{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T08:19:24Z","timestamp":1794385164511,"version":"4.9.0"},"reference-count":198,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Snakebite envenoming remains a predominant neglected disease in tropical and subtropical regions, with high rates of morbidity and mortality worldwide.\n                    <jats:italic>Bothrops<\/jats:italic>\n                    snakebite envenoming. is characterized by severe injuries at the site of venom injection, which include tissue necrosis, hemorrhage, blistering, and edema. Haemotoxicity is typically attributed to the strong procoagulant state induced by the majority\n                    <jats:italic>Bothrops<\/jats:italic>\n                    venoms leading to coagulation factor consumption and incoagulable blood. Concomitantly with this procoagulant state, a complex host response develops in the affected tissues, accompanied by the recruitment of inflammatory and immunocompetent cells, along with the activation of resident cells, and the synthesis of a plethora of pro-inflammatory mediators and damage-associated molecular patterns from injured tissue. An increasing body of evidence suggests that this intricate response is, in fact, related to the well-documented immunothrombosis and thromboinflammation integrated features. Of note, thrombotic complications are extremely rare in\n                    <jats:italic>Bothrops<\/jats:italic>\n                    snakebite envenoming. However, in the case of\n                    <jats:italic>Bothrops lanceolatus<\/jats:italic>\n                    and\n                    <jats:italic>B. caribbaeus<\/jats:italic>\n                    , which are respectively endemic to Martinique and St. Lucia, the absence of overt consumption coagulopathy due to their weak procoagulant effects may be related to the thrombotic effects, as clotting factors are present in the bloodstream by the time the thrombogenic and inflammatory mechanisms are operating in blood vessels. Prior to the era of immunotherapy,\n                    <jats:italic>B. lanceolatus<\/jats:italic>\n                    envenoming was associated with thrombotic complications in 25% of cases and was fatal in approximately 10% of cases. This review examines the potential role of thromboinflammation as a mechanism of thrombotic accidents in\n                    <jats:italic>B. lanceolatus<\/jats:italic>\n                    snakebite envenoming.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2025.1625165","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T04:17:51Z","timestamp":1757477871000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Thromboinflammatory complications of Bothrops snakebite envenoming: the case of B. lanceolatus endemic to the Caribbean Island of Martinique"],"prefix":"10.3389","volume":"16","author":[{"given":"Caroline","family":"Rapon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Florentin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Radouani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prisca","family":"Jalta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Negrello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papa","family":"Gueye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Pierre-Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remi","family":"Neviere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dabor","family":"Resiere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"Engelmann","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-463646","article-title":"Thrombosis: tangled up in NETs","volume":"123","author":"Martinod","year":"2014","journal-title":"Blood"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2020.1817360","article-title":"Immunothrombosis and thromboinflammation in host defense and disease","volume":"32","author":"Martinod","year":"2021","journal-title":"Platelets"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12041399","article-title":"Immunothrombosis: molecular aspects and new therapeutic perspectives","volume":"12","author":"Marcos-Jubilar","year":"2023","journal-title":"J Clin Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.htct.2023.05.008","article-title":"Immunothrombosis and its underlying biological mechanisms","volume":"46","author":"De Nardi","year":"2024","journal-title":"Hematol Transfus Cell Ther"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.038733","article-title":"Thromboinflammation in brain ischemia: recent updates and future perspectives","volume":"53","author":"De Meyer","year":"2022","journal-title":"Stroke"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00552-1","article-title":"Interplay between inflammation and thrombosis in cardiovascular pathology","volume":"18","author":"Stark","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.122.317162","article-title":"Thromboinflammation: from atherosclerosis to COVID-19","volume":"42","author":"Wagner","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s00281-023-00994-4","article-title":"Thromboinflammatory challenges in stroke pathophysiology","volume":"45","author":"Szepanowski","year":"2023","journal-title":"Semin Immunopathol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.955385","article-title":"Thrombo-inflammation and immunological response in ischemic stroke: focusing on platelet-Tregs interaction","volume":"16","author":"Cui","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"B11","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s10072-021-05679-0","article-title":"A review of ischemic stroke in COVID-19: currently known pathophysiological mechanisms","volume":"43","author":"Tang","year":"2022","journal-title":"Neurol Sci"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010047","article-title":"To gain insights into the pathophysiological mechanisms of the thrombo-inflammatory process in the atherosclerotic plaque","volume":"25","author":"Nappi","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jtha.2023.07.020","article-title":"Thromboinflammation in acute injury: infections heatstroke and trauma","volume":"22","author":"Iba","year":"2024","journal-title":"J Thromb Haemost"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxcx.2024.100211","article-title":"Diagnosis of human envenoming by terrestrial venomous animals: routine advances and perspectives","volume":"24","author":"Cavalcante","year":"2024","journal-title":"Toxicon X"},{"key":"B15","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.toxicon.2013.09.010","article-title":"Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms","volume":"76","author":"Leon","year":"2013","journal-title":"Toxicon"},{"key":"B16","doi-asserted-by":"publisher","first-page":"17063","DOI":"10.1038\/nrdp.2017.63","article-title":"Snakebite envenoming","volume":"3","author":"Gutierrez","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxcx.2020.100037","article-title":"Bothrops atrox the most important snake involved in human envenomings in