{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:46:22Z","timestamp":1792608382122,"version":"4.5.0"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease frequently leading to heart failure. Although sarcomeric gene mutations are known, they only account for a subset of cases. The role of immune dysregulation in HCM progression has gained increasing attention, necessitating the exploration of immune-related biomarkers and therapeutic targets. This study integrates Mendelian randomization (MR), transcriptomics, machine learning, and experimental validation to investigate the immune mechanisms underlying HCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed three transcriptomic datasets from the GEO database (210 healthy controls, 152 HCM patients) and identified differentially expressed genes (DEGs) using the R package limma. MR analysis was performed on 19,942 expression quantitative trait loci (eQTLs) and HCM cases using the TwoSampleMR package. Machine learning (10 algorithms) was employed to construct diagnostic models, and SHAP analysis was applied to assess key gene contributions. Functional enrichment was performed with clusterProfiler, diagnostic performance was evaluated via ROC curves, and immune cell infiltration was analyzed using CIBERSORT. A competing endogenous RNA (ceRNA) network was constructed, and drug targets were predicted via the DGIdb database. Key gene expression was validated by qPCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 472 DEGs and 205 HCM-associated loci, narrowing down to seven key genes: RNF165, SNCA, SRGN, MARCO, STEAP4, SIGLEC9, and TKT. These genes were enriched in immune-related pathways (e.g., cytokine activity, leukocyte migration, JAK-STAT signaling). The Random Forest model exhibited the highest diagnostic performance (AUC: 0.939), with SHAP analysis revealing MARCO as the top contributor. Gene expression was associated with immune cell infiltration: HCM samples showed increased CD4+ T cells and M0 macrophages but decreased M2 macrophages and neutrophils. The ceRNA network comprised 5 mRNAs, 40 miRNAs, and 152 lncRNAs. SRGN and SNCA were identified as potential targets for heparin and 33 other drugs, respectively. qRT-PCR performed on a small number of myocardial samples supported expression trends of the identified genes, in line with transcriptomic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study reveals immune-related mechanistic biomarkers and potential therapeutic targets in HCM, highlighting the role of immune dysregulation in disease progression. Machine learning and SHAP analysis improved diagnostic model interpretability, providing a basis for future development of non-invasive diagnostic tools.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2025.1645382","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T05:31:39Z","timestamp":1758864699000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Integration of multi-omics and machine learning strategies identifies immune related candidate biomarkers in inflammation-associated hypertrophic cardiomyopathy"],"prefix":"10.3389","volume":"16","author":[{"given":"Qingzhu","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxiao","family":"Nong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouwen","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.92.7.1680","article-title":"Hypertrophic cardiomyopathy. Clinical spectrum and treatment","volume":"92","author":"Wigle","year":"1995","journal-title":"Circulation"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04005-8","article-title":"Relation between severity of left-ventricular hypertrophy and prognosis in patients with hypertrophic cardiomyopathy","volume":"357","author":"Elliott","year":"2001","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.07.027","article-title":"Comparison of prevalence of apical hypertrophic cardiomyopathy in Japan and the United States","volume":"92","author":"Kitaoka","year":"2003","journal-title":"Am J Cardiol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.92.4.785","article-title":"Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults","volume":"92","author":"Maron","year":"1995","journal-title":"Circulation"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1710575","article-title":"Clinical course and management of hypertrophic cardiomyopathy","volume":"379","author":"Maron","year":"2018","journal-title":"N Engl J Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.08.1057","article-title":"Distinct subgroups in hypertrophic cardiomyopathy in the NHLBI HCM registry","volume":"74","author":"Neubauer","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-018-1810-2","article-title":"Hypertrophic cardiomyopathy genotype prediction models in a pediatric population","volume":"39","author":"Newman","year":"2018","journal-title":"Pediatr Cardiol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168933","article-title":"Pathogenic mechanisms of hypertrophic cardiomyopathy beyond sarcomere dysfunction","volume":"16","author":"Chou","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.3390\/ijms22052474","article-title":"Plasma Proteomic Profiling in Hypertrophic