{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:44:02Z","timestamp":1763739842285,"version":"3.45.0"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Psoriasis, a chronic inflammatory disease characterized by hyperactivation of the Th1\/Th17 axis, is increasingly recognized for its comorbid mechanisms with other immune-related disorders. This article reports a rare case. The case involves a 62-year-old woman with a 30-year history of chronic plaque psoriasis who developed sudden annular nodules on both lower limbs. Histopathology revealed non-caseating epithelioid granulomas, and PET-CT confirmed multi-system involvement, leading to a diagnosis of sarcoidosis. After three months of oral MTX therapy, the sarcoidosis skin lesions and psoriatic lesions showed significant improvement. The rare instance of coexistence suggests that chronic Th-cell immune activation may disrupt immune homeostasis through distinct pathways. This study presents clinical insights for an understanding of the mechanisms underlying immune-related comorbidities. It emphasizes the importance of implementing dynamic immune monitoring in the management of chronic inflammatory skin diseases<\/jats:p>","DOI":"10.3389\/fimmu.2025.1685695","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:11:32Z","timestamp":1763737892000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Exploring the underlying mechanisms of psoriasis comorbid with sarcoidosis: insights from a case of coexisting immune-related disorders"],"prefix":"10.3389","volume":"16","author":[{"given":"Yingbao","family":"Zhen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinlin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangfeng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuling","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.07.064","article-title":"Psoriasis and comorbid diseases: Epidemiology","volume":"76","author":"Takeshita","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.4256","article-title":"Sarcoidosis and psoriasis: a case series and review of the literature exploring co-incidence vs coincidence","volume":"149","author":"Wanat","year":"2013","journal-title":"JAMA Dermatol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1960.03730060099025","article-title":"Psoriasis in association with sarcoidosis. Report of a case","volume":"81","author":"Farmer","year":"1960","journal-title":"Arch Dermatol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.399","article-title":"Circulating Th17, Th22, and Th1 cells are increased in psoriasis","volume":"130","author":"Kagami","year":"2010","journal-title":"J Invest Dermatol"},{"key":"B5","article-title":"Sarcoidosis at onset of Psoriasis: a common immunopathogenesis. Review and case report","volume":"19","author":"Petroianni","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.140319","article-title":"Sarcoidosis is a Th1\/Th17 multisystem disorder","volume":"66","author":"Facco","year":"2011","journal-title":"Thorax"},{"key":"B7","doi-asserted-by":"publisher","first-page":"5803","DOI":"10.3390\/ijms21165803","article-title":"Psoriasis and connective tissue diseases","volume":"21","author":"Yamamoto","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1001\/jamadermatol.2022.0360","article-title":"Sarcoidosis of the skin","volume":"158","author":"Imadojemu","year":"2022","journal-title":"JAMA Dermatol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2016.07.002","article-title":"Sarcoidosis associated with psoriasis: 2 disease entities, one pathogenic pathway","volume":"52","author":"Santalla Mart\u00ednez","year":"2016","journal-title":"Arch Bronconeumol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109632","article-title":"Sarcoidosis in patients with psoriasis: a population-based cohort study","volume":"9","author":"Khalid","year":"2014","journal-title":"PloS One"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-022-02488-z","article-title":"Association of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research program","volume":"315","author":"Murphy","year":"2023","journal-title":"Arch Dermatol Res"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.ASW.0000755940.44258.ab","article-title":"Systemic sarcoidosis with psoriasiform plaques and patchy nonscarring alopecia","volume":"34","author":"Omar","year":"2021","journal-title":"Adv Skin Wound Care"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.4275-19","article-title":"Systemic sarcoidosis associated with certolizumab pegol treatment for rheumatoid arthritis: A case report and review of the literature","volume":"59","author":"Koda","year":"2020","journal-title":"Internal Med"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.004","article-title":"Psoriasis pathogenesis and the development of novel targeted immune therapies","volume":"140","author":"Hawkes","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000498","article-title":"Role of imbalance between Th17 and regulatory T-cells in sarcoidosis","volume":"24","author":"Crouser","year":"2018","journal-title":"Curr Opin Pulm Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/rheumatology\/ker316","article-title":"Increased IL-17A expression in granulomas and in circulating memory T cells in sarcoidosis","volume":"51","author":"Ten Berge","year":"2012","journal-title":"Rheumatol (Oxford)"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1685695\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:11:34Z","timestamp":1763737894000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1685695\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":16,"alternative-id":["10.3389\/fimmu.2025.1685695"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1685695","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,21]]},"article-number":"1685695"}}