{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T13:21:07Z","timestamp":1794057667092,"version":"4.8.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>IgG4-related disease (IgG4-RD), an immune-mediated fibroinflammatory disorder, has few reports in combination with monoclonal gammopathy of undetermined significance (MGUS). Herein, we present a case of a 69-year-old woman with manifestations of left orbital occupation and visual acuity decline. Ancillary tests indicated persistent positivity of IgG4 antibody, and IgG4-RD-related ophthalmopathy was diagnosed based on the criteria. Concurrently, serum protein electrophoresis revealed an M protein level of 12.23 g\/L. Immunofixation electrophoresis suggested a positive IgG \u03bb-type M protein, and MGUS was diagnosed in conjunction with bone marrow smear and flow cytometry.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1565388","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T04:13:15Z","timestamp":1747023195000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined 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