{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:20:06Z","timestamp":1760574006765,"version":"build-2065373602"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p><jats:italic>Corynebacterium striatum<\/jats:italic> is an emerging multidrug-resistant pathogen in immunocompromised patients. We report a 75-year-old male with paranoid schizophrenia on long-term clozapine who developed sepsis after gastric perforation repair. Within two days, genetically highly homologous <jats:italic>Corynebacterium striatum<\/jats:italic> strains were isolated from bronchoalveolar lavage fluid and ascitic fluid. Whole-genome sequencing revealed only 54 Single Nucleotide Polymorphisms (SNPs) differences, identical <jats:italic>ermX<\/jats:italic>-mediated resistance, and susceptibility to vancomycin and linezolid. Targeted therapy combined with drainage led to full recovery. This case highlights the potential for multi-site clonal infection via ICU environmental spread or endogenous translocation in the setting of postoperative immune suppression and invasive devices. Early multi-site sampling, molecular typing, and tailored antimicrobial therapy are essential, particularly in psychiatric patients requiring coordinated infection and psychiatric care.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1685509","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T05:43:04Z","timestamp":1760506984000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: From lung to peritoneum: genomic and immunologic insights into a rare dual-site Corynebacterium striatum infection"],"prefix":"10.3389","volume":"16","author":[{"given":"Ying","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xincheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guolin","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-021-02246-1","article-title":"Worldwide survey of Corynebacterium striatum increasingly associated with human invasive infections, nosocomial outbreak, and antimicrobial multidrug-resistance, 1976\u20132020","volume":"203","author":"Silva-Santana","year":"2021","journal-title":"Arch Microbiol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11060685","article-title":"Corynebacterium striatum\u2014Got worse by a pandemic","volume":"11","author":"Orosz","year":"2022","journal-title":"Pathogens"},{"key":"B3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12941-022-00546-y","article-title":"Antibiofilm effects of extracellular matrix degradative agents on the biofilm of different strains of multi-drug resistant Corynebacterium striatum","volume":"21","author":"Wen","year":"2022","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00075-17","article-title":"Toll-like receptor 2 and mincle cooperatively sense corynebacterial cell wall glycolipids","volume":"85","author":"Schick","year":"2017","journal-title":"Infect Immun"},{"key":"B5","volume-title":"Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria; 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