{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:04:17Z","timestamp":1761894257208,"version":"build-2065373602"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>This study examines the impact of pretransplant vitamin D deficiency on immune recovery and clinical outcomes in multiple myeloma patients undergoing autologous stem cell transplantation (ASCT). Given vitamin D\u2019s known immunomodulatory effects, the research describes its influence on neutrophil and platelet engraftment, lymphocyte recovery, and overall response rates post-ASCT. By analyzing a retrospective cohort, the study highlights potential associations between vitamin D status and post-transplant immune reconstitution, contributing to understanding vitamin D\u2019s role in optimizing treatment strategies for multiple myeloma patients. Multiple myeloma (MM), considered the second most common hematological malignancy, is a plasma cell neoplasm that causes morbidity and mortality through its effects on organs, organ systems, and immunity. Clinical manifestations of MM include renal dysfunction, hypercalcemia, osteolytic bone lesions, anemia (CRAB Criteria), pathological fractures, and immunosuppression. The majority of myeloma patients suffer from long-term immunoparesis, which means suppression of uninvolved immunoglobulins (Igs), and these findings have been reported to be associated with poor prognosis in patients with multiple myeloma (MM).<\/jats:p>","DOI":"10.3389\/fimmu.2025.1588919","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T05:23:35Z","timestamp":1761888215000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of pretransplant vitamin D deficiency on immune recovery and clinical outcomes in multiple myeloma patients undergoing autologous stem cell transplantation"],"prefix":"10.3389","volume":"16","author":[{"given":"Amany R.","family":"Keruakous","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil","family":"Ghani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreya","family":"Desai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Terrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrzad","family":"Zamani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Youn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sindu","family":"Iska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Keruakous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-21-1627","article-title":"Partial immunoparesis contributes to risk of early infections in patients with multiple myeloma","volume":"10","author":"Huang","year":"2021","journal-title":"Transl Cancer Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011442","article-title":"Multiple myeloma","volume":"364","author":"Palumbo","year":"2011","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2006.09.010","article-title":"High-dose therapy with single autologous transplantation versus chemotherapy for newly diagnosed multiple myeloma: A systematic review and meta-analysis of randomized controlled trials","volume":"13","author":"Koreth","year":"2007","journal-title":"Biol Blood Marrow Transplant"},{"key":"B4","doi-asserted-by":"publisher","first-page":"772.e1","DOI":"10.1016\/j.jtct.2024.06.001","article-title":"Trends in outcomes after upfront autologous transplant for multiple myeloma over three decades","volume":"30","author":"Pasvolsky","year":"2024","journal-title":"Transplant Cell Ther"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40320-5_12","article-title":"Role of the immune response in disease progression and therapy in multiple myeloma","volume":"169","author":"Lee","year":"2016","journal-title":"Cancer Treat Res"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062387","article-title":"Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy","volume":"204","author":"Spisek","year":"2007","journal-title":"J Exp Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"101544","DOI":"10.1016\/j.trim.2022.101544","article-title":"Prognostic impact of natural killer cell recovery on minimal residual disease after autologous stem cell transplantation in multiple myeloma","volume":"71","author":"Keruakous","year":"2022","journal-title":"Transpl Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"16030","DOI":"10.1038\/boneres.2016.30","article-title":"Vitamin D receptor expression in human bone tissue and dose-dependent activation in resorbing osteoclasts","volume":"4","author":"Zarei","year":"2016","journal-title":"Bone Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.clim.2016.02.011","article-title":"Comparative effect of 25(OH)D3 and 1,25(OH)2D3 on Th17 cell differentiation","author":"Fawaz","year":"2016","journal-title":"Clin Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"300060520943421","DOI":"10.1177\/0300060520943421","article-title":"Vitamin D levels in patients with non-Hodgkin lymphoma\/diffuse large B-cell lymphoma, chronic lymphocytic leukemia and multiple myeloma","volume":"48","author":"Graklanov","year":"2020","journal-title":"J Int Med Res"},{"key":"B11","article-title":"Prevalence of vitamin D deficiency in patients with bone metastases and multiple myeloma","volume":"35","author":"Maier","year":"2015","journal-title":"Anticancer Res"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21619","article-title":"Vitamin D status may effect the skeletal complications of multiple myeloma","volume":"85","author":"Diamond","year":"2010","journal-title":"Am J Hematol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.yexmp.2008.10.002","article-title":"Regulatory role of 1, 25-dihydroxyvitamin D3 and vitamin D receptor gene variants on intracellular granzyme A expression in pulmonary tuberculosis","volume":"86","author":"Vidyarani","year":"2009","journal-title":"Exp Mol Pathol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092663","article-title":"Vitamin D: effect on haematopoiesis and immune system and clinical applications","volume":"19","author":"Medrano","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1177\/10815589241249998","article-title":"Prevalence, outcomes, and complications of vitamin D deficiency among patients with multiple myeloma: Nationwide burden of disease","volume":"72","author":"Gujarathi","year":"2024","journal-title":"J Investig Med"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06414-3","article-title":"High prevalence of peripheral neuropathy in multiple myeloma patients and the impact of vitamin D levels, a cross-sectional study","volume":"30","author":"Oortgiesen","year":"2022","journal-title":"Support Care Cancer"},{"key":"B17","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1002\/ajh.21412","article-title":"Impact of vitamin D deficiency on the clinical presentation and prognosis of patients with newly diagnosed multiple myeloma","volume":"84","author":"Ng","year":"2009","journal-title":"Am J Hematol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1157969","article-title":"Vitamin D deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis","volume":"14","author":"Bao","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3126-1","article-title":"Low serum vitamin D occurs commonly among multiple myeloma patients treated with bortezomib and\/or thalidomide and is associated with severe neuropathy","volume":"24","author":"Wang","year":"2016","journal-title":"Support Care Cancer"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04942-7","article-title":"A retrospective analysis of the prevalence and clinical outcomes of vitamin D deficiency in myeloma patients in tropical Australia","volume":"28","author":"Nath","year":"2020","journal-title":"Support Care Cancer"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001411","article-title":"Vitamin D deficiency predicts for poor overall survival in white but not African American patients with multiple myeloma","volume":"4","author":"Yellapragada","year":"2020","journal-title":"Blood Adv"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1588919\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T05:23:36Z","timestamp":1761888216000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1588919\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":21,"alternative-id":["10.3389\/fimmu.2025.1588919"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1588919","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,31]]},"article-number":"1588919"}}