{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:05:56Z","timestamp":1793736356862,"version":"4.6.1"},"reference-count":161,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease with severe complications. Ferroptosis, an iron-dependent form of apoptosis, encompasses mechanisms including iron overload, lipid peroxidation, redox homeostasis, and reactive oxygen species accumulation, all of which are closely related to RA pathogenesis. This study focused on the mechanism of ferroptosis and RA, detailing their relationship and outlining the reported roles of ferroptosis inhibitors in RA treatment to provide a useful research basis in drug discovery and development and for clinicians.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1610121","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T04:10:40Z","timestamp":1749528640000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Targeting the ferroptosis pathway for rheumatoid arthritis: molecular mechanisms and prospects for inhibitor development"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhuoling","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huahua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyu","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingdan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiming","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/prd.12432","article-title":"Pros and cons of causative association between periodontitis and rheumatoid arthritis","volume":"89","author":"Koziel","year":"2000","journal-title":"Periodontol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-021-08890-1","article-title":"Autoantibodies in rheumatoid arthritis: historical background and novel findings","volume":"63","author":"Sokolova","year":"2022","journal-title":"Clin Rev Allergy Immunol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-023-01896-z","article-title":"Role of PET\/CT in diagnosing and monitoring disease activity in rheumatoid arthritis: a review","volume":"38","author":"Singh","year":"2024","journal-title":"Ann Nucl Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-070856","article-title":"Therapeutic advances in rheumatoid arthritis","volume":"384","author":"Brown","year":"2024","journal-title":"BMJ (Clinical Res ed.)"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1177\/1759720x221137127","article-title":"Health disparities in rheumatoid arthritis","volume":"14","author":"Ciofoaia","year":"2022","journal-title":"Ther Adv musculoskeletal Dis"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2147\/jir.S403925","article-title":"Possible future avenues for rheumatoid arthritis therapeutics: hippo pathway","volume":"16","author":"Wang","year":"2023","journal-title":"J Inflammation Res"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.859400","article-title":"Epigenetic regulation in the pathogenesis of rheumatoid arthritis","volume":"13","author":"Yang","year":"2022","journal-title":"Front Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/s2665-9913(23)00211-4","article-title":"Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021","volume":"5","year":"2023","journal-title":"Lancet Rheumatol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(17)31472-1","article-title":"Pathogenetic insights from the treatment of rheumatoid arthritis","volume":"389","author":"McInnes","year":"2017","journal-title":"Lancet (London England)"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2021.01022","article-title":"Immunopathogenic mechanisms of rheumatoid arthritis and the use of anti-inflammatory drugs","volume":"10","author":"Zhang","year":"2021","journal-title":"Intractab le rare Dis Res"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.09.043","article-title":"The development of the concept of ferroptosis","volume":"133","author":"Hirschhorn","year":"2019","journal-title":"Free Radical Biol Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.05.221","article-title":"Ferroptosis - An iron- and disorder-dependent programmed cell death","volume":"135","author":"Djulbegovic","year":"2019","journal-title":"Int J Biol macromolecules"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yin","year":"2014","journal-title":"Cell"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/nu14214599","article-title":"The ferroptosis inhibitor liproxstatin-1 ameliorates LPS-induced cognitive impairment in mice","volume":"14","author":"Li","year":"2022","journal-title":"Nutrients"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214022","article-title":"Significant joint-destructive association of HLA-DRB1*04:05 independent of DAS28 in rheumatoid arthritis","volume":"78","author":"Tsuji","year":"2019","journal-title":"Ann rheumatic Dis"},{"key":"B16","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00281-022-00912-0","article-title":"Genetics of rheumatoid arthritis","volume":"44","author":"Padyukov","year":"2022","journal-title":"Semin immunopathology"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.05.012","article-title":"Complement and its environmental determinants in the progression of human rheumatoid arthritis","volume":"112","author":"Bemis","year":"2019","journal-title":"Mol Immunol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.692041","article-title":"In rheumatoid arthritis patients, HLA-DRB1*04:01 and