the amazon: how venomics contributes to the knowledge of snake biology and clinical toxinology","volume":"6","author":"Monteiro","year":"2020","journal-title":"Toxicon X"},{"key":"B18","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1056\/NEJMra2105228","article-title":"Snake envenomation","volume":"386","author":"Seifert","year":"2022","journal-title":"N Engl J Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1995.52.419","article-title":"Prevention of thromboses in human patients with Bothrops lanceolatus envenoming in Martinique: failure of anticoagulants and efficacy of a monospecific antivenom research group on snake bites in Martinique","volume":"52","author":"Thomas","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"B20","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/S0140-6736(96)90590-5","article-title":"Early infusion of a purified monospecific F(ab\u2019)2 antivenom serum for Bothrops lanceolatus bites in Martinique","volume":"347","author":"Thomas","year":"1996","journal-title":"Lancet"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2002.67.287","article-title":"Multiple cerebral infarctions following a snakebite by Bothrops caribbaeus","volume":"67","author":"Numeric","year":"2002","journal-title":"Am J Trop Med Hyg"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.04.007","article-title":"Thrombotic stroke following snake bites by the \u201cFer-de-lance\u201d Bothrops lanceolatus in Martinique despite antivenom treatment: A report of three recent cases","volume":"48","author":"Thomas","year":"2006","journal-title":"Toxicon"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2008.78.856","article-title":"Fatal Diffuse Thrombotic Microangiopathy after a Bite by the \u201cFer-de-Lance\u201d Pit Viper (Bothrops lanceolatus) of Martinique","volume":"78","author":"Malbranque","year":"2008","journal-title":"Am J Trop Med Hyg"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/toxins2010163","article-title":"Bothrops lanceolatus bites: guidelines for severity assessment and emergent management","volume":"2","author":"Resiere","year":"2010","journal-title":"Toxins"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/toxins16030146","article-title":"Bothrops lanceolatus envenoming in Martinique: A historical perspective of the clinical effectiveness of bothrofav antivenom treatment","volume":"16","author":"Resiere","year":"2024","journal-title":"Toxins"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179643","article-title":"Bleeding and thrombosis: insights into pathophysiology of bothrops venom-related hemostasis disorders","volume":"22","author":"Larreche","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/toxins15100614","article-title":"Bothrops atrox and Bothrops lanceolatus Venoms In Vitro Investigation: Composition Procoagulant Effects Co-Factor Dependency and Correction Using Antivenoms","volume":"15","author":"Larreche","year":"2023","journal-title":"Toxins"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011786","article-title":"Bothrops venom-induced hemostasis disorders in the rat: between scylla and charybdis","volume":"17","author":"Larreche","year":"2023","journal-title":"PLoS Negl Trop Dis"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0012335","article-title":"A murine experimental model of the pulmonary thrombotic effect induced by the venom of the snake Bothrops lanceolatus","volume":"18","author":"Rucavado","year":"2024","journal-title":"PLoS Negl Trop Dis"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/toxins16090400","article-title":"The Contrasting Effects of Bothrops lanceolatus and Bothrops atrox Venom on Procoagulant Activity and Thrombus Stability under Blood Flow Conditions","volume":"16","author":"Radouani","year":"2024","journal-title":"Toxins"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0374-2020","article-title":"Severe tissue complications in patients of Bothrops snakebite at a tertiary health unit in the Brazilian amazon: clinical characteristics and associated factors","volume":"54","author":"Silva","year":"2021","journal-title":"Rev Soc Bras Med Trop"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01882","article-title":"An immunological stairway to severe tissue complication assembly in Bothrops atrox snakebites","volume":"10","author":"Ibiapina","year":"2019","journal-title":"Front Immunol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2022.05.043","article-title":"Role of toll-like receptors in local effects in a model of experimental envenoming induced by Bothrops jararacussu snake venom and by two phospholipases A2","volume":"214","author":"Fontana","year":"2022","journal-title":"Toxicon"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2016.04.042","article-title":"The role of TLR2 in the acute inflammatory response induced by Bothrops atrox snake venom","volume":"118","author":"Moreira","year":"2016","journal-title":"Toxicon"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8120349","article-title":"Viperid envenomation wound exudate contributes to increased vascular permeability via a DAMPs\/TLR-4 mediated pathway","volume":"8","author":"Rucavado","year":"2016","journal-title":"Toxins"},{"key":"B36","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/s42003-024-06019-6","article-title":"Tissue damaging toxins in snake venoms: mechanisms of action pathophysiology and treatment strategies","volume":"7","author":"Bittenbinder","year":"2024","journal-title":"Commun Biol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2021.08.016","article-title":"Pain modulated by Bothrops snake venoms: mechanisms of nociceptive signaling and therapeutic perspectives","volume":"201","author":"Cavalcante","year":"2021","journal-title":"Toxicon"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.779473","article-title":"Pain and cellular migration induced by Bothrops jararaca venom in mice selected for an acute inflammatory response: involvement of mast cells","volume":"12","author":"Kondo","year":"2022","journal-title":"Front Immunol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152649","article-title":"Inflammatory mediators in the pronociceptive effects induced by Bothrops leucurus snake venom: The role of biogenic amines nitric oxide and eicosanoids","volume":"448","author":"Maia-Marques","year":"2021","journal-title":"Toxicology"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12040734","article-title":"Understanding local reactions induced by Bothrops jararaca venom: the role of inflammatory mediators in leukocyte-endothelium interactions","volume":"12","author":"Zychar","year":"2024","journal-title":"Biomedicines"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13110800","article-title":"Observation of Bothrops atrox snake envenoming blister formation from five patients: pathophysiological insights","volume":"13","author":"Gimenes","year":"2021","journal-title":"Toxins"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011167","article-title":"Gomes Martins de Moura Tomich