{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:22:01Z","timestamp":1793816521537,"version":"4.6.1"},"reference-count":172,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Gastric cancer (GC) continues to rank among the leading causes of cancer-related mortality globally, with treatment resistance and recurrence posing significant clinical hurdles. While surgical interventions, chemotherapy, and targeted therapies are available, their efficacy in managing advanced or metastatic forms of the disease remains constrained. This review provided an overview of the role of glycolytic reprogramming in gastric cancer, emphasizing the complex regulation by epigenetic mechanisms, non-coding RNAs, post-translational modifications, and oncogenic signaling pathways. This review discusses how epigenetic mechanisms, including m6A methylation and ceRNA networks involving circRNAs and microRNAs, modulate key glycolytic enzymes such as PKM2, HK2, and PGK1, thereby promoting tumor growth, metastasis, and chemoresistance. The study also emphasizes the impact of post-translational modifications like succinylation and ubiquitination on enzyme activity, affecting glycolytic flux and tumor adaptability. Additionally, the article details the crosstalk between glycolytic pathways and oncogenic signaling networks, including hypoxia-inducible factors and YAP\/TAZ transcriptional regulators, which sustain tumor stemness and immune evasion. Therapeutic strategies targeting these metabolic vulnerabilities\u2014such as inhibiting m6A regulators, disrupting ceRNA interactions, and modulating enzyme modifications\u2014are discussed as potential approaches to improve gastric cancer treatment. Overall, we underscores the complexity of metabolic regulation in gastric cancer and proposes that targeting its epigenetic and signaling networks offers promising avenues for innovative therapies to overcome resistance and hinder tumor progression.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1628937","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T05:34:27Z","timestamp":1756964067000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Harnessing glycolysis in gastric cancer: molecular targets, therapeutic strategies, and clinical horizons"],"prefix":"10.3389","volume":"16","author":[{"given":"Zexing","family":"Shan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yefu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13045-023-01451-3","article-title":"Gastric cancer treatment: recent progress and future perspectives","volume":"16","author":"Guan","year":"2023","journal-title":"J Hematol Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-328514","article-title":"Steps forward in understanding gastric cancer risk","volume":"72","author":"Rugge","year":"2023","journal-title":"Gut"},{"key":"B4","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13045-025-01698-y","article-title":"The current landscape of gastric cancer and gastroesophageal junction cancer diagnosis and treatment in China: a comprehensive nationwide cohort analysis","volume":"18","author":"Chen","year":"2025","journal-title":"J Hematol Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2025.03.036","article-title":"Preventive effect of Helicobacter pylori treatment on gastric cancer incidence and mortality: A Korean population study","volume":"169","author":"Jung","year":"2025","journal-title":"Gastroenterology"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(25)00044-1","article-title":"Three decades of population health changes in Japan, 1990-2021: a subnational analysis for the Global Burden of Disease Study 2021","volume":"10","year":"2025","journal-title":"Lancet Public Health"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.70017","article-title":"Global trends and epidemiological shifts in gastrointestinal cancers: insights from the past four decades","volume":"45","author":"Li","year":"2025","journal-title":"Cancer Commun (Lond)"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0008","article-title":"Gastric cancer, version 2.2022, NCCN clinical practice guidelines in oncology","volume":"20","author":"Ajani","year":"2022","journal-title":"J Natl Compr Canc Netw"},{"key":"B9","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13045-024-01654-2","article-title":"Helicobacter pylori and gastric cancer: mechanisms and new perspectives","volume":"18","author":"Duan","year":"2025","journal-title":"J Hematol Oncol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1053\/j.gastro.2023.08.028","article-title":"Gastric intestinal metaplasia: real culprit or innocent bystander as a precancerous condition for gastric cancer","volume":"165","author":"Sugano","year":"2023","journal-title":"Gastroenterol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-320839","article-title":"Helicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis","volume":"69","author":"Ford","year":"2020","journal-title":"Gut"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330215","article-title":"Potential of personalised approaches in gastric cancer prevention","volume":"72","author":"Leja","year":"2023","journal-title":"Gut"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.12.004","article-title":"Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer","volume":"86","author":"Zeng","year":"2022","journal-title":"Semin Cancer Biol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2024.03.008","article-title":"Gastric cancer immunosuppressive microenvironment heterogeneity: implications for therapy development","volume":"10","author":"Yasuda","year":"2024","journal-title":"Trends Cancer"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202408451","article-title":"Artificial intelligence for predicting HER2 status of gastric cancer based on whole-slide histopathology images: A retrospective multicenter study","volume":"12","author":"Liao","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"B16","doi-asserted-by":"publisher","first-page":"217412","DOI":"10.1016\/j.canlet.2024.217412","article-title":"TIM3 