rheumatoid nodules are associated with ACPA to a particular fibrin epitope","volume":"12","author":"Larid","year":"2021","journal-title":"Front Immunol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120784","article-title":"Metaanalysis of the association of smoking and PTPN22 R620W genotype on autoantibody status and radiological erosions in rheumatoid arthritis","volume":"40","author":"Taylor","year":"2013","journal-title":"J Rheumatol"},{"key":"B20","volume-title":"Association between rs7574865 polymorphism in STAT4 gene and rheumatoid arthritis: An updated meta-analysis","author":"Gao","year":"2023"},{"key":"B21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ejmhg.2012.08.007","article-title":"et al: Lack of association between single nucleotide polymorphism rs10818488 in TRAF1\/C5 region and rheumatoid arthritis in Iranian population","volume":"13","author":"Ahmadlou","year":"2014","journal-title":"Iranian J allergy asthma Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/art.40879","article-title":"New relationships for old autoantibodies in rheumatoid arthritis","volume":"71","author":"Shelef","year":"2019","journal-title":"Arthritis Rheumatol (Hoboken N.J.)"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246111","article-title":"Potential applicability of cytokines as biomarkers of disease activity in rheumatoid arthritis: Enzyme-linked immunosorbent spot assay-based evaluation of TNF-\u03b1, IL-1\u03b2, IL-10 and IL-17A","volume":"16","author":"Dissanayake","year":"2021","journal-title":"PloS One"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-021-00800-3","article-title":"Orchestrated modulation of rheumatoid arthritis via crosstalking intracellular signaling pathways","volume":"29","author":"Ibrahim","year":"2021","journal-title":"Inflammopharmacology"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-022-00930-2","article-title":"Nerolidol: a potential approach in rheumatoid arthritis through reduction of TNF-\u03b1, IL-1\u03b2, IL-6, NF-kB, COX-2 and antioxidant effect in CFA-induced arthritic model","volume":"30","author":"Akhter","year":"2022","journal-title":"Inflammopharmacology"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-025-01401-8","article-title":"Rheumatoid arthritis severity is mediated by crosstalk between synoviocytes and mature osteoclasts through a calcium and cytokine feedback loop","volume":"57","author":"Lee","year":"2025","journal-title":"Exp Mol Med"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065173","article-title":": new insights into the role of synovial fibroblasts leading to joint destruction in rheumatoid arthritis","volume":"24","author":"Matsuda","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2023.111869","article-title":"Cardiac iron metabolism during aging - Role of inflammation and proteolysis","volume":"215","author":"Muckenthaler","year":"2023","journal-title":"Mech Ageing Dev"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169395","article-title":": iron metabolism and ferroptosis in physiological and pathological pregnancy","volume":"23","author":"Zhang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/biom14070856","article-title":": ischemic neuroprotection by insulin with down-regulation of divalent metal transporter 1 (DMT1) expression and ferrous iron-dependent cell death","volume":"14","author":"Fenaroli","year":"2024","journal-title":"Biomolecules"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.139752","article-title":"Casein phosphopeptide interferes the interactions between ferritin and ion irons","volume":"454","author":"Sha","year":"2024","journal-title":"Food Chem"},{"key":"B32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1182\/blood.2024024731","article-title":"Transferrin: the iron transporter takes control","volume":"144","author":"Weichhart","year":"2024","journal-title":"Blood"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.601193","article-title":"Iron metabolism and ferroptosis in epilepsy","volume":"14","author":"Chen","year":"2020","journal-title":"Front Neurosci"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1039241","article-title":"ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis","volume":"13","author":"Zheng","year":"2022","journal-title":"Front Immunol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3390\/cells12040611","article-title":"Mitochondrial lipid peroxidation is responsible for ferroptosis","volume":"12","author":"Lyamzaev","year":"2023","journal-title":"Cells"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147544","article-title":"Oxidative Metabolism as a cause of lipid peroxidation in the execution of ferroptosis","volume":"25","author":"Fujii","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2023.101683","article-title":"How do different lipid peroxidation mechanisms contribute to ferroptosis? Cell reports","volume":"4","author":"Do","year":"2023","journal-title":"Phys Sci"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.910292","article-title":"System X(c) (-)\/GSH\/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy","volume":"13","author":"Li","year":"2022","journal-title":"Front Pharmacol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2218764","article-title":"GPX4 in cell death, autophagy, and