{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:38:34Z","timestamp":1792521514193,"version":"4.5.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"Objective<\/jats:title>To illuminate the pathological characteristics and treatment of synchronous pancreatic sarcomatoid carcinoma(SCP) and gastric cancer using a case report and comprehensive literature review.<\/jats:p><\/jats:sec>Methods<\/jats:title>Clinical presentation, pathological findings and immunohistochemical results of a patient with SCP and gastric cancer were reviewed. A surgical treatment strategy with best supportive care, including nutrition support, was adopted. A comprehensive literature review was conducted.<\/jats:p><\/jats:sec>Results<\/jats:title>A 69-year-old female patient presented to the general surgery clinic with ten days of abdominal pain. A Type IIc lesion measuring 30 mm in diameter was found in the gastric angle. Additionally,a thick-walled, solid mass with dimensions of 33 mm by 30 mm was detected in the pancreatic tail. HE staining revealed a moderately to poorly differentiated adenocarcinoma and partial mucinous adenocarcinoma in gastric angle and a sarcomatoid carcinoma with low-grade adenocarcinoma components in pancreatic tail. Immunohistochemical assay of the mass in pancreatic tail showed partial positivity for CK(pan), CK7, CD56, CD138, CEA, EMA, and Ki-67 (60%). The patient\u2019s serum levels of CA199, CEA, CA125, and CA242 were sharply decreased postoperatively but remained above normal limits. However, these markers were predominantly increased in the presence of multiple liver metastases.Malnutrition and progressive disease occurred despite the adoption of EN plus PN and best supportive care, and the patient died on postoperative day 107.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Synchronous SCP and gastric cancer are first reported in this study. Surgical treatment remains effective despite an even poorer prognosis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2025.1584504","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T05:24:37Z","timestamp":1748323477000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Synchronous pancreatic sarcomatoid carcinoma and gastric cancer: a case study with literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Genlin","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renya","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.55927","article-title":"Laparoscopic radical total gastrectomy and pancreatosplenectomy for synchronous cancer of the stomach and pancreas","volume":"16","author":"Ebihara","year":"2024","journal-title":"Cureus"},{"key":"B3","first-page":"2855","article-title":"Pancreatic-type acinar cell carcinoma of the stomach included in multiple primary carcinomas","volume":"36","author":"Yonenaga","year":"2016","journal-title":"Anticancer Res"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2739\/kurumemedj.47.169","article-title":"A case of synchronous double cancers of the pancreas and stomach","volume":"47","author":"Eriguchi","year":"2000","journal-title":"Kurume Med J"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i28.8509","article-title":"Synchronous concomitant pancreatic acinar cell carcin and gastric adenocarcinoma: A case report and review of literature","author":"Fang","year":"2021","journal-title":"World J Clin cases"},{"key":"B6","article-title":"Synchronous cancer duplicities of pancreas and stomach\/kidney and their surgical treatment","volume":"94","author":"Ghothim","year":"2015","journal-title":"Rozhl Chir"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.4892","article-title":"Synchronous gastric cancer and carcinoma in situ of the pancreas","volume":"9","author":"Inoue","year":"2021","journal-title":"Clin Case Rep"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2012.09.008","article-title":"Double pancreatic and gastric adenocarcinomas: a rare association","volume":"37","author":"Kourie","year":"2013","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"B9","article-title":"Advanced stomach and pancreas cancer successfully treated with combination chemotherapy with S-1\/paclitaxel\/lentinan","volume":"56","author":"Kubota","year":"2009","journal-title":"Hepatogastroenterology"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i10.2400","article-title":"Pancreatic cancer secondary to intraductal papillary mucinous neoplasm with collision between gastric cancer and B-cell lymphoma: A case report","volume":"9","author":"Ma","year":"2021","journal-title":"World J Clin Cases"},{"key":"B11","article-title":"Synchronous gastric adenocarcinoma and pancreatic ductal adenocarcinoma","volume":"9","author":"Muroni","year":"2010","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.6092\/1590-8577\/1719","article-title":"Synchronous triple cancers of the pancreas, stomach, and cecum treated with S-1 followed by pancrelipase treatment of pancreatic exocrine insufficiency","volume":"14","author":"Ohtsubo","year":"2013","journal-title":"JOP"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1177\/00031348231201884","article-title":"Presentation of gastrointestinal stromal tumor, pancreatic adenocarcinoma, and gastric adenocarcinoma in a woman with no identifiable genetic abnormalities","volume":"89","author":"Read","year":"2023","journal-title":"Am Surg"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.17235\/reed.2015.3720\/2014","article-title":"Synchronic gastric and pancreatic ductal adenocarcinoma. 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