{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:40:19Z","timestamp":1794008419414,"version":"4.8.0"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post-acute sequelae of SARS-CoV-2 infection (PASC), also known as post-COVID-19 condition (here abbreviated as post-COVID) is an escalating global health issue. The aim of our study was to investigate the mechanisms and clinical manifestations of post-COVID following a mild SARS-CoV-2 infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed the gene expression profile in PBMCs from 60 middle-aged post-COVID patients and 50 age-matched controls at a median time of 28 months following a mild SARS-CoV-2 infection. The clinical assessments included intensity of post-COVID symptoms, physical and mental fatigue, depression and anxiety. Sixty-seven participants performed a mild exertion ergometer test with assessment of lactate concentrations. Transcriptome analysis was performed on mRNA selected by poly-A enrichment and SARS-CoV-2 RNA fragments were analyzed using the ARTIC protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 463 differentially expressed transcripts in PBMCs, of which 324 were upregulated and 129 downregulated in post-COVID patients. Upregulated genes in post-COVID individuals were enriched for processes involving JAK-STAT signaling, negative regulation of ubiquitination, IL9 signaling, and negative regulation of viral process, suggesting chronic inflammation. Downregulated genes were enriched for processes involving mitochondrial ATP synthesis, and oxidative phosphorylation, suggesting mitochondrial dysfunction. No SARS-CoV-2 gene fragments were detected in PBMCs of patients with post-COVID and no IFN genes were found differentially expressed in post-COVID patients. Post-COVID was associated with elevated lactate levels in blood, both at rest and after a short recovery phase following exertion, suggesting increased anaerobic activity in skeletal muscles. We did not find differences in the transcriptional profiles or clinical manifestations when comparing patients who contracted the infection from early SARS-CoV-2 variants with those who contracted the infection during the period when the Omicron variant was prevalent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings highlight molecular changes compatible with a persistent immune response in PBMCs of post-COVID subjects at a median follow-up of 28 months after a mild infection, supporting the hypothesis that post-COVID is a chronic inflammatory condition. The upregulation of JAK\/STAT signaling suggests a potential therapeutic target in post-COVID.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2025.1589589","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T01:47:25Z","timestamp":1748569645000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK\/STAT signaling and a prolonged immune response"],"prefix":"10.3389","volume":"16","author":[{"given":"Serena","family":"Fineschi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joakim","family":"Klar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Ramon","family":"Lopez Egido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Bergquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Kaden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00703-9","article-title":"A clinical case definition of post-COVID-19 condition by a Delphi consensus","volume":"22","author":"Soriano","year":"2022","journal-title":"Lancet Infect Dis"},{"key":"B2","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1038\/s41579-023-00896-0","article-title":"Author Correction: Long COVID: major findings, mechanisms and recommendations","volume":"21","author":"Davis","year":"2023","journal-title":"Nat Rev Microbiol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02987-8","article-title":"Three-year outcomes of post-acute sequelae of COVID-19","volume":"30","author":"Cai","year":"2024","journal-title":"Nat Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.0750","article-title":"Risk factors associated with post-COVID-19 condition: A systematic review and meta-analysis","volume":"183","author":"Tsampasian","year":"2023","journal-title":"JAMA Intern Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02051-3","article-title":"Acute and postacute sequelae associated with SARS-CoV-2 reinfection","volume":"28","author":"Bowe","year":"2022","journal-title":"Nat Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/bmjmed-2022-000385","article-title":"Effect of covid-19 vaccination on long covid: Systematic review","volume":"2","author":"Byambasuren","year":"2023","journal-title":"BMJ Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2403211","article-title":"Postacute sequelae of SARS-coV-2 infection in the pre-delta, delta, and omicron eras","volume":"391","author":"Xie","year":"2024","journal-title":"N Engl J Med"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1101\/2022.06.21.22276660","article-title":"Impact of pre-existing chronic viral infection and reactivation on the development