{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:59:33Z","timestamp":1782932373466,"version":"3.54.5"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Scalp seborrheic dermatitis (SSD) is a common, chronic inflammatory skin disease. Its pathogenesis and immunological features have been poorly studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To elucidate the molecular profile of adult patients with SSD in  lesional scalps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using punch biopsies, we assessed 92 inflammatory biomarkers in the lesional scalps of SSD patients (n=16) and demographically matched healthy controls (HCs; n=12) via Olink high-throughput proteomics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 16 differentially expressed proteins (DEPs) between lesional scalps of patients with SSD and those of HCs. SSD lesional scalps demonstrated significantly greater expressions of proteins related to T-cell\/lymphocyte activation, the cytokine storm signaling pathway and the CGAS-STING signaling pathway. Ingenuity pathway analysis (IPA) highlighted Th1 skewing. These data suggest that SSD is associated with Th1 skewing and the dysregulation of lipid metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These analyses provide a rationale for novel treatment approaches for SSD patients, mainly those targeting Th1 pathways.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2025.1638710","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T04:12:41Z","timestamp":1759119161000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Scalp seborrheic dermatitis demonstrates a skewing of Th1 activation: a proteomic study in lesional 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