Cardiomyopathy Patients before and after Surgical Myectomy Reveals Post-Procedural Reduction in Systemic Inflammation","volume":"5","author":"Larson","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B10","doi-asserted-by":"publisher","first-page":"13644","DOI":"10.3390\/ijms222413644","article-title":"Mass-spectrometry-based functional proteomic and phosphoproteomic technologies and their application for analyzing ex vivo and in vitro models of hypertrophic cardiomyopathy","volume":"24","author":"Moore","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.973279","article-title":"Dysregulation and imbalance of innate and adaptive immunity are involved in the cardiomyopathy progression","volume":"9","author":"He","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S454446","article-title":"Unveiling immune infiltration characterizing genes in hypertrophic cardiomyopathy through transcriptomics and bioinformatics","volume":"17","author":"Gong","year":"2024","journal-title":"J Inflammation Res"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.10.001","article-title":"Macrophage-specific NLRC5 protects from cardiac remodeling through interaction with HSPA8","volume":"8","author":"Yu","year":"2023","journal-title":"JACC Basic Transl Sci"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.230427","article-title":"MYH7 R453C induced cardiac remodelling via activating TGF-beta\/Smad2\/3, ERK1\/2 and Nox4\/ROS\/NF-kappaB signalling pathways","volume":"14","author":"Wang","year":"2024","journal-title":"Open Biol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"14845","DOI":"10.3390\/ijms241914845","article-title":"Myocardial fibrosis in hypertrophic cardiomyopathy: A perspective from fibroblasts","volume":"19","author":"Schlittler","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2024.1293786","article-title":"Necroptosis and immune infiltration in hypertrophic cardiomyopathy: novel insights from bioinformatics analyses","volume":"11","author":"Hou","year":"2024","journal-title":"Front Cardiovasc Med"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.069398","article-title":"Low penetrance sarcomere variants contribute to additive risk in hypertrophic cardiomyopathy","volume":"151","author":"Meisner","year":"2025","journal-title":"Circulation"},{"key":"B18","article-title":"Systemic inflammation is associated with myocardial fibrosis, diastolic dysfunction, and cardiac hypertrophy in patients with hypertrophic cardiomyopathy","volume":"9","author":"Fang","year":"2017","journal-title":"Am J Transl Res"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.15109","article-title":"Systemic inflammation is associated with myocardial fibrosis in patients with obstructive hypertrophic cardiomyopathy","volume":"12","author":"Guo","year":"2025","journal-title":"ESC Heart Fail"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1237208","article-title":"Cardiac cellular diversity and functionality in cardiac repair by single-cell transcriptomics","volume":"10","author":"Chen","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e1581","DOI":"10.1002\/ctm2.1581","article-title":"Resolving the heterogeneous tumour microenvironment in cardiac myxoma through single-cell and spatial transcriptomics","volume":"14","author":"Liu","year":"2024","journal-title":"Clin Transl Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"15017","DOI":"10.1038\/s41598-025-97534-x","article-title":"Protein interactions, network pharmacology, and machine learning work together to predict genes linked to mitochondrial dysfunction in hypertrophic cardiomyopathy","volume":"15","author":"Chen","year":"2025","journal-title":"Sci Rep"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-025-02087-4","article-title":"Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy","volume":"57","author":"Tadros","year":"2025","journal-title":"Nat Genet"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.670787","article-title":"Systemic bioinformatic analyses of nuclear-encoded mitochondrial genes in hypertrophic cardiomyopathy","volume":"12","author":"Tan","year":"2021","journal-title":"Front Genet"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104851","article-title":"Probing long COVID through a proteomic lens: a comprehensive two-year longitudinal cohort study of hospitalised survivors","volume":"98","author":"Gu","year":"2023","journal-title":"EBioMedicine"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e1001538","DOI":"10.1371\/journal.pbio.1001538","article-title":"Rnf165\/Ark2C enhances BMP-Smad signaling to mediate motor axon extension","volume":"11","author":"Kelly","year":"2013","journal-title":"PloS Biol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109783","article-title":"MARCO is a potential prognostic and immunotherapy biomarker","volume":"116","author":"Dong","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-1885","article-title":"Targeting MARCO and IL37R on immunosuppressive macrophages in lung cancer blocks regulatory T cells and supports cytotoxic lymphocyte function","volume":"81","author":"La Fleur","year":"2021","journal-title":"Cancer Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/s11033-023-09201-x","article-title":"The