of long COVID","volume":"22","author":"Peluso","year":"2022","journal-title":"medRxiv"},{"key":"B9","doi-asserted-by":"publisher","first-page":"100849","DOI":"10.1016\/S2666-5247(24)00055-7","article-title":"Blood transcriptomic analyses reveal persistent SARS-CoV-2 RNA and candidate biomarkers in post-COVID-19 condition","volume":"5","author":"Menezes","year":"2024","journal-title":"Lancet Microbe"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac017","article-title":"Persistent autoimmune activation and proinflammatory state in post-coronavirus disease 2019 syndrome","volume":"225","author":"Acosta-Ampudia","year":"2022","journal-title":"J Infect Dis"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00171-3","article-title":"The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China","volume":"24","author":"Zuo","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac722","article-title":"Persistent circulating severe acute respiratory syndrome coronavirus 2 spike is associated with post-acute coronavirus disease 2019 sequelae","volume":"76","author":"Swank","year":"2023","journal-title":"Clin Infect Dis"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911058","article-title":"Transcriptomics and RNA-based therapeutics as potential approaches to manage SARS-coV-2 infection","volume":"23","author":"Arriaga-Canon","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B14","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s13073-023-01227-x","article-title":"SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile","volume":"15","author":"Zhang","year":"2023","journal-title":"Genome Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1186\/s12967-022-03751-7","article-title":"Longitudinal transcriptional analysis of peripheral blood leukocytes in COVID-19 convalescent donors","volume":"20","author":"Gedda","year":"2022","journal-title":"J Transl Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1186\/s12967-024-05117-7","article-title":"Bulk RNA sequencing for analysis of post COVID-19 condition in adolescents and young adults","volume":"22","author":"Sommen","year":"2024","journal-title":"J Transl Med"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1254899","article-title":"Immunological profiling in long COVID: overall low grade inflammation and T-lymphocyte senescence and increased monocyte activation correlating with increasing fatigue severity","volume":"14","author":"Berentschot","year":"2023","journal-title":"Front Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12916-021-02228-6","article-title":"Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection","volume":"20","author":"Ryan","year":"2022","journal-title":"BMC Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/23744235.2024.2389481","article-title":"Interferon gene expression declines over time post-COVID infection and in long COVID patients","volume":"20","author":"G\u00f3mez-Carballa","year":"2024","journal-title":"Infect Dis (Lond)"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1212745","article-title":"Mild to moderate post-COVID-19 alters markers of lymphocyte activation, exhaustion, and immunometabolic responses that can be partially associated by physical activity level- an observational sub-analysis fit- COVID study","volume":"14","author":"Silva","year":"2023","journal-title":"Front Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-024-01165-5","article-title":"Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches","volume":"46","author":"Molnar","year":"2024","journal-title":"Geroscience"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2024.102554","article-title":"Attenuating post-exertional malaise in Myalgic encephalomyelitis\/chronic fatigue syndrome and long-COVID: Is blood lactate monitoring the answer","volume":"49","author":"Faghy","year":"2024","journal-title":"Curr Probl Cardiol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01724-6","article-title":"Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2","volume":"25","author":"Yin","year":"2024","journal-title":"Nat Immunol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107132","article-title":"Heme metabolism in nonerythroid cells","volume":"300","author":"Dunaway","year":"2024","journal-title":"J Biol Chem"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02107-4","article-title":"Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae","volume":"29","author":"Thompson","year":"2023","journal-title":"Nat Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520460115022","article-title":"The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus","volume":"46","author":"Krupp","year":"1989","journal-title":"Arch Neurol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3109\/02699050903452961","article-title":"A self-assessment questionnaire for mental fatigue and related symptoms after neurological disorders and injuries","volume":"24","author":"Johansson","year":"2010","journal-title":"Brain Inj"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br