disease","volume":"19","author":"Xie","year":"2023","journal-title":"Autophagy"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116512","article-title":"GPX4, ferroptosis, and diseases","volume":"174","author":"Zhang","year":"2024","journal-title":"Biomedicine pharmacotherapy = Biomedecine pharmacotherapie"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13060697","article-title":"GSH and ferroptosis: side-by-side partners in the fight against tumors","volume":"13","author":"Jiang","year":"2024","journal-title":"Antioxidants (Basel Switzerland)"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: The role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radical Biol Med"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1080\/10715762.2021.2016735","article-title":"Comparison of three methods for in vivo quantification of glutathione in tissues of hypertensive rats","volume":"55","author":"Kalinovic","year":"2021","journal-title":"Free Radical Res"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3390\/cells12091263","article-title":": LKB1 regulates inflammation of fibroblast-like synoviocytes from patients with rheumatoid arthritis via AMPK-dependent SLC7A11-NOX4-ROS signaling","volume":"12","author":"Li","year":"2023","journal-title":"Cells"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01656","article-title":"Abnormal ferroptosis in myelodysplastic syndrome","volume":"10","author":"Lv","year":"2020","journal-title":"Front Oncol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/278261a0","article-title":"T antigen is bound to a host protein in SV40-transformed cells","volume":"278","author":"Lane","year":"1979","journal-title":"Nature"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026120","article-title":"Autophagy and p53","volume":"6","author":"White","year":"2016","journal-title":"Cold Spring Harbor Perspect Med"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjz010","article-title":"Understanding p53 functions through p53 antibodies","volume":"11","author":"Sabapathy","year":"2019","journal-title":"J Mol Cell Biol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41420-023-01517-8","article-title":"Ferroptosis and the bidirectional regulatory factor p53","volume":"9","author":"Xu","year":"2023","journal-title":"Cell Death Discov"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.106013","article-title":"p53: A double-edged sword in tumor ferroptosis","volume":"177","author":"Ji","year":"2022","journal-title":"Pharmacol Res"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110083","article-title":"p53-Dependent ferroptosis pathways in sepsis","volume":"118","author":"Gao","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/s41418-022-00943-y","article-title":"p53 in ferroptosis regulation: the new weapon for the old guardian","volume":"29","author":"Liu","year":"2022","journal-title":"Cell Death differentiation"},{"key":"B54","doi-asserted-by":"publisher","first-page":"5985","DOI":"10.2147\/jir.S479794","article-title":"The dual role of NRF2 in colorectal cancer: targeting NRF2 as a potential therapeutic approach","volume":"17","author":"Hu","year":"2024","journal-title":"J Inflammation Res"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2021.05.013","article-title":"MGST1, a new soldier of NRF2 in the battle against ferroptotic death","volume":"28","author":"Dodson","year":"2021","journal-title":"Cell Chem Biol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2023.06.022","article-title":"Nrf2 targeting in overcoming ferroptosis evasion in head and neck cancer","volume":"671","author":"Roh","year":"2023","journal-title":"Biochem Biophys Res Commun"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12091739","article-title":"NRF2, a superstar of ferroptosis","volume":"12","author":"Yan","year":"2023","journal-title":"Antioxidants (Basel Switzerland)"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.23705","article-title":"Mevalonate pathway and male reproductive aging","volume":"90","author":"Zhang","year":"2023","journal-title":"Mol Reprod Dev"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e27084","article-title":"Pitavastatin induces autophagy-dependent ferroptosis in MDA-MB-231 cells via the mevalonate pathway","volume":"10","author":"Tang","year":"2024","journal-title":"Heliyon"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.2147\/jhc.S433332","article-title":"miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway","volume":"10","author":"Xing","year":"2023","journal-title":"J\u00a0hepatocellular carcinoma"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/s41419-021-04306-2","article-title":"Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells","volume":"12","author":"Sun","year":"2021","journal-title":"Cell Death Dis"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2023.05.013","article-title":"FSP1: a key regulator of ferroptosis","volume":"29","author":"Li","year":"2023","journal-title":"Trends Mol Med"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.0c00030","article-title":"Ferroptosis suppressor protein 1 (FSP1) and coenzyme Q(10) cooperatively suppress ferroptosis","volume":"59","author":"Hadian","year":"2020","journal-title":"Biochemistry"},{"key":"B64","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/s41419-022-04924-4","article-title":"Involvement of