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Meanwhile, the major cytokine secretion function and the correlation between Breg and Treg or other immune checkpoints to balance the immune responses are addressed. Furthermore, we summarized the intrinsic and extrinsic pathways or costimulatory stimuli for the differentiation from na\u00efve B cells. More importantly, we summarized the progression of the immune tolerance induction role of Breg in solid organ (kidney, liver, heart, lung, and islet) transplantation. This is an up-to-date review from the origin of Breg to the function of Breg in solid organ transplantation and how it induces immune tolerance in both murine models and human solid organ transplantation.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1561171","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T07:10:35Z","timestamp":1744096235000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Regulatory B cells, the key regulator to induce immune tolerance in organ 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