{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:39:25Z","timestamp":1793212765774,"version":"4.5.0"},"reference-count":105,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lung adenocarcinoma (LUAD) is a major subtype of lung cancer and one of the deadliest cancers in humans. Dysregulation of miRNA activity in tumor-associated neutrophils (TANs) in the tumor microenvironment plays an important role in the occurrence and development of LUAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      In this study, the miReact algorithm was used to analyze the single-cell RNA sequencing data of LUAD samples to reveal the miRNA profile characteristics of TANs in LUAD patients. The function of miR-941 was investigated\n                      <jats:italic>in vivo<\/jats:italic>\n                      and\n                      <jats:italic>in vitro<\/jats:italic>\n                      . The target gene and underlying signaling pathway of miR-941 were predicted and validated with qPCR, luciferase assay, WB and ELISA assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results indicated the crucial role of TANs, especially N2-TANs in LUAD and miR-941 activity was significantly upregulated in TANs of LUAD patients. MiR-941 overexpression promoted the proliferation, invasion, migration and anti-apoptosis of A549 and H1299.\n                      <jats:italic>In vivo<\/jats:italic>\n                      xenograft mouse model confirmed that miR-941 overexpression enhanced the growth of tumors formed by H1299 cells. Bioinformatics analysis showed that miR-941 targeted the tumor suppressor gene FOXN4, and we confirmed that FOXN4 overexpression could counteract the malignant effects of miR-941. In addition, miR-941 may drive LUAD progression through the FOXN4\/TGF-\u03b2 feedback signaling loop and participate in the N2-TAN polarization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In summary, these findings reveal the key role of N2-TANs and the miR-941\/FOXN4\/TGF-\u03b2 signaling loop in LUAD progression and provide potential therapeutic targets for future interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2025.1561081","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T01:23:18Z","timestamp":1745544198000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["The miR-941\/FOXN4\/TGF-\u03b2 feedback loop induces N2 polarization of neutrophils and enhances tumor progression of lung adenocarcinoma"],"prefix":"10.3389","volume":"16","author":[{"given":"Xiaojing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xitong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peibin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanfang","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dazhong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongbo","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zisheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2023.01.006","article-title":"Artificial intelligence in lung cancer diagnosis and prognosis: Current application and future perspective","volume":"89","author":"Huang","year":"2023","journal-title":"Semin Cancer Biol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2024.05.026","article-title":"The proposed ninth edition TNM classification of lung cancer","volume":"166","author":"Detterbeck","year":"2024","journal-title":"Chest"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.v42.10","article-title":"Non-small cell lung cancer in China","volume":"42","author":"Chen","year":"2022","journal-title":"Cancer Commun (Lond)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/ncb3286","article-title":"Isoform diversity in the Arp2\/3 complex determines actin filament dyna mics","volume":"18","author":"Abella","year":"2016","journal-title":"Nat Cell Biol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"100915","DOI":"10.1016\/j.drup.2022.100915","article-title":"Exosomal LOC85009 inhibits docetaxel resistance in lung adenocarcinoma through regulating ATG5-induced autophagy","volume":"67","author":"Yu","year":"2023","journal-title":"Drug Resist Updat"},{"key":"B6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12943-023-01924-6","article-title":"Aberrant R-loop-mediated immune evasion, cellular communication, and metabolic reprogramming affect cancer progression: a single-cell analysis","volume":"23","author":"Zhang","year":"2024","journal-title":"Mol Cancer"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-010008","article-title":"Leveraging mitochondrial-programmed cell death dynamics to enhance prognostic accuracy and immunotherapy efficacy in lung adenocarcinoma","volume":"12","author":"Zhang","year":"2024","journal-title":"J IO Cancer"},{"key":"B8","doi-asserted-by":"publisher","first-page":"113043","DOI":"10.1016\/j.intimp.2024.113043","article-title":"DUS4L suppresses invasion and metastasis in LUAD via modulation of PI3K\/AKT and ERK\/MAPK signaling through GRB2","volume":"142","author":"Li","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"217153","DOI":"10.1016\/j.canlet.2024.217153","article-title":"TGF-\u03b2-induced