L. Epidemiology of Secondary Infection after Snakebites in Center-West Brazil","volume":"17","author":"Soares Coriolano Coutinho","year":"2023","journal-title":"PLoS Negl Trop Dis"},{"key":"B43","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0003-9861(89)90350-0","article-title":"Degradation of extracellular matrix proteins by hemorrhagic metalloproteinases","volume":"275","author":"Baramova","year":"1989","journal-title":"Arch Biochem Biophys"},{"key":"B44","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.toxicon.2020.07.025","article-title":"Analysis of Wound Exudates Reveals Differences in the Patterns of Tissue Damage and Inflammation Induced by the Venoms of Daboia russelii and Bothrops asper in Mice","volume":"186","author":"Rucavado","year":"2020","journal-title":"Toxicon"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11050246","article-title":"Proteomic analysis of human blister fluids following envenomation by three snake species in India: differential markers for venom mechanisms of action","volume":"11","author":"Mac\u00eado","year":"2019","journal-title":"Toxins"},{"key":"B46","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.toxicon.2013.02.010","article-title":"The crucial role of the MyD88 adaptor protein in the inflammatory response induced by Bothrops atrox venom","volume":"67","author":"Moreira","year":"2013","journal-title":"Toxicon"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168643","article-title":"Effects of PI and PIII snake venom haemorrhagic metalloproteinases on the microvasculature: A confocal microscopy study on the mouse cremaster muscle","volume":"11","author":"Herrera","year":"2016","journal-title":"PLoS One"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000727","article-title":"Mechanisms of vascular damage by hemorrhagic snake venom metalloproteinases: tissue distribution and in situ hydrolysis","volume":"4","author":"Baldo","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12090554","article-title":"Bleeding disorders in Bothrops atrox envenomations in the Brazilian amazon: participation of hemostatic factors and the impact of tissue factor","volume":"12","author":"Oliveira","year":"2020","journal-title":"Toxins"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411508","article-title":"Crosstalk of inflammation and coagulation in Bothrops snakebite envenoming: endogenous signaling pathways and pathophysiology","volume":"24","author":"Cavalcante","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1177\/1535370215590818","article-title":"Bothrops jararaca envenomation: pathogenesis of hemostatic disturbances and intravascular hemolysis","volume":"240","author":"Senise","year":"2015","journal-title":"Exp Biol Med"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008936","article-title":"Snakebite associated thrombotic microangiopathy: A systematic review of clinical features outcomes and evidence for interventions including plasmapheresis","volume":"14","author":"Noutsos","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2024.107793","article-title":"Long-Term Disability after Cerebral Ischemic Stroke Following a Bothrops atrox Snakebite in the Brazilian Amazon","volume":"247","author":"Bentes","year":"2024","journal-title":"Toxicon"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(02)00156-3","article-title":"Renal toxicity of Bothrops moojeni snake venom and its main myotoxins","volume":"40","author":"Barbosa","year":"2002","journal-title":"Toxicon"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.10.005","article-title":"Purification and biological activity of the thrombin-like substance isolated from Bothrops insularis venom","volume":"49","author":"Braga","year":"2007","journal-title":"Toxicon"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2009.12.004","article-title":"Renal and cardiovascular effects of Bothrops marajoensis venom and phospholipase A2","volume":"55","author":"Evangelista","year":"2010","journal-title":"Toxicon"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2015.09.031","article-title":"Bothropoides pauloensis venom effects on isolated perfused kidney and cultured renal tubular epithelial cells","volume":"108","author":"Marinho","year":"2015","journal-title":"Toxicon"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.2174\/1568026619666190809100319","article-title":"Bothrops alternatus snake venom induces cytokine expression and oxidative stress on renal function","volume":"19","author":"J\u00fanior","year":"2019","journal-title":"Curr Top Med Chem"},{"key":"B59","doi-asserted-by":"publisher","first-page":"106922","DOI":"10.1016\/j.toxicon.2022.09.008","article-title":"Effects of cilostazol a phosphodiesterase-3 inhibitor on kidney function and redox imbalance in acute kidney injury caused by Bothrops alternatus venom","volume":"220","author":"Marinho","year":"2022","journal-title":"Toxicon"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2018.1510129","article-title":"Acute kidney injury induced by thrombotic microangiopathy in two cases of Bothrops envenomation","volume":"57","author":"Malaque","year":"2019","journal-title":"Clin Toxicol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1590\/1678-9199-jvatitd-2019-0076","article-title":"Clinical assessment and pathophysiology of Bothrops venom-related acute kidney injury: A scoping review","volume":"26","author":"Albuquerque","year":"2020","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011083","article-title":"Bothrops (Fer-de-lance) snakebites in the French departments of the Americas (Martinique and Guyana): clinical and experimental studies and treatment by immunotherapy","volume":"17","author":"Resiere","year":"2023","journal-title":"PloS Negl Trop Dis"},{"key":"B63","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1097\/00001721-199807000-00001","article-title":"Use of snake venom fractions in the coagulation laboratory","volume":"9","author":"Marsh","year":"1998","journal-title":"Blood Coagul Fibrinolysis"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(89)90146-3","article-title":"Haemostatic changes caused by the venoms of South American snakes","volume":"27","author":"Kamiguti","year":"1989","journal-title":"Toxicon"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1021\/pr8003826","article-title":"Snake Venomics of the Lesser Antillean Pit Vipers Bothrops caribbaeus and Bothrops lanceolatus: Correlation with Toxicological Activities and Immunoreactivity of a Heterologous Antivenom","volume":"7","author":"Gutierrez","year":"2008","journal-title":"J Proteome Res"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3390\/toxins15010001","article-title":"Commercial antivenoms exert broad paraspecific immunological binding and in vitro inhibition of medically important Bothrops pit viper venoms","volume":"15","author":"Alsolaiss","year":"2022","journal-title":"Toxins"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/s0041-0101(98)00193-7","article-title":"Neutralization by a monospecific Bothrops