{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:34:02Z","timestamp":1782495242364,"version":"3.54.5"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Rheumatoid arthritis (RA) is an autoimmune inflammatory disease. The mechanism by which telomeres are involved in the development of RA remains unclear. This study aimed to investigate the relationship between RA and telomeres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we identified differentially expressed genes (DEGs) between RA and control samples by analyzing transcriptome data from a public database. Candidate genes were determined through the intersection of DEGs and telomere-related genes. Biomarkers were subsequently identified using machine learning algorithms, receiver operating characteristic analysis, and expression level comparisons between RA and control samples. Additionally, a nomogram model was employed to predict the diagnostic ability of biomarkers for RA. Subsequently, the potential mechanisms of these biomarkers in RA were further explored using gene set enrichment analysis (GSEA), subcellular localization, chromosome localization, immune infiltration, functional analysis, molecular regulatory networks, drug prediction, and molecular docking. Furthermore, the expression of biomarkers between RA and control samples was validated through <jats:italic>in vitro<\/jats:italic> experiments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ABCC4, S100A8, VAMP2, PIM2, and ISG20 were identified as biomarkers. These biomarkers demonstrated excellent diagnostic ability for RA through a nomogram. Most of the biomarkers were found to be enriched in processes related to allograft rejection and the cell cycle. Subcellular and chromosomal localization analyses indicated that ABCC4 is localized to the plasma membrane, ISG20 to the mitochondria, PIM2 and S100A8 to the cytoplasm, and VAMP2 to the nucleus. Additionally, nine differential immune cells were identified between RA and control samples, with a strong correlation observed between the biomarkers and activated CD4 memory T cells. S100A8, PIM2, and VAMP2 exhibited high similarity to other biomarkers. Furthermore, three transcription factors (TFs), 121 microRNAs (miRNAs), and six long non-coding RNAs (lncRNAs) were identified as targeted biomarkers. Five drugs\u2014methotrexate, adefovir, furosemide, azathioprine, and cefmetazole\u2014were also identified as targeted biomarkers. Notably, ABCC4 interacted with all five drugs and exhibited the strongest binding energy with methotrexate. The results of the <jats:italic>in vitro<\/jats:italic> experiments were consistent with those obtained from the bioinformatics analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study identified five biomarkers\u2014ABCC4, S100A8, VAMP2, PIM2, and ISG20\u2014and offered new insights into potential therapeutic strategies for RA.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2025.1585895","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T05:25:54Z","timestamp":1747891554000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Transcriptomic insights into the mechanism of action of telomere-related biomarkers in rheumatoid arthritis"],"prefix":"10.3389","volume":"16","author":[{"given":"Lijuan","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limeng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"454","DOI":"10.3390\/pharmaceutics13040454","article-title":"Liposomal nanosystems in rheumatoid arthritis","volume":"13","author":"Ferreira-Silva","year":"2021","journal-title":"Pharmaceutics"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.200367","article-title":"The prevalence of rheumatoid arthritis: a systematic review of population-based studies","volume":"48","author":"Almutairi","year":"2021","journal-title":"J Rheumatol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202003399","article-title":"Tocilizumab-conjugated polymer nanoparticles for NIR-II photoacoustic-imaging-guided therapy of rheumatoid arthritis","volume":"32","author":"Chen","year":"2020","journal-title":"Adv Mater"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13317-020-00145-x","article-title":"Transformation of fibroblast-like synoviocytes in rheumatoid arthritis; from a friend to foe","volume":"12","author":"Mousavi","year":"2021","journal-title":"Auto Immun Highlights"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.692242","article-title":"Pathogenic role of circulating citrullinated antigens and anti-cyclic monoclonal citrullinated peptide antibodies in rheumatoid arthritis","volume":"12","author":"Won","year":"2021","journal-title":"Front Immunol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1080\/25785826.2021.1944547","article-title":"Arthritis-associated osteoclastogenic macrophages (AtoMs) participate in pathological bone erosion in rheumatoid arthritis","volume":"45","author":"Agemura","year":"2021","journal-title":"Immunol Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.954848","article-title":"Analysis and experimental validation of rheumatoid arthritis innate immunity gene CYFIP2 and