application of MARCO for immune regulation and treatment","volume":"51","author":"Zhou","year":"2024","journal-title":"Mol Biol Rep"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111771","article-title":"Siglec9 + tumor-associated macrophages predict prognosis and therapeutic vulnerability in patients with colon cancer","volume":"130","author":"Chang","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e0475322","DOI":"10.1128\/spectrum.04753-22","article-title":"MARCO inhibits porcine reproductive and respiratory syndrome virus infection through intensifying viral GP5-induced apoptosis","volume":"11","author":"Zhang","year":"2023","journal-title":"Microbiol Spectr"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6243819","article-title":"The roles of siglec7 and siglec9 on natural killer cells in virus infection and tumour progression","volume":"2020","author":"Zheng","year":"2020","journal-title":"J Immunol Res"},{"key":"B33","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s13054-016-1208-6","article-title":"36th international symposium on intensive care and emergency medicine: brussels, Belgium","volume":"20","author":"Bateman","year":"2016","journal-title":"15\u201318 March 2016 Crit Care"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.974353","article-title":"Identification and exploration of novel M2 macrophage-related biomarkers in the development of acute myocardial infarction","volume":"9","author":"Zhou","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108311","article-title":"STEAP4 knockdown inhibits the proliferation of prostate cancer cells by activating the cGMP-PKG pathway under lipopolysaccharide-induced inflammatory microenvironment","volume":"101","author":"Li","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2022.153870","article-title":"STEAP4 promoter methylation correlates with tumorigenesis of hepatocellular carcinoma","volume":"233","author":"Tang","year":"2022","journal-title":"Pathol Res Pract"},{"key":"B37","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12974-021-02146-7","article-title":"STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis","volume":"18","author":"Zhao","year":"2021","journal-title":"J Neuroinflamm"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31545","article-title":"Expression of scavenger receptor MARCO defines a targetable tumor-associated macrophage subset in non-small cell lung cancer","volume":"143","author":"La Fleur","year":"2018","journal-title":"Int J Cancer"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403538200","article-title":"Negative regulation of T cell receptor signaling by Siglec-7 (p70\/AIRM) and Siglec-9","volume":"279","author":"Ikehara","year":"2004","journal-title":"J Biol Chem"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.2174\/1874467215666220128161647","article-title":"Moving towards dawn: KRas signaling and treatment in pancreatic ductal adenocarcinoma","volume":"15","author":"Rajpurohit","year":"2022","journal-title":"Curr Mol Pharmacol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"494","DOI":"10.24171\/j.phrp.2023.0209","article-title":"Genetic diversity and evolutionary patterns of SARS-CoV-2 among the Bhutanese population during the pandemic","volume":"14","author":"Dorji","year":"2023","journal-title":"Osong Public Health Res Perspect"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.05.002","article-title":"Stachydrine ameliorates isoproterenol-induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF-kappaB and JAK\/STAT signaling pathways in rats","volume":"48","author":"Zhao","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.yjmcc.2018.08.005","article-title":"Interleukin-17 enhances cardiac ventricular remodeling via activating MAPK pathway in ischemic heart failure","volume":"122","author":"Chang","year":"2018","journal-title":"J Mol Cell Cardiol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.jacbts.2019.03.004","article-title":"Extracellular matrix from hypertrophic myocardium provokes impaired twitch dynamics in healthy cardiomyocytes","volume":"4","author":"Sewanan","year":"2019","journal-title":"JACC Basic Transl Sci"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043504","article-title":"Integrin beta1D deficiency-mediated ryR2 dysfunction contributes to catecholamine-sensitive ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy","volume":"141","author":"Wang","year":"2020","journal-title":"Circulation"},{"key":"B46","doi-asserted-by":"publisher","first-page":"11227","DOI":"10.1038\/s41598-018-29072-8","article-title":"Leukocyte telomere length correlates with hypertrophic cardiomyopathy severity","volume":"8","author":"Chatterjee","year":"2018","journal-title":"Sci Rep"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-024-01193-3","article-title":"Prmt7 regulates the JAK\/STAT\/Socs3 signaling pathway in postmenopausal cardiomyopathy","volume":"56","author":"Ahn","year":"2024","journal-title":"Exp Mol Med"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e23296","DOI":"10.1002\/jbt.23296","article-title":"Umbelliferone attenuates diabetic cardiomyopathy by suppression of