{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:32:38Z","timestamp":1790947958796,"version":"4.1.0"},"reference-count":229,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Autoimmune diseases are characterized by their involvement of multiple organ systems and the presence of overlapping clinical manifestations among distinct disease entities. Both primary Sjogren\u2019s syndrome (pSS) and primary biliary cholangitis (PBC) are chronic inflammatory disorders driven by immune-mediated injury to glandular or ductal epithelial cells. Due to shared genetic susceptibility, epidemiological patterns, and pathophysiological mechanisms, these two diseases frequently coexist in clinical practices and demonstrate a common tissue immune microenvironment. Recent advances have greatly enhanced the understanding of pSS and PBC pathogenesis, particularly regarding autoantibody profiles and pro-inflammatory cytokine expression in serum, as well as the functional activity of immune cells within affected tissues. These insights provide new perspectives and potential avenues for the development of targeted therapeutic strategies. This review examines the associations between pSS and PBC, explores the shared immunological pathways involved in disease onset and progression, and summarizes common therapeutic targets within the context of clinical treatment. The goal is to provide a comprehensive perspective that may guide future research and inform improved diagnostic and therapeutic strategies for both conditions.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1620073","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:26:49Z","timestamp":1759123609000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Common pathological mechanisms and therapeutic strategies in primary Sjogren\u2019s syndrome and primary biliary cholangitis: from tissue immune microenvironment to targeted therapy"],"prefix":"10.3389","volume":"16","author":[{"given":"Keying","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingqi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/art.39859","article-title":"2016 American college of rheumatology\/European league against rheumatism classification criteria for primary sj\u00f6gren's syndrome: A consensus and data-Driven methodology involving three international patient cohorts","volume":"69","author":"Shiboski","year":"2017","journal-title":"Arthritis Rheumatol (Hoboken NJ)"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16036432","article-title":"Primary biliary cirrhosis is a generalized autoimmune epithelitis","volume":"16","author":"Gao","year":"2015","journal-title":"Int J Mol Sci"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.041","article-title":"The diagnosis of primary biliary cirrhosis","volume":"13","author":"Bowlus","year":"2014","journal-title":"Autoimmun Rev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2024.103289","article-title":"Epidemiologic and genetic associations between primary biliary cholangitis and extrahepatic rheumatic diseases","volume":"148","author":"Qian","year":"2024","journal-title":"J Autoimmun"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-008-0917-x","article-title":"Interstitial lung disease and sj\u00f6gren's syndrome in primary biliary cirrhosis: A causal or casual association","volume":"27","author":"Liu","year":"2008","journal-title":"Clin Rheumatol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2013.06.016","article-title":"Liver abnormalities in connective tissue diseases","volume":"27","author":"De Santis","year":"2013","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"B7","article-title":"Prevalence and longterm course of primary biliary cirrhosis in primary sj\u00f6gren's syndrome","volume":"35","author":"Hatzis","year":"2008","journal-title":"J Rheumatol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202405_36292","article-title":"Primary biliary cholangitis and sjogren's syndrome: bi-directional mendelian randomization analysis","volume":"28","author":"Wang","year":"2024","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.02.019","article-title":"Demographic, lifestyle, medical and familial factors associated with primary biliary cirrhosis","volume":"53","author":"Corpechot","year":"2010","journal-title":"J Hepatol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/art.39127","article-title":"Familial risk of sj\u00f6gren's syndrome and co-aggregation of autoimmune diseases in affected families: A nationwide population study","volume":"67","author":"Kuo","year":"2015","journal-title":"Arthritis Rheumatol (Hoboken NJ)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21316","article-title":"Hla class ii alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: A large-scale study","volume":"44","author":"Donaldson","year":"2006","journal-title":"Hepatol (Baltimore Md)"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.10.002","article-title":"Hla and sj\u00f6gren's syndrome susceptibility. A meta-analysis of worldwide studies","volume":"11","author":"Cruz-Tapias","year":"2012","journal-title":"Autoimmun Rev"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2792","article-title":"Variants at multiple loci implicated in both innate and adaptive immune responses are associated with sj\u00f6gren's syndrome","volume":"45","author":"Lessard","year":"2013","journal-title":"Nat Genet"},{"key":"B14","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jaut.2015.07.004","article-title":"The immunogenetics of primary biliary cirrhosis: A comprehensive review","volume":"64","author":"Webb","year":"2015","journal-title":"J Autoimmun"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/art.11103","article-title":"In primary sj\u00f6gren's syndrome, hla class ii is associated exclusively with autoantibody production and spreading of the autoimmune response","volume":"48","author":"Gottenberg","year":"2003","journal-title":"Arthritis rheumatism"},{"key":"B16","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/s41584-023-00932-6","article-title":"Genetics and epigenetics of primary sj\u00f6gren syndrome: implications for future therapies","volume":"19","author":"Thorlacius","year":"2023","journal-title":"Nat Rev Rheumatol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1136\/gut.48.3.397","article-title":"Hla and interleukin 1 gene polymorphisms in primary biliary cirrhosis: associations with disease progression and disease susceptibility","volume":"48","author":"Donaldson","year":"2001","journal-title":"Gut"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810440","article-title":"Primary biliary cirrhosis associated with hla, il12a, and il12rb2 variants","volume":"360","author":"Hirschfield","year":"2009","journal-title":"New Engl J Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1186\/s12951-021-01154-2","article-title":"Single cell sequencing analysis identifies genetics-modulated ormdl3(+) cholangiocytes having higher metabolic effects on primary biliary cholangitis","volume":"19","author":"Xiang","year":"2021","journal-title":"J nanobiotechnology"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22567","article-title":"Human leukocyte antigen polymorphisms in italian primary biliary cirrhosis: A multicenter study of 664 patients and 1992 healthy controls","volume":"48","author":"Invernizzi","year":"2008","journal-title":"Hepatol (Baltimore Md)"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.12","article-title":"Stronger inflammatory\/cytotoxic T-cell response in women identified by microarray analysis","volume":"10","author":"Hewagama","year":"2009","journal-title":"Genes Immun"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.10.015","article-title":"The immunobiology of female predominance in primary biliary cholangitis","volume":"95","author":"Gerussi","year":"2018","journal-title":"J Autoimmun"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/art.39560","article-title":"X chromosome dose and sex bias in autoimmune diseases: increased prevalence of 47,Xxx in systemic lupus erythematosus and sj\u00f6gren's syndrome","volume":"68","author":"Liu","year":"2016","journal-title":"Arthritis Rheumatol (Hoboken NJ)"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e11778","DOI":"10.1002\/acr2.11778","article-title":"Synergistic effects of extra X chromosome on development of systemic lupus erythematosus and sj\u00f6gren disease in klinefelter and triple X syndrome: A retrospective cohort study","volume":"7","author":"Palmer","year":"2025","journal-title":"ACR Open Rheumatol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-007-8051-0","article-title":"X chromosome inactivation and female predisposition to autoimmunity","volume":"34","author":"Ozcelik","year":"2008","journal-title":"Clin Rev Allergy Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"95","DOI":"10.4161\/epi.6.1.13405","article-title":"Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis","volume":"6","author":"Mitchell","year":"2011","journal-title":"Epigenetics"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(04)15541-4","article-title":"Frequency of monosomy X in women with primary biliary cirrhosis","volume":"363","author":"Invernizzi","year":"2004","journal-title":"Lancet (London England)"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21696","article-title":"Preferential X chromosome loss but random inactivation characterize primary biliary cirrhosis","volume":"46","author":"Miozzo","year":"2007","journal-title":"Hepatol (Baltimore Md)"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1053\/j.gastro.2021.02.061","article-title":"X chromosome contribution to the genetic architecture of primary biliary cholangitis","volume":"160","author":"Asselta","year":"2021","journal-title":"Gastroenterology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jaut.2012.01.004","article-title":"Sex steroids in sj\u00f6gren's syndrome","volume":"39","author":"Konttinen","year":"2012","journal-title":"J Autoimmun"},{"key":"B31","doi-asserted-by":"publisher","first-page":"5301","DOI":"10.3390\/ijms24065301","article-title":"Dhea and its metabolites reduce the cytokines involved in the inflammatory response and fibrosis in primary biliary cholangitis","volume":"24","author":"Blatkiewicz","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)65111-5","article-title":"Estrogen deficiency accelerates autoimmune exocrinopathy in murine sj\u00f6gren's syndrome through fas-mediated apoptosis","volume":"155","author":"Ishimaru","year":"1999","journal-title":"Am J Pathol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28641","article-title":"Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance","volume":"64","author":"Bae","year":"2016","journal-title":"Hepatol (Baltimore Md)"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2169\/internalmedicine.50.4462","article-title":"Risk factors and prediction of long-term outcome in primary biliary cirrhosis","volume":"50","author":"Ishibashi","year":"2011","journal-title":"Internal Med (Tokyo Japan)"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06474-8","article-title":"Risk factors for primary sj\u00f6gren's syndrome: A systematic review and meta-analysis","volume":"42","author":"Jin","year":"2023","journal-title":"Clin Rheumatol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230x-2-21","article-title":"The liver is a common non-exocrine target in primary sj\u00f6gren's syndrome: A retrospective review","volume":"2","author":"Kaplan","year":"2002","journal-title":"BMC Gastroenterol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.6.2191","article-title":"Detection of epstein-barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with sjogren's syndrome","volume":"169","author":"Saito","year":"1989","journal-title":"J Exp Med"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/bf02806528","article-title":"Increased expression of epstein-barr virus in primary biliary cirrhosis patients","volume":"27","author":"Morshed","year":"1992","journal-title":"Gastroenterologia Japonica"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2023.156227","article-title":"Chronic epstein-barr virus infection: A potential junction between primary sj\u00f6gren's syndrome and lymphoma","volume":"168","author":"Yang","year":"2023","journal-title":"Cytokine"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21591","article-title":"American college of rheumatology classification criteria for sj\u00f6gren's syndrome: A data-driven, expert consensus approach in the sj\u00f6gren's international collaborative clinical alliance cohort","volume":"64","author":"Shiboski","year":"2012","journal-title":"Arthritis Care Res"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(10)61965-4","article-title":"Primary biliary cirrhosis","volume":"377","author":"Selmi","year":"2011","journal-title":"Lancet (London England)"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/art.42789","article-title":"Association of combined anti-ro52\/trim21 and anti-ro60\/ssa antibodies with increased sj\u00f6gren disease severity through interferon pathway activation","volume":"76","author":"Bettacchioli","year":"2024","journal-title":"Arthritis Rheumatol (Hoboken NJ)"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167168","article-title":"Seronegative patients with primary sj\u00f6gren's syndrome and non-pss sicca test positive for anti-ssa\/ro52 and -ro60 in saliva","volume":"1870","author":"Kamounah","year":"2024","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"key":"B44","article-title":"Anti-ro52 antibody testing influences the classification and clinical characterisation of primary sj\u00f6gren's syndrome","volume":"30","author":"Retamozo","year":"2012","journal-title":"Clin Exp Rheumatol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24597","article-title":"Antibodies to both ro52 and ro60 for identifying sj\u00f6gren's syndrome patients best suited for clinical trials of disease-modifying therapies","volume":"74","author":"Arma\u011fan","year":"2022","journal-title":"Arthritis Care Res"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113652","article-title":"Analysis of the relationships between interferon-stimulated genes and anti-ssa\/ro 60 antibodies in primary sj\u00f6gren's syndrome patients via multiomics and machine learning methods","volume":"144","author":"Liu","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1756-1","article-title":"Prevalence of autoimmune liver disease related autoantibodies in chinese patients with primary biliary cirrhosis","volume":"56","author":"Hu","year":"2011","journal-title":"Digestive Dis Sci"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i34.5075","article-title":"Role of biochemical markers and autoantibodies in diagnosis of early-stage primary biliary cholangitis","volume":"29","author":"Zhu","year":"2023","journal-title":"World J Gastroenterol"},{"key":"B49","article-title":"Anticentromere antibodies identify patients with sj\u00f6gren's syndrome and autoimmune overlap syndrome","volume":"34","author":"Salliot","year":"2007","journal-title":"J Rheumatol"},{"key":"B50","article-title":"Clinical and serological heterogeneity in patients with anticentromere antibodies","volume":"32","author":"Miyawaki","year":"2005","journal-title":"J Rheumatol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218881","article-title":"Anti-centromere antibodies target centromere-kinetochore macrocomplex: A comprehensive autoantigen profiling","volume":"80","author":"Kajio","year":"2021","journal-title":"Ann rheumatic Dis"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-140","article-title":"Anti-centromere antibody-seropositive sj\u00f6gren's syndrome differs from conventional subgroup in clinical and pathological study","volume":"11","author":"Nakamura","year":"2010","journal-title":"BMC musculoskeletal Disord"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.22-0231","article-title":"Importance of anti-centromere antibodies in the diagnosis of sj\u00f6gren's syndrome","volume":"64","author":"Kitagawa","year":"2022","journal-title":"J Oral Sci"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185x.12684","article-title":"Anti-centromere antibody-positive sj\u00f6gren's syndrome: A distinct clinical subgroup","volume":"18","author":"Lee","year":"2015","journal-title":"Int