{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:53:55Z","timestamp":1792533235221,"version":"4.5.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The PDZ-LIM domain-containing protein PDLIM2 serves as a unique tumor suppressor and immune modulator. Its repression in either lung epithelial or myeloid cells has been shown to promote lung cancer and therapy resistance. However, whether PDLIM2 plays a broader role in other lung diseases remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Gene expression data on human samples were exploited to investigate if PDLIM2 is repressed in the lung of patients with chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD\/idiopathic pulmonary fibrosis (IPF). PDLIM2 conditional knockout (KO) mice and wild type (WT) control mice were intratracheally instilled with the bacterial endotoxin lipopolysaccharide (LPS) to induce acute lung injury (ALI), a murine model of human acute respiratory distress syndrome (ARDS) that can also provide mechanistic insights into COPD, pulmonary fibrosis (PF) and infectious disease. Kaplan-Meier estimator was used to determine animal survival rate, and histological analysis and single-cell RNA sequencing (scRNA-seq) of mouse lung tissues were performed to systematically define the roles of PDLIM2 at the population and single-cell level.\n                      <jats:italic>Ex vivo<\/jats:italic>\n                      phagocytosis and neutrophil extracellular trap (NET) formation assays were also performed to validate the scRNA-seq analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PDLIM2 was repressed in the lungs of COPD and ILD\/IPF patients, and this repression was associated with disease severity. Selective deletion of PDLIM2 in myeloid cells rendered mice more vulnerable to lung injury and mortality by LPS intratracheal instillation. The increased susceptibility was linked to exacerbated pro-inflammation signaling and diminished anti-inflammation signaling in the lung, and particularly, in lung macrophages and neutrophils.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PDLIM2 plays an indispensable role in preventing ALI\/ARDS and death, and its repression is associated with COPD and ILD progression. These data suggest that PDLIM2 repression, especially in lung myeloid cells, is a common mechanism driving COPD, ILD\/IPF, and lung cancer and increasing patients\u2019 susceptibility to infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2025.1669117","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T05:17:38Z","timestamp":1763529458000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Myeloid PDLIM2 repression as a common mechanism of infection susceptibility in lung diseases"],"prefix":"10.3389","volume":"16","author":[{"given":"Feng","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gutian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxia","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7149a3","article-title":"Chronic obstructive pulmonary disease mortality by industry and occupation \u2014 United States, 2020","volume":"71","author":"Syamlal","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"B2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.21871","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J Clin"},{"key":"B3","doi-asserted-by":"publisher","first-page":"180076","DOI":"10.1183\/16000617.0076-2018","article-title":"Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases","volume":"27","author":"Cottin","year":"2018","journal-title":"Eur Respir Rev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp18X696149","article-title":"Idiopathic pulmonary fibrosis: a clinical update","volume":"68","author":"Shaw","year":"2018","journal-title":"Br J Gen Pract"},{"key":"B5","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3390\/jcm7120476","article-title":"Interstitial lung disease and pulmonary fibrosis: a practical approach for general medicine physicians with focus on the medical history","volume":"7","author":"Kalchiem-Dekel","year":"2018","journal-title":"J Clin Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.10.54","article-title":"Chronic obstructive pulmonary disease (COPD) and lung cancer: common pathways for pathogenesis","volume":"11","author":"Parris","year":"2019","journal-title":"J Thorac Dis"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00003214","article-title":"Cellular interactions in the pathogenesis of interstitial lung diseases","volume":"24","author":"Bagnato","year":"2015","journal-title":"Eur Respir Rev"},{"key":"B8","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.rmed.2018.12.015","article-title":"Inflammation and immunity in IPF pathogenesis and treatment","volume":"147","author":"Heukels","year":"2019","journal-title":"Respir Med"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI143226","article-title":"Immune dysregulation as a driver of idiopathic