on natural killer cells regulates antibody-dependent cellular cytotoxicity in HER2-positive gastric cancer","volume":"611","author":"Tsutsumi","year":"2024","journal-title":"Cancer Lett"},{"key":"B17","doi-asserted-by":"publisher","first-page":"189277","DOI":"10.1016\/j.bbcan.2025.189277","article-title":"Advancements in immunotherapy for gastric cancer: Unveiling the potential of immune checkpoint inhibitors and emerging strategies","volume":"1880","author":"Song","year":"2025","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2025.0522","article-title":"Atezolizumab and trastuzumab plus chemotherapy for ERBB2-positive locally advanced resectable gastric cancer: A randomized clinical trial","volume":"11","author":"Peng","year":"2025","journal-title":"JAMA Oncol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"100543","DOI":"10.1016\/j.medj.2024.10.020","article-title":"Integrating immunotherapy in the treatment of resectable gastric cancer: Are we on the right track","volume":"6","author":"Pazo-Cid","year":"2025","journal-title":"Med"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.56735","article-title":"Progress of gastric cancer surgery in the era of precision medicine","volume":"17","author":"Wang","year":"2021","journal-title":"Int J Biol Sci"},{"key":"B21","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1053\/j.gastro.2024.01.027","article-title":"Oncogenic fatty acid metabolism rewires energy supply chain in gastric carcinogenesis","volume":"166","author":"Won","year":"2024","journal-title":"Gastroenterology"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12285","article-title":"Intercellular communications and metabolic reprogramming as new predictive markers for immunotherapy responses in gastric cancer","volume":"42","author":"Sung","year":"2022","journal-title":"Cancer Commun (Lond)"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-025-01286-x","article-title":"Starvation induces metabolic hepatocyte reprogramming","volume":"7","author":"Slabber","year":"2025","journal-title":"Nat Metab"},{"key":"B24","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.semcancer.2025.03.003","article-title":"Metabolic reprogramming of tumor microenviroment by engineered bacteria","volume":"112","author":"Wang","year":"2025","journal-title":"Semin Cancer Biol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70055","article-title":"Metabolic reprogramming in cancer and senescence","volume":"6","author":"Zhang","year":"2025","journal-title":"MedComm (2020)"},{"key":"B26","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.apsb.2023.12.003","article-title":"Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer","volume":"14","author":"Liao","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"B27","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.semcancer.2025.03.006","article-title":"The Warburg effect: The hacked mitochondrial-nuclear communication in cancer","volume":"112","author":"Jiang","year":"2025","journal-title":"Semin Cancer Biol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"101920","DOI":"10.1016\/j.xcrm.2024.101920","article-title":"Enabling tumor-specific drug delivery by targeting the Warburg effect of cancer","volume":"6","author":"Zhang","year":"2025","journal-title":"Cell Rep Med"},{"key":"B29","doi-asserted-by":"publisher","first-page":"189089","DOI":"10.1016\/j.bbcan.2024.189089","article-title":"Exploring the diverse role of pyruvate kinase M2 in cancer: Navigating beyond glycolysis and the Warburg effect","volume":"1879","author":"Upadhyay","year":"2024","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade3697","article-title":"Metabolite-driven antitumor immunity","volume":"377","author":"Nathan","year":"2022","journal-title":"Science"},{"key":"B31","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s13045-022-01358-5","article-title":"Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications","volume":"15","author":"Zhong","year":"2022","journal-title":"J Hematol Oncol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.02.008","article-title":"Lactate: A key regulator of the immune response","volume":"58","author":"Llibre","year":"2025","journal-title":"Immunity"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1172\/JCI144871","article-title":"Folliculin impairs breast tumor growth by repressing TFE3-dependent induction of the Warburg effect and angiogenesis","volume":"131","author":"El-Houjeiri","year":"2021","journal-title":"J Clin Invest"},{"key":"B34","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1186\/s12943-024-02165-x","article-title":"Metabolic reprogramming and therapeutic resistance in primary and metastatic breast cancer","volume":"23","author":"Liu","year":"2024","journal-title":"Mol Cancer"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.7150\/thno.62378","article-title":"Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"B36","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41392-021-00473-y","article-title":"Knockdown of RNA N6-methyladenosine methyltransferase METTL3 represses Warburg effect in colorectal cancer via regulating HIF-1alpha","volume":"6","author":"Yang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"B37","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12943-024-02009-8","article-title":"ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment","volume":"23","author":"Zhang","year":"2024","journal-title":"Mol Cancer"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-023-01838-0","article-title":"SLITRK6 promotes the progression of lung adenocarcinoma by regulating PI3K\/AKT\/mTOR signaling and Warburg effect","volume":"28","author":"Yu","year":"2023","journal-title":"Apoptosis"},{"key":"B39","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s10020-023-00690-x","article-title":"Interferon-gamma regulates immunosuppression in septic mice by promoting the Warburg effect through the PI3K\/AKT\/mTOR