J rheumatic Dis"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21472","article-title":"Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis","volume":"45","author":"Nakamura","year":"2007","journal-title":"Hepatol (Baltimore Md)"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2024.12.024","article-title":"The prognostic value of anti-gp210 and anti-centromere antibodies in patients with primary biliary cholangitis: enhancing the prognostic utility on the globe scoring system","volume":"57","author":"Ding","year":"2025","journal-title":"Digestive liver disease: Off J Ital Soc Gastroenterol Ital Assoc Study Liver"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/fcjoqx","article-title":"Nuts and bolts of salivary gland pathology in primary sj\u00f6gren's syndrome","volume":"41","author":"Zabotti","year":"2023","journal-title":"Clin Exp Rheumatol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1405126","article-title":"Advances in cellular and molecular pathways of salivary gland damage in sj\u00f6gren's syndrome","volume":"15","author":"Qi","year":"2024","journal-title":"Front Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.144782","article-title":"Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of Malignant lymphoma in primary sj\u00f6gren's syndrome","volume":"70","author":"Theander","year":"2011","journal-title":"Ann rheumatic Dis"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315259","article-title":"The british society of gastroenterology\/uk-pbc primary biliary cholangitis treatment and management guidelines","volume":"67","author":"Hirschfield","year":"2018","journal-title":"Gut"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2018.03.008","article-title":"Liver biopsy in primary biliary cholangitis: indications and interpretation","volume":"22","author":"Tan","year":"2018","journal-title":"Clinics liver Dis"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.32074\/1591-951x-245","article-title":"Autoimmune biliary diseases: primary biliary cholangitis and primary sclerosing cholangitis","volume":"113","author":"Sarcognato","year":"2021","journal-title":"Pathologica"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1159\/000098211","article-title":"Possible involvement of oxidative stress in salivary gland of patients with sjogren's syndrome","volume":"73","author":"Ryo","year":"2006","journal-title":"Pathobiology: J immunopathology Mol Cell Biol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.033","article-title":"Control of T(H)17\/T(Reg) balance by hypoxia-inducible factor 1","volume":"146","author":"Dang","year":"2011","journal-title":"Cell"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/art.40659","article-title":"Salivary gland stem cells age prematurely in primary sj\u00f6gren's syndrome","volume":"71","author":"Pringle","year":"2019","journal-title":"Arthritis Rheumatol (Hoboken NJ)"},{"key":"B66","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1186\/s13075-020-02317-6","article-title":"Autophagy occurs in lymphocytes infiltrating sj\u00f6gren's syndrome minor salivary glands and correlates with histological severity of salivary gland lesions","volume":"22","author":"ColaFrancesco","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102418","article-title":"Correction of autophagy impairment inhibits pathology in the nod.H-2h4 mouse model of primary sj\u00f6gren's syndrome","volume":"108","author":"Voynova","year":"2020","journal-title":"J Autoimmun"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2024.102512","article-title":"A heterogeneous subtype of biliary epithelial senescence may be involved in the pathogenesis of primary biliary cholangitis","volume":"49","author":"Sasaki","year":"2025","journal-title":"Clinics Res Hepatol Gastroenterol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.56","article-title":"Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis","volume":"90","author":"Sasaki","year":"2010","journal-title":"Lab investigation; J Tech Methods Pathol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102377","article-title":"Increased P16(Ink4a)-expressing senescent bile ductular cells are associated with inadequate response to ursodeoxycholic acid in primary biliary cholangitis","volume":"107","author":"Sasaki","year":"2020","journal-title":"J Autoimmun"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107943","article-title":"Single-cell transcriptome profiling reveals immune and stromal cell heterogeneity in primary sj\u00f6gren's syndrome","volume":"26","author":"Xiang","year":"2023","journal-title":"iScience"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1905301116","article-title":"Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology","volume":"116","author":"Nayar","year":"2019","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54686-0","article-title":"Molecular and spatial analysis of tertiary lymphoid structures in sjogren's syndrome","volume":"16","author":"Nayar","year":"2025","journal-title":"Nat Commun"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.22.10745-10751.2000","article-title":"Cd21-mediated entry and stable infection by epstein-barr virus in canine and rat cells","volume":"74","author":"Yang","year":"2000","journal-title":"J Virol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2022.12.005","article-title":"Fibroblast activation protein activates macrophages and promotes parenchymal liver inflammation and fibrosis","volume":"15","author":"Yang","year":"2023","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/srep13462","article-title":"Expression of hepatic fibroblast growth factor 19 is enhanced in primary biliary cirrhosis and correlates with severity of the disease","volume":"5","author":"Wunsch","year":"2015","journal-title":"Sci Rep"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2006.04.001","article-title":"Increased killing activity and decreased cytokine production in nk cells in patients with primary biliary cirrhosis","volume":"26","author":"Chuang","year":"2006","journal-title":"J Autoimmun"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2023113714","article-title":"Mica\/B-dependent activation of natural killer cells by cd64(+) inflammatory type 2 dendritic cells contributes to autoimmunity","volume":"42","author":"S\u00e1nchez-Cerrillo","year":"2023","journal-title":"EMBO J"},{"key":"B79","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.immuni.2023.01.016","article-title":"Infection induces tissue-resident memory nk cells that safeguard tissue health","volume":"56","author":"Schuster","year":"2023","journal-title":"Immunity"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02594","article-title":"Ccl22-producing resident macrophages enhance T cell response in sj\u00f6gren's syndrome","volume":"9","author":"Ushio","year":"2018","journal-title":"Front Immunol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1292146","article-title":"Characterisation of macrophage infiltration and polarisation based on integrated transcriptomic and histological analyses in primary sj\u00f6gren's syndrome","volume":"14","author":"Zong","year":"2023","journal-title":"Front Immunol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2024.05.012","article-title":"Elmo1 regulates macrophage directed migration and attenuates inflammation via nf-Kb signaling pathway in primary biliary cholangitis","volume":"56","author":"Ma","year":"2024","journal-title":"Digestive liver disease: Off J Ital Soc Gastroenterol Ital Assoc Study Liver"},{"key":"B83","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1365-2249.2012.04606.x","article-title":"Selective localization of T helper subsets in labial salivary glands from primary sj\u00f6gren's syndrome patients","volume":"169","author":"Maehara","year":"2012","journal-title":"Clin Exp Immunol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/s1386-6346(02)00091-8","article-title":"Type1 and type2 memory T cells imbalance shown by expression of intrahepatic chemokine receptors relates to pathogenesis of primary biliary cirrhosis","volume":"24","author":"Harada","year":"2002","journal-title":"Hepatol research: Off J Japan