FSP1-CoQ(10)-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis","volume":"13","author":"Yang","year":"2022","journal-title":"Cell Death Dis"},{"key":"B65","doi-asserted-by":"publisher","first-page":"368","DOI":"10.21037\/atm-21-6942","article-title":"The critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review","volume":"10","author":"Liu","year":"2022","journal-title":"Ann Trans Med"},{"key":"B66","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"GTP cyclohydrolase 1\/tetrahydrobiopterin counteract ferroptosis through lipid remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent Sci"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11061182","article-title":"Measurement of tetrahydrobiopterin in animal tissue samples by HPLC with electrochemical detection-Protocol optimization and pitfalls","volume":"11","author":"Milski","year":"2022","journal-title":"Antioxidants (Basel Switzerland)"},{"key":"B68","doi-asserted-by":"publisher","first-page":"vi79","DOI":"10.1093\/neuonc\/noab196.306","article-title":"Ddre-22. Disrupting redox balance via the tetrahydrobiopterin pathway in glioblastoma","volume":"23","author":"Tuy","year":"2021","journal-title":"Neuro-Oncology"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.810327","article-title":"Blockade of GCH1\/BH4 axis activates ferritinophagy to mitigate the resistance of colorectal cancer to erastin-Induced ferroptosis","volume":"10","author":"Hu","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2022.06.016","article-title":"Tetrahydrobiopterin modulates the behavioral neuroinflammatory response to an LPS challenge in mice","volume":"105","author":"Vancassel","year":"2022","journal-title":"Brain behavior Immun"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3390\/cells11081266","article-title":"Switching of redox signaling by prdx6 expression decides cellular fate by hormetic phenomena involving nrf2 and reactive oxygen species","volume":"11","author":"Chhunchha","year":"2022","journal-title":"Cells"},{"key":"B72","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.freeradbiomed.2024.04.208","article-title":"Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells","volume":"218","author":"Torres-Villalobos","year":"2024","journal-title":"Free Radical Biol Med"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-024-01329-z","article-title":"PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis","volume":"31","author":"Fujita","year":"2024","journal-title":"Nat Struct Mol Biol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155912","article-title":"Analyzing how SiMiao Wan regulates ferroptosis to prevent RA-ILD using metabolomics and cyberpharmacology","volume":"133","author":"Chen","year":"2024","journal-title":"Phytomedicine: Int J phytotherapy phytopharmacology"},{"key":"B75","doi-asserted-by":"publisher","first-page":"9882","DOI":"10.1038\/s41598-020-66945-3","article-title":"Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis","volume":"10","author":"Sato","year":"2020","journal-title":"Sci Rep"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06708-y","article-title":"Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes","volume":"623","author":"Zhang","year":"2023","journal-title":"Nature"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1136\/ard.27.4.345","article-title":"Nature of anaemia in rheumatoid arthritis. 8. Iron content of synovial tissue in patients with rheumatoid arthritis and in normal individuals","volume":"27","author":"Mowat","year":"1968","journal-title":"Ann rheumatic Dis"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.4.516","article-title":"Effect of iron complexes on adjuvant arthritis in rats","volume":"51","author":"Dabbagh","year":"1992","journal-title":"Ann rheumatic Dis"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1260839","article-title":"Ferroptosis as an emerging target in rheumatoid arthritis","volume":"14","author":"Zhao","year":"2023","journal-title":"Front Immunol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2019.00116","article-title":"The role of iron regulation in immunometabolism and immune-Related disease","volume":"6","author":"Cronin","year":"2019","journal-title":"Front Mol Biosci"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116540","article-title":"Targeted delivery of NO donor and ROS scavenger for synergistic treatment of rheumatoid arthritis","volume":"174","author":"Luo","year":"2024","journal-title":"Biomedicine pharmacotherapy = Biomedecine pharmacotherapie"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1190607","article-title":"Lipid metabolism and rheumatoid arthritis","volume":"14","author":"Qian","year":"2023","journal-title":"Front Immunol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1149665","article-title":"Non-alcoholic fatty liver disease combined with rheumatoid arthritis exacerbates liver fibrosis by stimulating co-localization of PTRF and TLR4 in rats","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Pharmacol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10010045","article-title":"Insights in the role of lipids, oxidative stress and inflammation in rheumatoid arthritis unveiled by new trends in lipidomic investigations","volume":"10","author":"Ferreira","year":"2021","journal-title":"Antioxidants (Basel Switzerland)"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107879","article-title":"Celastrol