lanceolatus antivenom of toxic activities induced by homologous and heterologous Bothrops snake venoms","volume":"37","author":"Bogarin","year":"1999","journal-title":"Toxicon"},{"key":"B68","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3390\/toxins14050297","article-title":"Clinical and evolutionary implications of dynamic coagulotoxicity divergences in Bothrops (Lancehead Pit Viper) Venoms","volume":"14","author":"Bourke","year":"2022","journal-title":"Toxins"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(00)00139-2","article-title":"Coagulant and Anticoagulant Activities of Bothrops lanceolatus (Fer de Lance) Venom","volume":"39","author":"Lobo de Araujo","year":"2001","journal-title":"Toxicon"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0264-2024","article-title":"Brain death due to intracranial hemorrhage in a child following suspected Bothrops snakebite","volume":"57","author":"Dellandrea","year":"2024","journal-title":"Rev Soc Bras Med Trop"},{"key":"B71","doi-asserted-by":"publisher","first-page":"9","DOI":"10.7705\/biomedica.6114","article-title":"Massive Acute Ischemic Stroke after Bothrops spp Envenomation in Southwestern Colombia: Case Report and Literature Review","volume":"42","author":"Mart\u00ednez-Villota","year":"2022","journal-title":"Biomedica"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2016.08.005","article-title":"Brainstem Ischemic Stroke after Bothrops atrox Snakebite","volume":"120","author":"Ca\u00f1as","year":"2016","journal-title":"Toxicon"},{"key":"B73","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s40409-015-0052-5","article-title":"Hemorrhagic stroke in children caused by Bothrops marajoensis envenoming: A case report","volume":"21","author":"de Oliveira Pardal","year":"2015","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0115-2019","article-title":"Hemorrhagic stroke following viper bites and delayed antivenom administration: three case reports from the western Brazilian amazon","volume":"52","author":"P\u00e9rez-G\u00f3mez","year":"2019","journal-title":"Rev Soc Bras Med Trop"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2017.08.021","article-title":"Fatal stroke after Bothrops snakebite in the amazonas state Brazil: A case report","volume":"138","author":"Silva de Oliveira","year":"2017","journal-title":"Toxicon"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.wem.2020.04.009","article-title":"Cerebrovascular accidents related to snakebites in the amazon\u2014Two case reports","volume":"31","author":"Sachett","year":"2020","journal-title":"Wilderness Environ Med"},{"key":"B77","article-title":"Hemorragia Cerebelosa Secundaria a Accidente Of\u00eddico por Bothrops sp","volume":"627","author":"Cordero","year":"2019","journal-title":"Rev M\u00e9dica Costa Rica"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822010000500029","article-title":"Acidente Vascular Cerebral Hemorr\u00e1gico Associado \u00e0 Acidente Of\u00eddico por Serpente do G\u00eanero Bothrops: Relato de Caso","volume":"43","author":"MaChado","year":"2010","journal-title":"Rev Soc Bras Med Trop"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.73.583","article-title":"Occipital infarction revealed by quadranopsia following snakebite by Bothrops lanceolatus","volume":"73","author":"Merle","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.100160","article-title":"Coagulation biomarkers for ischemic stroke","volume":"7","author":"Barakzie","year":"2023","journal-title":"Res Pract Thromb Haemost"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-014-1122-1","article-title":"Hyperfibrinogenemia predicts long-term risk of death after ischemic stroke","volume":"38","author":"Swarowska","year":"2014","journal-title":"J Thromb Thrombolysis"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.34335","article-title":"Association of fibrinogen with ischemic stroke: A systematic review and meta-analysis","volume":"15","author":"Prasad","year":"2023","journal-title":"Cureus"},{"key":"B83","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.toxicon.2012.03.018","article-title":"Batroxase a new metalloproteinase from B atrox snake venom with strong fibrinolytic activity","volume":"60","author":"Cintra","year":"2012","journal-title":"Toxicon"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1021\/bi00377a019","article-title":"Blood coagulation induced by the venom of Bothrops atrox 2 identification purification and properties of two factor X activators","volume":"26","author":"Hofmann","year":"1987","journal-title":"Biochemistry"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1159\/000048069","article-title":"Factor V activation and inactivation by venom proteases","volume":"31","author":"Rosing","year":"2001","journal-title":"Haemostasis"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1021\/bi00583a020","article-title":"Thrombocytin a serine protease from Bothrops atrox venom 1 purification and characterization of the enzyme","volume":"18","author":"Kirby","year":"1979","journal-title":"Biochemistry"},{"key":"B87","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.toxicon.2012.10.023","article-title":"Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model","volume":"63","author":"Herrera","year":"2013","journal-title":"Toxicon"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.06.008","article-title":"Shortened activated partial thromboplastin time is associated with acute ischemic stroke stroke severity and neurological worsening","volume":"24","author":"Lin","year":"2015","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.9734\/ibrr\/2024\/v15i3341","article-title":"An investigative study of prothrombin time activated partial thromboplastin time and antithrombin levels in patients with ischaemic stroke","volume":"15","author":"Nnachi","year":"2024","journal-title":"Int Blood Res Rev"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3390\/toxins14110802","article-title":"Inflammation and oxidative stress in snakebite envenoming: A brief descriptive review and clinical implications","volume":"14","author":"Resiere","year":"2022","journal-title":"Toxins"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.05.006","article-title":"Causes and consequences of snake venom variation","volume":"41","author":"Casewell","year":"2020","journal-title":"Trends Pharmacol Sci"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2022.106983","article-title":"Half a century of research on Bothrops asper venom variation: biological and biomedical implications","volume":"221","author":"Mora-Obando","year":"2023","journal-title":"Toxicon"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253050","article-title":"From birth to adulthood: An analysis of the Brazilian lancehead (Bothrops moojeni) venom at different life stages","volume":"16","author":"Hatakeyama","year":"2021","journal-title":"PLoS One"},{"key":"B94","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.toxicon.2022.05.007","article-title":"Analyzing the influence of age and sex