{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:15:47Z","timestamp":1787026547226,"version":"build-2736575974"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K07063, 24K18433"],"award-info":[{"award-number":["21K07063, 24K18433"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      C-type lectin receptors (CLRs) are innate sensors crucial for antifungal and antimycobacterial responses, contributing to host defenses against pathogens, including the ubiquitous mold\n                      <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                      . Dendritic cell immunoreceptor (Dcir) modulates immune responses by limiting the development of inflammation and autoimmunity; however, its involvement in fungal infections has not been previously established.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Wild-type and Dcir-knockout C57BL\/6J mice were infected with\n                      <jats:italic>A. fumigatus<\/jats:italic>\n                      intratracheally to establish a model of pulmonary aspergillosis. For\n                      <jats:italic>in vitro<\/jats:italic>\n                      analysis, neutrophils were purified from the bone marrow and incubated with\n                      <jats:italic>A. fumigatus<\/jats:italic>\n                      hyphae.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mice lacking Dcir exhibited improved clearance of\n                      <jats:italic>A. fumigatus<\/jats:italic>\n                      from the lungs, while tissue inflammation\u2014assessed by phagocyte recruitment and inflammatory cytokine levels within the lungs\u2014did not change significantly compared to Dcir competent mice. Neutrophils from Dcir-deficient mice exhibited enhanced killing of\n                      <jats:italic>A. fumigatus<\/jats:italic>\n                      hyphae, attributed to higher degranulatory activity, triggered by intracellular Ca\n                      <jats:sup>2+<\/jats:sup>\n                      mobilization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The results indicate a potential association between Dcir and downregulation of signalling pathways associated with neutrophil exocytosis. Thus, Dcir is a potential novel fungal sensor that, unlike other CLR family members, primarily fine-tunes host effector responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2025.1639400","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T05:26:35Z","timestamp":1754285195000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The C-type lectin receptor Dcir (Clec4a2) restrains Aspergillus fumigatus elimination by limiting the degranulatory activity of neutrophils"],"prefix":"10.3389","volume":"16","author":[{"given":"Fabio Seiti 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