{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:38:42Z","timestamp":1787161122258,"version":"build-2736575974"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["10.55776\/P36995"],"award-info":[{"award-number":["10.55776\/P36995"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Stromal cells are important bone marrow (BM) niche components that regulate immune cell homeostasis through the production of cytokines such as interleukin 15 (IL-15). Although stromal-derived IL-15 is known to support lymphocyte survival, it remains unclear which stromal cell subsets are capable of IL-15 transpresentation, and how they influence specific lymphocyte populations. By using conditional IL-15 receptor alpha (IL-15R\u03b1) deletion models, we demonstrate that IL-15R\u03b1 expression by BM stromal cells is essential for the maintenance of multiple IL-15-dependent lymphocyte populations. Deletion of IL-15R\u03b1 in Lepr\n                    <jats:sup>+<\/jats:sup>\n                    or IL-7\n                    <jats:sup>+<\/jats:sup>\n                    stromal cells selectively reduced central memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in the BM, whereas deletion of IL-15R\u03b1 in Osx\n                    <jats:sup>+<\/jats:sup>\n                    stromal cells resulted in a marked loss of natural killer T (NKT) cells and tissue-resident memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Surprisingly, endothelial-specific IL-15R\u03b1 deletion did not affect lymphocyte maintenance in the BM, but specifically impaired natural killer (NK) maturation and survival in the periphery, uncovering a role of endothelial IL-15 in mature NK cell maintenance. Together, our findings establish that transpresentation of IL-15 by distinct BM stromal cell subsets creates functionally specialized BM niches to support specific lymphocyte populations.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2025.1673309","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:34:18Z","timestamp":1768545258000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Transpresentation of interleukin 15 by stromal cell subsets regulates immune cell homeostasis"],"prefix":"10.3389","volume":"16","author":[{"given":"Carmen","family":"Stecher","sequence":"first","affiliation":[{"name":"Center for Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna","place":["Vienna, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romana","family":"Bischl","sequence":"additional","affiliation":[{"name":"Center for Cancer 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