J Psychiatry"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1435218","article-title":"Comprehensive MRI assessment reveals subtle brain findings in non-hospitalized post-COVID patients with cognitive impairment","volume":"18","author":"Fineschi","year":"2024","journal-title":"Front Neurosci"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012","article-title":"Psychophysical bases of perceived exertion","volume":"14","author":"Borg","year":"1982","journal-title":"Med Sci Sports Exerc"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.2103","article-title":"Isolation of peripheral blood mononuclear cells using vacutainer\u00ae Cellular preparation tubes (CPT\u2122)","volume":"7","author":"Puleo","year":"2017","journal-title":"Bio Protoc"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0439-x","article-title":"The nf-core framework for community-curated bioinformatics pipelines","volume":"38","author":"Ewels","year":"2020","journal-title":"Nat Biotechnol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-018-2191-5","article-title":"RnaSeqSampleSize: real data based sample size estimation for RNA sequencing","volume":"19","author":"Zhao","year":"2018","journal-title":"BMC Bioinf"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1215","article-title":"Interferome v2.0: an updated database of annotated interferon-regulated genes","volume":"41","author":"Rusinova","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics9030113","article-title":"An easy and reliable strategy for making type I interferon signature analysis comparable among research centers","volume":"9","author":"Pin","year":"2019","journal-title":"Diagnostics (Basel)"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/art.20798","article-title":"Coordinate overexpression of interferon-alpha-induced genes in systemic lupus erythematosus","volume":"50","author":"Kirou","year":"2004","journal-title":"Arthritis Rheumatol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239403","article-title":"A proposal of an alternative primer for the ARTIC Network\u2019s multiplex PCR to improve coverage of SARS-CoV-2 genome sequencing","volume":"15","author":"Itokawa","year":"2020","journal-title":"PLoS One"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts199","article-title":"Geneious Basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data","volume":"28","author":"Kearse","year":"2012","journal-title":"Bioinformatics"},{"key":"B42","doi-asserted-by":"publisher","first-page":"6645","DOI":"10.3390\/ijms25126645","article-title":"From SARS-coV-2 to global preparedness: A graphical interface for standardised high-throughput bioinformatics analysis in pandemic scenarios and surveillance of drug resistance","volume":"25","author":"Cumlin","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty191","article-title":"Minimap2: pairwise alignment for nucleotide sequences","volume":"34","author":"Li","year":"2018","journal-title":"Bioinformatics"},{"key":"B44","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41419-019-1765-0","article-title":"Long non-coding RNA Rpph1 promotes inflammation and proliferation of mesangial cells in diabetic nephropathy via an interaction with Gal-3","volume":"10","author":"Zhang","year":"2019","journal-title":"Cell Death Dis"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.3c00418","article-title":"Ubiquitin ligase parkin regulates the stability of SARS-coV-2 main protease and suppresses viral replication","volume":"10","author":"Zhou","year":"2024","journal-title":"ACS Infect Dis"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.coviro.2015.09.005","article-title":"Interplay between the virus and the ubiquitin-proteasome system: molecular mechanism of viral pathogenesis","volume":"17","author":"Luo","year":"2016","journal-title":"Curr Opin Virol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1103","article-title":"Elevated ubiquitination contributes to protective immunity against severe SARS-CoV-2 infection","volume":"12","author":"Che","year":"2022","journal-title":"Clin Transl Med"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071093","article-title":"Modulating the ubiquitin-proteasome system: A therapeutic strategy for autoimmune diseases","volume":"11","author":"Yadav","year":"2022","journal-title":"Cells"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00778-4","article-title":"Disorders of ubiquitylation: unchained inflammation","volume":"18","author":"Beck","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1523799","article-title":"Ubiquitin-proteasome system: a potential participant and therapeutic target in antiphospholipid syndrome","volume":"16","author":"Wang","year":"2025","journal-title":"Front Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3390\/v15030782","article-title":"The role of viral infections in the onset of autoimmune diseases","volume":"15","author":"Sundaresan","year":"2023","journal-title":"Viruses"},{"key":"B52","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1001\/jama.2024.24894","article-title":"New