Soc Hepatol"},{"key":"B85","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00795-006-0321-z","article-title":"Molecular mechanisms of cholangiopathy in primary biliary cirrhosis","volume":"39","author":"Harada","year":"2006","journal-title":"Med Mol morphology"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2020.09.006","article-title":"Blockade of th17 response by il-38 in primary sj\u00f6gren's syndrome","volume":"127","author":"Luo","year":"2020","journal-title":"Mol Immunol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-024-09566-6","article-title":"Usp18-mediated protein stabilization of notch1 is associated with altered th17\/treg cell ratios and B cell-mediated autoantibody secretion in sj\u00f6gren syndrome","volume":"73","author":"Jin","year":"2024","journal-title":"Immunologic Res"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26979","article-title":"Il-12\/th1 and il-23\/th17 biliary microenvironment in primary biliary cirrhosis: implications for therapy","volume":"59","author":"Yang","year":"2014","journal-title":"Hepatol (Baltimore Md)"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000001888","article-title":"The distribution and the fibrotic role of elevated inflammatory th17 cells in patients with primary biliary cirrhosis","volume":"94","author":"Shi","year":"2015","journal-title":"Medicine"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700550","article-title":"Satb1 conditional knockout results in sj\u00f6gren's syndrome in mice","volume":"199","author":"Tanaka","year":"2017","journal-title":"J Immunol (Baltimore Md: 1950)"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28517","article-title":"Human intrahepatic regulatory T cells are functional, require il-2 from effector cells for survival, and are susceptible to fas ligand-mediated apoptosis","volume":"64","author":"Chen","year":"2016","journal-title":"Hepatol (Baltimore Md)"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000015952","article-title":"Th17\/treg cell level and clinical characteristics of peripheral blood of patients with sjogren's syndrome complicated with primary biliary cirrhosis","volume":"98","author":"Hao","year":"2019","journal-title":"Medicine"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1038\/nature08750","article-title":"Role of conserved non-coding DNA elements in the foxp3 gene in regulatory T-cell fate","volume":"463","author":"Zheng","year":"2010","journal-title":"Nature"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.080246","article-title":"Foxp3+ T-regulatory cells in sjogren's syndrome: correlation with the grade of the autoimmune lesion and certain adverse prognostic factors","volume":"173","author":"Christodoulou","year":"2008","journal-title":"Am J Pathol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107820","article-title":"5-aza-2-deoxycytidine alleviates the progression of primary biliary cholangitis by suppressing the foxp3 methylation and promoting the treg\/th17 balance","volume":"96","author":"Jiang","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22651","article-title":"Deficiency in regulatory T cells results in development of antimitochondrial antibodies and autoimmune cholangitis","volume":"49","author":"Zhang","year":"2009","journal-title":"Hepatol (Baltimore Md)"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217646","article-title":"Unique expansion of il-21+ Tfh and tph cells under control of icos identifies sj\u00f6gren's syndrome with ectopic germinal centres and malt lymphoma","volume":"79","author":"Pontarini","year":"2020","journal-title":"Ann rheumatic Dis"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12616","article-title":"Dysregulation of circulating tfr\/tfh ratio in primary biliary cholangitis","volume":"86","author":"Zheng","year":"2017","journal-title":"Scandinavian J Immunol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.639975","article-title":"The imbalance of circulating follicular T helper cell subsets in primary sj\u00f6gren's syndrome associates with serological alterations and abnormal B-cell distribution","volume":"12","author":"Szab\u00f3","year":"2021","journal-title":"Front Immunol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2024.100248","article-title":"Single-cell transcriptomic analysis uncovers heterogeneity in the labial gland microenvironment of primary sj\u00f6gren's syndrome","volume":"9","author":"Huang","year":"2024","journal-title":"J Trans Autoimmun"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14752","article-title":"Emperipolesis mediated by cd8(+) T cells correlates with biliary epithelia cell injury in primary biliary cholangitis","volume":"24","author":"Zhao","year":"2020","journal-title":"J Cell Mol Med"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-024-10715-0","article-title":"The relationship between cxcr6+Cd8+T cells and clinicopathological parameters in patients with primary biliary cholangitis","volume":"18","author":"Shi","year":"2024","journal-title":"Hepatol Int"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1002\/art.40676","article-title":"Tissue-resident memory cd8+ T cells acting as mediators of salivary gland damage in a murine model of sj\u00f6gren's syndrome","volume":"71","author":"Gao","year":"2019","journal-title":"Arthritis Rheumatol (Hoboken NJ)"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.2147\/ijgm.S327304","article-title":"Molecular mechanism of sphingosine-1-phosphate receptor 1 regulating cd4(+) tissue memory in situ T cells in primary sjogren's syndrome","volume":"14","author":"Yang","year":"2021","journal-title":"Int J Gen Med"},{"key":"B105","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1038\/s41467-024-44910-2","article-title":"Expression of E-cadherin by cd8(+) T cells promotes their invasion into biliary epithelial cells","volume":"15","author":"Davies","year":"2024","journal-title":"Nat Commun"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.684999","article-title":"The multiple roles of B cells in the pathogenesis of sj\u00f6gren's syndrome","volume":"12","author":"Du","year":"2021","journal-title":"Front Immunol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.28.2.75","article-title":"Regulatory B cells in autoimmune rheumatic diseases","volume":"28","author":"Sakkas","year":"2017","journal-title":"Mediterr J Rheumatol"},{"key":"B108","doi-asserted-by":"publisher","first-page":"R118","DOI":"10.1186\/ar4571","article-title":"B cell subsets and dysfunction of regulatory B cells in igg4-related diseases and primary sj\u00f6gren's syndrome: the similarities and differences","volume":"16","author":"Lin","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3019378","article-title":"Cd19(+)Cd24(Hi)Cd38(Hi) B cell dysfunction in primary biliary cholangitis","volume":"2020","author":"Chen","year":"2020","journal-title":"Mediators Inflammation"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1002\/art.10445","article-title":"Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with sj\u00f6gren's syndrome","volume":"46","author":"Hansen","year":"2002","journal-title":"Arthritis rheumatism"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1002\/art.21129","article-title":"Dysregulation of chemokine receptor expression and function by B cells of patients with primary sj\u00f6gren's syndrome","volume":"52","author":"Hansen","year":"2005","journal-title":"Arthritis rheumatism"},{"key":"B112","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/ar2210","article-title":"B cells in sj\u00f6gren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue","volume":"9","author":"Hansen","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3372-3","article-title":"Increased numbers of circulating icos+ Follicular helper T and cd38+ Plasma cells in patients with newly diagnosed primary biliary cirrhosis","volume":"60","author":"Wang","year":"2015","journal-title":"Digestive Dis Sci"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216588","article-title":"Salivary gland epithelial cells from patients with sj\u00f6gren's syndrome induce B-lymphocyte survival and activation","volume":"79","author":"Rivi\u00e8re","year":"2020","journal-title":"Ann