lncRNA TBUR1 promotes EMT and metastasis in lung adenocarcinoma via hnRNPC-mediated GRB2 mRNA stabilization","volume":"600","author":"Huang","year":"2024","journal-title":"Cancer Lett"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.05.010","article-title":"Molecular subtyping of small cell lung cancer","volume":"86","author":"Liang","year":"2022","journal-title":"Semin Cancer Biol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-04686-2","article-title":"Low diffusion capacity predicts poor prognosis in extensive stage small cell lung cancer: a single-center analysis of 10 years","volume":"149","author":"Kim","year":"2023","journal-title":"J\u00a0Cancer Res Clin Oncol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.960738","article-title":"Prediction of prognosis, immunogenicity and efficacy of immunotherapy based on glutamine metabolism in lung adenocarcinoma","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"107402","DOI":"10.1016\/j.compbiomed.2023.107402","article-title":"Identification of a disulfidptosis-related genes signature for prognostic implication in lung adenocarcinoma","volume":"165","author":"Huang","year":"2023","journal-title":"Comput Biol Med"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1366096","article-title":"Integrative single-cell analysis of LUAD: Elucidating immune cell dynamics and prognostic modeling based on exhausted CD8+ T cells","volume":"15","author":"Zhang","year":"2024","journal-title":"Front Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41568-018-0081-9","article-title":"The lung microenvironment: an important regulator of tumour growth and metastasis","volume":"19","author":"Altorki","year":"2019","journal-title":"Nat Rev Cancer"},{"key":"B16","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12943-015-0302-8","article-title":"MicroRNA modulators of epigenetic regulation, the tumor microenvironment and the immune system in lung cancer","volume":"14","author":"Rusek","year":"2015","journal-title":"Mol Cancer"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2013.10.001","article-title":"The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets","volume":"40","author":"Wood","year":"2014","journal-title":"Cancer Treat Rev"},{"key":"B18","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.it.2018.11.006","article-title":"Therapeutic epigenetic reprogramming of trained immunity in myeloid cells","volume":"40","author":"Rodriguez","year":"2019","journal-title":"Trends Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"107500","DOI":"10.1016\/j.pharmthera.2020.107500","article-title":"Targeting defective pulmonary innate immunity - A new therapeutic option","volume":"209","author":"Belchamber","year":"2020","journal-title":"Pharmacol Ther"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01395","article-title":"Innate immune defense mechanisms by myeloid cells that hamper cancer immunotherapy","volume":"11","author":"Lebegge","year":"2020","journal-title":"Front Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01977","article-title":"Turn back the TIMe: Targeting tumor infiltrating myeloid cells to revert cancer progression","volume":"9","author":"Awad","year":"2018","journal-title":"Front Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.cell.2021.01.010","article-title":"A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells","volume":"184","author":"Cheng","year":"2021","journal-title":"Cell"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2939","article-title":"Molecular pathways: Tumor-infiltrating myeloid cells and reactive oxygen species in regulation of tumor microenvironment","volume":"18","author":"Lu","year":"2012","journal-title":"Clin Cancer Res"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00787-0","article-title":"Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases","volume":"23","author":"Wigerblad","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00832-3","article-title":"Neutrophils in chronic inflammatory diseases","volume":"19","author":"Herrero-Cervera","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"106231","DOI":"10.1016\/j.biocel.2022.106231","article-title":"The role of neutrophils in antibody-driven autoimmune cytopenias","volume":"147","author":"Kr\u00e9mer","year":"2022","journal-title":"Int J Biochem Cell Biol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00571-6","article-title":"Neutrophils in cancer: Heterogeneous and multifaceted","volume":"22","author":"Hedrick","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"188762","DOI":"10.1016\/j.bbcan.2022.188762","article-title":"Tumor-associated neutrophils and neutrophil-targeted cancer therapies","volume":"1877","author":"Que","year":"2022","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B29","doi-asserted-by":"publisher","first-page":"104576","DOI":"10.1016\/j.cellimm.2022.104576","article-title":"Neutrophils in the tumor microenvironment and their functional modulation by mesenchymal stromal