{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:02:33Z","timestamp":1793764953614,"version":"4.6.1"},"reference-count":156,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Tissue-resident memory T (T<jats:sub>RM<\/jats:sub>) cells are a type of tissue-restricted memory T cells with terminal differentiation and a memory function. They exist in mucosal tissues for a long period. In the absence of disease, T<jats:sub>RM<\/jats:sub> cells promote essential inflammation, which reinforces the intestinal barrier and prevents bacterial translocation. However, in inflammatory or autoimmune environments, T<jats:sub>RM<\/jats:sub> cells are hyperactivated. This heightened activity causes the host to release excessive pro-inflammatory cytokines, resulting in local immune imbalances and damage to the barrier, ultimately leading to tissue lesions. Numbers of studies have shown that T<jats:sub>RM<\/jats:sub> cells play a crucial role in the development and progression of inflammatory bowel disease (IBD), suggesting that targeted regulation of T<jats:sub>RM<\/jats:sub> cells homeostasis may be an important strategy for treating IBD. Here, we compiled the existing understanding of the role of T<jats:sub>RM<\/jats:sub> cells in IBD, with particular emphasis on the associated mechanisms and approaches for targeting T<jats:sub>RM<\/jats:sub> cells in IBD treatment. This review will serve as a foundation for a better understanding of IBD development and enhancing the effectiveness of clinical treatments for IBD.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1591584","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T04:10:15Z","timestamp":1748923815000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Immunological pathogenesis of inflammatory bowel disease: focus on tissue resident memory T 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