{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:50:12Z","timestamp":1790034612550,"version":"4.0.1"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    v-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (\n                    <jats:italic>MAFB<\/jats:italic>\n                    ) is a candidate gene associated with early tuberculosis onset identified by a genome-wide association study. Here, we investigated the role of\n                    <jats:italic>Mafb<\/jats:italic>\n                    in susceptibility to\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (\n                    <jats:italic>Mtb<\/jats:italic>\n                    ) infection in myeloid-specific\n                    <jats:italic>Mafb<\/jats:italic>\n                    -knockout (\n                    <jats:italic>Mafb<\/jats:italic>\n                    -cKO) mice\n                    <jats:italic>. Mtb<\/jats:italic>\n                    infection was performed both\n                    <jats:italic>in vitro<\/jats:italic>\n                    using bone marrow-derived macrophages (BMMs) from\n                    <jats:italic>Mafb<\/jats:italic>\n                    -cKO mice and\n                    <jats:italic>in vivo<\/jats:italic>\n                    in\n                    <jats:italic>Mafb<\/jats:italic>\n                    -cKO mice. The absence of\n                    <jats:italic>Mafb<\/jats:italic>\n                    promoted\n                    <jats:italic>Mtb<\/jats:italic>\n                    proliferation in BMMs. RNA sequencing (RNA-seq) revealed activation of the metabolic process and impairment of the response to type I interferons (IFNs) in\n                    <jats:italic>Mtb<\/jats:italic>\n                    -infected BMMs from\n                    <jats:italic>Mafb<\/jats:italic>\n                    -cKO mice, which conforms to our previous findings in\n                    <jats:italic>Mtb<\/jats:italic>\n                    -infected human macrophages with\n                    <jats:italic>MAFB<\/jats:italic>\n                    knockdown.\n                    <jats:italic>Mafb<\/jats:italic>\n                    deficiency increased mortality and bacterial burden in the lungs and spleens during\n                    <jats:italic>Mtb<\/jats:italic>\n                    infection in mice. RNA-seq revealed weakened leukocyte or lymphocyte chemotaxis in\n                    <jats:italic>Mtb<\/jats:italic>\n                    -infected\n                    <jats:italic>Mafb<\/jats:italic>\n                    -cKO mouse lungs. Flow cytometry demonstrated an alteration in the proportion of immune cells in\n                    <jats:italic>Mtb<\/jats:italic>\n                    -infected mouse lungs due to\n                    <jats:italic>Mafb<\/jats:italic>\n                    deficiency. Together,\n                    <jats:italic>Mafb<\/jats:italic>\n                    in myeloid cells is involved not only in the functional antibacterial process of macrophages but also in immune cell recruitment in the lungs, thereby contributing to host defense against\n                    <jats:italic>Mtb<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2025.1660933","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:46:19Z","timestamp":1769150779000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Mafb deficiency in myeloid cells increases susceptibility to Mycobacterium tuberculosis infection in mice"],"prefix":"10.3389","volume":"16","author":[{"given":"Haruka","family":"Hikichi","sequence":"first","affiliation":[{"name":"Department of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association","place":["Tokyo, Japan"]},{"name":"Department of Basic Mycobacteriosis, Nagasaki University Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association","place":["Tokyo, Japan"]},{"name":"Department of Basic Mycobacteriosis, Nagasaki University Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Omori","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Seto","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association","place":["Tokyo, Japan"]},{"name":"Department of Basic Mycobacteriosis, Nagasaki University Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minako","family":"Hijikata","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Host Defense, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michito","family":"Hamada","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba","place":["Ibaraki, Japan"]},{"name":"Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences","place":["Ibaraki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba","place":["Ibaraki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Keicho","sequence":"additional","affiliation":[{"name":"Department of Basic Mycobacteriosis, Nagasaki University Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]},{"name":"Vice Director, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"B1","volume-title":"Global Tuberculosis Report 2024","year":"2024"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1275140","article-title":"Finding and treating both tuberculosis disease and latent infection during population-wide active case finding for tuberculosis elimination","volume":"10","author":"Coleman","year":"2023","journal-title":"Front Med (Lausanne)"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/ftubr.2024.1487518","article-title":"Ending tuberculosis: challenges and opportunities","volume":"2","author":"Gilmour","year":"2024","journal-title":"Front Tuberculosis"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.84394","article-title":"Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic 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