cells","volume":"379","author":"Zheng","year":"2022","journal-title":"Cell Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/procel\/pwac045","article-title":"A YAP\/TAZ-CD54 axis is required for CXCR2-CD44- tumor-specific neutrophils to suppress gastric cancer","volume":"14","author":"Nie","year":"2023","journal-title":"Protein Cell"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325272","article-title":"Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6\/AXL signalling axis","volume":"71","author":"Bellomo","year":"2022","journal-title":"Gut"},{"key":"B32","doi-asserted-by":"publisher","first-page":"106996","DOI":"10.1016\/j.phrs.2023.106996","article-title":"Neutrophils as potential therapeutic targets for breast cancer","volume":"198","author":"Gong","year":"2023","journal-title":"Pharmacol Res"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00568-5","article-title":"Neutrophils as potential therapeutic targets in hepatocellular carcinoma","volume":"19","author":"Geh","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105631","article-title":"Remodeling tumor-associated neutrophils to enhance dendritic cell-based HCC neoantigen nano-vaccine efficiency","volume":"9","author":"Wang","year":"2022","journal-title":"Adv Sci (Weinh)"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-2870","article-title":"GLUT1 expression in tumor-associated neutrophils promotes lung cancer growth and resistance to radiotherapy","volume":"81","author":"Ancey","year":"2021","journal-title":"Cancer Res"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.06.017","article-title":"Polarization of tumor-associated neutrophil phenotype by TGF-beta: \u201cN1 \u201c versus \u201cN2\u201d TAN","volume":"16","author":"Fridlender","year":"2009","journal-title":"Cancer Cell"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1038\/s41467-023-37515-8","article-title":"Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma","volume":"14","author":"Chung","year":"2023","journal-title":"Nat Commun"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1155","article-title":"Multiplex immunofluorescence and single-cell transcriptomic profiling reveal the spatial cell interaction networks in the non-small cell lun g cancer microenvironment","volume":"13","author":"Peng","year":"2023","journal-title":"Clin Trans Med"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1340","article-title":"Cellular dynamics in tumour microenvironment along with lung cancer pr ogression underscore spatial and evolutionary heterogeneity of neutrop hil","volume":"13","author":"Peng","year":"2023","journal-title":"Clin Trans Med"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3166","article-title":"Epigenetics and genetics. MicroRNAs en route to the clinic: Progress in validating and targeting microRNAs for cancer therapy","volume":"11","author":"Kasinski","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"B41","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrg2936","article-title":"Gene silencing by microRNAs: Contributions of translational repression and mRNA decay","volume":"12","author":"Huntzinger","year":"2011","journal-title":"Nat Rev Genet"},{"key":"B42","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s12943-017-0710-z","article-title":"MicroRNA-218 functions as a tumor suppressor in lung cancer by targeting IL-6\/STAT3 and negatively correlates with poor prognosis","volume":"16","author":"Yang","year":"2017","journal-title":"Mol Cancer"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-017-0393-7","article-title":"Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer","volume":"8","author":"Gu","year":"2017","journal-title":"Protein Cell"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.32604\/or.2023.044491","article-title":"miR-125b reverses cisplatin resistance by regulating autophagy via targeting RORA\/BNIP3L axis in lung adenocarcinoma","volume":"32","author":"Liu","year":"2024","journal-title":"Oncol Res"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.32604\/or.2023.030293","article-title":"MicroRNA (let-7b-5p)-targeted DARS2 regulates lung adenocarcinoma growth by PI3K\/AKT signaling pathway","volume":"32","author":"Xu","year":"2024","journal-title":"Oncol Res"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.3390\/vaccines11061028","article-title":"Neutrophils in cancer and potential therapeutic strategies using neutr ophil-derived exosomes","volume":"11","author":"Dutta","year":"2023","journal-title":"Vaccines"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02322-w","article-title":"Exosomal miR-4466 from nicotine-activated neutrophils promotes tumor c ell stemness and metabolism in lung cancer metastasis","volume":"41","author":"Tyagi","year":"2022","journal-title":"Oncogene"},{"key":"B48","doi-asserted-by":"publisher","first-page":"9170","DOI":"10.1038\/s41598-021-88480-5","article-title":"miRNA activity inferred from single cell mRNA expression","volume":"11","author":"Nielsen","year":"2021","journal-title":"Sci Rep"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3690","article-title":"Single-cell