rheumatic Dis"},{"key":"B115","doi-asserted-by":"publisher","first-page":"R2","DOI":"10.1186\/ar3220","article-title":"Salivary glands of primary sj\u00f6gren's syndrome patients express factors vital for plasma cell survival","volume":"13","author":"Szyszko","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.01.001","article-title":"T follicular helper cell diversity and plasticity","volume":"34","author":"Cannons","year":"2013","journal-title":"Trends Immunol"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1002\/hep.27725","article-title":"Chemokine (C-X-C motif) ligand 13 promotes intrahepatic chemokine (C-X-C motif) receptor 5+ Lymphocyte homing and aberrant B-cell immune responses in primary biliary cirrhosis","volume":"61","author":"Li","year":"2015","journal-title":"Hepatol (Baltimore Md)"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27313","article-title":"Ongoing activation of autoantigen-specific B cells in primary biliary cirrhosis","volume":"60","author":"Zhang","year":"2014","journal-title":"Hepatol (Baltimore Md)"},{"key":"B119","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s12876-023-02859-4","article-title":"Laboratory risk factors for coexistent primary biliary cholangitis in patients with sj\u00f6gren's syndrome: A retrospective study","volume":"23","author":"Gao","year":"2023","journal-title":"BMC Gastroenterol"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03433.x","article-title":"Antibodies to ss-a\/ro-52kd and centromere in autoimmune liver disease: A clue to diagnosis and prognosis of primary biliary cirrhosis","volume":"26","author":"Granito","year":"2007","journal-title":"Alimentary Pharmacol Ther"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/nri2637","article-title":"Dysregulation of germinal centres in autoimmune disease","volume":"9","author":"Vinuesa","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-020-04524-5","article-title":"Serum cxcl13 levels are associated with lymphoma risk and lymphoma occurrence in primary sj\u00f6gren's syndrome","volume":"40","author":"Traianos","year":"2020","journal-title":"Rheumatol Int"},{"key":"B123","doi-asserted-by":"publisher","first-page":"R51","DOI":"10.1186\/ar1912","article-title":"B cell-activating factor of the tumor necrosis factor family (Baff) is expressed under stimulation by interferon in salivary gland epithelial cells in primary sj\u00f6gren's syndrome","volume":"8","author":"Ittah","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00430","article-title":"Ectopic lymphoid structures: powerhouse of autoimmunity","volume":"7","author":"Corsiero","year":"2016","journal-title":"Front Immunol"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328277ef4c","article-title":"An important role for B-cell activation factor and B cells in the pathogenesis of sj\u00f6gren's syndrome","volume":"19","author":"Mackay","year":"2007","journal-title":"Curr Opin Rheumatol"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1002\/art.11311","article-title":"Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with sj\u00f6gren's syndrome","volume":"48","author":"Salomonsson","year":"2003","journal-title":"Arthritis rheumatism"},{"key":"B127","article-title":"Serological implications of germinal center-like structures in primary sj\u00f6gren's syndrome","volume":"34","author":"Jonsson","year":"2007","journal-title":"J Rheumatol"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002738","article-title":"Possible role for il-40 and il-40-producing cells in the lymphocytic infiltrated salivary glands of patients with primary sj\u00f6gren's syndrome","volume":"9","author":"Guggino","year":"2023","journal-title":"RMD Open"},{"key":"B129","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1016\/j.celrep.2019.11.010","article-title":"Interleukin-27 is essential for type 1 diabetes development and sj\u00f6gren syndrome-like inflammation","volume":"29","author":"Ciecko","year":"2019","journal-title":"Cell Rep"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108758","article-title":"Association between il-7 and primary sj\u00f6gren's syndrome: A single-center study and a systematic scoping review","volume":"108","author":"Liang","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102756","article-title":"Pathophysiologic role of interleukin-33\/st2 in sj\u00f6gren's syndrome","volume":"20","author":"Soyfoo","year":"2021","journal-title":"Autoimmun Rev"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.995223","article-title":"The effect of serum il-2 levels on the prognosis of primary biliary cholangitis-related liver failure and the preliminary exploration of its mechanism","volume":"13","author":"Wang","year":"2022","journal-title":"Front Immunol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23132","article-title":"Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type ii mice","volume":"50","author":"Yoshida","year":"2009","journal-title":"Hepatol (Baltimore Md)"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113086","article-title":"Interleukin-37 exacerbates liver inflammation and promotes ifn-\u0393 Production in nk cells","volume":"142","author":"Lin","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B135","doi-asserted-by":"publisher","first-page":"e24646","DOI":"10.1002\/jcla.24646","article-title":"The role of th9 cd4(+) T cells and il-9 during primary sjogren's syndrome","volume":"36","author":"Yang","year":"2022","journal-title":"J Clin Lab Anal"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-016-8570-7","article-title":"Significance of interleukin-6\/stat pathway for the gene expression of reg I\u03b1, a new autoantigen in sj\u00f6gren's syndrome patients, in salivary duct epithelial cells","volume":"52","author":"Fujimura","year":"2017","journal-title":"Clin Rev Allergy Immunol"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2022.8147","article-title":"Reduced circulating interleukin 35 is associated with enhanced peripheral T cell function in primary biliary cholangitis","volume":"23","author":"Liu","year":"2023","journal-title":"Biomolecules biomedicine"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2020.153137","article-title":"Immunohistochemical detection of il-17 and il-23 improves the identification of patients with a possible diagnosis of sjogren's syndrome","volume":"216","author":"Fusconi","year":"2020","journal-title":"Pathology Res Pract"},{"key":"B139","doi-asserted-by":"publisher","first-page":"389","DOI":"10.21037\/atm.2019.07.100","article-title":"The expression and clinical significance of serum il-17 in patients with primary biliary cirrhosis","volume":"7","author":"Sun","year":"2019","journal-title":"Ann Trans Med"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.07.005","article-title":"Increased il-23 and il-17 expression by peripheral blood cells of patients with primary biliary cirrhosis","volume":"64","author":"Qian","year":"2013","journal-title":"Cytokine"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-10-1114","article-title":"Direct effects of type I interferons on cells of the immune system","volume":"17","author":"Hervas-Stubbs","year":"2011","journal-title":"Clin Cancer research: an Off J Am Assoc Cancer Res"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00904-y","article-title":"Treatment with a jak1\/2 inhibitor ameliorates murine autoimmune cholangitis induced by ifn overexpression","volume":"19","author":"Shao","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B143","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s13075-022-02860-4","article-title":"The potential roles of type I interferon activated neutrophils and neutrophil extracellular traps (Nets) in the pathogenesis of primary sj\u00f6gren's syndrome","volume":"24","author":"Peng","year":"2022","journal-title":"Arthritis Res Ther"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.05.027","article-title":"Interferon-\u0393 Induces salivary gland epithelial cell ferroptosis in sjogren's syndrome via jak\/stat1-mediated inhibition of system xc()","volume":"205","author":"Cao","year":"2023","journal-title":"Free Radical Biol