pathway","volume":"29","author":"Fu","year":"2023","journal-title":"Mol Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s13046-022-02412-3","article-title":"NCAPD3 enhances Warburg effect through c-myc and E2F1 and promotes the occurrence and progression of colorectal cancer","volume":"41","author":"Jing","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.12.054","article-title":"Gold nanoparticles inhibit tumor growth via targeting the Warburg effect in a c-Myc-dependent way","volume":"158","author":"Sun","year":"2023","journal-title":"Acta Biomater"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.26383","article-title":"Screening for helicobacter pylori to prevent gastric cancer","volume":"333","author":"Yii","year":"2025","journal-title":"JAMA"},{"key":"B43","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/s41575-025-01042-2","article-title":"Helicobacter pylori, microbiota and gastric cancer - principles of microorganism-driven carcinogenesis","volume":"22","author":"Wizenty","year":"2025","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.semcancer.2024.03.001","article-title":"Two primary and essential key players in tumor glycolysis","volume":"100","author":"Yadav","year":"2024","journal-title":"Semin Cancer Biol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"188457","DOI":"10.1016\/j.bbcan.2020.188457","article-title":"Power of two: combination of therapeutic approaches involving glucose transporter (GLUT) inhibitors to combat cancer","volume":"1874","author":"Tilekar","year":"2020","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B46","doi-asserted-by":"publisher","first-page":"216179","DOI":"10.1016\/j.canlet.2023.216179","article-title":"Glucose transporter 4: Insulin response mastermind, glycolysis catalyst and treatment direction for cancer progression","volume":"563","author":"Chang","year":"2023","journal-title":"Cancer Lett"},{"key":"B47","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12943-024-02008-9","article-title":"Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma","volume":"23","author":"Li","year":"2024","journal-title":"Mol Cancer"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.7150\/thno.102014","article-title":"Plasma extracellular vesicles from recurrent GBMs carrying LDHA to activate glioblastoma stemness by enhancing glycolysis","volume":"15","author":"Zhang","year":"2025","journal-title":"Theranostics"},{"key":"B49","doi-asserted-by":"publisher","first-page":"108710","DOI":"10.1016\/j.envint.2024.108710","article-title":"Persistent organic pollutants dysregulate energy homeostasis in human ovaries in vitro","volume":"187","author":"Li","year":"2024","journal-title":"Environ Int"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202310109","article-title":"Hsp90 promotes gastric cancer cell metastasis and stemness by regulating the regional distribution of glycolysis-related metabolic enzymes in the cytoplasm","volume":"11","author":"Liu","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309298","article-title":"M2 tumor-associated macrophages-derived exosomal MALAT1 promotes glycolysis and gastric cancer progression","volume":"11","author":"Wang","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301190","article-title":"PUM1 promotes tumor progression by activating DEPTOR-meditated glycolysis in gastric cancer","volume":"10","author":"Yin","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-023-00821-w","article-title":"MAOA suppresses the growth of gastric cancer by interacting with NDRG1 and regulating the Warburg effect through the PI3K\/AKT\/mTOR pathway","volume":"46","author":"Wang","year":"2023","journal-title":"Cell Oncol (Dordr)"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.52586\/4946","article-title":"PLOD1 promotes cell growth and aerobic glycolysis by regulating the SOX9\/PI3K\/Akt\/mTOR signaling pathway in gastric cancer","volume":"26","author":"Zhang","year":"2021","journal-title":"Front Biosci (Landmark Ed)"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300898","article-title":"N4-acetylcytidine drives glycolysis addiction in gastric cancer via NAT10\/SEPT9\/HIF-1alpha positive feedback loop","volume":"10","author":"Yang","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.279","article-title":"Hypoxia-induced FOXO4\/LDHA axis modulates gastric cancer cell glycolysis and progression","volume":"11","author":"Wang","year":"2021","journal-title":"Clin Transl Med"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/RLU.0000000000003378","article-title":"Will baseline total lesion glycolysis play a role in improving the prognostic value of the NCCN-IPI in primary gastric diffuse large B-cell lymphoma patients treated with the R-CHOP regimen","volume":"46","author":"Jiang","year":"2021","journal-title":"Clin Nucl Med"},{"key":"B58","doi-asserted-by":"publisher","first-page":"215598","DOI":"10.1016\/j.canlet.2022.215598","article-title":"PMN-MDSCs accumulation induced by CXCL1 promotes CD8(+) T cells exhaustion in gastric cancer","volume":"532","author":"Zhou","year":"2022","journal-title":"Cancer Lett"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-1820","article-title":"Disrupting circadian rhythm via the PER1-HK2 axis reverses trastuzumab resistance in gastric cancer","volume":"82","author":"Wang","year":"2022","journal-title":"Cancer Res"},{"key":"B60","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41419-023-06067-6","article-title":"N(6)-methyladenosine modification of REG1alpha facilitates colorectal cancer progression via beta-catenin\/MYC\/LDHA axis mediated glycolytic reprogramming","volume":"14","author":"Zhou","year":"2023","journal-title":"Cell Death Dis"},{"key":"B61","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00018-024-05510-x","article-title":"Lactate promotes H3K18 lactylation in human neuroectoderm differentiation","volume":"81","author":"Wu","year":"2024","journal-title":"Cell Mol Life Sci"},{"key":"B62","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12974-023-02905-8","article-title":"Downregulation of the glucose transporter