{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T22:26:18Z","timestamp":1766787978688,"version":"3.44.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The shortage of suitable donor organs represents an ongoing global challenge for organ transplantation. During the COVID-19 pandemic, the number of transplantable organs was especially limited. To date, the impact of recent coronavirus-19 (COVID-19) infection on liver and kidney transplant recipients has not been systematically analyzed, which is essential for the development of future transplant management. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic review and meta-analysis to assess the clinical outcomes of recent COVID-19 infection in the donor (1) or the recipient (2). A total of 17 studies were considered for systematic review, seven of these were included for meta-analysis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Transplantation of COVID-19 positive donors did not result in an impaired graft survival for liver or kidney transplantation up to 180-days of follow up. Additionally, a positive COVID-19 donor status was not associated with decreased overall survival in kidney transplant recipients within 180 days of transplantation. Nevertheless, an association was found with decreased overall survival in liver transplant recipients within the 180-day follow-up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>However, the heterogeneity of studies investigating COVID-19 infection of the recipient did not allow a classification of the significance of COVID-19 positive recipients. Conclusively, a COVID-19 positive donor status should not be considered as an exclusive factor for declining a suitable liver or kidney for transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p><jats:uri>https:\/\/www.crd.york.ac.uk\/PROSPERO\/<\/jats:uri>, identifier CRD42024562551.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2025.1626391","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T04:12:47Z","timestamp":1759119167000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of recent COVID-19 infection on liver and kidney transplantation \u2013 a worldwide meta-analysis and systematic review"],"prefix":"10.3389","volume":"16","author":[{"given":"Nicola Sariye","family":"Pollmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Dondorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Falk","family":"Rauchfu\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Utz","family":"Settmacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Pollmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Selzner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.01.118","article-title":"Three waves changes, new variant strains, and vaccination effect against COVID-19 pandemic","volume":"204","author":"El-Shabasy","year":"2022","journal-title":"Int J Biol macromolecules"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.744696","article-title":"A systematic review and meta-analysis of inpatient mortality associated with nosocomial and community COVID-19 exposes the vulnerability of immunosuppressed adults","volume":"12","author":"Ponsford","year":"2021","journal-title":"Front Immunol"},{"key":"B3","doi-asserted-by":"crossref","unstructured":"COVID-19 epidemiological update \u2013 16 November 2024\n          \n          2024","DOI":"10.1002\/vetr.5081"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00200-0","article-title":"COVID-19 pandemic and worldwide organ transplantation: a population-based study","volume":"6","author":"Aubert","year":"2021","journal-title":"Lancet Public Health"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1272961","article-title":"Impact of COVID-19 vaccination: a global perspective","volume":"11","author":"Singh","year":"2023","journal-title":"Front Public Health"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0279222","article-title":"COVID-19 mortality may be reduced among fully vaccinated solid organ transplant recipients","volume":"17","author":"Sandoval","year":"2022","journal-title":"PloS One"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.70071","article-title":"Increased mortality in kidney transplant recipients during the delta\/omicron era of the COVID-19 pandemic despite widespread vaccination","volume":"39","author":"Smith","year":"2025","journal-title":"Clin Transplantation."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004420","article-title":"Perioperative morbidity and mortality of patients with COVID-19 who undergo urgent and emergent surgical procedures","volume":"273","author":"Knisely","year":"2021","journal-title":"Ann Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"100628","DOI":"10.1016\/j.trre.2021.100628","article-title":"The association between severe or death COVID-19 and solid organ transplantation: A systematic review and meta-analysis","volume":"35","author":"Ao","year":"2021","journal-title":"Transplant Rev (Orlando Fla.)"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22132","article-title":"Early-onset pneumonia after liver transplantation: microbiological findings and therapeutic consequences","volume":"16","author":"Weiss","year":"2010","journal-title":"Liver Transplant Off Publ Am Assoc Study Liver Dis Int Liver Transplant Soc"},{"key":"B11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/jcm10132877","article-title":"Kidney transplantation in COVID pandemic-A review of guidelines","author":"Gut","year":"2021","journal-title":"J Clin Med"},{"key":"B12","unstructured":"Covid-19 clinical best practice advice for hepatology and liver transplant providers\n          \n          2024"},{"key":"B13","unstructured":"Recommendations for Organ Donation and Transplantation after COVID-19 - 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