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However, the responsiveness of pDCs from SLE patients to stimuli that produce IFN\u03b1 differs depending on the type of TLR pathway involved. In addition to pDCs, monocytes from SLE patients were found to produce IFN\u03b1 when responding to the cGAS-STING pathway. Here, we outline the major pathways that induce IFN\u03b1 production by myeloid cells in SLE, and the possible mechanisms by which IFN\u03b1 overproduction occurs by these cells. Finally, we discuss the current and future therapeutic strategies to regulate IFN\u03b1 production in patients with SLE.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1562221","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T05:26:01Z","timestamp":1752729961000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Myeloid cells as IFN\u03b1 producers in systemic lupus 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