JAK\/STAT signaling pathway through amelioration of oxidative stress and inflammation in rats","volume":"37","author":"Khadrawy","year":"2023","journal-title":"J Biochem Mol Toxicol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.696321","article-title":"Bioinformatics and immune infiltration analyses reveal the key pathway and immune cells in the pathogenesis of hypertrophic cardiomyopathy","volume":"8","author":"Zhang","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"B50","doi-asserted-by":"publisher","first-page":"398","DOI":"10.26502\/fccm.92920277","article-title":"Single nucleus RNA-sequencing reveals altered intercellular communication and dendritic cell activation in nonobstructive hypertrophic cardiomyopathy","volume":"6","author":"Codden","year":"2022","journal-title":"Cardiol Cardiovasc Med"},{"key":"B51","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.thromres.2020.05.003","article-title":"The potential roles of Von Willebrand factor and neutrophil extracellular traps in the natural history of hypertrophic and hypertensive cardiomyopathy","volume":"192","author":"Becker","year":"2020","journal-title":"Thromb Res"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-023-02327-9","article-title":"High neutrophil-to-lymphocyte ratio is associated with cancer therapy-related cardiovascular toxicity in high-risk cancer patients under immune checkpoint inhibitor therapy","volume":"113","author":"Haj-Yehia","year":"2024","journal-title":"Clin Res Cardiol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.05.068","article-title":"Clinical impact of the pathological quantification of myocardial fibrosis and infiltrating T lymphocytes using an endomyocardial biopsy in patients with hypertrophic cardiomyopathy","volume":"362","author":"Shintani","year":"2022","journal-title":"Int J Cardiol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.2174\/1566524022666220114122839","article-title":"Immune mechanisms and related targets for the treatment of fibrosis in various organs","volume":"22","author":"Pinar","year":"2022","journal-title":"Curr Mol Med"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/3131633","article-title":"Integrative single-cell analysis of cardiomyopathy identifies differences in cell stemness and transcriptional regulatory networks among fibroblast subpopulations","volume":"2024","author":"Nie","year":"2024","journal-title":"Cardiol Res Pract"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-022-00138-1","article-title":"Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis","volume":"1","author":"Mantri","year":"2022","journal-title":"Nat Cardiovasc Res"},{"key":"B57","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00395-021-00897-1","article-title":"Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level","volume":"116","author":"Rao","year":"2021","journal-title":"Basic Res Cardiol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.043","article-title":"Gender-related differences in the clinical presentation and outcome of hypertrophic cardiomyopathy","volume":"46","author":"Olivotto","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2023.09.033","article-title":"Gender-based outcome discrepancies in patients who underwent alcohol septal ablation or septal myectomy for hypertrophic obstructive cardiomyopathy: A systematic review and meta-analysis","volume":"208","author":"Saravanabavanandan","year":"2023","journal-title":"Am J Cardiol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2020.1779218","article-title":"Novel drug delivery systems of beta2 adrenoreceptor agonists to suppress SNCA gene expression and mitochondrial oxidative stress in Parkinson\u2019s disease management","volume":"17","author":"Sola","year":"2020","journal-title":"Expert Opin Drug Delivery"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1038\/s41419-021-04281-8","article-title":"Loss of exosomal LncRNA HCG15 prevents acute myocardial ischemic injury through the NF-kappaB\/p65 and p38 pathways","volume":"12","author":"Lin","year":"2021","journal-title":"Cell Death Dis"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114080","article-title":"The combination of exercise and metformin inhibits TGF-beta1\/Smad pathway to attenuate myocardial fibrosis in db\/db mice by reducing NF-kappaB-mediated inflammatory response","volume":"157","author":"Liu","year":"2023","journal-title":"BioMed Pharmacother"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2024.2331768","article-title":"Modulating oxidative stress, apoptosis, and mitochondrial dysfunctions on cardiotoxicity induced by aluminum phosphide pesticide using resveratrol","volume":"34","author":"Sabir","year":"2024","journal-title":"Toxicol Mech Methods"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1645382\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T05:31:41Z","timestamp":1758864701000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1645382\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":63,"alternative-id":["10.3389\/fimmu.2025.1645382"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1645382","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"article-number":"1645382"}}