GLUT 1 in the cerebral microvasculature contributes to postoperative neurocognitive disorders in aged mice","volume":"20","author":"Chen","year":"2023","journal-title":"J Neuroinflamm"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042433","article-title":"TIGAR deficiency blunts angiotensin-II-induced cardiac hypertrophy in mice","volume":"25","author":"He","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30790","article-title":"Knockout of TIGAR enhances myocardial phosphofructokinase activity and preserves diastolic function in heart failure","volume":"237","author":"He","year":"2022","journal-title":"J Cell Physiol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac184","article-title":"GLUT-1\/PKM2 loop dysregulation in patients with non-ST-segment elevation myocardial infarction promotes metainflammation","volume":"119","author":"Canonico","year":"2023","journal-title":"Cardiovasc Res"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00033.2024","article-title":"A comprehensive view of muscle glucose uptake: regulation by insulin, contractile activity and exercise","volume":"105","author":"Richter","year":"2025","journal-title":"Physiol Rev"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.05.003","article-title":"Metabolic reprogramming in liver fibrosis","volume":"36","author":"Horn","year":"2024","journal-title":"Cell Metab"},{"key":"B68","doi-asserted-by":"publisher","first-page":"101248","DOI":"10.1016\/j.drup.2025.101248","article-title":"Lactylation in cancer progression and drug resistance","volume":"81","author":"Sun","year":"2025","journal-title":"Drug Resist Update"},{"key":"B69","doi-asserted-by":"publisher","first-page":"6328","DOI":"10.1038\/s41467-023-42093-w","article-title":"Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice","volume":"14","author":"Venit","year":"2023","journal-title":"Nat Commun"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300756","article-title":"MTA1, a novel ATP synthase complex modulator, enhances colon cancer liver metastasis by driving mitochondrial metabolism reprogramming","volume":"10","author":"Wang","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"B71","doi-asserted-by":"publisher","first-page":"102480","DOI":"10.1016\/j.arr.2024.102480","article-title":"Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment","volume":"101","author":"Reiter","year":"2024","journal-title":"Ageing Res Rev"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05661-6","article-title":"Slow TCA flux and ATP production in primary solid tumours but not metastases","volume":"614","author":"Bartman","year":"2023","journal-title":"Nature"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1065","article-title":"Endogenous retroelement activation by epigenetic therapy reverses the warburg effect and elicits mitochondrial-mediated cancer cell death","volume":"11","author":"Fresquet","year":"2021","journal-title":"Cancer Discov"},{"key":"B74","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.molcel.2020.12.012","article-title":"Increased demand for NAD(+) relative to ATP drives aerobic glycolysis","volume":"81","author":"Luengo","year":"2021","journal-title":"Mol Cell"},{"key":"B75","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.devcel.2021.12.020","article-title":"Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells","volume":"57","author":"Ojha","year":"2022","journal-title":"Dev Cell"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-23-0049","article-title":"Mitochondrial uncoupling inhibits reductive carboxylation in cancer cells","volume":"21","author":"Jiang","year":"2023","journal-title":"Mol Cancer Res"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011563","article-title":"Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and Malignant cell growth","volume":"139","author":"Man","year":"2022","journal-title":"Blood"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adi6148","article-title":"G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic alpha cells","volume":"17","author":"Bahl","year":"2025","journal-title":"Sci Transl Med"},{"key":"B79","doi-asserted-by":"publisher","first-page":"2732","DOI":"10.1016\/j.molcel.2024.06.009","article-title":"Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress","volume":"84","author":"Pilic","year":"2024","journal-title":"Mol Cell"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065710","article-title":"Counteracting colon cancer by inhibiting mitochondrial respiration and glycolysis with a selective PKC\u03b4 Activator","volume":"24","author":"Bessa","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3390\/biom14060654","article-title":"VDAC in retinal health and disease","volume":"14","author":"Xu","year":"2024","journal-title":"Biomolecules"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.04.019","article-title":"Inhibition of xanthine oxidase alleviated pancreatic necrosis via HIF-1alpha-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis","volume":"14","author":"Rong","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000569","article-title":"Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A\/HIF-1alpha transcriptional complex","volume":"79","author":"Wang","year":"2024","journal-title":"Hepatology"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-024-01134-4","article-title":"Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis","volume":"6","author":"Das","year":"2024","journal-title":"Nat Metab"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16145","article-title":"The Warburg effect and tumour immune microenvironment in extramammary Paget\u2019s disease: overexpression of lactate dehydrogenase A correlates with immune resistance","volume":"34","author":"Urata","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-004856","article-title":"Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion","volume":"10","author":"Ren","year":"2022","journal-title":"J Immunother