inhibits rheumatoid arthritis through the ROS-NF-\u03baB-NLRP3 inflammasome axis","volume":"98","author":"Jing","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175530","article-title":"Kallistatin attenuates inflammatory response in rheumatoid arthritis via the NF-\u03baB signaling pathway","volume":"943","author":"Wang","year":"2023","journal-title":"Eur J Pharmacol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2081756","article-title":"Plumbagin relieves rheumatoid arthritis through nuclear factor kappa-B (NF-\u03baB) pathway","volume":"13","author":"Shu","year":"2022","journal-title":"Bioengineered"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.00104-20","article-title":"Looking down on NF-\u03baB","volume":"40","author":"Williams","year":"2020","journal-title":"Mol Cell Biol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac069","article-title":"Glycine increased ferroptosis via SAM-mediated GPX4 promoter methylation in rheumatoid arthritis","volume":"6","author":"Ling","year":"2022","journal-title":"Rheumatol (Oxford England)"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155109","article-title":"Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids","volume":"121","author":"Xian","year":"2023","journal-title":"Phytomedicine: Int J phytotherapy phytopharmacology"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.02.007","article-title":"The potential development of drug resistance in rheumatoid arthritis patients identified with p53 mutations","volume":"10","author":"Qiu","year":"2023","journal-title":"Genes Dis"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-022-01094-9","article-title":"Anti-inflammatory effects of PRIMA-1(MET) (mutant p53 reactivator) induced by inhibition of nuclear factor-\u03baB on rheumatoid arthritis fibroblast-like synoviocytes","volume":"31","author":"Adib","year":"2023","journal-title":"Inflammopharmacology"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.retram.2020.05.002","article-title":"Role of Nrf2 in rheumatoid arthritis","volume":"68","author":"Chada","year":"2020","journal-title":"Curr Res Trans Med"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c00163","article-title":"An overview of therapeutic targeting of nrf2 signaling pathway in rheumatoid arthritis","volume":"9","author":"Saha","year":"2024","journal-title":"ACS omega"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.07.016","article-title":"Nrf2 activation improves experimental rheumatoid arthritis","volume":"207","author":"Zhang","year":"2023","journal-title":"Free Radical Biol Med"},{"key":"B96","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/imm.12902","article-title":"Immune modulatory effects of statins","volume":"154","author":"Zeiser","year":"2018","journal-title":"Immunology"},{"key":"B97","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.freeradbiomed.2021.07.019","article-title":"Glycyrrhetinic acid induces oxidative\/nitrative stress and drives ferroptosis through activating NADPH oxidases and iNOS, and depriving glutathione in triple-negative breast cancer cells","volume":"173","author":"Wen","year":"2021","journal-title":"Free Radical Biol Med"},{"key":"B98","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.bbrc.2022.10.017","article-title":"18\u03b2-glycyrrhetinic acid protects neuronal cells from ferroptosis through inhibiting labile iron accumulation and preventing coenzyme Q10 reduction","volume":"635","author":"Ma","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.681525","article-title":"Anti-inflammatory and pro-apoptotic effects of 18beta-Glycyrrhetinic acid in vitro and in vivo models of rheumatoid arthritis","volume":"12","author":"Feng","year":"2021","journal-title":"Front Pharmacol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.2174\/18715206113139990115","article-title":"Molecular evidence of cryptotanshinone for treatment and prevention of human cancer","volume":"13","author":"Chen","year":"2013","journal-title":"Anti-cancer Agents medicinal Chem"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/9875726","article-title":"Retracted: Cryptotanshinone Protects against PCOS-Induced Damage of Ovarian Tissue via Regulating Oxidative Stress, Mitochondrial Membrane Potential, Inflammation, and Apoptosis via Regulating Ferroptosis","volume":"2023","author":"Longevity","year":"2023","journal-title":"Oxid Med Cell Longevity"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.05.006","article-title":"Therapeutic effect of Cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation","volume":"138","author":"Wang","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9541080","article-title":"To explore the inhibitory mechanism of quercetin in thyroid papillary carcinoma through network pharmacology and experiments","volume":"2022","author":"Sun","year":"2022","journal-title":"Dis Markers"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3390\/life13081730","article-title":": quercetin and ferroptosis","volume":"13","author":"Cruz-Gregorio","year":"2023","journal-title":"Life (Basel Switzerland)"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.S364759","article-title":"Pharmacological aspects of natural quercetin in rheumatoid arthritis","volume":"16","author":"Tang","year":"2022","journal-title":"Drug design Dev Ther"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1148814","article-title":"Epigallocatechin gallate alleviates high-fat diet-induced hepatic lipotoxicity by targeting mitochondrial ROS-mediated ferroptosis","volume":"14","author":"Ding","year":"2023","journal-title":"Front Pharmacol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-022-00544-0","article-title":"Epigallocatechin-3-Gallate pretreatment improves autologous adipose-derived stem cells against rheumatoid arthritis-induced neuroinflammation in the brain of collagen-induced rats","volume":"40","author":"Chen","year":"2022","journal-title":"Neurotoxicity Res"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2024.09.006","article-title":"The evolutionary advantage of artemisinin production by Artemisia annua","volume":"30","author":"Yin","year":"2025","journal-title":"Trends Plant Sci"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-024-01378-6","article-title":"Artemisinin inhibits neuronal ferroptosis in Alzheimer\u2019s disease models by targeting KEAP1","volume":"46","author":"Deng","year":"2025","journal-title":"Acta pharmacologica Sin"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.3233\/jad-201369","article-title":"The potential role of ferroptosis in alzheimer\u2019s disease","volume":"80","author":"Zhang","year":"2021","journal-title":". J Alzheimer\u2019s disease: JAD"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1148","article-title":"Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3-mediated N6-methyladenosine modification of ICAM2 mRNA in fibroblast-like synoviocytes","volume":"12","author":"Chen","year":"2022","journal-title":"Clin Trans Med"},{"key":"B112","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1080\/87559120802525459","article-title":"Resveratrol as a health and disease benefit agent","volume":"26","author":"Tosun","year":"2009","journal-title":"Food Rev Int"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1473939","article-title":"Therapeutic potential of resveratrol through ferroptosis modulation: insights and future directions in disease therapeutics","volume":"15","author":"Liu","year":"2024","journal-title":"Front Pharmacol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185x.14356","article-title":"A comprehensive insight into effects of resveratrol on molecular mechanism in rheumatoid arthritis: A literature systematic review","volume":"25","author":"Karimi","year":"2022","journal-title":"Int J Rheum Dis"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061305","article-title":"The therapeutic potential of apigenin","volume":"20","author":"Salehi","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.2174\/1389557523666230119110744","article-title":"Induction of cancer cell death by apigenin: A review on different cell death pathways","volume":"23","author":"Amini","year":"2023","journal-title":"Mini Rev medicinal Chem"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2024.156616","article-title":"Targeting TNF-\u03b1-induced expression of TTR and RAGE in rheumatoid arthritis: Apigenin\u2019s mediated therapeutic approach","volume":"179","author":"Monu","year":"2024","journal-title":"Cytokine"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12122119","article-title":"Silibinin inhibits cell ferroptosis and ferroptosis-Related tissue injuries","volume":"12","author":"Duan","year":"2023","journal-title":"Antioxidants (Basel Switzerland)"},{"key":"B119","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1038\/s41598-018-21674-6","article-title":"Silibinin alleviates inflammation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes and has a therapeutic effect on arthritis in rats","volume":"8","author":"Tong","year":"2018","journal-title":"Sci Rep"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c03239","article-title":"\u03b2-caryophyllene confers cardioprotection by scavenging radicals and blocking ferroptosis","volume":"72","author":"Li","year":"2024","journal-title":"J Agric Food Chem"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232416055","article-title":"\u03b2-caryophyllene acts as a ferroptosis inhibitor to ameliorate experimental colitis","volume":"23","author":"Wu","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B122","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1186\/s12906-021-03410-2","article-title":"Myrtenal and \u03b2-caryophyllene oxide screened from Liquidambaris Fructus suppress NLRP3 inflammasome components in rheumatoid arthritis","volume":"21","author":"Li","year":"2021","journal-title":"BMC complementary Med therapies"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2008","article-title":"Vitamin E: regulatory redox interactions","volume":"71","author":"Miyazawa","year":"2019","journal-title":"IUBMB Life"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-021-03483-y","article-title":"Vitamin E exerts neuroprotective effects in pentylenetetrazole kindling epilepsy via suppression of ferroptosis","volume":"47","author":"Zhang","year":"2022","journal-title":"Neurochemical Res"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1002\/bab.2176","article-title":"Vitamin E at a high dose as an anti-ferroptosis drug and not just a supplement for COVID-19 treatment","volume":"69","author":"Tavakol","year":"2022","journal-title":"Biotechnol Appl