{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:03:12Z","timestamp":1784264592827,"version":"3.55.0"},"reference-count":89,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this systematic review with meta-analysis was to examine the association between the polymorphisms rs1801274 (<jats:italic>FCGR2A <\/jats:italic>H131R) and rs396991 (<jats:italic>FCGR3A<\/jats:italic> F158V) and susceptibility to autoimmune diseases (ADs), with a focus on the progress and novelty of studies published over the last two decades.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A meta-analysis systematically evaluated <jats:italic>FCGR2A\/3A<\/jats:italic> gene variants in autoimmune diseases (ADs) using four genetic models: dominant, recessive, overdominant, and allelic contrast.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:italic>FCGR3A<\/jats:italic> F158V polymorphism was significantly associated with immune thrombocytopenia in all four genetic models tested (dominant: OR = 2.67, 95% CI 1.94-3.67, for FV + VV vs. FF, recessive: OR = 2.38, 95% CI 1.78-3.19, for VV vs. FF + FV, overdominant: OR = 1.58, 95% CI 1.15-2.17, for FV vs. FF+VV, and allele comparison: OR = 1.97, 95% CI 1.70-2.29, for V vs. F, in the overall analyses). Statistically significant associations were also found between rheumatoid arthritis and <jats:italic>FCGR3A<\/jats:italic> F158V polymorphisms (recessive: OR = 1.36, 95% CI 1.09-1.69, for VV vs. FF + FV, and allele comparison: OR = 1.15, 95% CI 1.03-1.29, for V vs. F, in the overall analyses). Conversely, the overall analysis identified a negative association between the <jats:italic>FCGR2A<\/jats:italic> H131R polymorphism and rheumatoid arthritis in two genetic models (dominant: OR 0.83, 95% CI 0.69-1.00, for HR + RR vs. HH; allelic comparison: OR 0.86, 95% CI 0.76-0.97, for R vs. H).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta-analysis revealed an association between <jats:italic>FCGR3A<\/jats:italic> V158 and an increased risk of immune thrombocytopenia and rheumatoid arthritis. However, this polymorphism is likely to explain only part of the pathogenesis of both diseases. Conversely, a protective association was found between <jats:italic>FCGR2A<\/jats:italic> R131 and rheumatoid arthritis. Nevertheless, the quantification of the total genetic contribution of a single gene remains challenging.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2025.1661502","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T05:27:09Z","timestamp":1757482029000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of FCGR2A rs1801274 and FCGR3A rs396991 polymorphisms with various autoimmune diseases: a 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