research suggests increased risk of some autoimmune disorders after COVID-19","volume":"333","author":"Anderer","year":"2025","journal-title":"JAMA"},{"key":"B53","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41584-023-00964-y","article-title":"High risk of autoimmune diseases after COVID-19","volume":"19","author":"Sharma","year":"2023","journal-title":"Nat Rev Rheumatol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4049\/jimmunol.2300094","article-title":"The world according to IL-9","volume":"211","author":"Pajulas","year":"2023","journal-title":"J Immunol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"4060","DOI":"10.1038\/s41467-023-39815-5","article-title":"IL-9 aggravates SARS-CoV-2 infection and exacerbates associated airway inflammation","volume":"14","author":"Sadhu","year":"2023","journal-title":"Nat Commun"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3390\/immuno4020010","article-title":"Systematic review: JAK-STAT regulation and its impact on inflammation response in ARDS from COVID-19","volume":"4","author":"Rodriguez","year":"2024","journal-title":"Immuno"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/cells11020306","article-title":"Janus kinase signaling pathway and its role in COVID-19 inflammatory, vascular, and thrombotic manifestations","volume":"11","author":"Ravid","year":"2022","journal-title":"Cells"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.145325","article-title":"The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2","volume":"768","author":"Luo","year":"2021","journal-title":"Gene"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD015209","article-title":"Janus kinase inhibitors for the treatment of COVID-19","volume":"6","author":"Kramer","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.4103\/tjem.tjem_363_22","article-title":"Role of Janus Kinase inhibitors in the management of pulmonary involvement due to Long COVID-19 disease: A case control study","volume":"23","author":"Singh","year":"2023","journal-title":"Turk J Emerg Med"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00726-8","article-title":"Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach","volume":"18","author":"Tanaka","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1120281","article-title":"Editorial: JAK inhibition in autoimmune and inflammatory diseases","volume":"13","author":"Telliez","year":"2022","journal-title":"Front Immunol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00985-20","article-title":"Type I and type III interferons restrict SARS-coV-2 infection of human airway epithelial cultures","volume":"94","author":"Vanderheiden","year":"2020","journal-title":"J Virol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3390\/v12121374","article-title":"Non-coding RNAs and SARS-related coronaviruses","volume":"12","author":"Henzinger","year":"2020","journal-title":"Viruses"},{"key":"B65","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.ncrna.2019.02.001","article-title":"C\/D box snoRNAs in viral infections: RNA viruses use old dogs for new tricks","volume":"4","author":"Stamm","year":"2019","journal-title":"Noncoding RNA Res"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213666","article-title":"Analysis of expression pattern of snoRNAs in human cells A549 infected by influenza A virus","volume":"23","author":"Zhuravlev","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3390\/v15020562","article-title":"The host non-coding RNA response to alphavirus infection","volume":"15","author":"Behnia","year":"2023","journal-title":"Viruses"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11195571","article-title":"COVID-19 salivary protein profile: unravelling molecular aspects of SARS-coV-2 infection","volume":"11","author":"Esteves","year":"2022","journal-title":"J Clin Med"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.08.052","article-title":"Quantitative lipid droplet proteome analysis identifies annexin A3 as a cofactor for HCV particle production","volume":"16","author":"R\u00f6sch","year":"2016","journal-title":"Cell Rep"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011028","article-title":"Molecular insights on the possible role of annexin A2 in COVID-19 pathogenesis and post-infection complications","volume":"22","author":"Patil","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-023-01096-x","article-title":"SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence","volume":"25","author":"Gioia","year":"2023","journal-title":"Nat Cell Biol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1589589\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T01:47:27Z","timestamp":1748569647000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1589589\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":71,"alternative-id":["10.3389\/fimmu.2025.1589589"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1589589","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,30]]},"article-number":"1589589"}}