Med"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700285","article-title":"Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis","volume":"85","author":"Takii","year":"2005","journal-title":"Lab investigation; J Tech Methods Pathol"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2014.12.002","article-title":"Tlr7, ifn\u03b3, and T-bet: their roles in the development of abcs in female-biased autoimmunity","volume":"294","author":"Rubtsova","year":"2015","journal-title":"Cell Immunol"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.702037","article-title":"DNA methylation-based interferon scores associate with sub-phenotypes in primary sj\u00f6gren's syndrome","volume":"12","author":"Imgenberg-Kreuz","year":"2021","journal-title":"Front Immunol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.149.12.4067","article-title":"Ifn enhance expression of sp100, an autoantigen in primary biliary cirrhosis","volume":"149","author":"Guldner","year":"1992","journal-title":"J Immunol (Baltimore Md: 1950)"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7111445","article-title":"The proinflammatory cytokines il-18, il-21, and ifn-\u0393 Differentially regulate liver inflammation and anti-mitochondrial antibody level in a murine model of primary biliary cholangitis","volume":"2022","author":"Xu","year":"2022","journal-title":"J Immunol Res"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106878","article-title":"Relationships between increased circulating ykl-40, il-6 and tnf-A Levels and phenotypes and disease activity of primary sj\u00f6gren's syndrome","volume":"88","author":"Chen","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"B151","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1034\/j.1600-0676.2003.01707.x","article-title":"Tumor necrosis factor-alpha and interferon-gamma directly impair epithelial barrier function in cultured mouse cholangiocytes","volume":"23","author":"Hanada","year":"2003","journal-title":"Liver international: Off J Int Assoc Study Liver"},{"key":"B152","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s10875-005-4091-5","article-title":"Association between circulating levels of the novel tnf family members april and baff and lymphoid organization in primary sj\u00f6gren's syndrome","volume":"25","author":"Jonsson","year":"2005","journal-title":"J Clin Immunol"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-020-00637-0","article-title":"Expression of baff and baff receptors in primary sj\u00f6gren's syndrome patients with ectopic germinal center-like structures","volume":"20","author":"Carrillo-Ballesteros","year":"2020","journal-title":"Clin Exp Med"},{"key":"B154","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1002\/path.1533","article-title":"Expression of baff (Blys) in T cells infiltrating labial salivary glands from patients with sj\u00f6gren's syndrome","volume":"202","author":"Lavie","year":"2004","journal-title":"J Pathol"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900391","article-title":"Blockade of baff reshapes the hepatic B cell receptor repertoire and attenuates autoantibody production in cholestatic liver disease","volume":"204","author":"Thapa","year":"2020","journal-title":"J Immunol (Baltimore Md: 1950)"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20132665","article-title":"Baff promotes regulatory T-cell apoptosis and blocks cytokine production by activating B cells in primary biliary cirrhosis","volume":"46","author":"Zhang","year":"2013","journal-title":"Braz J Med Biol Res = Rev Bras pesquisas medicas e biologicas"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.09.007","article-title":"Serum baff and april levels in patients with pbc","volume":"134","author":"Migita","year":"2010","journal-title":"Clin Immunol (Orlando Fla)"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1002\/art.39315","article-title":"Cxcl13 and ccl11 serum levels and lymphoma and disease activity in primary sj\u00f6gren's syndrome","volume":"67","author":"Nocturne","year":"2015","journal-title":"Arthritis Rheumatol (Hoboken NJ)"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-023-06783-6","article-title":"Clinical significance of the expression levels of serum transforming growth factor-B and cxc type chemokine ligand 13 in primary sjogren's syndrome patients","volume":"42","author":"He","year":"2023","journal-title":"Clin Rheumatol"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12852","article-title":"Decreased circulating cxcr3 + ccr9+T helper cells are associated with elevated levels of their ligands cxcl10 and ccl25 in the salivary gland of patients with sj\u00f6gren's syndrome to facilitate their concerted migration","volume":"91","author":"Blokland","year":"2020","journal-title":"Scandinavian J Immunol"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00795","article-title":"Elevated ccl19\/ccr7 expression during the disease process of primary sj\u00f6gren's syndrome","volume":"10","author":"Liu","year":"2019","journal-title":"Front Immunol"},{"key":"B162","doi-asserted-by":"publisher","first-page":"593","DOI":"10.4049\/jimmunol.177.1.593","article-title":"Epithelial inflammation is associated with ccl28 production and the recruitment of regulatory T cells expressing ccr10","volume":"177","author":"Eksteen","year":"2006","journal-title":"J Immunol (Baltimore Md: 1950)"},{"key":"B163","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jaut.2015.08.011","article-title":"Human liver-resident cd56(Bright)\/cd16(Neg) nk cells are retained within hepatic sinusoids via the engagement of ccr5 and cxcr6 pathways","volume":"66","author":"Hudspeth","year":"2016","journal-title":"J Autoimmun"},{"key":"B164","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s12072-021-10267-7","article-title":"Reciprocal alterations in circulating and hepatic gamma-delta T cells in patients with primary biliary cholangitis","volume":"16","author":"Chen","year":"2022","journal-title":"Hepatol Int"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.12.026","article-title":"Association of ccl11, ccl24 and ccl26 with primary biliary cholangitis","volume":"67","author":"Lin","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket401","article-title":"Cx3cl1 and cx3cr1 expression in tertiary lymphoid structures in salivary gland infiltrates: fractalkine contribution to lymphoid neogenesis in sjogren's syndrome","volume":"53","author":"Astorri","year":"2014","journal-title":"Rheumatol (Oxford England)"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-013-2920-6","article-title":"Chemokine-chemokine receptor ccl2-ccr2 and cx3cl1-cx3cr1 axis may play a role in the aggravated inflammation in primary biliary cirrhosis","volume":"59","author":"Sasaki","year":"2014","journal-title":"Digestive Dis Sci"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.7.5130","article-title":"Cxcl13, ccl21, and cxcl12 expression in salivary glands of patients with sjogren's syndrome and malt lymphoma: association with reactive and Malignant areas of lymphoid organization","volume":"180","author":"Barone","year":"2008","journal-title":"J Immunol (Baltimore Md: 1950)"},{"key":"B169","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s00018-023-05032-y","article-title":"Disruption of cholangiocyte-B cell crosstalk by blocking the cxcl12-cxcr4 axis alleviates liver fibrosis","volume":"80","author":"Zhang","year":"2023","journal-title":"Cell Mol Life sciences: CMLS"},{"key":"B170","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s10238-024-01401-4","article-title":"Role of chemokines cxcl9, cxcl10, cxcl11, and cxcr3 in the serum and minor salivary gland tissues of patients with sj\u00f6gren's syndrome","volume":"24","author":"Kim","year":"2024","journal-title":"Clin Exp Med"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2005.08.009","article-title":"Increased levels of chemokine receptor cxcr3 and chemokines ip-10 and mig in patients with primary biliary cirrhosis and their first degree relatives","volume":"25","author":"Chuang","year":"2005","journal-title":"J Autoimmun"},{"key":"B172","article-title":"Predictive significance of ccl21 and cxcl13 levels in the