{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:32:05Z","timestamp":1788535925475,"version":"build-2803163510"},"reference-count":91,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Psoriasis is an inflammatory disease driven by immune dysregulation. Numerous epidemiological studies have confirmed a significant association between psoriasis and mental health disorders, particularly depression. Recent research has increasingly underscored the common pathogenic mechanisms between psoriasis and depression. The release of factors such as TNF, IL-6, and IL-8 not only directly drives abnormal proliferation of skin keratinocytes and immune infiltration but also disrupts the blood-brain barrier, inducing neuroinflammation. Hypothalamic-pituitary-adrenal (HPA) axis dysfunction leads to inflammation amplification. Additionally, microbiota dysbiosis\u2014such as a reduced abundance of Actinobacteria and Firmicutes\u2014decreases the production of short-chain fatty acids and increases the absorption of lipopolysaccharides into the bloodstream via the \u201cgut-brain-skin axis,\u201d thereby exacerbating systemic and neuroinflammatory conditions. Based on this understanding, clinical practice demands an integrated \u201cbiological-psychological-social\u201d approach. Biologics (e.g., adalimumab, secukinumab, and guselkumab) can simultaneously ameliorate skin lesions and depressive symptoms. When combined with psychological interventions\u2014including cognitive behavioral therapy and mindfulness therapy\u2014a multidisciplinary collaboration involving dermatology, rheumatology, and psychology is essential to formulate a tailored treatment plan. This review systematically outlines the core mechanisms underlying comorbidity of these two diseases, as well as multidimensional treatment strategies.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1659346","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:30:23Z","timestamp":1763706623000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["The complex interplay between psoriasis and depression: from molecular mechanisms to holistic treatment 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