{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:55:12Z","timestamp":1793912112042,"version":"4.8.0"},"reference-count":109,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Periodontitis is a common dysbiotic bacteria-induced inflammatory disease characterized by alveolar bone resorption, leading to tooth loss. Interleukin-17 (IL-17) is a critical cytokine with dual roles in periodontium, which exerts the function of host defense, including neutrophil recruitment, phagocytosis, and mucosal immunity. However, excessive expression of IL-17 causes persistent chronic inflammation, local tissue breakdown, and bone loss. This review highlights the protective and pathological functions of IL-17 on immunity and bone homeostasis in inflammatory bone-related diseases. We also provide the latest findings with IL-17 knockout mice in periodontitis and highlight complex immune responses under various experimental models. This may provide a critical perception of inflammatory bone-related disease management using an immune-modulating strategy.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1578635","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:12:55Z","timestamp":1743639175000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":37,"title":["The dual role of IL-17 in periodontitis regulating immunity and bone homeostasis"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhongyuan","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijian","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12539","article-title":"Modelling changes in clinical attachment loss to classify periodontal disease progression","volume":"43","author":"Teles","year":"2016","journal-title":"J Clin Periodontol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/jcpe.12827","article-title":"Patterns of periodontal disease progression based on linear mixed models of clinical attachment loss","volume":"45","author":"Teles","year":"2018","journal-title":"J Clin Periodontol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050020","article-title":"Periodontitis is associated with preeclampsia in pregnant women","volume":"77","author":"Contreras","year":"2006","journal-title":"J Periodontol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12233","article-title":"Effect of micronutrient malnutrition on periodontal disease and periodontal therapy","volume":"78","author":"Dommisch","year":"2018","journal-title":"Periodontol 2000"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12270","article-title":"Diabetes as a potential risk for periodontitis: association studies","volume":"83","author":"Genco","year":"2020","journal-title":"Periodontol 2000"},{"key":"B6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12344","article-title":"Clinical and public health implications of periodontal and systemic diseases: an overview","volume":"83","author":"Genco","year":"2020","journal-title":"Periodontol 2000"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12238","article-title":"Stress, allostatic load, and periodontal diseases","volume":"78","author":"Sabbah","year":"2018","journal-title":"Periodontol 2000"},{"key":"B8","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41577-022-00746-9","article-title":"Il-17 and il-17-producing cells in protection versus pathology","volume":"23","author":"Mills","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3742","article-title":"Interleukin 17 is a chief orchestrator of immunity","volume":"18","author":"Veldhoen","year":"2017","journal-title":"Nat Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41541-020-00270-8","article-title":"Suppression of mucosal th17 memory responses by acellular pertussis vaccines enhances nasal bordetella pertussis carriage","volume":"6","author":"Dubois","year":"2021","journal-title":"NPJ Vaccines"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1279837","article-title":"Interactions between neutrophils and T-helper 17 cells","volume":"14","author":"Fan","year":"2023","journal-title":"Front Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e20221751","DOI":"10.1084\/jem.20221751","article-title":"Neutrophil extracellular traps and extracellular histones potentiate il-17 inflammation in periodontitis","volume":"220","author":"Kim","year":"2023","journal-title":"J Exp Med"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1236856","article-title":"Targeting th17 cells: A promising strategy to treat oral mucosal inflammatory diseases","volume":"14","author":"Wang","year":"2023","journal-title":"Front Immunol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001432","article-title":"Local sustained delivery of anti-il-17a antibodies limits inflammatory bone loss in murine experimental periodontitis","volume":"206","author":"Pacheco","year":"2021","journal-title":"J Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0265486","article-title":"Interleukin-17 is disease promoting in early stages and protective in late stages of experimental periodontitis","volume":"17","author":"Wilharm","year":"2022","journal-title":"PloS One"},{"key":"B16","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12237","article-title":"Lifestyle and periodontitis: the emergence of personalized periodontics","volume":"78","author":"Bartold","year":"2018","journal-title":"Periodontol 2000"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.02.010","article-title":"Dancing with the stars: how choreographed bacterial interactions dictate nososymbiocity and give rise to keystone pathogens, accessory pathogens, and pathobionts","volume":"24","author":"Hajishengallis","year":"2016","journal-title":"Trends Microbiol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/prd.12362","article-title":"Microbial