in Bothrops pauloensis snake venom","volume":"214","author":"Tasima","year":"2022","journal-title":"Toxicon"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(97)90219-4","article-title":"Clinical indicators of envenoming and serum levels of venom antigens in patients bitten by Bothrops lanceolatus in Martinique","volume":"91","author":"Bucher","year":"1997","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2010.08.011","article-title":"Comparative analysis of newborn and adult Bothrops jararaca snake venoms","volume":"56","author":"Antunes","year":"2010","journal-title":"Toxicon"},{"key":"B97","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.toxlet.2021.05.005","article-title":"Clinical implications of ontogenetic differences in the coagulotoxic activity of Bothrops jararacussu venoms","volume":"348","author":"Rodrigues","year":"2021","journal-title":"Toxicol Lett"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2020.05.028","article-title":"Sexual and ontogenetic variation of Bothrops leucurus venom","volume":"184","author":"MaChado Braga","year":"2020","journal-title":"Toxicon"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1186\/1477-5956-4-11","article-title":"Ontogenetic variations in the venom proteome of the Amazonian snake Bothrops atrox","volume":"4","author":"Gu\u00e9rcio","year":"2006","journal-title":"Proteome Sci"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1590\/1519-6984.279474","article-title":"Ontogenetic and sexual differences in the venom of Bothrops moojeni: insights from a litter and its mother","volume":"84","author":"Ferreira-Rodrigues","year":"2024","journal-title":"Braz J Biol"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(23)00330-2","article-title":"Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine","volume":"12","author":"Cajander","year":"2024","journal-title":"Lancet Respir Med"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.10.012","article-title":"The immunology of sepsis","volume":"54","author":"van der Poll","year":"2021","journal-title":"Immunity"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02082","article-title":"Inflammation induced by platelet-activating viperid snake venoms: perspectives on thromboinflammation","volume":"10","author":"Teixeira","year":"2019","journal-title":"Front Immunol"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3390\/toxins16120519","article-title":"The role of snake venom proteins in inducing inflammation post-envenomation: an overview on mechanistic insights and treatment strategies","volume":"16","author":"Rao","year":"2024","journal-title":"Toxins"},{"key":"B105","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/bs.ircmb.2015.10.005","article-title":"Leukocytes crossing the endothelium: A matter of communication","volume":"322","author":"Timmerman","year":"2016","journal-title":"Int Rev Cell Mol Biol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(01)00131-3","article-title":"The effect of jararhagin a metalloproteinase from Bothrops jararaca venom on pro-inflammatory cytokines released by murine peritoneal adherent cells","volume":"39","author":"Clissa","year":"2001","journal-title":"Toxicon"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.abb.2005.06.007","article-title":"Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: in vitro and in vivo gene expression analysis of the effects of the toxin","volume":"441","author":"Gallagher","year":"2005","journal-title":"Arch Biochem Biophys"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.02.023","article-title":"Effects of two serine proteases from Bothrops pirajai snake venom on the complement system and the inflammatory response","volume":"15","author":"Menaldo","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1080\/09629350020025728","article-title":"Bothrops asper snake venom and its metalloproteinase BaP-1 activate the complement system role in leukocyte recruitment","volume":"9","author":"Farsky","year":"2000","journal-title":"Mediators Inflammation"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.01.009","article-title":"Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines","volume":"47","author":"Fernandes","year":"2006","journal-title":"Toxicon"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2005.044","article-title":"The snake venom metalloproteases berythractivase and jararhagin activate endothelial cells","volume":"386","author":"Schattner","year":"2005","journal-title":"Biol Chem"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.02.014","article-title":"Releasing or expression modulating mediator involved in hemostasis by berythractivase and jararhagin (SVMPs)","volume":"47","author":"Pereira","year":"2006","journal-title":"Toxicon"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1533-6","article-title":"Moojenactivase a novel pro-coagulant PIIId metalloprotease isolated from Bothrops moojeni snake venom activates coagulation factors II and X and induces tissue factor up-regulation in leukocytes","volume":"90","author":"Sartim","year":"2016","journal-title":"Arch Toxicol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1021\/bi00221a032","article-title":"Isolation and chemical characterization of two structurally and functionally distinct forms of botrocetin the platelet coagglutinin isolated from the venom of Bothrops jararaca","volume":"30","author":"Fujimura","year":"1991","journal-title":"Biochemistry"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1081","article-title":"Jararhagin and Jaracetin: novel snake venom inhibitors of the integrin collagen receptor alpha 2 beta 1","volume":"206","author":"De Luca","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021353","article-title":"The phospholipase A2 superfamily: structure isozymes catalysis physiologic and pathologic roles","volume":"24","author":"Khan","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12020068","article-title":"Amplification of snake venom toxicity by endogenous signaling pathways","volume":"12","author":"Bickler","year":"2020","journal-title":"Toxins"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-023-00543-8","article-title":"Unraveling snake venom phospholipase A2: an overview of its structure pharmacology and inhibitors","volume":"75","author":"Sampat","year":"2023","journal-title":"Pharmacol Rep"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(00)00107-0","article-title":"Leucocyte recruitment induced by type II phospholipases A2 into the rat pleural cavity","volume":"38","author":"de Castro","year":"2000","journal-title":"Toxicon"},{"key":"B120","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40409-018-0170-y","article-title":"Cytotoxic and inflammatory potential of a phospholipase A2 from Bothrops jararaca snake venom","volume":"24","author":"Cedro","year":"2018","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00248-3","article-title":"Inflammatory oedema induced by the lys-49 phospholipase A2 homologue piratoxin-I in the rat and rabbit effect of polyanions