pan-cancer","volume":"13","author":"Zhao","year":"2022","journal-title":"Front Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.coph.2020.08.002","article-title":"Drug-resistance in rheumatoid arthritis: the role of p53 gene mutations, ABC family transporters and personal factors","volume":"54","author":"Zhang","year":"2020","journal-title":"Curr Opin Pharmacol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.799440","article-title":"RNA-seq and network analysis reveal unique chemokine activity signatures in the synovial tissue of patients with rheumatoid arthritis","volume":"9","author":"Zhang","year":"2022","journal-title":"Front Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"103774","DOI":"10.1016\/j.dnarep.2024.103774","article-title":"How to write an ending: Telomere replication as a multistep process","volume":"144","author":"Douglas","year":"2024","journal-title":"DNA repair"},{"key":"B11","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00018-019-03369-x","article-title":"Structural biology of telomeres and telomerase","volume":"77","author":"Smith","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"B12","doi-asserted-by":"publisher","first-page":"106943","DOI":"10.1016\/j.rmed.2022.106943","article-title":"Associations between shortened telomeres and rheumatoid arthritis-associated interstitial lung disease among U.S. Veterans","volume":"201","author":"Natalini","year":"2022","journal-title":"Respir Med"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz6876","article-title":"Determinants of telomere length across human tissues","volume":"369","author":"Demanelis","year":"2020","journal-title":"Science"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03055","article-title":"DNA damage response signals transduce stress from rheumatoid arthritis risk factors into T cell dysfunction","volume":"9","author":"Shao","year":"2018","journal-title":"Front Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1023991","article-title":"Assessing the association of leukocyte telomere length with ankylosing spondylitis and rheumatoid arthritis: A bidirectional Mendelian randomization study","volume":"14","author":"Wei","year":"2023","journal-title":"Front Immunol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez524","article-title":"Association of telomere length with risk of rheumatoid arthritis: a meta-analysis and Mendelian randomization","volume":"59","author":"Wen","year":"2020","journal-title":"Rheumatology"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.18632\/aging.v12i20","article-title":"Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson\u2019s disease","volume":"12","author":"Wu","year":"2020","journal-title":"Aging"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.975057","article-title":"Telomere-related gene risk model for prognosis and drug treatment efficiency prediction in kidney cancer","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac409","article-title":"ggtranscript: an R package for the visualization and interpretation of transcript isoforms usingggplot2","volume":"38","author":"Gustavsson","year":"2022","journal-title":"Bioinformatics"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab806","article-title":"Make interactive complex heatmaps in R","volume":"38","author":"Gu","year":"2022","journal-title":"Bioinformatics"},{"key":"B22","doi-asserted-by":"publisher","first-page":"521","DOI":"10.3892\/etm.2022.11449","article-title":"Inhibition of cell survival and invasion by Tanshinone IIA via FTH1: A key therapeutic target and biomarker in head and neck squamous cell carcinoma","volume":"24","author":"Mao","year":"2022","journal-title":"Exp Ther Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"B25","doi-asserted-by":"publisher","first-page":"10238","DOI":"10.1038\/s41467-024-54405-9","article-title":"High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China","volume":"15","author":"Lu","year":"2024","journal-title":"Nat Commun"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.990888","article-title":"Bioinformatics analysis to screen for genes related to myocardial infarction","volume":"13","author":"Yang","year":"2022","journal-title":"Front Genet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinf"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21147","article-title":"A nomogram for predicting prognosis of patients with cervical cerclage","volume":"9","author":"Xu","year":"2023","journal-title":"Heliyon"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.65.5654","article-title":"Assessing the clinical impact of risk prediction models with decision curves: guidance for correct interpretation and appropriate use","volume":"34","author":"Kerr","year":"2016","journal-title":"J Clin Oncol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3390\/ani12010060","article-title":"Worldwide traceability of antibiotic residues from livestock in wastewater and soil: a systematic review","volume":"12","author":"Robles-Jimenez","year":"2021","journal-title":"Animals"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.989286","article-title":"Cuproptosis related genes associated with Jab1 shapes tumor microenvironment and