pulmonary fibrosis","volume":"131","author":"Shenderov","year":"2021","journal-title":"J Clin Invest"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900801)66:3<593::AID-CNCR2820660331>3.0.CO;2-R","article-title":"The impact of pulmonary infections on the survival of lung cancer patients","volume":"66","author":"Perlin","year":"1990","journal-title":"Cancer"},{"key":"B11","first-page":"8","article-title":"Infectious complications in patients with lung cancer","volume":"17","author":"Akinosoglou","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.5603\/ARM.27817","article-title":"Chronic obstructive pulmonary disease and risk of infection","volume":"77","author":"Lange","year":"2009","journal-title":"Pneumonol Alergol Pol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"160027","DOI":"10.1183\/16000617.0027-2016","article-title":"Comorbidities in interstitial lung diseases","volume":"26","author":"Margaritopoulos","year":"2017","journal-title":"Eur Respir Rev"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00126011","article-title":"Early detection of COPD is important for lung cancer surveillance","volume":"39","author":"Sekine","year":"2012","journal-title":"Eur Respir J"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2015.08.017","article-title":"The relationship between COPD and lung cancer","volume":"90","author":"Durham","year":"2015","journal-title":"Lung Cancer"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.05.75","article-title":"Lung cancer and interstitial lung disease: a literature review","volume":"10","author":"Naccache","year":"2018","journal-title":"J Thorac Dis"},{"key":"B17","doi-asserted-by":"publisher","first-page":"593","DOI":"10.3390\/ijms20030593","article-title":"Idiopathic pulmonary fibrosis and lung cancer: mechanisms and molecular targets","volume":"20","author":"Ballester","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B18","doi-asserted-by":"publisher","first-page":"220147","DOI":"10.1183\/20734735.0147-2022","article-title":"Idiopathic pulmonary fibrosis and lung cancer: future directions and challenges","volume":"18","author":"Abu Qubo","year":"2022","journal-title":"Breathe (Sheff)"},{"key":"B19","doi-asserted-by":"publisher","first-page":"188630","DOI":"10.1016\/j.bbcan.2021.188630","article-title":"PDLIM2: Signaling pathways and functions in cancer suppression and host immunity","volume":"1876","author":"Guo","year":"2021","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B20","doi-asserted-by":"publisher","first-page":"5324","DOI":"10.1038\/s41467-019-13331-x","article-title":"Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance","volume":"10","author":"Sun","year":"2019","journal-title":"Nat Commun"},{"key":"B21","doi-asserted-by":"publisher","first-page":"RP89638R1","DOI":"10.7554\/eLife.89638.2","article-title":"Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2","volume":"9","author":"Sun","year":"2024","journal-title":"eLife"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.144394","article-title":"PDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis","volume":"6","author":"Li","year":"2021","journal-title":"JCI Insight"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3263","article-title":"DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target","volume":"70","author":"Qu","year":"2010","journal-title":"Cancer Res"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.086561","article-title":"Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer","volume":"285","author":"Qu","year":"2010","journal-title":"J Biol Chem"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C115.637918","article-title":"Oncovirus Kaposi sarcoma herpesvirus (KSHV) represses tumor suppressor PDLIM2 to persistently activate nuclear factor \u03baB (NF-\u03baB) and STAT3 transcription factors for tumorigenesis and tumor maintenance","volume":"290","author":"Sun","year":"2015","journal-title":"J Biol Chem"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1593\/neo.09752","article-title":"Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax","volume":"11","author":"Yan","year":"2009","journal-title":"Neoplasia"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.04.008","article-title":"SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling","volume":"22","author":"Tanaka","year":"2005","journal-title":"Immunity"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0721","article-title":"Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins and filamin A","volume":"45","author":"Torrado","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-12-1052","article-title":"Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses anchorage-independent growth","volume":"16","author":"Loughran","year":"2005","journal-title":"Mol Biol Cell"},{"key":"B30","doi-asserted-by":"publisher","first-page":"5201","DOI":"10.1158\/1538-7445.AM2024-5201","article-title":"Characterization