signatures of health, gingivitis, and periodontitis","volume":"86","author":"Abusleme","year":"2021","journal-title":"Periodontol 2000"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01679.x","article-title":"Has the use of molecular methods for the characterization of the human oral microbiome changed our understanding of the role of bacteria in the pathogenesis of periodontal disease","volume":"38","author":"Wade","year":"2011","journal-title":"J Clin Periodontol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J Clin Periodontol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512453589","article-title":"Porphyromonas gingivalis as a potential community activist for disease","volume":"91","author":"Darveau","year":"2012","journal-title":"J Dental Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nri2918","article-title":"Microbial manipulation of receptor crosstalk in innate immunity","volume":"11","author":"Hajishengallis","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24299","article-title":"Disruption of immune regulation by microbial pathogens and resulting chronic inflammation","volume":"228","author":"Barth","year":"2013","journal-title":"J Cell Physiol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.chom.2011.10.006","article-title":"Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement","volume":"10","author":"Hajishengallis","year":"2011","journal-title":"Cell Host Microbe"},{"key":"B25","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.jaut.2012.03.003","article-title":"Porphyromonas gingivalis promotes th17 inducing pathways in chronic periodontitis","volume":"39","author":"Moutsopoulos","year":"2012","journal-title":"J Autoimmun"},{"key":"B26","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1189\/jlb.0512220","article-title":"Role of tlr2-dependent il-10 production in the inhibition of the initial ifn-\u0393 T cell response to porphyromonas gingivalis","volume":"93","author":"Gaddis","year":"2013","journal-title":"J Leukocyte Biol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070516","article-title":"Analysis of the activity to induce toll-like receptor (Tlr)2- and tlr4-mediated stimulation of supragingival plaque","volume":"79","author":"Yoshioka","year":"2008","journal-title":"J Periodontol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2873","article-title":"The keystone-pathogen hypothesis","volume":"10","author":"Hajishengallis","year":"2012","journal-title":"Nat Rev Microbiol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00340.x","article-title":"Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis","volume":"53","author":"Stabholz","year":"2010","journal-title":"Periodontol 2000"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019270108","article-title":"Signaling mechanisms in the restoration of impaired immune function due to diet-induced obesity","volume":"108","author":"Zhou","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"B31","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/j.1600-0757.2011.00415.x","article-title":"Genetic susceptibility to periodontitis","volume":"58","author":"Laine","year":"2012","journal-title":"Periodontol 2000"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt065","article-title":"Exploring the genetic basis of chronic periodontitis: A genome-wide association study","volume":"22","author":"Divaris","year":"2013","journal-title":"Hum Mol Genet"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2013.43.3.111","article-title":"Epigenetic biomarkers: A step forward for understanding periodontitis","volume":"43","author":"Lindroth","year":"2013","journal-title":"J Periodontal Implant Sci"},{"key":"B34","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.2041-1014.2009.00562.x","article-title":"Too old to fight? Aging and its toll on innate immunity","volume":"25","author":"Hajishengallis","year":"2010","journal-title":"Mol Oral Microbiol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2260","article-title":"The leukocyte integrin antagonist del-1 inhibits il-17-mediated inflammatory bone loss","volume":"13","author":"Eskan","year":"2012","journal-title":"Nat Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/prd.12146","article-title":"Molecular basis for immunohistochemical and inflammatory changes during progression of gingivitis to periodontitis","volume":"76","author":"Kurgan","year":"2018","journal-title":"Periodontol 2000"},{"key":"B37","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1177\/154405910508400102","article-title":"The junctional epithelium: from health to disease","volume":"84","author":"Bosshardt","year":"2005","journal-title":"J Dental Res"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01678.x","article-title":"How has neutrophil research improved our understanding of periodontal pathogenesis","volume":"38","author":"Nussbaum","year":"2011","journal-title":"J Clin Periodontol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"14574","DOI":"10.3390\/ijms232314574","article-title":"Il-6 and il-8: an overview of their roles in healthy and pathological pregnancies","volume":"23","author":"Viloti\u0107","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13634","article-title":"Role of cd14 in human disease","volume":"169","author":"Sharygin","year":"2023","journal-title":"Immunology"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05622-z","article-title":"Programming multicellular assembly with synthetic cell adhesion molecules","volume":"614","author":"Stevens","year":"2023","journal-title":"Nature"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmac032","article-title":"Defensins: defenders of human reproductive health","volume":"29","author":"Zhai","year":"2023","journal-title":"Hum Reprod Update"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.03.004","article-title":"Decoding toll-like receptors: recent insights and perspectives in innate immunity","volume":"57","author":"Kawai","year":"2024","journal-title":"Immunity"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1401399","article-title":"E-selectin in vascular pathophysiology","volume":"15","author":"Zhang","year":"2024","journal-title":"Front Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1038\/s41467-024-47553-5","article-title":"Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat Commun"},{"key":"B46","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41392-023-01620-3","article-title":"The il-17 family in diseases: from bench to bedside","volume":"8","author":"Huangfu","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.150.12.5445","article-title":"Ctla-8, cloned from an activated T cell, bearing au-rich messenger rna instability sequences, and homologous to a herpesvirus saimiri gene","volume":"150","author":"Rouvier","year":"1993","journal-title":"J Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1813","article-title":"Structural basis of receptor sharing by interleukin 17 cytokines","volume":"10","author":"Ely","year":"2009","journal-title":"Nat Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1365-2567.2011.03465.x","article-title":"The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases","volume":"134","author":"Pappu","year":"2011","journal-title":"Immunology"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041257","article-title":"Il-23 drives a pathogenic T cell population that induces autoimmune inflammation","volume":"201","author":"Langrish","year":"2005","journal-title":"J Exp Med"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.09.012","article-title":"Identification of a soluble isoform of human il-17ra generated by alternative splicing","volume":"64","author":"Sohda","year":"2013","journal-title":"Cytokine"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23963","article-title":"Il-23\/il-17 axis and soluble receptors isoforms sil-23r and sil-17ra in patients with rheumatoid arthritis-presenting periodontitis","volume":"35","author":"Rodr\u00edguez-Monta\u00f1o","year":"2021","journal-title":"J Clin Lab Anal"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-103019-085803","article-title":"In vivo cd4(+) T cell differentiation and function: revisiting the th1\/th2 paradigm","volume":"38","author":"Ruterbusch","year":"2020","journal-title":"Annu Rev Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"Tgfbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of il-17-producing T cells","volume":"24","author":"Veldhoen","year":"2006","journal-title":"Immunity"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/ni1496","article-title":"Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells","volume":"8","author":"Acosta-Rodriguez","year":"2007","journal-title":"Nat Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor rorgammat directs the differentiation program of proinflammatory il-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"key":"B57","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1016\/j.neuron.2021.06.015","article-title":"Il-23\/il-17a\/trpv1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice","volume":"109","author":"Luo","year":"2021","journal-title":"Neuron"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082580","article-title":"B cells contribute to heterogeneity of il-17 producing cells in rheumatoid arthritis and healthy controls","volume":"8","author":"Schlegel","year":"2013","journal-title":"PloS One"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbrc.2014.09.004","article-title":"Potential role of myeloid cell\/eosinophil-derived il-17 in lps-induced endotoxin shock","volume":"453","author":"Shimura","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/nature17655","article-title":"Normalizing the environment recapitulates adult human immune traits in laboratory mice","volume":"532","author":"Beura","year":"2016","journal-title":"Nature"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3791\/53736","article-title":"Isolation, characterization and functional examination of the gingival immune cell network","author":"Dutzan","year":"2016","journal-title":"J Vis Exp"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.136","article-title":"Characterization of the human immune cell network at the gingival barrier","volume":"9","author":"Dutzan","year":"2016","journal-title":"Mucosal Immunol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"eaat0797","DOI":"10.1126\/scitranslmed.aat0797","article-title":"A dysbiotic microbiome triggers T(H)17 cells to mediate oral mucosal immunopathology in mice and humans","volume":"10","author":"Dutzan","year":"2018","journal-title":"Sci Transl Med"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/nm1710","article-title":"Il-22 mediates mucosal host defense against gram-negative bacterial pneumonia","volume":"14","author":"Aujla","year":"2008","journal-title":"Nat Med"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.06.006","article-title":"The neutrophil","volume":"54","author":"Burn","year":"2021","journal-title":"Immunity"},{"key":"B66","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/s41392-023-01553-x","article-title":"Mechanisms and regulation of defensins in host defense","volume":"8","author":"Fu","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B67","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/s41392-024-01933-x","article-title":"Neutrophil