pharmacological profile in nasopharyngeal carcinoma","volume":"13","author":"Wang","year":"2022","journal-title":"Front Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/1471-2105-14-244","article-title":"RCircos: an R package for Circos 2D track plots","volume":"14","author":"Zhang","year":"2013","journal-title":"BMC Bioinf"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.944683","article-title":"Bioinformatics identification and validation of biomarkers and infiltrating immune cells in endometriosis","volume":"13","author":"Jiang","year":"2022","journal-title":"Front Immunol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.15437","article-title":"Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic candidate genes for diabetic nephropathy using bioinformatics analysis","volume":"11","author":"Hu","year":"2023","journal-title":"PeerJ"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.26","article-title":"Transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1 for targeting prostate tumors","volume":"18","author":"Lee","year":"2010","journal-title":"Mol Ther"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J Chem Inf Model"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406877","article-title":"Dual targeting biomimetic carrier-free nanosystems for photo-chemotherapy of rheumatoid arthritis via macrophage apoptosis and re-polarization","volume":"12","author":"Xue","year":"2025","journal-title":"Adv Sci"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-022-01649-0","article-title":"Immunosenescence of T cells: a key player in rheumatoid arthritis","volume":"71","author":"Gao","year":"2022","journal-title":"Inflammation Res"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4318-5","article-title":"Telomere dysfunction-related serological markers and oxidative stress markers in rheumatoid arthritis patients: correlation with diseases activity","volume":"37","author":"Gamal","year":"2018","journal-title":"Clin Rheumatol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s40203-024-00204-5","article-title":"Computational inhibition of S100A8 (calgranulin A) as a potential non-invasive biomarker for rheumatoid arthritis","volume":"12","author":"Choudhury","year":"2024","journal-title":"In Silico Pharmacol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep452","article-title":"Synovial fluid proteomic fingerprint: S100A8, S100A9 and S100A12 proteins discriminate rheumatoid arthritis from other inflammatory joint diseases","volume":"49","author":"Baillet","year":"2010","journal-title":"Rheumatology"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X221114105","article-title":"Plasma calprotectin as a biomarker of ultrasound synovitis in rheumatoid arthritis patients receiving IL-6 antagonists or JAK inhibitors","volume":"14","author":"Frade-Sosa","year":"2022","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072138","article-title":"S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-\u03baB(1.)","volume":"8","author":"Simard","year":"2013","journal-title":"PloS One"},{"key":"B44","doi-asserted-by":"publisher","first-page":"6818","DOI":"10.1038\/ncomms7818","article-title":"NF\u03baB1 is a suppressor of neutrophil-driven hepatocellular carcinoma","volume":"6","author":"Wilson","year":"2015","journal-title":"Nat Commun"},{"key":"B45","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12865-024-00646-8","article-title":"Transcriptomics explores potential mechanisms for the development of Primary Sjogren\u2019s syndrome to diffuse large B-cell lymphoma in B cells","volume":"25","author":"Xu","year":"2024","journal-title":"BMC Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2007.03.006","article-title":"ISG20, an actor of the innate immune response","volume":"89","author":"Degols","year":"2007","journal-title":"Biochimie"},{"key":"B47","article-title":"Dissecting the imbalance of synovial macrophages in rheumatoid arthritis","volume":"29","author":"Li","year":"2023","journal-title":"Altern Ther Health Med"},{"key":"B48","doi-asserted-by":"publisher","first-page":"101017","DOI":"10.1016\/j.drup.2023.101017","article-title":"ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity","volume":"72","author":"Ranjit","year":"2024","journal-title":"Drug Resist Updat"},{"key":"B49","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jacbts.2017.10.005","article-title":"Platelet transcriptome profiling in HIV and ATP-binding cassette subfamily C member 4 (ABCC4) as a mediator of platelet activity","volume":"3","author":"Marcantoni","year":"2018","journal-title":"JACC Basic Transl Sci"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.jaci.2017.10.011","article-title":"Inhibition of ABCC4 potentiates combination beta agonist and glucocorticoid responses in human airway epithelial cells","volume":"141","author":"Huff","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.948160","article-title":"The function of VAMP2 in mediating membrane fusion: An overview","volume":"15","author":"Yan","year":"2022","journal-title":"Front Mol Neurosci"},{"key":"B52","doi-asserted-by":"publisher","first-page":"152170","DOI":"10.1016\/j.acthis.2024.152170","article-title":"Immunohistochemical