of PDLIM2 in non-small cell lung cancer","volume":"84","author":"Ashouri","year":"2024","journal-title":"Cancer Res"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.5437","article-title":"NanoPDLIM2-based combination therapy for lung cancer treatment in mouse preclinical studies","volume":"15","author":"Le","year":"2025","journal-title":"Bio Protoc"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-16-0073","article-title":"Myeloid STAT3 promotes lung tumorigenesis by transforming tumor immunosurveillance into tumor-promoting inflammation","volume":"5","author":"Zhou","year":"2017","journal-title":"Cancer Immunol Res"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1435250","article-title":"NF-\u03baB RelA renders tumor-associated macrophages resistant to and capable of directly suppressing CD8+ T cells for tumor promotion","volume":"7","author":"Li","year":"2018","journal-title":"Oncoimmunology"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000294","article-title":"Dual but not single PD-1 or TIM-3 blockade enhances oncolytic virotherapy in refractory lung cancer","volume":"8","author":"Sun","year":"2020","journal-title":"J Immunother Cancer"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"Acute lung injury in animals study group. an official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B36","article-title":"Alveolar epithelial NF-\u03baB\/RelA guards the lung against bacterial infection","author":"Zhang","year":"","journal-title":"J Immunol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.41.4.467","article-title":"Simple method of estimating severity of pulmonary fibrosis on a numerical scale","volume":"41","author":"Ashcroft","year":"1988","journal-title":"J Clin Pathol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007313","article-title":"Orbit image analysis: an open-source whole slide image analysis tool","volume":"16","author":"Stritt","year":"2020","journal-title":"PloS Comput Biol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.2287","article-title":"Murine bronchoalveolar lavage","volume":"7","author":"Sun","year":"2017","journal-title":"Bio Protoc"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.318","article-title":"Differential roles of STAT3 in the initiation and growth of lung cancer","volume":"34","author":"Zhou","year":"2015","journal-title":"Oncogene"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-3042","article-title":"Interleukin-6 prevents the initiation but enhances the progression of lung cancer","volume":"75","author":"Qu","year":"2015","journal-title":"Cancer Res"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.164188","article-title":"Critical and distinct roles of cell type-specific NF-\u03baB2 in lung cancer","volume":"9","author":"Sun","year":"2024","journal-title":"JCI Insight"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1669-7_13","article-title":"Methods to Detect NF-\u03baB Activity in tumor-associated macrophage (TAM) populations","volume":"2366","author":"Sun","year":"2021","journal-title":"Methods Mol Biol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.77522.sa2","article-title":"Decoding the IGF1 signaling gene regulatory network behind alveologenesis from a mouse model of bronchopulmonary dysplasia","volume":"11","author":"Gao","year":"2022","journal-title":"eLife"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.10.008","article-title":"High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer","volume":"40","author":"Salcher","year":"2022","journal-title":"Cancer Cell"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0310OC","article-title":"A novel genomic signature with translational significance for human idiopathic pulmonary fibrosis","volume":"52","author":"Bauer","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609914104","article-title":"Endoproteolytic processing of C-terminally truncated NF-\u03baB2 precursors at kappaB-containing promoters","volume":"104","author":"Qing","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B48","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/2045-3701-1-18","article-title":"Lithium promotes neural precursor cell proliferation: evidence for the involvement of the non-conical GSK3\u03b2-NF-AT signaling","volume":"1","author":"Qu","year":"2011","journal-title":"Cell Biosci"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.299","article-title":"NF-\u03baB1 p105 suppresses lung tumorigenesis through the Tpl2 kinase but independently of its NF-\u03baB function","volume":"35","author":"Sun","year":"2016","journal-title":"Oncogene"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2100046","article-title":"Alveolar macrophages inherently express programmed death-1 ligand 1 for optimal protective immunity and tolerance","volume":"207","author":"Sun","year":"2021","journal-title":"J