and p-bromophenacyl bromide","volume":"59","author":"Landucci","year":"2000","journal-title":"Biochem Pharmacol"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/105879","article-title":"An Asp49 Phospholipase A2 from Snake Venom Induces Cyclooxygenase-2 Expression and Prostaglandin E2 Production via Activation of NF-\u03baB p38MAPK and PKC in Macrophages","volume":"2014","author":"Moreira","year":"2014","journal-title":"Mediators Inflammation"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24129931","article-title":"New Insights into Immunopathology Associated to Bothrops lanceolatus Snake Envenomation: Focus on PLA2 Toxin","volume":"24","author":"Gabrili","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-12-10","article-title":"Human neutrophil migration and activation by BJcuL a galactose binding lectin purified from Bothrops jararacussu venom","volume":"12","author":"Elifio-Esposito","year":"2011","journal-title":"BMC Immunol"},{"key":"B125","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.tiv.2017.02.003","article-title":"Effect of bjcuL a lectin isolated from Bothrops jararacussu on human peripheral blood mononuclear cells","volume":"41","author":"Pires","year":"2017","journal-title":"Toxicol In Vitro"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwu061","article-title":"Galatrox is a C-type lectin in bothrops atrox snake venom that selectively binds lacNAc-terminated glycans and can induce acute inflammation","volume":"24","author":"Sartim","year":"2014","journal-title":"Glycobiology"},{"key":"B127","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s00018-023-04839-z","article-title":"A C-type lectin induces NLRP3 inflammasome activation via TLR4 interaction in human peripheral blood mononuclear cells","volume":"80","author":"Ikenohuchi","year":"2023","journal-title":"Cell Mol Life Sci"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220898","article-title":"Batroxobin accelerated tissue repair via neutrophil extracellular trap regulation and defibrinogenation in a murine ischemic hind limb model","volume":"14","author":"Masuda","year":"2019","journal-title":"PloS One"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13120906","article-title":"Bitis arietans snake venom and Kn-Ba a snake venom serine protease induce the production of inflammatory mediators in THP-1 macrophages","volume":"13","author":"Megale","year":"2021","journal-title":"Toxins"},{"key":"B130","article-title":"Kallikrein enzymes","volume-title":"Venomous Reptiles and Their Toxins: Evolution Pathophysiology and Biodiscovery","author":"Vaiyapuri","year":"2015"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2005.12.033","article-title":"Purification and properties of a coagulant thrombin-like enzyme from the venom of Bothrops leucurus","volume":"146","author":"Magalh\u00e3es","year":"2007","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2007.10.005","article-title":"Molecular characterization of BjussuSP-I a new thrombin-like enzyme with procoagulant and kallikrein-like activity isolated from Bothrops jararacussu snake venom","volume":"90","author":"Sant\u2019Ana","year":"2008","journal-title":"Biochimie"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2009.05.040","article-title":"Biochemical and functional properties of a thrombin-like enzyme isolated from Bothrops pauloensis snake venom","volume":"54","author":"Costa","year":"2009","journal-title":"Toxicon"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.3390\/ph13090215","article-title":"Kinins and their receptors in infectious diseases","volume":"13","author":"Dagnino","year":"2020","journal-title":"Pharmaceuticals"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-07539-2","article-title":"A comprehensive review on current understanding of bradykinin in COVID-19 and inflammatory diseases","volume":"49","author":"Rex","year":"2022","journal-title":"Mol Biol Rep"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S488237","article-title":"Novel insights into the kallikrein-kinin system in fulminant myocarditis: physiological basis and potential therapeutic advances","volume":"17","author":"Ji","year":"2024","journal-title":"J Inflammation Res"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.3390\/toxins16060276","article-title":"Investigating snake-venom-induced dermonecrosis and inflammation using an ex vivo human skin model","volume":"16","author":"Alsolaiss","year":"2024","journal-title":"Toxins"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1021\/pr900489m","article-title":"Wound exudate as a proteomic window to reveal different mechanisms of tissue damage by snake venom toxins","volume":"8","author":"Escalante","year":"2009","journal-title":"J Proteome Res"},{"key":"B139","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/toxins2010010","article-title":"Structure and function of snake venom proteins affecting platelet plug formation","volume":"2","author":"Matsui","year":"2010","journal-title":"Toxins"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2020.09.006","article-title":"Polymorphonuclear neutrophil leukocytes in snakebite envenoming","volume":"187","author":"Zuliani","year":"2020","journal-title":"Toxicon"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.885223","article-title":"Bothrops jararaca snake venom inflammation induced in human whole blood: role of the complement system","volume":"13","author":"Leonel","year":"2022","journal-title":"Front Immunol"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02959-0","article-title":"Bothrops lanceolatus snake (Fer-de-lance) venom triggers inflammatory mediators\u2019 Storm in human blood","volume":"95","author":"Silva de Franca","year":"2021","journal-title":"Arch Toxicol"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3462136","article-title":"Venom from Bothrops lanceolatus a snake species native to Martinique potently activates the complement system","volume":"2018","author":"Delafontaine","year":"2018","journal-title":"J Immunol Res"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.07.003","article-title":"Human complement activation and anaphylatoxins generation induced by snake venom toxins from Bothrops genus","volume":"47","author":"Pidde-Queiroz","year":"2010","journal-title":"Mol Immunol"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2003.11.032","article-title":"The Complement System Is Involved in Acute Inflammation but Not in the Hemorrhage Produced by a Bothrops atrox Snake Venom Low Molecular Mass Proteinase","volume":"40","author":"Rodrigues","year":"2004","journal-title":"Mol Immunol"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-010-1034-0","article-title":"The complement system","volume":"343","author":"Sarma","year":"2011","journal-title":"Cell Tissue Res"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201591881","article-title":"Complement activation regulation and molecular basis for complement-related diseases","volume":"34","author":"Bajic","year":"2015","journal-title":"EMBO