minor salivary glands of patients with sj\u00f6gren's syndrome","volume":"35","author":"Lee","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)62570-9","article-title":"Hepatic expression of secondary lymphoid chemokine (Ccl21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease","volume":"160","author":"Grant","year":"2002","journal-title":"Am J Pathol"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1465938","article-title":"Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates sj\u00f6gren's syndrome via suppression of the cx3cl1\/cx3cr1 axis","volume":"15","author":"Yang","year":"2024","journal-title":"Front Immunol"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/564062","article-title":"The role of cxcr3 in the induction of primary biliary cirrhosis","volume":"2011","author":"Zhang","year":"2011","journal-title":"Clin Dev Immunol"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110431","article-title":"Ccl21\/ccr7 axis as a therapeutic target for autoimmune diseases","volume":"121","author":"Han","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1455969","article-title":"Network meta-analysis of integrated traditional chinese and western medicine in the treatment of sjogren's syndrome","volume":"15","author":"Ma","year":"2024","journal-title":"Front Pharmacol"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.01.003","article-title":"Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursodeoxycholic acid","volume":"136","author":"Kuiper","year":"2009","journal-title":"Gastroenterology"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.01.028","article-title":"Tofacitinib (Cp-690,550), a janus kinase inhibitor for dry eye disease: results from a phase 1\/2 trial","volume":"119","author":"Liew","year":"2012","journal-title":"Ophthalmology"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.04.055","article-title":"An international genome-wide meta-analysis of primary biliary cholangitis: novel risk loci and candidate drugs","volume":"75","author":"Cordell","year":"2021","journal-title":"J Hepatol"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac167","article-title":"Safety and efficacy of filgotinib, lanraplenib and tirabrutinib in sj\u00f6gren's syndrome: A randomized, phase 2, double-blind, placebo-controlled study","volume":"61","author":"Price","year":"2022","journal-title":"Rheumatol (Oxford England)"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-222053","article-title":"Pilot study of baricitinib for active sjogren's syndrome","volume":"81","author":"Bai","year":"2022","journal-title":"Ann rheumatic Dis"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2021.100107","article-title":"Baricitinib and primary biliary cholangitis","volume":"4","author":"Gordon","year":"2021","journal-title":"J Trans Autoimmun"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2018-000701","article-title":"Increased mtorc1 activation in salivary gland B cells and T cells from patients with sj\u00f6gren's syndrome: mtor inhibition as a novel therapeutic strategy to halt immunopathology","volume":"5","author":"Blokland","year":"2019","journal-title":"RMD Open"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2023.05.013","article-title":"Zebrafish ppp1r21 mutant as a model for the study of primary biliary cholangitis","volume":"50","author":"Wu","year":"2023","journal-title":"J Genet Genomics = Yi Chuan xue bao"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.621208","article-title":"Effectiveness and safety of iguratimod in treating primary sj\u00f6gren's syndrome: A systematic review and meta-analysis","volume":"12","author":"Pu","year":"2021","journal-title":"Front Pharmacol"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28359","article-title":"Ustekinumab for patients with primary biliary cholangitis who have an inadequate response to ursodeoxycholic acid: A proof-of-concept study","volume":"64","author":"Hirschfield","year":"2016","journal-title":"Hepatol (Baltimore Md)"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2015.1207","article-title":"Long-term ustekinumab therapy of psoriasis in patients with coexisting rheumatoid arthritis and sj\u00f6gren syndrome","volume":"9","author":"Chimenti","year":"2015","journal-title":"Rep Two cases Rev Literature J Dermatol Case Rep"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.41451","article-title":"Efficacy and safety of low-dose interleukin 2 for primary sj\u00f6gren syndrome: A randomized clinical trial","volume":"5","author":"He","year":"2022","journal-title":"JAMA network Open"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.888392","article-title":"Systematic review of safety and efficacy of il-1-targeted biologics in treating immune-mediated disorders","volume":"13","author":"Arnold","year":"2022","journal-title":"Front Immunol"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218467","article-title":"Interleukin 6 receptor inhibition in primary sj\u00f6gren syndrome: A multicentre double-blind randomised placebo-controlled trial","volume":"80","author":"Felten","year":"2021","journal-title":"Ann rheumatic Dis"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.63.6.12","article-title":"Ppar-A Agonist fenofibrate ameliorates sj\u00f6gren syndrome-like dacryoadenitis by modulating th1\/th17 and treg cell responses in nod mice","volume":"63","author":"Guo","year":"2022","journal-title":"Invest Ophthalmol Visual Sci"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v10.i6.894","article-title":"Fenofibrate for patients with asymptomatic primary biliary cirrhosis","volume":"10","author":"Dohmen","year":"2004","journal-title":"World J Gastroenterol"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30552","article-title":"Bezafibrate improves globe and uk-pbc scores and long-term outcomes in patients with primary biliary cholangitis","volume":"70","author":"Honda","year":"2019","journal-title":"Hepatol (Baltimore Md)"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312100","article-title":"A phase 3 trial of seladelpar in primary biliary cholangitis","volume":"390","author":"Hirschfield","year":"2024","journal-title":"New Engl J Med"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15039","article-title":"Seladelpar improved measures of pruritus, sleep, and fatigue and decreased serum bile acids in patients with primary biliary cholangitis","volume":"42","author":"Kremer","year":"2022","journal-title":"Liver international: Off J Int Assoc Study Liver"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.01.013","article-title":"A randomized placebo-controlled trial of elafibranor in patients with primary biliary cholangitis and incomplete response to udca","volume":"74","author":"Schattenberg","year":"2021","journal-title":"J Hepatol"},{"key":"B198","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1056\/NEJMoa2306185","article-title":"Efficacy and safety of elafibranor in primary biliary cholangitis","volume":"390","author":"Kowdley","year":"2024","journal-title":"New Engl J Med"},{"key":"B199","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jhep.2021.08.025","article-title":"Proof-of-concept study to evaluate the safety and efficacy of saroglitazar in patients with primary biliary cholangitis","volume":"76","author":"Vuppalanchi","year":"2022","journal-title":"J Hepatol"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1002\/art.40165","article-title":"Attenuation of follicular helper T cell-dependent B cell hyperactivity by abatacept treatment in primary sj\u00f6gren's syndrome","volume":"69","author":"Verstappen","year":"2017","journal-title":"Arthritis Rheumatol (Hoboken NJ)"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218599","article-title":"Efficacy and safety of abatacept in active primary sj\u00f6gren's syndrome: results of a phase iii, randomised, placebo-controlled trial","volume":"80","author":"Baer","year":"2021","journal-title":"Ann rheumatic Dis"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-224205","article-title":"Improvement of primary biliary cholangitis (Pbc) under treatment with sulfasalazine and abatacept","volume":"2018","author":"Popp","year":"2018","journal-title":"BMJ Case Rep"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev257","article-title":"Efficacy and safety of belimumab given for 12 months in primary sj\u00f6gren's syndrome: the beliss open-label phase ii study","volume":"54","author":"De Vita","year":"2015","journal-title":"Rheumatol (Oxford England)"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203991","article-title":"Efficacy and safety of belimumab in primary sj\u00f6gren's syndrome: results of the beliss open-label phase ii study","volume":"74","author":"Mariette","year":"2015","journal-title":"Ann rheumatic Dis"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2023.100189","article-title":"Belimumab treatment in autoimmune hepatitis and primary biliary cholangitis - a case series","volume":"6","author":"Kolev","year":"2023","journal-title":"J Trans Autoimmun"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(21)02251-0","article-title":"Safety and efficacy of subcutaneous ianalumab (Vay736) in patients with primary sj\u00f6gren's syndrome: A randomised, double-blind, placebo-controlled, phase 2b dose-finding trial","volume":"399","author":"Bowman","year":"2022","journal-title":"Lancet (London England)"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224691","article-title":"Efficacy and safety of remibrutinib, a selective potent oral btk inhibitor, in sj\u00f6gren's syndrome: results from a randomised, double-blind, placebo-controlled phase 2 trial","volume":"83","author":"D\u00f6rner","year":"2024","journal-title":"Ann rheumatic Dis"},{"key":"B208","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1093\/rheumatology\/kead265","article-title":"Efficacy and safety of telitacicept in primary sj\u00f6gren's syndrome: A randomized, double-blind, placebo-controlled, phase 2 trial","volume":"63","author":"Xu","year":"2024","journal-title":"Rheumatol (Oxford England)"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03009-3","article-title":"Cd40 ligand antagonist dazodalibep in sj\u00f6gren's disease: A randomized, double-blinded, placebo-controlled, phase 2 trial","volume":"30","author":"St Clair","year":"2024","journal-title":"Nat Med"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(24)01211-x","article-title":"Safety and efficacy of subcutaneous iscalimab (Cfz533) in two distinct populations of patients with sj\u00f6gren's disease (Twinss): week 24 results of a randomised, double-blind, placebo-controlled, phase 2b dose-ranging study","volume":"404","author":"Fisher","year":"2024","journal-title":"Lancet (London England)"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.7326\/m13-1085","article-title":"Treatment of primary sj\u00f6gren syndrome with rituximab: A randomized trial","volume":"160","author":"Devauchelle-Pensec","year":"2014","journal-title":"Ann Internal Med"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30099","article-title":"Rituximab is ineffective for treatment of fatigue in primary biliary cholangitis: A phase 2 randomized controlled trial","volume":"70","author":"Khanna","year":"2019","journal-title":"Hepatol (Baltimore Md)"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24748","article-title":"Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid","volume":"55","author":"Tsuda","year":"2012","journal-title":"Hepatol (Baltimore Md)"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.51","article-title":"B-cell depletion with rituximab in patients with primary biliary cirrhosis refractory to ursodeoxycholic acid","volume":"108","author":"Myers","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7236118","article-title":"Pi3k\/akt\/mtor signaling pathway is downregulated by runzaoling (Rzl) in sj\u00f6gren's syndrome","volume":"2022","author":"Zeng","year":"2022","journal-title":"Mediators Inflammation"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.887354","article-title":"Low dose interleukin-2 ameliorates sj\u00f6gren's syndrome in a murine model","volume":"9","author":"Wang","year":"2022","journal-title":"Front Med"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-024-03176-0","article-title":"The effects of low-dose il-2 on th17\/treg cell imbalance in primary biliary cholangitis mouse models","volume":"24","author":"Wang","year":"2024","journal-title":"BMC Gastroenterol"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118458109","article-title":"Peroxisome proliferator-activated receptor (Ppar)A and -\u0393 Regulate ifn\u03b3 and il-17a production by human T cells in a sex-specific way","volume":"109","author":"Zhang","year":"2012","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.2103","article-title":"Efficacy and safety of fenofibrate addition therapy in patients with cirrhotic primary biliary cholangitis with incomplete response to ursodeoxycholic acid","volume":"6","author":"Ding","year":"2022","journal-title":"Hepatol Commun"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04512.x","article-title":"Pilot study: fenofibrate for patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid","volume":"33","author":"Levy","year":"2011","journal-title":"Alimentary Pharmacol Ther"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2016.1158773","article-title":"Effectiveness of abatacept for patients with sj\u00f6gren's syndrome associated with rheumatoid arthritis. An open label, multicenter, one-year, prospective study: rose (Rheumatoid arthritis with orencia trial toward sj\u00f6gren's syndrome endocrinopathy) trial","volume":"26","author":"Tsuboi","year":"2016","journal-title":"Modern Rheumatol"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2022.151955","article-title":"Long-term abatacept treatment for 48 weeks in patients with primary sj\u00f6gren's syndrome: the open-label extension phase of the asap-iii trial","volume":"53","author":"de Wolff","year":"2022","journal-title":"Semin Arthritis rheumatism"},{"key":"B223","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/s41584-020-0390-8","article-title":"Abatacept no better than placebo for pss","volume":"16","author":"Onuora","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26067","article-title":"Therapeutic effect of cytotoxic T lymphocyte antigen 4\/immunoglobulin on a murine model of primary biliary cirrhosis","volume":"57","author":"Dhirapong","year":"2013","journal-title":"Hepatol (Baltimore Md)"},{"key":"B225","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jaut.2019.04.005","article-title":"Therapeutic trials of biologics in primary biliary cholangitis: an open label study of abatacept and review of the literature","volume":"101","author":"Bowlus","year":"2019","journal-title":"J Autoimmun"},{"key":"B226","doi-asserted-by":"publisher","first-page":"R172","DOI":"10.1186\/ar4359","article-title":"Efficacy and safety of rituximab treatment in early primary sj\u00f6gren's syndrome: A prospective, multi-center, follow-up study","volume":"15","author":"Carubbi","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201189","article-title":"Persistence of immunoglobulin-producing cells in parotid salivary glands of patients with primary sj\u00f6gren's syndrome after B cell depletion therapy","volume":"71","author":"Hamza","year":"2012","journal-title":"Ann rheumatic Dis"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.163030","article-title":"A randomized, phase ii study of sequential belimumab and rituximab in primary sj\u00f6gren's syndrome","volume":"7","author":"Mariette","year":"2022","journal-title":"JCI Insight"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102897","article-title":"Dual B-cell targeting therapy ameliorates autoimmune cholangitis","volume":"132","author":"Zhang","year":"2022","journal-title":"J Autoimmun"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1620073\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:26:52Z","timestamp":1759123612000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1620073\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":229,"alternative-id":["10.3389\/fimmu.2025.1620073"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1620073","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"article-number":"1620073"}}