extracellular traps in homeostasis and disease","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-010116","article-title":"An essential role for il-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires il-17 receptor-dependent signals","volume":"109","author":"Yu","year":"2007","journal-title":"Blood"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1128\/iai.01209-07","article-title":"The interleukin-17 receptor plays a gender-dependent role in host protection against porphyromonas gingivalis-induced periodontal bone loss","volume":"76","author":"Yu","year":"2008","journal-title":"Infect Immun"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.11.7980","article-title":"Tlr4 mediates vaccine-induced protective cellular immunity to bordetella pertussis: role of il-17-producing T cells","volume":"177","author":"Higgins","year":"2006","journal-title":"J Immunol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000159","article-title":"Interleukin-17a mediates acquired immunity to pneumococcal colonization","volume":"4","author":"Lu","year":"2008","journal-title":"PloS Pathog"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00474-2022","article-title":"Bacterial DNA amplifies neutrophilic inflammation in il-17-exposed airways","volume":"9","author":"Mues","year":"2023","journal-title":"ERJ Open Res"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00407-5","article-title":"Il-17 mediates protective immunity against nasal infection with bordetella pertussis by mobilizing neutrophils, especially siglec-F(+) neutrophils","volume":"14","author":"Borkner","year":"2021","journal-title":"Mucosal Immunol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0073-9","article-title":"Il-17-dependent siga-mediated protection against nasal bordetella pertussis infection by live attenuated bpze1 vaccine","volume":"11","author":"Solans","year":"2018","journal-title":"Mucosal Immunol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0080-x","article-title":"Sustained protective immunity against bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces il-17-secreting T(Rm) cells","volume":"11","author":"Allen","year":"2018","journal-title":"Mucosal Immunol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2018.1564630","article-title":"Immunization with Whole Cell but Not Acellular Pertussis Vaccines Primes Cd4 T(Rm) Cells That Sustain Protective Immunity against Nasal Colonization with Bordetella Pertussis","volume":"8","author":"Wilk","year":"2019","journal-title":"Emerg Microbes Infect"},{"key":"B77","doi-asserted-by":"publisher","first-page":"229ra40","DOI":"10.1126\/scitranslmed.3007696","article-title":"Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local il-17-driven inflammatory bone loss","volume":"6","author":"Moutsopoulos","year":"2014","journal-title":"Sci Transl Med"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600409","article-title":"Mmps, il-1, and tnf are regulated by il-17 in periodontitis","volume":"86","author":"Beklen","year":"2007","journal-title":"J Dent Res"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.3390\/biom13101437","article-title":"The role of doxycycline and il-17 in regenerative potential of periodontal ligament stem cells: implications in periodontitis","volume":"13","author":"Oki\u0107 \u0110or\u0111evi\u0107","year":"2023","journal-title":"Biomolecules"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-216085","article-title":"Evidence for a cross-talk between human neutrophils and th17 cells","volume":"115","author":"Pelletier","year":"2010","journal-title":"Blood"},{"key":"B81","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.imlet.2007.09.011","article-title":"Oral administration of type-ii collagen suppresses il-17-associated rankl expression of cd4+ T cells in collagen-induced arthritis","volume":"117","author":"Ju","year":"2008","journal-title":"Immunol Lett"},{"key":"B82","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s13075-018-1582-3","article-title":"Il-17a induces osteoblast differentiation by activating jak2\/stat3 in ankylosing spondylitis","volume":"20","author":"Jo","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102388","article-title":"Bimekizumab versus adalimumab in plaque psoriasis","volume":"385","author":"Warren","year":"2021","journal-title":"N Engl J Med"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509339889","article-title":"The involvement of il-23 and the th17 pathway in periodontitis","volume":"88","author":"Ohyama","year":"2009","journal-title":"J Dent Res"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01752.x","article-title":"Il-23-producing cd68 + Macrophage-like cells predominate within an il-17-polarized infiltrate in chronic periodontitis lesions","volume":"38","author":"Allam","year":"2011","journal-title":"J Clin Periodontol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512446341","article-title":"The presence of il-17+\/foxp3+ Double-positive cells in periodontitis","volume":"91","author":"Okui","year":"2012","journal-title":"J Dent Res"},{"key":"B87","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41467-018-03147-6","article-title":"Host defense against oral microbiota by bone-damaging T cells","volume":"9","author":"Tsukasaki","year":"2018","journal-title":"Nat Commun"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202194","article-title":"Il-17 receptor a signaling is protective in infection-stimulated periapical bone destruction","volume":"191","author":"AlShwaimi","year":"2013","journal-title":"J Immunol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2009.00123.x","article-title":"Il-17 is involved in bone resorption in mouse periapical