J"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-021-00872-x","article-title":"Complement as driver of systemic inflammation and organ failure in trauma burn and sepsis","volume":"43","author":"Mannes","year":"2021","journal-title":"Semin Immunopathol"},{"key":"B149","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41423-018-0024-0","article-title":"NETosis complement and coagulation: A triangular relationship","volume":"16","author":"de Bont","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070166","article-title":"The role of complement in inflammatory diseases from behind the scenes into the spotlight","volume":"171","author":"Markiewski","year":"2007","journal-title":"Am J Pathol"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(92)90004-U","article-title":"Ultrastructural Alterations in Mouse Capillary Blood Vessels after Experimental Injection of Venom from the Snake Bothrops asper (Terciopelo)","volume":"57","author":"Moreira","year":"1992","journal-title":"Exp Mol Pathol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(94)90302-6","article-title":"Activity of hemorrhagic metalloproteinase baH-1 and myotoxin II from Bothrops asper snake venom on capillary endothelial cells in vitro","volume":"32","author":"Lomonte","year":"1994","journal-title":"Toxicon"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1006\/exmp.1995.1042","article-title":"Local tissue damage induced by BaP1 a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom","volume":"63","author":"Rucavado","year":"1995","journal-title":"Exp Mol Pathol"},{"key":"B154","doi-asserted-by":"publisher","first-page":"11157","DOI":"10.1038\/s41598-024-60282-5","article-title":"Using organ-on-a-chip technology to study haemorrhagic activities of snake venoms on endothelial tubules","volume":"14","author":"Bittenbinder","year":"2024","journal-title":"Sci Rep"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(02)00171-X","article-title":"Vascular endothelial cell injury induced by Bothrops jararaca venom, non-significance of hemorrhagic metalloproteinase","volume":"40","author":"Kawano","year":"2002","journal-title":"Toxicon"},{"key":"B156","doi-asserted-by":"publisher","first-page":"12912","DOI":"10.1038\/s41598-020-69396-y","article-title":"Cleavage of proteoglycans plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases","volume":"10","author":"Asega","year":"2020","journal-title":"Sci Rep"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.3390\/toxins9080244","article-title":"Enzymatic and pro-inflammatory activities of Bothrops lanceolatus venom: relevance for envenomation","volume":"9","author":"Delafontaine","year":"2017","journal-title":"Toxins"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2019.0119","article-title":"Significance of complement system in ischemic stroke: A comprehensive review","volume":"10","author":"Ma","year":"2019","journal-title":"Aging Dis"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2015.251314","article-title":"Complement C3 and high risk of venous thromboembolism: 80517 individuals from the copenhagen general population study","volume":"62","author":"N\u00f8rgaard","year":"2016","journal-title":"Clin Chem"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-121113","article-title":"Links between complement activation and thrombosis","volume":"134","author":"Ruf","year":"2019","journal-title":"Blood"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1177\/1076029620943293","article-title":"COVID-19-associated coagulopathy: an exacerbated immunothrombosis response","volume":"26","author":"Jayarangaiah","year":"2020","journal-title":"Clin Appl Thromb Hemost"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15476","article-title":"Complement inflammation and thrombosis","volume":"178","author":"Rawish","year":"2021","journal-title":"Br J Pharmacol"},{"key":"B163","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1159\/000321641","article-title":"Coagulation systems of invertebrates and vertebrates and their roles in innate immunity: the same side of two coins","volume":"3","author":"Loof","year":"2011","journal-title":"J Innate Immun"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.628302","article-title":"Sepsis-pathophysiology and therapeutic concepts","volume":"8","author":"Jarczak","year":"2021","journal-title":"Front Med"},{"key":"B165","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.thromres.2023.05.018","article-title":"Tissue factor expression in monocyte subsets during human immunothrombosis endotoxemia and sepsis","volume":"228","author":"Musgrave","year":"2023","journal-title":"Thromb Res"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2024.05.014","article-title":"The convergent model of coagulation","volume":"22","author":"Yong","year":"2024","journal-title":"J Thromb Haemost"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005743107","article-title":"Extracellular DNA traps promote thrombosis","volume":"107","author":"Fuchs","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.910908","article-title":"Impact of neutrophil extracellular traps on thrombosis formation: new findings and future perspective front cell","volume":"12","author":"Zhou","year":"2022","journal-title":"Infect Microbiol"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.3390\/biology12101332","article-title":"Immune thrombosis: exploring the significance of immune complexes and NETosis","volume":"12","author":"Perdomo","year":"2023","journal-title":"Biology"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25053025","article-title":"Neutrophil extracellular DNA traps in response to infection or inflammation and the roles of platelet interactions","volume":"25","author":"Chen","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B171","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1055\/s-0044-1782660","article-title":"The role of myeloid cells in thromboinflammatory disease","volume":"50","author":"Noone","year":"2024","journal-title":"Semin Thromb Hemost"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1055\/a-1151-9519","article-title":"Platelets in thrombo-inflammation: concepts mechanisms and therapeutic strategies for ischemic stroke","volume":"40","author":"Burkard","year":"2020","journal-title":"Hamostaseologie"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.11.001","article-title":"Platelet polyphosphates are proinflammatory and procoagulant mediators","volume":"139","author":"Muller","year":"2009","journal-title":"In Vivo Cell"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00381.2014","article-title":"Neutrophil extracellular traps in ischemia-reperfusion injury-induced myocardial no-reflow: therapeutic potential of DNase-based reperfusion strategy","volume":"308","author":"Ge","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B175","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.thromres.2016.01.009","article-title":"NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation","volume":"139","author":"Thalin","year":"2016","journal-title":"Thromb