{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:58:17Z","timestamp":1753891097909,"version":"3.41.2"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Central diabetes insipidus secondary to hypophysitis in eosinophilic granulomatosis with polyangiitis (EGPA) is very rare, and this article summarizes one case reported from our site as well as two previously reported patients with EGPA, both of whom had central diabetes insipidus, suggesting that new, rare organ involvement (pituitary gland) may occur in the early stages of EGPA or years later. The aim is to improve our understanding of central diabetes insipidus caused by EGPA involving the pituitary gland and avoid misdiagnosis or missed diagnosis.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1557555","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T05:22:45Z","timestamp":1749187365000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pituitary dysfunction with eosinophilic granulomatosis with polyangiitis presenting with diabetes insipidus: a case report and review of the literature"],"prefix":"10.3389","volume":"16","author":[{"given":"Aifei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengjia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longyan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiashun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2009.02.004","article-title":"Churg-Strauss angiitis","volume":"23","author":"Sinico","year":"2009","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2016-134148","article-title":"Diabetes insipidus induced by suspected eosinophilic granulomatous with polyangiitis","volume":"93","author":"Xie","year":"2017","journal-title":"Postgrad Med J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"17562864231182519","DOI":"10.1177\/17562864231182519","article-title":"Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis","volume":"16","author":"Chen","year":"2023","journal-title":"Ther Adv Neurol Disord"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/art.21250","article-title":"Prevalence and clinical significance of antineutrophil cytoplasmic antibodies in Churg-Strauss syndrome","volume":"52","author":"Sinico","year":"2005","journal-title":"Arthritis Rheum"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.05.004","article-title":"Churg-Strauss syndrome in childhood: a systematic literature review and clinical comparison with adult patients","volume":"39","author":"Zwerina","year":"2009","journal-title":"Semin Arthritis Rheumatol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.07.007","article-title":"Central nervous system involvement in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): Report of 26 patients and review of the literature","volume":"16","author":"Andr\u00e9","year":"2017","journal-title":"Autoimmun Rev"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/art.37721","article-title":"Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): clinical characteristics and long-term followup of the 383 patients enrolled in the French Vasculitis Study Group cohort","volume":"65","author":"Comarmond","year":"2013","journal-title":"Arthritis Rheum"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-9-200511010-00006","article-title":"Antineutrophil cytoplasmic antibodies and the Churg-Strauss syndrome","volume":"143","author":"Sabl\u00e9-Fourtassou","year":"2005","journal-title":"Ann Intern Med"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.98","article-title":"Eosinophils in vasculitis: characteristics and roles in pathogenesis","volume":"10","author":"Khoury","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s13023-021-01780-x","article-title":"Clinical features of central nervous system involvement in patients with eosinophilic granulomatosis with polyangiitis: a retrospective cohort study in China","volume":"16","author":"Liu","year":"2021","journal-title":"Orphanet J Rare Dis"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13233","article-title":"New developments and concepts in the diagnosis and management of diabetes insipidus (AVP-deficiency and resistance)","volume":"35","author":"Angelousi","year":"2023","journal-title":"J Neuroendocrinol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1962","article-title":"Pituitary dysfunction in granulomatosis with polyangiitis: the Mayo Clinic experience","volume":"99","author":"Kapoor","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"B13","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1007\/s11102-017-0811-0","article-title":"Pituitary dysfunction in granulomatosis with polyangiitis","volume":"20","author":"Esposito","year":"2017","journal-title":"Pituitary"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-023-00886-5","article-title":"Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement","volume":"19","author":"Petersenn","year":"2023","journal-title":"Nat Rev Endocrinol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-023-00958-w","article-title":"Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis","volume":"19","author":"Emmi","year":"2023","journal-title":"Nat Rev Rheumatol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/00005792-199601000-00003","article-title":"Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study in 342 patients","volume":"75","author":"Guillevin","year":"1996","journal-title":"Med (Baltimore)"},{"key":"B17","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/MD.0b013e318205a4c6","article-title":"The Five-Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohort","volume":"90","author":"Guillevin","year":"2011","journal-title":"Med (Baltimore)"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1191\/096120301671376017","article-title":"Cyclophosphamide for the treatment of systemic lupus erythematosus","volume":"10","author":"Takada","year":"2001","journal-title":"Lupus"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1557555\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T05:22:45Z","timestamp":1749187365000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1557555\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,6]]},"references-count":18,"alternative-id":["10.3389\/fimmu.2025.1557555"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1557555","relation":{},"ISSN":["1664-3224"],"issn-type":[{"type":"electronic","value":"1664-3224"}],"subject":[],"published":{"date-parts":[[2025,6,6]]},"article-number":"1557555"}}