{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:47:31Z","timestamp":1791946051247,"version":"4.3.4"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Vitiligo is a chronic autoimmune disorder in which melanocyte\u2212specific CD8<jats:sup>+<\/jats:sup> T cells destroy pigment\u2212forming cells, producing persistent depigmented macules. Recurrence after treatment implicates tissue\u2212resident memory T (TRM) cells that are maintained by interleukin\u221215 (IL\u221215) signaling. Here we review current insights into TRM\u2212cell biology, summarize experimental and emerging clinical data targeting the IL\u221215\/CD122 axis\u2014including the ongoing Phase 2a AMG 714 trial\u2014and discuss combination strategies with approved topical Janus kinase inhibitors such as ruxolitinib cream. Disrupting IL\u221215 may offer durable repigmentation with minimal systemic immunosuppression.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1639732","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T05:31:31Z","timestamp":1753680691000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Targeting the IL-15\/CD122 signaling pathway: reversing TRM cell-mediated immune memory in vitiligo"],"prefix":"10.3389","volume":"16","author":[{"given":"Xiangxi","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-100919-023531","article-title":"Vitiligo: mechanisms of pathogenesis 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