Immunol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/2045-3701-2-23","article-title":"PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease","volume":"2","author":"Qu","year":"2012","journal-title":"Cell Biosci"},{"key":"B52","doi-asserted-by":"publisher","first-page":"3.20.1","DOI":"10.1002\/0471142735.im0320s110","article-title":"Isolation of mouse neutrophils","volume":"110","author":"Swamydas","year":"2015","journal-title":"Curr Protoc Immunol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1172\/JCI170501","article-title":"Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting","volume":"133","author":"Malainou","year":"2023","journal-title":"J Clin Invest"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00435","article-title":"Role of alveolar macrophages in chronic obstructive pulmonary disease","volume":"5","author":"Vlahos","year":"2014","journal-title":"Front Immunol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00010.2008","article-title":"Animal models of acute lung injury","volume":"295","author":"Matute-Bello","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"L1","DOI":"10.1152\/ajplung.90200.2008","article-title":"Animal models of chronic obstructive pulmonary disease","volume":"295","author":"Wright","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.5.2001061","article-title":"Fibroproliferation occurs early in the acute respiratory distress syndrome and impacts on outcome","volume":"162","author":"Marshall","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-019-00286-5","article-title":"Deletion of LysM in LysMCre recombinase homozygous mice is non-contributory in LPS-induced acute lung injury","volume":"197","author":"Gong","year":"2019","journal-title":"Lung"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2006.04.005","article-title":"Alternative pathways of NF-\u03baB activation: a double-edged sword in health and disease","volume":"17","author":"Xiao","year":"2006","journal-title":"Cytokine Growth Factor Rev"},{"key":"B60","first-page":"192","article-title":"NF-\u03baB and cancer: a paradigm of Yin-Yang","volume":"1","author":"Xiao","year":"2011","journal-title":"Am J Cancer Res"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/ni1464","article-title":"PDLIM2-mediated termination of transcription factor NF-\u03baB activation by intranuclear sequestration and degradation of the p65 subunit","volume":"8","author":"Tanaka","year":"2007","journal-title":"Nat Immunol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1101\/2025.09.12.675949","article-title":"PDLIM2 repression: a common mechanism in viral lung infection","author":"Gao","year":"2025","journal-title":"BioRxiv"},{"key":"B63","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s13578-024-01281-x","article-title":"PDLIM2 is a novel E5 ubiquitin ligase enhancer that stabilizes ROC1 and recruits the ROC1-SCF ubiquitin ligase to ubiquitinate and degrade NF-\u03baB RelA","volume":"14","author":"Sun","year":"2024","journal-title":"Cell Biosci"},{"key":"B64","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13578-024-01196-7","article-title":"NF-\u03baB RelA is a cell-intrinsic metabolic checkpoint restricting glycolysis","volume":"14","author":"Li","year":"2024","journal-title":"Cell Biosci"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-303073","article-title":"The tumor suppressor gene WWOX links the canonical and noncanonical NF-\u03baB pathways in HTLV-I Tax-mediated tumorigenesis","volume":"117","author":"Fu","year":"2011","journal-title":"Blood"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0303138","article-title":"NF-\u03baB1 deficiency promotes macrophage-derived adrenal tumors but decreases neurofibromas in HTLV-I LTR-Tax transgenic mice","volume":"19","author":"Song","year":"2024","journal-title":"PloS One"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.907387","article-title":"TREM-1 modulation strategies for sepsis","volume":"13","author":"Siskind","year":"2022","journal-title":"Front Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-013-0384-6","article-title":"Molecular mechanisms regulating NETosis in infection and disease","volume":"35","author":"Branzk","year":"2013","journal-title":"Semin Immunopathol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"548","DOI":"10.3390\/antiox12030548","article-title":"Oxidative stress and inflammation in acute and chronic lung injuries","volume":"12","author":"Bezerra","year":"2023","journal-title":"Antioxid (Basel)"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1669117\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T05:17:40Z","timestamp":1763529460000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1669117\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":69,"alternative-id":["10.3389\/fimmu.2025.1669117"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1669117","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,19]]},"article-number":"1669117"}}