localization of proteins involved in exocytosis of glutamate from P2X3 purinoceptor-expressing subserosal afferent nerve endings in the rat gastric antrum","volume":"126","author":"Hirakawa","year":"2024","journal-title":"Acta Histochem"},{"key":"B53","doi-asserted-by":"publisher","first-page":"3123","DOI":"10.3390\/ijms25063123","article-title":"PIM kinases as potential biomarkers and therapeutic targets in inflammatory arthritides","volume":"25","author":"Assirelli","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2010.03286.x","article-title":"Proviral integration site 2 is required for interleukin-6 expression induced by interleukin-1, tumour necrosis factor-\u03b1 and lipopolysaccharide","volume":"131","author":"Yang","year":"2010","journal-title":"Immunology"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.5.3316","article-title":"A critical role for allograft inflammatory factor-1 in the pathogenesis of rheumatoid arthritis","volume":"178","author":"Kimura","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.3390\/biom10071064","article-title":"Over-expression of allograft inflammatory factor-1 (AIF-1) in patients with rheumatoid arthritis","volume":"10","author":"Piotrowska","year":"2020","journal-title":"Biomolecules"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.06.017","article-title":"Influence of Cyclooxygenase-2 (COX-2) gene promoter-1195 and allograft inflammatory factor-1 (AIF-1) polymorphisms on allograft outcome in Hispanic kidney transplant recipients","volume":"74","author":"Vu","year":"2013","journal-title":"Hum Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.imlet.2019.12.002","article-title":"Role of allograft inflammatory factor-1 in pathogenesis of diseases","volume":"218","author":"Sikora","year":"2020","journal-title":"Immunol Lett"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-1818-x","article-title":"Metastatic lymph node 51 and fibroblast-like synoviocyte hyperproliferation in rheumatoid arthritis pathogenesis","volume":"31","author":"Lim","year":"2011","journal-title":"Rheumatol Int"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgaa053","article-title":"Sorafenib suppresses proliferation rate of fibroblast-like synoviocytes through the arrest of cell cycle in experimental adjuvant arthritis","volume":"73","author":"Gong","year":"2021","journal-title":"J Pharm Pharmacol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00816-x","article-title":"The immunology of rheumatoid arthritis","volume":"22","author":"Weyand","year":"2021","journal-title":"Nat\u00a0Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/imm.v162.1","article-title":"Tolerance induction in memory CD4 T cells is partial and reversible","volume":"162","author":"Gray","year":"2020","journal-title":"Immunology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"29338","DOI":"10.1038\/srep29338","article-title":"Immunophenotyping of rheumatoid arthritis reveals a linkage between HLA-DRB1 genotype, CXCR4 expression on memory CD4+ T cells and disease activity","volume":"6","author":"Nagafuchi","year":"2016","journal-title":"Sci Rep"},{"key":"B64","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s10020-022-00563-9","article-title":"SIGIRR deficiency contributes to CD4 T cell abnormalities by facilitating the IL1\/C\/EBP\u03b2\/TNF-\u03b1 signaling axis in rheumatoid arthritis","volume":"28","author":"Teng","year":"2022","journal-title":"Mol Med"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2017.1413591","article-title":"Calprotectin in patients with chronic rheumatoid arthritis correlates with disease activity and responsiveness to methotrexate","volume":"78","author":"Nielsen","year":"2018","journal-title":"Scand J Clin Lab Inv"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1455899","article-title":"Suppression of overactivated immunity in the early stage is the key to improve the prognosis in severe burns","volume":"15","author":"Xiang","year":"2024","journal-title":"Front Immunol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-eular.3749","article-title":"AB0014 methotrexate-implications of pharmacogenetics in the treatment of patients with rheumatoid arthritis","volume":"80","author":"Pinheiro Torres","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"B68","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1136\/annrheumdis-2020-eular.4083","article-title":"OP0031 an increase in serum calprotectin level in ANCA-associated vasculitides during maintenance therapy is associated with more relapse and accelerated renal function decline","volume":"79","author":"Romand","year":"2020","journal-title":"Ann Rheum Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1585895\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T05:25:59Z","timestamp":1747891559000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1585895\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":68,"alternative-id":["10.3389\/fimmu.2025.1585895"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1585895","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,22]]},"article-number":"1585895"}}