{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T23:29:12Z","timestamp":1780356552147,"version":"3.54.1"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis is a chronic, relapsing, immune-mediated skin disease with a complex pathogenesis and significant individual variability in treatment response. It is characterized by a high relapse rate. In recent years, the critical role of natural killer (NK) cells in the onset and relapse of psoriasis has increasingly attracted attention, and related immune intervention strategies have become a research hotspot.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to systematically review the research progress in the field of \u201cNK cells and psoriasis\u201d using bibliometric methods. It identifies research hotspots and key trends, constructs the knowledge structure of this field, and provides data support for related mechanistic studies and clinical translation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Based on the Web of Science Core Collection and PubMed databases, we retrieved relevant English-language literature from 2000 to 2025. Using tools such as CiteSpace and VOSviewer, we conducted keyword clustering, author and institutional collaboration analysis, journal co-citation analysis, and highly cited literature mining to create knowledge maps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 432 publications were included, with a sustained increase in the number of publications over time. The United States, China, and Germany were the main contributing countries, while Rockefeller University and Karolinska Institute were core institutions. The journal Frontiers in Immunology was identified as an important publication venue. Current research focuses on three hotspots: (1) the role of tissue-resident NK cells in \u201ctrained immunity\u201d during psoriasis relapse; (2) metabolic reprogramming of NK cells in lesions, with a close correlation between their metabolic status and pro-inflammatory functions; and (3) the development of NK cell-targeted therapeutic strategies, such as dimethyl fumarate (DMF) and IL - 23 inhibitors, which show promising prospects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study constructed a comprehensive knowledge map of \u201cNK cells\u2013psoriasis\u201d research, clarifying the hotspots and structural characteristics. Future research will focus on two trends: (1) exploring the pivotal role of NK cells in multi-systemic immune comorbidities and (2) developing specific intervention strategies for different stages of disease progression to advance the development of precision immunotherapy for psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2025.1656398","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T13:42:48Z","timestamp":1761226968000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["New hope for the treatment of recurrent and refractory psoriasis: NK cell immunotherapy\u2014A scientometric analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Li","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/08820139.2025.2519666","article-title":"Psoriasis relapse: exploring the role of epigenetics, metabolic reprogramming, and inflammatory memory","author":"Wadhavane","year":"2025","journal-title":"Immunol Invest"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.145213","article-title":"Biomaterial-enhanced delivery of stem cell-derived exosomes for skin inflammatory diseases: Mechanisms and therapeutic advances","volume":"318","author":"Wang","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.622306","article-title":"The role of natural killer cells in autoimmune diseases","volume":"12","author":"Kucuksezer","year":"2021","journal-title":"Front Immunol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107361","article-title":"The role of KIR positive NK cells in diseases and its importance in clinical intervention","volume":"92","author":"Dizaji Asl","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1369238311","DOI":"10.1177\/10732748241310937","article-title":"Research hotspots and trends of NK cell immunotherapy for acute myeloid leukemia: A bibliometric analysis from 2000 to 2023","volume":"31","author":"Chen","year":"2024","journal-title":"Cancer Control"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108682","article-title":"NK cells - Dr. Jekyll and Mr. Hyde in autoimmune rheumatic diseases","volume":"107","author":"Hojjatipour","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"5117","DOI":"10.2147\/JMDH.S495330","article-title":"Research hotspots and trends in global cancer immunometabolism:A bibliometric analysis from 2000 to 2023","volume":"17","author":"Chen","year":"2024","journal-title":"J Multidiscip Healthc"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/nature08949","article-title":"Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology","volume":"464","author":"Buonocore","year":"2010","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2025","article-title":"Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22","volume":"12","author":"Sonnenberg","year":"2011","journal-title":"Nat Immunol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.01.011","article-title":"The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies","volume":"139","author":"Brunner","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.cell.2017.12.014","article-title":"The dynamic landscape of open chromatin during human cortical neurogenesis","volume":"172","author":"de la Torre-Ubieta","year":"2018","journal-title":"Cell"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.01.010","article-title":"Feeling depressed? 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