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.3390\/books978-3-0365-5899-8","article-title":"Placental related disorders of pregnancy","volume":"23","author":"Lee","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000253RR","article-title":"Induction of TGF-\u03b2 receptor I expression in a DNA methylation-independent manner mediated by DNMT3A downregulation is involved in early-onset severe preeclampsia","volume":"34","author":"Jia","year":"2020","journal-title":"FASEB J"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2020-0318","article-title":"Placental growth factor and Fms related tyrosine kinase-1 are hypomethylated in preeclampsia placentae","volume":"13","author":"D.","year":"2021","journal-title":"Epigenomics"},{"key":"B140","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s13148-020-00873-x","article-title":"DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases","volume":"12","author":"Tekola-Ayele","year":"2020","journal-title":"Clin Epigenet"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1007\/s13258-020-01020-9","article-title":"Genome wide methylation analysis to uncover genes related to recurrent pregnancy loss","volume":"43","author":"Zhou","year":"2021","journal-title":"Genes Genomics"},{"key":"B142","doi-asserted-by":"publisher","first-page":"100044","DOI":"10.1016\/j.bbih.2020.100044","article-title":"DNA methylation patterns in T lymphocytes are generally stable in human pregnancies but CD3 methylation is associated with perinatal psychiatric symptoms","volume":"3","author":"Robakis","year":"2020","journal-title":"Brain behavior Immun - Health"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10598","article-title":"Association of downregulated HDAC 2 with the impaired mitochondrial function and cytokine secretion in the monocytes\/macrophages from gestational diabetes mellitus patients","volume":"40","author":"Qu","year":"2016","journal-title":"Cell Biol Int"},{"key":"B144","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s13148-018-0508-x","article-title":"H3K27 acetylation and gene expression analysis reveals differences in placental chromatin activity in fetal growth restriction","volume":"10","author":"Paauw","year":"2018","journal-title":"Clin Epigenet"},{"key":"B145","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1038\/s41467-022-28657-2","article-title":"Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling","volume":"13","author":"Liu","year":"2022","journal-title":"Nat Commun"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"B147","doi-asserted-by":"publisher","first-page":"101456","DOI":"10.1016\/j.jbc.2021.101456","article-title":"A proteomic atlas of ligand-receptor interactions at the ovine maternal-fetal interface reveals the role of histone lactylation in uterine remodeling","volume":"298","author":"Yang","year":"2022","journal-title":"J Biol Chem"},{"key":"B148","doi-asserted-by":"publisher","first-page":"5602","DOI":"10.1038\/s41467-024-49930-6","article-title":"KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2","volume":"15","author":"Bi","year":"2024","journal-title":"Nat Commun"},{"key":"B149","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/s41420-022-01284-y","article-title":"Elevated histone demethylase KDM5C increases recurrent miscarriage risk by preventing trophoblast proliferation and invasion","volume":"8","author":"Xiao","year":"2022","journal-title":"Cell Death Discovery"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.3390\/biom12050707","article-title":"Gal-2 increases H3K4me(3) and H3K9ac in trophoblasts and preeclampsia","volume":"12","author":"Hahn","year":"2022","journal-title":"Biomolecules"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212469","article-title":"Regulation of epigenetic modifications in the placenta during preeclampsia: PPAR\u03b3 Influences H3K4me3 and H3K9ac in extravillous trophoblast cells","volume":"22","author":"Meister","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B152","doi-asserted-by":"publisher","first-page":"106981","DOI":"10.1016\/j.intimp.2020.106981","article-title":"Exosomes released from decidual macrophages deliver miR-153-3p, which inhibits trophoblastic biological behavior in unexplained recurrent spontaneous abortion","volume":"88","author":"Ying","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"B153","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/mrd.23649","article-title":"Effect and mechanism of microRNA-515-5p in proliferation and apoptosis of trophoblast cells in preeclampsia via manipulating histone deacetylase 2","volume":"90","author":"Zhang","year":"2023","journal-title":"Mol Reprod Dev"},{"key":"B154","doi-asserted-by":"publisher","first-page":"118358","DOI":"10.1016\/j.lfs.2020.118358","article-title":"Elevated miR-23a impairs trophoblast migration and invasiveness through HDAC2 inhibition and NF-\u03baB activation","volume":"261","author":"Fan","year":"2020","journal-title":"Life Sci"},{"key":"B155","doi-asserted-by":"publisher","first-page":"108805","DOI":"10.1016\/j.biopha.2019.108805","article-title":"Histone deacetylase 6 negatively regulated microRNA-199a-5p induces the occurrence of preeclampsia by targeting VEGFA in vitro","volume":"114","author":"Mei","year":"2019","journal-title":"Biomed pharmacother = Biomed pharmacotherapie"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002595","article-title":"Emerging role of miRNAs, lncRNAs, and circRNAs in pregnancy-associated diseases","volume":"136","author":"Fu","year":"2023","journal-title":"Chin Med J"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.10.016","article-title":"Upregulation of METTL3 expression and m6A RNA methylation in placental trophoblasts in preeclampsia","volume":"103","author":"Gu","year":"2021","journal-title":"Placenta"},{"key":"B158","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.placenta.2022.05.008","article-title":"Upregulation of METTL14 contributes to trophoblast dysfunction by elevating FOXO3a expression in an m(6)A-dependent manner","volume":"124","author":"Fan","year":"2022","journal-title":"Placenta"},{"key":"B159","doi-asserted-by":"publisher","first-page":"24357","DOI":"10.1038\/s41598-021-03662-5","article-title":"circRNA N6-methyladenosine methylation in preeclampsia and the potential role of N6-methyladenosine-modified circPAPPA2 in trophoblast invasion","volume":"11","author":"Zhang","year":"2021","journal-title":"Sci Rep"},{"key":"B160","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s10020-023-00615-8","article-title":"RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4","volume":"29","author":"Fang","year":"2023","journal-title":"Mol Med (Cambridge Mass.)"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.894810","article-title":"METTL3-mediated m(6)A RNA methylation of ZBTB4 interferes with trophoblast invasion and maybe involved in RSA","volume":"10","author":"Huang","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1164706","article-title":"N6-methyladenosine modifications in maternal-fetal crosstalk and gestational diseases","volume":"11","author":"Wu","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.646326","article-title":"Placenta-derived microRNAs in the pathophysiology of human pregnancy","volume":"9","author":"Xu","year":"2021","journal-title":"Front Cell Dev Biol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1549839\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T05:14:04Z","timestamp":1743657244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1549839\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,3]]},"references-count":163,"alternative-id":["10.3389\/fimmu.2025.1549839"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1549839","relation":{"has-part":[{"id-type":"doi","id":"https:\/\/doi.org\/10.3389\/fimmu.2025.1549839.s001","asserted-by":"subject"}]},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,3]]},"article-number":"1549839"}}