Biochem"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-022-01148-9","article-title":"Effect of vitamin E supplementation in rheumatoid arthritis: a systematic review and meta-analysis","volume":"77","author":"Kou","year":"2023","journal-title":"Eur J Clin Nutr"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2023.103323","article-title":"Non-pharmacological interventions in the treatment of rheumatoid arthritis: A systematic review and meta-analysis","volume":"22","author":"Turk","year":"2023","journal-title":"Autoimmun Rev"},{"key":"B128","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1080\/27697061.2024.2401055","article-title":"Association of vitamin E intake with all-Cause mortality among individuals with rheumatoid arthritis: A cohort study from the NHANES 1999-2018","volume":"44","author":"Yin","year":"2025","journal-title":"J Am Nutr Assoc"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7877","article-title":"Ginkgols and bilobols in Ginkgo biloba L. A review of their extraction and bioactivities","volume":"37","author":"Boateng","year":"2023","journal-title":"Phytotherapy research: PTR"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113953","article-title":"Ginkgolide B alleviates oxidative stress and ferroptosis by inhibiting GPX4 ubiquitination to improve diabetic nephropathy","volume":"156","author":"Chen","year":"2022","journal-title":"Biomedicine pharmacotherapy = Biomedecine pharmacotherapie"},{"key":"B131","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.21037\/atm-20-6420","article-title":"Ginkgolide B attenuates collagen-induced rheumatoid arthritis and regulates fibroblast-like synoviocytes-mediated apoptosis and inflammation","volume":"8","author":"Xie","year":"2020","journal-title":"Ann Trans Med"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c03120","article-title":"Research on the regulation of plipastatin production by the quorum-Sensing comQXPA system of bacillus amyloliquefaciens","volume":"71","author":"Zhou","year":"2023","journal-title":"J Agric Food Chem"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgad024","article-title":"The pleiotropic effects of statins in rheumatoid arthritis","volume":"75","author":"Aminifar","year":"2023","journal-title":"J Pharm Pharmacol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155380","article-title":"Celastrol inhibits oligodendrocyte and neuron ferroptosis to promote spinal cord injury recovery","volume":"128","author":"Shen","year":"2024","journal-title":"Phytomedicine: Int J phytotherapy phytopharmacology"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115333","article-title":"Celastrol alleviated acute kidney injury by inhibition of ferroptosis through Nrf2\/GPX4 pathway","volume":"166","author":"Pan","year":"2023","journal-title":"Biomedicine pharmacotherapy = Biomedecine pharmacotherapie"},{"key":"B136","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1038\/s41598-023-48248-5","article-title":"Exploring the mechanism of Celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omics","volume":"14","author":"Zeng","year":"2024","journal-title":"Sci Rep"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.11.028","article-title":"Celastrol-loaded bovine serum albumin nanoparticles target inflamed neutrophils for improved rheumatoid arthritis therapy","volume":"174","author":"Liu","year":"2024","journal-title":"Acta biomaterialia"},{"key":"B138","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1186\/s12964-024-01751-2","article-title":"Selenium nanoparticles alleviate renal ischemia\/reperfusion injury by inhibiting ferritinophagy via the XBP1\/NCOA4 pathway","volume":"22","author":"Zuo","year":"2024","journal-title":"Cell communication signaling: CCS"},{"key":"B139","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.3390\/antiox12111973","article-title":"Biogenic selenium nanoparticles synthesized with alginate oligosaccharides alleviate heat stress-Induced oxidative damage to organs in broilers through activating nrf2-Mediated anti-Oxidation and anti-Ferroptosis pathways","volume":"12","author":"Zhao","year":"2023","journal-title":"Antioxidants (Basel Switzerland)"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2024.103554","article-title":"Metabolomic analysis reveals biogenic selenium nanoparticles improve the meat quality of thigh muscle in heat-stressed broilers is related to the regulation of ferroptosis pathway","volume":"103","author":"Huang","year":"2024","journal-title":"Poultry Sci"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103268","article-title":"BSA-stabilized selenium nanoparticles ameliorate intracerebral hemorrhage\u2019s-like pathology by inhibiting ferroptosis-mediated neurotoxicology via Nrf2\/GPX4 axis activation","volume":"75","author":"Li","year":"2024","journal-title":"Redox Biol"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S243718","article-title":"Toxicological and anti-rheumatic potential of trachyspermum ammi derived biogenic selenium nanoparticles in arthritic balb\/c mice","volume":"15","author":"Qamar","year":"2020","journal-title":"nternational J nanomedicine"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13736","article-title":"A novel tetrahedral framework nucleic acid-derived chemodynamic therapy agent for effective glioblastoma