Cancer"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-003543","article-title":"G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes","volume":"10","author":"Lu","year":"2022","journal-title":"J Immunother Cancer"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326350","article-title":"PD-L1 blockade liberates intrinsic antitumourigenic properties of glycolytic macrophages in hepatocellular carcinoma","volume":"71","author":"Lu","year":"2022","journal-title":"Gut"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12158","article-title":"The role of the HIF-1alpha\/ALYREF\/PKM2 axis in glycolysis and tumorigenesis of bladder cancer","volume":"41","author":"Wang","year":"2021","journal-title":"Cancer Commun (Lond)"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/j.molcel.2020.05.004","article-title":"Ectosomal PKM2 promotes HCC by inducing macrophage differentiation and remodeling the tumor microenvironment","volume":"78","author":"Hou","year":"2020","journal-title":"Mol Cell"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190613","article-title":"PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation","volume":"217","author":"Damasceno","year":"2020","journal-title":"J Exp Med"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.02.003","article-title":"Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery","volume":"14","author":"Qian","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.03.021","article-title":"Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2","volume":"11","author":"Wu","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-00669-9","article-title":"Inhibiting the Pkm2\/b-catenin axis drives in vivo replication of adult cardiomyocytes following experimental MI","volume":"28","author":"Hauck","year":"2021","journal-title":"Cell Death Differ"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02717","article-title":"Recent progress in the development of glucose transporter (GLUT) inhibitors","volume":"68","author":"Wang","year":"2025","journal-title":"J Med Chem"},{"key":"B96","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1136\/gutjnl-2022-328408","article-title":"NNMT enriches for AQP5(+) cancer stem cells to drive Malignant progression in early gastric cardia adenocarcinoma","volume":"73","author":"Wang","year":"2023","journal-title":"Gut"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.7150\/thno.48954","article-title":"Reciprocal change in Glucose metabolism of Cancer and Immune Cells mediated by different Glucose Transporters predicts Immunotherapy response","volume":"10","author":"Na","year":"2020","journal-title":"Theranostics"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.976628","article-title":"Enforcing GLUT3 expression in CD8(+) T cells improves fitness and tumor control by promoting glucose uptake and energy storage","volume":"13","author":"Cribioli","year":"2022","journal-title":"Front Immunol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12141","article-title":"Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4","volume":"41","author":"Guo","year":"2021","journal-title":"Cancer Commun (Lond)"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.561956","article-title":"Aloperine relieves type 2 diabetes mellitus via enhancing GLUT4 expression and translocation","volume":"11","author":"Song","year":"2020","journal-title":"Front Pharmacol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/s41598-018-37283-2","article-title":"GLUT1 and GLUT3 involvement in anthocyanin gastric transport- Nanobased targeted approach","volume":"9","author":"Oliveira","year":"2019","journal-title":"Sci Rep"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15351","article-title":"circ_0006089 promotes gastric cancer growth, metastasis, glycolysis, and angiogenesis by regulating miR-361-3p\/TGFB1","volume":"113","author":"Zhou","year":"2022","journal-title":"Cancer Sci"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.817192","article-title":"circDNMT1 promotes Malignant progression of gastric cancer through targeting miR-576-3p\/hypoxia inducible factor-1 alpha axis","volume":"12","author":"Li","year":"2022","journal-title":"Front Oncol"},{"key":"B104","doi-asserted-by":"publisher","first-page":"101479","DOI":"10.1016\/j.tranon.2022.101479","article-title":"Cancer-derived exosomal circ_0038138 enhances glycolysis, growth, and metastasis of gastric adenocarcinoma via the miR-198\/EZH2 axis","volume":"25","author":"Zheng","year":"2022","journal-title":"Transl Oncol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2023.5546","article-title":"circRPS19 affects HK2\u2212mediated aerobic glycolysis and cell viability via the miR\u2212125a\u22125p\/USP7 pathway in gastric cancer","volume":"63","author":"Zheng","year":"2023","journal-title":"Int J Oncol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1511247","article-title":"Hsa_circ_0001756 drives gastric cancer glycolysis by increasing the expression and stability of PGK1 mRNA","volume":"16","author":"Qian","year":"2025","journal-title":"Front Immunol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/s41598-024-84548-0","article-title":"Silencing circ_0043256 inhibited CoCl2-induced proliferation, migration, and aerobic glycolysis in gastric cancer cells","volume":"15","author":"Ou","year":"2025","journal-title":"Sci Rep"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2022_220225N209","article-title":"hsa_circ_0067514 suppresses gastric cancer progression and glycolysis via miR-654-3p\/LATS2 axis","volume":"69","author":"Jiang","year":"2022","journal-title":"Neoplasma"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-023-10529-z","article-title":"Exosomal circKIAA1797 Regulates Cell Progression and Glycolysis by Targeting miR-4429\/PBX3 Pathway in Gastric Cancer","volume":"62","author":"Zheng","year":"2024","journal-title":"Biochem Genet"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1088","article-title":"Long non-coding RNA VAL facilitates PKM2 enzymatic activity to promote glycolysis and Malignancy of gastric