{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:34:22Z","timestamp":1794011662990,"version":"4.8.0"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Lumbar disc herniation (LDH) is a prevalent condition driven by inflammation, which mediates both radicular pain and spontaneous resorption of herniated material. Traditional anti-inflammatory therapies alleviate pain but may impede disc regression. We propose an Inflammation Preservation Strategy (IPS) to harness inflammation\u2019s reparative potential while managing symptoms. Molecular, clinical, and translational evidence reveals inflammation drives resorption in 60\u201390% of LDH cases. Key mechanisms include neovascularization, dynamic macrophage polarization (where M1 degrades matrix while M2 promotes repair), and apoptosis-autophagy synergy. Traditional anti-inflammatory therapies risk suppressing this reparative cascade, whereas IPS advocates precision modulation\u2014avoiding pan-anti-inflammatory agents during acute phases and employing targeted interventions to balance analgesia with tissue healing. Clinical data support IPS in achieving near-complete resorption and sustained pain relief, suggesting a paradigm shift from symptomatic palliation to disease-modifying regeneration. Future directions include real-time inflammation phenotyping and smart biomaterials to advance precision IPS implementation.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1653681","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T04:13:54Z","timestamp":1756786434000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Inflammation preservation strategy: reconciling pain control and disc resorption in lumbar disc herniation"],"prefix":"10.3389","volume":"16","author":[{"given":"Guanyi","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilong","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijie","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-34126-7_15","article-title":"Lumbar disc herniation","volume-title":"Spine surgery basics","author":"Spiker","year":"2014"},{"key":"B2","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1186\/s12889-025-21659-x","article-title":"Global, regional, and national burdens of low back pain in women of childbearing age from 1990 to 2021: an analysis based on the global burden of disease study 2021","volume":"25","author":"Zhang","year":"2025","journal-title":"BMC Public Health"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v15.i12.1200","article-title":"Low back pain in China: Disease burden and bibliometric analysis","volume":"15","author":"Yang","year":"2024","journal-title":"World J Orthop"},{"key":"B4","doi-asserted-by":"publisher","first-page":"393","DOI":"10.4103\/njcp.njcp_814_24","article-title":"Inflammatory and analgesic profiles in intervertebral disc herniation: variability with respect to neurological deficit","volume":"28","author":"Morko\u00e7","year":"2025","journal-title":"Niger J Clin Pract"},{"key":"B5","doi-asserted-by":"publisher","first-page":"147997","DOI":"10.1016\/j.brainres.2022.147997","article-title":"IL-10 alleviates radicular pain by inhibiting TNF-\u03b1\/p65 dependent Nav1","volume":"1791","author":"Huang","year":"2022","journal-title":"7 up-regulation DRG neurons rats. 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