treatment","volume":"58","author":"Li","year":"2025","journal-title":"Cell proliferation"},{"key":"B144","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1186\/s12951-024-02963-x","article-title":"Tetrahedral framework nucleic acids inhibit A\u03b2-mediated ferroptosis and ameliorate cognitive and synaptic impairments in Alzheimer\u2019s disease","volume":"22","author":"Tan","year":"2024","journal-title":"J nanobiotechnology"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-024-00319-7","article-title":"A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis","volume":"12","author":"Li","year":"2024","journal-title":". Bone Res"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.06.003","article-title":"Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis","volume":"8","author":"Zhang","year":"2022","journal-title":"Bioactive materials"},{"key":"B147","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1002\/adfm.202310749","article-title":"Tetrahedral framework nucleic acid loaded miR-23b inhibits synovial inflammation and cartilage matrix degradation in the treatment of rheumatoid arthritis","volume":"34","author":"Wang","year":"2023","journal-title":"Advanced Funct Materials"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194179","article-title":"Niosomes, an alternative for liposomal delivery","volume":"13","author":"Bartelds","year":"2018","journal-title":"PloS One"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155835","article-title":"Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs","volume":"132","author":"Jia","year":"2024","journal-title":"Phytomedicine: Int J phytotherapy phytopharmacology"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02162","article-title":"Liposomal glutathione as a promising candidate for immunological rheumatoid arthritis therapy","volume":"5","author":"Kadry","year":"2019","journal-title":"Heliyon"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2024-24822","article-title":"Role of hypoxia-inducible-factor-1\u03b1 (HIF-1\u03b1) in ferroptosis of adipose tissue during ketosis","volume":"107","author":"Fan","year":"2024","journal-title":"J dairy Sci"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04170-z","article-title":"PGK1 is involved in the HIF-1 signaling pathway as a hub gene for ferroptosis after traumatic brain injury","volume":"62","author":"Wang","year":"2025","journal-title":"Mol Neurobiol"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444908","article-title":"HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1\u03b1 activation","volume":"45","author":"Park","year":"2015","journal-title":"Eur J Immunol"},{"key":"B154","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.actbio.2024.03.023","article-title":"Neuron-targeted liposomal coenzyme Q10 attenuates neuronal ferroptosis after subarachnoid hemorrhage by activating the ferroptosis suppressor protein 1\/coenzyme Q10 system","volume":"179","author":"Peng","year":"2024","journal-title":"Acta biomaterialia"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934664","article-title":"Treatment with coenzyme Q10, omega-3-polyunsaturated fatty acids and their combination improved bioenergetics and levels of coenzyme Q9 and Q10 in skeletal muscle mitochondria in experimental model of arthritis","volume":"70","author":"Kucharsk\u00e1","year":"2021","journal-title":"Physiol Res"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2024.111136","article-title":"Resveratrol alleviates depression-like behaviors by inhibiting ferroptosis via AKT\/NRF2 pathway","volume":"220","author":"Chen","year":"2025","journal-title":"Brain Res Bull"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1016\/j.enzmictec.2025.110618","article-title":"Recombinant alginate lyases and mannitol dehydrogenase enhance hydrolysis of macroalgal carbohydrates","volume":"186","author":"Rocher","year":"2025","journal-title":"Enzyme Microb Technol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27133970","article-title":"Novel iron oxide nanoparticles induce ferroptosis in a panel of cancer cell lines","volume":"27","author":"Fern\u00e1ndez-Acosta","year":"2022","journal-title":"Molecules (Basel Switzerland)"},{"key":"B159","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s11010-022-04492-3","article-title":"Rheumatoid arthritis: advances in treatment strategies","volume":"478","author":"Prasad","year":"2023","journal-title":"Mol Cell Biochem"},{"key":"B160","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.2147\/jir.s499345","article-title":"Programmed cell death in rheumatoid arthritis","volume":"2025","author":"Tong","year":"2025","journal-title":"J Inflammation Res"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1192153","article-title":"Bioinformatics identification of ferroptosis-related genes and therapeutic drugs in rheumatoid arthritis","author":"Li","year":"2023","journal-title":"Front Med"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1610121\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T04:10:41Z","timestamp":1749528641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1610121\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":161,"alternative-id":["10.3389\/fimmu.2025.1610121"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1610121","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]},"article-number":"1610121"}}