cancer","volume":"12","author":"Dai","year":"2022","journal-title":"Clin Transl Med"},{"key":"B111","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/s13046-023-02827-6","article-title":"LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement","volume":"42","author":"Zhang","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"key":"B112","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10120-023-01437-7","article-title":"N6-methyladenosine modification of OIP5-AS1 promotes glycolysis, tumorigenesis, and metastasis of gastric cancer by inhibiting Trim21-mediated hnRNPA1 ubiquitination and degradation","volume":"27","author":"Xie","year":"2024","journal-title":"Gastric Cancer"},{"key":"B113","doi-asserted-by":"publisher","first-page":"101731","DOI":"10.1016\/j.tranon.2023.101731","article-title":"Long noncoding RNA DLEU1 promotes proliferation and glycolysis of gastric cancer cells via APOC1 upregulation by recruiting SMYD2 to induce trimethylation of H3K4 modification","volume":"36","author":"Xu","year":"2023","journal-title":"Transl Oncol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1093\/carcin\/bgad080","article-title":"Long non-coding RNA NRAV in the 12q24.31 risk locus drives gastric cancer development through glucose metabolism reprogramming","volume":"45","author":"Zhang","year":"2024","journal-title":"Carcinogenesis"},{"key":"B115","doi-asserted-by":"publisher","first-page":"17181","DOI":"10.1038\/s41598-023-43744-0","article-title":"H19 encourages aerobic glycolysis and cell growth in gastric cancer cells through the axis of microRNA-19a-3p and phosphoglycerate kinase 1","volume":"13","author":"Chen","year":"2023","journal-title":"Sci Rep"},{"key":"B116","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s40170-022-00293-w","article-title":"Blocking lncRNA-SNHG16 sensitizes gastric cancer cells to 5-Fu through targeting the miR-506-3p-PTBP1-mediated glucose metabolism","volume":"10","author":"Ding","year":"2022","journal-title":"Cancer Metab"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-022-01348-z","article-title":"LOC101929709 promotes gastric cancer progression by aiding LIN28B to stabilize c-MYC mRNA","volume":"26","author":"Xu","year":"2023","journal-title":"Gastric Cancer"},{"key":"B118","doi-asserted-by":"publisher","first-page":"999","DOI":"10.32604\/or.2024.046679","article-title":"The Epstein-Barr virus-miRNA-BART6-5p regulates TGF-beta\/SMAD4 pathway to induce glycolysis and enhance proliferation and metastasis of gastric cancer cells","volume":"32","author":"Zhao","year":"2024","journal-title":"Oncol Res"},{"key":"B119","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/s41419-022-04859-w","article-title":"m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer","volume":"13","author":"Lin","year":"2022","journal-title":"Cell Death Dis"},{"key":"B120","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/s41419-022-05132-w","article-title":"m6A RNA methylation-mediated NDUFA4 promotes cell proliferation and metabolism in gastric cancer","volume":"13","author":"Xu","year":"2022","journal-title":"Cell Death Dis"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2022_220714N714","article-title":"PRKAA1, stabilized by FTO in an m6A-YTHDF2-dependent manner, promotes cell proliferation and glycolysis of gastric cancer by regulating the redox balance","volume":"69","author":"Zhang","year":"2022","journal-title":"Neoplasma"},{"key":"B122","doi-asserted-by":"publisher","first-page":"113176","DOI":"10.1016\/j.yexcr.2022.113176","article-title":"N(6)-methyladenosine (m(6)A) reader IGF2BP1 accelerates gastric cancer aerobic glycolysis in c-Myc-dependent manner","volume":"417","author":"Luo","year":"2022","journal-title":"Exp Cell Res"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.97091","article-title":"TRIM50 inhibits glycolysis and the Malignant progression of gastric cancer by ubiquitinating PGK1","volume":"20","author":"Gu","year":"2024","journal-title":"Int J Biol Sci"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-023-00778-z","article-title":"KAT2A promotes the succinylation of PKM2 to inhibit its activity and accelerate glycolysis of gastric cancer","volume":"66","author":"Zhang","year":"2024","journal-title":"Mol Biotechnol"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0290688","article-title":"USP4 promotes the proliferation and glucose metabolism of gastric cancer cells by upregulating PKM2","volume":"18","author":"Chen","year":"2023","journal-title":"PloS One"},{"key":"B126","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s10020-024-00832-9","article-title":"ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis","volume":"30","author":"He","year":"2024","journal-title":"Mol Med"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.7150\/thno.104310","article-title":"Glucose homeostasis controls N-acetyltransferase 10-mediated ac4C modification of HK2 to drive gastric tumorigenesis","volume":"15","author":"Wang","year":"2025","journal-title":"Theranostics"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-024-03243-6","article-title":"Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer","volume":"44","author":"Tsukihara","year":"2025","journal-title":"Oncogene"},{"key":"B129","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s10120-022-01340-7","article-title":"Ubiquitous mitochondrial creatine kinase promotes the progression of gastric cancer through a JNK-MAPK\/JUN\/HK2 axis regulated glycolysis","volume":"26","author":"Mi","year":"2023","journal-title":"Gastric Cancer"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-023-03840-z","article-title":"PDLIM1 interacts with HK2 to promote gastric cancer progression through enhancing the Warburg effect via Wnt\/beta-catenin signaling","volume":"395","author":"Lei","year":"2024","journal-title":"Cell Tissue Res"},{"key":"B131","doi-asserted-by":"publisher","first-page":"110995","DOI":"10.1016\/j.cellsig.2023.110995","article-title":"DDX24 promotes tumor progression by mediating hexokinase-1 induced glycolysis in gastric