transcriptome analysis reveals heterogeneity of neutrophils in non-small cell lung cancer","volume":"26","author":"Yunzhen","year":"2024","journal-title":"J Gene Med"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00159","article-title":"Insights into lung cancer immune-based biology, prevention, and treatment","volume":"11","author":"Saab","year":"2020","journal-title":"Front Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-019-02461-2","article-title":"The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer","volume":"69","author":"Patel","year":"2020","journal-title":"Cancer Immunol Immunother"},{"key":"B52","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12943-016-0551-1","article-title":"Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis","volume":"15","author":"Marshall","year":"2016","journal-title":"Mol Cancer"},{"key":"B53","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/path.5241","article-title":"The innate immune architecture of lung tumors and its implication in disease progression","volume":"247","author":"Milette","year":"2019","journal-title":"J Pathol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/j.immuni.2019.03.009","article-title":"Single-cell transcriptomics of human and mouse lung cancers reveals conserved\u00a0myeloid populations across individuals and species","volume":"50","author":"Zilionis","year":"2019","journal-title":"Immunity"},{"key":"B55","doi-asserted-by":"publisher","first-page":"3578","DOI":"10.1038\/s41467-019-11452-x","article-title":"Proteogenomic landscape of squamous cell lung cancer","volume":"10","author":"Stewart","year":"2019","journal-title":"Nat Commun"},{"key":"B56","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/s41568-020-0281-y","article-title":"Neutrophil diversity and plasticity in tumour progression and therapy. Nature reviews","volume":"20","author":"Jaillon","year":"2020","journal-title":"Cancer"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.4771","article-title":"Association of the lung immune prognostic index with immune checkpoint inhibitor outcomes in patients with advanced non-small cell lung cancer","volume":"4","author":"Mezquita","year":"2018","journal-title":"JAMA Oncol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx462","article-title":"Nomograms predict overall survival for patients with small-cell lung cancer incorporating pretreatment peripheral blood markers","volume":"10","author":"Xie","year":"2015","journal-title":"J Thorac Oncol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.jtho.2018.01.026","article-title":"Peripheral blood biomarkers associated with clinical outcome in non-small cell lung cancer patients treated with nivolumab","volume":"13","author":"Tanizaki","year":"2018","journal-title":"J Thorac Oncol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000617","article-title":"Prognostic impact of immune microenvironment in lung squamous cell carcinoma: Tumor-infiltrating CD10+ Neutrophil\/CD20+ Lymphocyte ratio as an independent prognostic factor","volume":"10","author":"Kadota","year":"2015","journal-title":"J Thorac Oncol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2013.02.001","article-title":"Immunomonitoring and prognostic relevance of neutrophils in clinical trials","volume":"23","author":"Donskov","year":"2013","journal-title":"Semin Cancer Biol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1007\/s00262-017-1976-0","article-title":"Phenotype and function of tumor-associated neutrophils and their subsets in early-stage human lung cancer","volume":"66","author":"Eruslanov","year":"2017","journal-title":"Cancer Immunol Immunother"},{"key":"B63","doi-asserted-by":"publisher","first-page":"4387","DOI":"10.1038\/s41467-020-18125-0","article-title":"Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status","volume":"11","author":"Li","year":"2020","journal-title":"Nat Commun"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77053","article-title":"Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer","volume":"124","author":"Eruslanov","year":"2014","journal-title":"J Clin Invest"},{"key":"B65","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/s41467-020-20733-9","article-title":"Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung","volume":"12","author":"Tyagi","year":"2021","journal-title":"Nat Commun"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2558","article-title":"Neutrophils promote aerogenous spread of lung adenocarcinoma with bronchioloalveolar carcinoma features","volume":"13","author":"Wislez","year":"2007","journal-title":"Clin Cancer Res"},{"key":"B67","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/1476-4598-12-154","article-title":"Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase","volume":"12","author":"Gong","year":"2013","journal-title":"Mol Cancer"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0520","article-title":"Loss of SMAD4 promotes lung metastasis of colorectal cancer by accumulation of CCR1+ Tumor-associated neutrophils