Res"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-022-01074-9","article-title":"The role of neutrophil extracellular traps in early microthrombosis and brain injury after subarachnoid hemorrhage in mice","volume":"14","author":"Hao","year":"2023","journal-title":"Transl Stroke Res"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01874","article-title":"Correlating fibrinogen consumption and profiles of inflammatory molecules in human envenomations by Bothrops atrox in the Brazilian amazon","volume":"11","author":"Wellmann","year":"2020","journal-title":"Front Immunol"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.953129","article-title":"Platelets in the NETworks interweaving inflammation and thrombosis","volume":"13","author":"Wienkamp","year":"2022","journal-title":"Front Immunol"},{"key":"B179","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.toxicon.2017.04.013","article-title":"The role of platelets in hemostasis and the effects of snake venom toxins on platelet function","volume":"133","author":"de Queiroz","year":"2017","journal-title":"Toxicon"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.09.031","article-title":"Snake bites and hemostasis\/thrombosis","volume":"132","author":"McCleary","year":"2013","journal-title":"Thromb Res"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(90)90155-Z","article-title":"Effects of snake venom proteins on blood platelets","volume":"28","author":"Kini","year":"1990","journal-title":"Toxicon"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-02-0120","article-title":"Platelet Dysfunction during Bothrops jararaca Snake Envenomation in Rabbits","volume":"92","author":"Santoro","year":"2004","journal-title":"Thromb Haemost"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2008.07.012","article-title":"Bothrops jararaca venom (BjV) induces differential leukocyte accumulation in mice genetically selected for acute inflammatory reaction: the role of host genetic background on expression of adhesion molecules and release of endogenous mediators","volume":"52","author":"Carneiro","year":"2008","journal-title":"Toxicon"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.08.011","article-title":"Inflammation induced by Bothrops asper venom: release of proinflammatory cytokines and eicosanoids and role of adhesion molecules in leukocyte infiltration","volume":"46","author":"Zamuner","year":"2005","journal-title":"Toxicon"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-004-1288-7","article-title":"Chronic blockade of nitric oxide biosynthesis in rats: effect on leukocyte endothelial interaction and on leukocyte recruitment","volume":"53","author":"Farsky","year":"2004","journal-title":"Inflammation Res"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.02.001","article-title":"Importance of jararhagin disintegrin-like and cysteine-rich domains in the early events of local inflammatory response","volume":"47","author":"Clissa","year":"2006","journal-title":"Toxicon"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.321750","article-title":"NETs-induced thrombosis impacts on cardiovascular and chronic kidney disease","volume":"132","author":"Thakur","year":"2023","journal-title":"Circ Res"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.838011","article-title":"NETosis and neutrophil extracellular traps in COVID-19: immunothrombosis and beyond","volume":"13","author":"Zhu","year":"2022","journal-title":"Front Immunol"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxcx.2020.100032","article-title":"Human Neutrophils Functionality under Effect of an Asp49 Phospholipase A2 Isolated from Bothrops atrox Venom","volume":"6","author":"Setubal","year":"2020","journal-title":"Toxicon X"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2013.09.019","article-title":"Effect of Bothrops bilineata snake venom on neutrophil function","volume":"76","author":"Setubal","year":"2013","journal-title":"Toxicon"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2022.106992","article-title":"Action of bjussuMP-II a snake venom metalloproteinase isolated from Bothrops jararacussu venom on human neutrophils","volume":"222","author":"Lisita","year":"2023","journal-title":"Toxicon"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009715","article-title":"Involvement of von Willebrand Factor and Botrocetin in the Thrombocytopenia Induced by Bothrops jararaca Snake Venom","volume":"15","author":"Thomazini","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2007.05895.x","article-title":"Interaction of the Cysteine-Rich Domain of Snake Venom Metalloproteinases with the A1 Domain of von Willebrand Factor Promotes Site-Specific Proteolysis of von Willebrand Factor and Inhibition of von Willebrand Factor-Mediated Platelet Aggregation","volume":"274","author":"Serrano","year":"2007","journal-title":"FEBS J"},{"key":"B194","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.thromres.2019.01.018","article-title":"Optimization of von willebrand factor multimer analysis in vertical mini-gel electrophoresis systems: A rapid procedure","volume":"175","author":"Thomazini","year":"2019","journal-title":"Thromb Res"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2022.104742","article-title":"Blood Plasma Proteome Alteration after Local Tissue Damage Induced by Bothrops erythromelas Snake Venom in Mice","volume":"269","author":"Cavalcante","year":"2022","journal-title":"J Proteomics"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.3390\/toxins14090613","article-title":"Experimental Bothrops atrox Envenomation: Blood Plasma Proteome Effects after Local Tissue Damage and Perspectives on Thromboinflammation","volume":"14","author":"Cavalcante","year":"2022","journal-title":"Toxins"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2021.104464","article-title":"A Fingerprint of Plasma Proteome Alteration after Local Tissue Damage Induced by Bothrops leucurus Snake Venom in Mice","volume":"253","author":"Cavalcante","year":"2022","journal-title":"J Proteomics"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.3390\/toxins15030180","article-title":"Challenges and opportunities in clinical diagnostic routine of envenomation using blood plasma proteomics","volume":"15","author":"Cavalcante","year":"2023","journal-title":"Toxins"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1625165\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T15:51:54Z","timestamp":1761925914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1625165\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,10]]},"references-count":198,"alternative-id":["10.3389\/fimmu.2025.1625165"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1625165","relation":{"has-part":[{"id-type":"doi","id":"https:\/\/doi.org\/10.3389\/fimmu.2025.1625165.s001","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.3389\/fimmu.2025.1625165.s002","asserted-by":"subject"}]},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,10]]},"article-number":"1625165"}}