{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:17:33Z","timestamp":1787026653287,"version":"build-2736575974"},"reference-count":94,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>LINC01410 is a recently identified long non-coding RNA located on chromosome 9 that plays a multifaceted role in human diseases. Its dysregulation is closely associated with tumor initiation, progression, and therapeutic response. LINC01410 promotes oncogenesis by modulating key signaling pathways, such as PTEN\/AKT, Notch, ErbB, and NF-\u03baB, interacting with non-coding RNA networks, and influencing the expression of proteins involved in tumor biology. Beyond these roles, it contributes to cancer metabolism by regulating glycolysis, lipid droplet accumulation, and exosome-mediated intercellular communication, thereby shaping the tumor microenvironment and enhancing malignancy. Intriguingly, LINC01410 exhibits opposite expression patterns in non-malignant conditions such as preeclampsia and diabetic nephropathy, highlighting its context-dependent biological function. 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