through CCL15-CCR1 axis","volume":"23","author":"Yamamoto","year":"2017","journal-title":"Clin Cancer Res"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0783-5","article-title":"Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis","volume":"21","author":"Li","year":"2020","journal-title":"Nat Immunol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/nature16140","article-title":"Neutrophils support lung colonization of metastasis-initiating breast cancer cells","volume":"528","author":"Wculek","year":"2015","journal-title":"Nature"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.06.001","article-title":"Origin and role of a subset of tumor-associated neutrophils with antigen-presenting cell features in early-stage human lung cancer","volume":"30","author":"Singhal","year":"2016","journal-title":"Cancer Cell"},{"key":"B72","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12943-021-01355-1","article-title":"Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin","volume":"20","author":"Cheng","year":"2021","journal-title":"Mol Cancer"},{"key":"B73","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.ccell.2020.12.012","article-title":"Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation","volume":"39","author":"Xiao","year":"2021","journal-title":"Cancer Cell"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202002739","article-title":"Targeting neutrophils for enhanced cancer theranostics","volume":"32","author":"Tang","year":"2020","journal-title":"Adv Mater"},{"key":"B75","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1186\/s13287-024-03882-2","article-title":"Xenogenous implanted dental follicle stem cells promote periodontal re generation through inducing the N2 phenotype of neutrophils","volume":"15","author":"Liu","year":"2024","journal-title":"Stem Cell Res Ther"},{"key":"B76","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s12943-024-02116-6","article-title":"Exosomal miR-4745-5p\/3911 from N2-polarized tumor-associated neutrophi ls promotes gastric cancer metastasis by regulating SLIT2","volume":"23","author":"Zhang","year":"2024","journal-title":"Mol Cancer"},{"key":"B77","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s12943-020-01235-0","article-title":"Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p\/miR-506-3p- TGF-\u03b21 axis","volume":"19","author":"Shang","year":"2020","journal-title":"Mol Cancer"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2019.11.019","article-title":"Circulating microRNAs predict the response to anti-PD-1 therapy in non-small cell lung cancer","volume":"112","author":"Fan","year":"2020","journal-title":"Genomics"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.05.022","article-title":"Circulating microRNAs and extracellular vesicle-containing microRNAs as response biomarkers of anti-programmed cell death protein 1 or programmed death-ligand 1 therapy in NSCLC","volume":"15","author":"Shukuya","year":"2020","journal-title":"J Thorac Oncol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.08.013","article-title":"Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21","volume":"18","author":"Hatley","year":"2010","journal-title":"Cancer Cell"},{"key":"B81","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ccr.2012.11.019","article-title":"Suppression of miRNA-708 by polycomb group promotes metastases by calcium-induced cell migration","volume":"23","author":"Ryu","year":"2013","journal-title":"Cancer Cell"},{"key":"B82","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.molcel.2013.08.017","article-title":"Circular intronic long noncoding RNAs","volume":"51","author":"Zhang","year":"2013","journal-title":"Mol Cell"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2024","article-title":"miR-9, a MYC\/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis","volume":"12","author":"Ma","year":"2010","journal-title":"Nat Cell Biol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1158\/2159-8290.CD-15-0854","article-title":"Stromal expression of miR-143\/145 promotes neoangiogenesis in lung cancer development","volume":"6","author":"Dimitrova","year":"2016","journal-title":"Cancer Discov"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.4134","article-title":"Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma","volume":"27","author":"Lebanony","year":"2009","journal-title":"J Clin Oncol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.0001","article-title":"Evaluating the use of circulating microRNA profiles for lung cancer detection in symptomatic patients","volume":"6","author":"Fehlmann","year":"2020","journal-title":"JAMA Oncol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2011.147","article-title":"Nanopore-based detection of circulating microRNAs in lung cancer patients","volume":"6","author":"Wang","year":"2011","journal-title":"Nat Nanotechnol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.9342","article-title":"Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer","volume":"28","author":"Hu","year":"2010","journal-title":"J