cancer","volume":"114","author":"Ni","year":"2024","journal-title":"Cell Signal"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15692","article-title":"HKDC1 upregulation promotes glycolysis and disease progression, and confers chemoresistance onto gastric cancer","volume":"114","author":"Wang","year":"2023","journal-title":"Cancer Sci"},{"key":"B133","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00018-024-05491-x","article-title":"Helicobacter pylori promotes gastric cancer progression by activating the TGF-beta\/Smad2\/EMT pathway through HKDC1","volume":"81","author":"Fang","year":"2024","journal-title":"Cell Mol Life Sci"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2123231119","article-title":"Dual roles of \u03b2-arrestin 1 in mediating cell metabolism and proliferation in gastric cancer","volume":"119","author":"Yu","year":"2022","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.527","article-title":"Tyrosine phosphatase SHP2 aggravates tumor progression and glycolysis by dephosphorylating PKM2 in gastric cancer","volume":"5","author":"Wang","year":"2024","journal-title":"MedComm (2020)"},{"key":"B136","doi-asserted-by":"publisher","first-page":"111586","DOI":"10.1016\/j.cellsig.2024.111586","article-title":"PRDX2 promotes gastric cancer progression by forming a feedback loop with PKM2\/STAT3 axis","volume":"127","author":"Zhou","year":"2025","journal-title":"Cell Signal"},{"key":"B137","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1186\/s12967-023-04658-7","article-title":"Transcription factor LHX9 (LIM Homeobox 9) enhances pyruvate kinase PKM2 activity to induce glycolytic metabolic reprogramming in cancer stem cells, promoting gastric cancer progression","volume":"21","author":"Zhao","year":"2023","journal-title":"J Transl Med"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24718","article-title":"Phosphoglycerate mutase 1 that is essential for glycolysis may act as a novel metabolic target for predicating poor prognosis for patients with gastric cancer","volume":"36","author":"Wei","year":"2022","journal-title":"J Clin Lab Anal"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-024-08568-6","article-title":"Fructose-1, 6-bisphosphate aldolase B suppresses glycolysis and tumor progression of gastric cancer","volume":"69","author":"Wu","year":"2024","journal-title":"Dig Dis Sci"},{"key":"B140","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40170-024-00330-w","article-title":"Deficiency of TOP1MT enhances glycolysis through the stimulation of PDK4 expression in gastric cancer","volume":"12","author":"Wang","year":"2024","journal-title":"Cancer Metab"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i45.5974","article-title":"Thioridazine reverses trastuzumab resistance in gastric cancer by inhibiting S-phase kinase associated protein 2-mediated aerobic glycolysis","volume":"29","author":"Yang","year":"2023","journal-title":"World J Gastroenterol"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.22-48","article-title":"HIF1alpha\/CCL7\/KIAA1199 axis mediates hypoxia-induced gastric cancer aggravation and glycolysis alteration","volume":"72","author":"Mi","year":"2023","journal-title":"J Clin Biochem Nutr"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.3390\/biom12121805","article-title":"Alteration of cellular energy metabolism through LPAR2-axin2 axis in gastric cancer","volume":"12","author":"Ara","year":"2022","journal-title":"Biomolecules"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15847","article-title":"Ubiquitin-specific peptidase 24 accelerates aerobic glycolysis and tumor progression in gastric carcinoma through stabilizing PLK1 to activate NOTCH1","volume":"114","author":"Zhi","year":"2023","journal-title":"Cancer Sci"},{"key":"B145","doi-asserted-by":"publisher","first-page":"216841","DOI":"10.1016\/j.canlet.2024.216841","article-title":"FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway","volume":"593","author":"Wang","year":"2024","journal-title":"Cancer Lett"},{"key":"B146","doi-asserted-by":"publisher","first-page":"19003","DOI":"10.1038\/s41598-024-69435-y","article-title":"Gypenoside inhibits gastric cancer proliferation by suppressing glycolysis via the Hippo pathway","volume":"14","author":"Pan","year":"2024","journal-title":"Sci Rep"},{"key":"B147","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s10020-025-01175-9","article-title":"Knockdown of SLC7A5 inhibits Malignant progression and attenuates oxaliplatin resistance in gastric cancer by suppressing glycolysis","volume":"31","author":"Zhang","year":"2025","journal-title":"Mol Med"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2023.23169","article-title":"Activation of glycolysis by MCM10 increases stemness and paclitaxel resistance in gastric cancer cells","volume":"34","author":"Wu","year":"2023","journal-title":"Turk J Gastroenterol"},{"key":"B149","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12935-023-03201-4","article-title":"RORalpha inhibits gastric cancer proliferation through attenuating G6PD and PFKFB3 induced glycolytic activity","volume":"24","author":"Wang","year":"2024","journal-title":"Cancer Cell Int"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1049713","article-title":"Pyrolyzed deketene curcumin controls regulatory T cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose","volume":"14","author":"MaruYama","year":"2023","journal-title":"Front Immunol"},{"key":"B151","doi-asserted-by":"publisher","first-page":"155045","DOI":"10.1016\/j.phymed.2023.155045","article-title":"Isoliquiritigenin inhibits gastric cancer growth through suppressing GLUT4 mediated glucose uptake and inducing PDHK1\/PGC-1alpha mediated energy metabolic collapse","volume":"121","author":"Yu","year":"2023","journal-title":"Phytomedicine"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-023-01153-0","article-title":"CS-NO suppresses inhibits glycolysis and gastric cancer progression through regulating YAP\/TAZ signaling pathway","volume":"81","author":"Guo","year":"2023","journal-title":"Cell