lesions","volume":"53","author":"Oseko","year":"2009","journal-title":"Microbiol Immunol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13075-016-0998-x","article-title":"Il-17a deficiency promotes periosteal bone formation in a model of inflammatory arthritis","volume":"18","author":"Shaw","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12743","article-title":"The aggravation of arthritis by periodontitis is dependent of il-17 receptor a activation","volume":"44","author":"de Aquino","year":"2017","journal-title":"J Clin Periodontol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.1.329","article-title":"Development of proteoglycan-induced arthritis is independent of il-17","volume":"181","author":"Doodes","year":"2008","journal-title":"J Immunol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"694","DOI":"10.3858\/emm.2012.44.11.078","article-title":"Il-17-deficient allogeneic bone marrow transplantation prevents the induction of collagen-induced arthritis in dba\/1j mice","volume":"44","author":"Park","year":"2012","journal-title":"Exp Mol Med"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116310","article-title":"Deletion of il-17ra in osteoclast precursors increases bone mass by decreasing osteoclast precursor abundance","volume":"157","author":"Roberts","year":"2022","journal-title":"Bone"},{"key":"B95","doi-asserted-by":"publisher","first-page":"5692","DOI":"10.1038\/s41598-020-62562-2","article-title":"Interleukin 17a: A janus-faced regulator of osteoporosis","volume":"10","author":"Scheffler","year":"2020","journal-title":"Sci Rep"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.2147\/copd.S235384","article-title":"Interleukin-17a deficiency attenuated emphysema and bone loss in mice exposed to cigarette smoke","volume":"15","author":"Xiong","year":"2020","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3600","article-title":"Il-17 receptor signaling in osteoblasts\/osteocytes mediates pth-induced bone loss and enhances osteocytic rankl production","volume":"34","author":"Li","year":"2019","journal-title":"J Bone Miner Res"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10928","article-title":"Il-17-producing \u0393\u03b4 T cells enhance bone regeneration","volume":"7","author":"Ono","year":"2016","journal-title":"Nat Commun"},{"key":"B99","doi-asserted-by":"publisher","first-page":"3751","DOI":"10.3390\/ijms25073751","article-title":"Il-17ra signaling in prx1+ Mesenchymal cells influences fracture healing in mice","volume":"25","author":"Roberts","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B100","doi-asserted-by":"publisher","first-page":"8900","DOI":"10.3390\/ijms22168900","article-title":"Application of ligature-induced periodontitis in mice to explore the molecular mechanism of periodontal disease","volume":"22","author":"Lin","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1038\/nri1574","article-title":"Regulatory T-cell therapy: is it ready for the clinic","volume":"5","author":"Bluestone","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"B102","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.archoralbio.2014.05.009","article-title":"Il-17 inhibits osteoblast differentiation and bone regeneration in rat","volume":"59","author":"Kim","year":"2014","journal-title":"Arch Oral Biol"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939670","article-title":"A bone-protective role for il-17 receptor signaling in ovariectomy-induced bone loss","volume":"39","author":"Goswami","year":"2009","journal-title":"Eur J Immunol"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0091-8","article-title":"Effects of the il-23-il-17 pathway on bone in spondyloarthritis","volume":"14","author":"Gravallese","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130225","article-title":"Evaluation of the host response in various models of induced periodontal disease in mice","volume":"85","author":"de Molon","year":"2014","journal-title":"J Periodontol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1002\/art.41156","article-title":"Polyfunctional, proinflammatory, tissue-resident memory phenotype and function of synovial interleukin-17a+Cd8+ T cells in psoriatic arthritis","volume":"72","author":"Steel","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.715510","article-title":"Targeting the interleukin-23\/interleukin-17 inflammatory pathway: successes and failures in the treatment of axial spondyloarthritis","volume":"12","author":"Wang","year":"2021","journal-title":"Front Immunol"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209831","article-title":"A randomised phase ii study evaluating the efficacy and safety of subcutaneously administered ustekinumab and guselkumab in patients with active rheumatoid arthritis despite treatment with methotrexate","volume":"76","author":"Smolen","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"B109","doi-asserted-by":"publisher","first-page":"8051","DOI":"10.3390\/app12168051","article-title":"Levels of il-23\/il-17 axis in plasma and gingival tissue of periodontitis patients according to the new classification","volume":"12","author":"Rodr\u00edguez-Monta\u00f1o","year":"2022","journal-title":"Appl Sci"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1578635\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:12:56Z","timestamp":1743639176000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1578635\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,3]]},"references-count":109,"alternative-id":["10.3389\/fimmu.2025.1578635"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1578635","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,3]]},"article-number":"1578635"}}