Clin Oncol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.01.025","article-title":"Unique microRNA molecular profiles in lung cancer diagnosis and prognosis","volume":"9","author":"Yanaihara","year":"2006","journal-title":"Cancer Cell"},{"key":"B90","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ccr.2007.12.008","article-title":"MicroRNA signature predicts survival and relapse in lung cancer","volume":"13","author":"Yu","year":"2008","journal-title":"Cancer Cell"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.v144.11","article-title":"Circulating mir-320a promotes immunosuppressive macrophages M2 phenotype associated with lung cancer risk","volume":"144","author":"Fortunato","year":"2019","journal-title":"Int J Cancer"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-14-0448","article-title":"miR141-CXCL1-CXCR2 signaling-induced Treg recruitment regulates metastases and survival of non-small cell lung cancer","volume":"13","author":"Lv","year":"2014","journal-title":"Mol Cancer Ther"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2016.08.005","article-title":"Autophagy inhibition upregulates CD4(+) tumor infiltrating lymphocyte expression via miR-155 regulation and TRAIL activation","volume":"10","author":"Zarogoulidis","year":"2016","journal-title":"Mol Oncol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.03.005","article-title":"Serum miR-338-3p and miR-199b-5p are associated with the absolute neutrophil count in patients with resectable pancreatic cancer","volume":"505","author":"van der Sijde","year":"2020","journal-title":"Clin Chim Acta"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30630","article-title":"A positive feedback loop between cancer stem-like cells and tumor-associated neutrophils controls hepatocellular carcinoma progression","volume":"70","author":"Zhou","year":"2019","journal-title":"Hepatology"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.10070275","article-title":"MiR-125a Is a critical modulator for neutrophil development","volume":"13","author":"Qin","year":"2017","journal-title":"PLoS Genet"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.7150\/jca.45394","article-title":"Serum Exosomal miR-941 as a promising Oncogenic Biomarker for Laryngeal Squamous Cell Carcinoma","volume":"11","author":"Zhao","year":"2020","journal-title":"J Cancer"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.567818","article-title":"DNA methylation-mediated repression of miR-941 enhances lysine (K)-specific demethylase 6B expression in hepatoma cells","volume":"289","author":"Zhang","year":"2014","journal-title":"J Biol Chem"},{"key":"B99","doi-asserted-by":"publisher","first-page":"17954","DOI":"10.1038\/s41598-020-74847-7","article-title":"MicroRNA-941 regulates the proliferation of breast cancer cells by altering histone H3 Ser 10 phosphorylation","volume":"10","author":"Surapaneni","year":"2020","journal-title":"Sci Rep"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v12.i10.1195","article-title":"Blood exosomal micro ribonucleic acid profiling reveals the complexity of hepatocellular carcinoma and identifies potential biomarkers for differential diagnosis","volume":"12","author":"Sheng","year":"2020","journal-title":"World J Gastrointest Oncol"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2017_602","article-title":"Screening key miRNAs for human hepatocellular carcinoma based on miRNA-mRNA functional synergistic network","volume":"64","author":"Zhang","year":"2017","journal-title":"Neoplasma"},{"key":"B102","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2147\/PGPM.S283414","article-title":"Identification of four genes as prognosis signatures in lung adenocarcinoma microenvironment","volume":"14","author":"Yao","year":"2021","journal-title":"Pharmgenomics Pers Med"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2016.10.007","article-title":"Sec8 modulates TGF-\u03b2 induced EMT by controlling N-cadherin via regulat ion of Smad3\/4","volume":"29","author":"Tanaka","year":"2017","journal-title":"Cell Signal"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64464-1","article-title":"Differential expression of the epithelial-mesenchymal transition regul ators snail, SIP1, and twist in gastric cancer","volume":"161","author":"Rosivatz","year":"2002","journal-title":"Am J Pathol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.06.017","article-title":"Polarization of tumor-associated neutrophil phenotype by TGF-beta: \u201cN1\u201d versus \u201cN2\u201d TAN","volume":"16","author":"Fridlender","year":"2009","journal-title":"Cancer Cell"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1561081\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T01:23:19Z","timestamp":1745544199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1561081\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":105,"alternative-id":["10.3389\/fimmu.2025.1561081"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1561081","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"article-number":"1561081"}}