Biochem Biophys"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0309700","article-title":"Dual inhibition of oxidative phosphorylation and glycolysis exerts a synergistic antitumor effect on colorectal and gastric cancer by creating energy depletion and preventing metabolic switch","volume":"19","author":"Aisu","year":"2024","journal-title":"PloS One"},{"key":"B154","doi-asserted-by":"publisher","first-page":"107278","DOI":"10.1016\/j.phrs.2024.107278","article-title":"Akkermansia muciniphila-derived pentadecanoic acid enhances oxaliplatin sensitivity in gastric cancer by modulating glycolysis","volume":"206","author":"Xu","year":"2024","journal-title":"Pharmacol Res"},{"key":"B155","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1007\/s10142-024-01495-9","article-title":"BHLHE40-mediated transcriptional activation of GRIN2D in gastric cancer is involved in metabolic reprogramming","volume":"24","author":"Liu","year":"2024","journal-title":"Funct Integr Genomics"},{"key":"B156","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/s12967-025-06196-w","article-title":"HSP90 co-regulates the formation and nuclear distribution of the glycolytic output complex to promote resistance and poor prognosis in gastric cancer patients","volume":"23","author":"Shen","year":"2025","journal-title":"J Transl Med"},{"key":"B157","doi-asserted-by":"publisher","first-page":"286","DOI":"10.3892\/ol.2025.15032","article-title":"Targeting ETHE1 inhibits tumorigenesis in vitro and in vivo by preventing aerobic glycolysis in gastric adenocarcinoma cells","volume":"29","author":"Li","year":"2025","journal-title":"Oncol Lett"},{"key":"B158","doi-asserted-by":"publisher","first-page":"123622","DOI":"10.1016\/j.lfs.2025.123622","article-title":"MZT1 protects gastric cancer against glucose starvation through targeting NEDD1","volume":"372","author":"Zhao","year":"2025","journal-title":"Life Sci"},{"key":"B159","doi-asserted-by":"publisher","first-page":"217589","DOI":"10.1016\/j.canlet.2025.217589","article-title":"Neural-cancer crosstalk: Reciprocal molecular circuits driving gastric tumorigenesis and emerging therapeutic opportunities","volume":"616","author":"Li","year":"2025","journal-title":"Cancer Lett"},{"key":"B160","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41419-023-05568-8","article-title":"Hippo pathway dysregulation in gastric cancer: from Helicobacter pylori infection to tumor promotion and progression","volume":"14","author":"Messina","year":"2023","journal-title":"Cell Death Dis"},{"key":"B161","doi-asserted-by":"publisher","first-page":"133247","DOI":"10.1016\/j.ijbiomac.2024.133247","article-title":"HER-2 positive gastric cancer: Current targeted treatments","volume":"274","author":"Malla","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.02.202","article-title":"The role of SOX family transcription factors in gastric cancer","volume":"180","author":"Abadi","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2020-000728","article-title":"Molecular target: pan-AKT in gastric cancer","volume":"5","author":"Kang","year":"2020","journal-title":"ESMO Open"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-023-01056-1","article-title":"Cell-free ascites from ovarian cancer patients induces Warburg metabolism and cell proliferation through TGF\u03b2-ERK signaling","volume":"46","author":"Sze\u0151cs","year":"2024","journal-title":"Geroscience"},{"key":"B165","doi-asserted-by":"publisher","first-page":"114637","DOI":"10.1016\/j.colsurfb.2025.114637","article-title":"ROS-responsive oridonin and dihydroartemisinin hetero-polymeric prodrug NPs for potentiating ferroptosis in gastric cancer by disrupting redox balance","volume":"252","author":"Xu","year":"2025","journal-title":"Colloids Surf B Biointerfaces"},{"key":"B166","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1053\/j.gastro.2024.03.037","article-title":"Impaired glycosylation of gastric mucins drives gastric tumorigenesis and serves as a novel therapeutic target","volume":"167","author":"Arai","year":"2024","journal-title":"Gastroenterology"},{"key":"B167","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s13046-020-01707-7","article-title":"The role of TRPV1 ion channels in the suppression of gastric cancer development","volume":"39","author":"Gao","year":"2020","journal-title":"J Exp Clin Cancer Res"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-332815","article-title":"Stomach microbiota in gastric cancer development and clinical implications","volume":"73","author":"Zeng","year":"2024","journal-title":"Gut"},{"key":"B169","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/s41392-023-01406-7","article-title":"Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1558091","article-title":"Reprogramming tumor-associated macrophages in gastric cancer: a pathway to enhanced immunotherapy","volume":"16","author":"He","year":"2025","journal-title":"Front Immunol"},{"key":"B171","doi-asserted-by":"publisher","first-page":"46","DOI":"10.55730\/1300-0152.2681","article-title":"CircRNA LDLR promotes proliferation and aerobic glycolysis of gastric cancer cells by targeting CHD1 with miR-449b-5p","volume":"48","author":"Zeng","year":"2024","journal-title":"Turk J Biol"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajg.2024.07.012","article-title":"CircFLNA facilitates gastric cancer cell proliferation and glycolysis via regulating SOX5 by sponging miR-1200","volume":"25","author":"Yang","year":"2024","journal-title":"Arab J Gastroenterol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1628937\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T05:34:29Z","timestamp":1756964069000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1628937\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,4]]},"references-count":172,"alternative-id":["10.3389\/fimmu.2025.1628937"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1628937","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,4]]},"article-number":"1628937"}}