{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T16:43:06Z","timestamp":1772556186353,"version":"3.50.1"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Long noncoding RNAs (lncRNAs) have emerged as critical regulators of gene expression, yet their role in shaping human responses to vaccination remains largely uncharacterized. Here, we analyzed RNA-sequencing data from three independent human cohorts vaccinated with the rVSV\u0394G-ZEBOV-GP Ebola vaccine to profile lncRNA expression dynamics. Using differential expression analysis and correlation meta-analysis across cohorts, we identified an expression signature with several lncRNAs, including\n                    <jats:italic>LEF1-AS1<\/jats:italic>\n                    and\n                    <jats:italic>DOCK8-AS1<\/jats:italic>\n                    , that exhibit conserved transcriptional activation following vaccination. Correlation of lncRNA expression with gene targets and IgG titers revealed putative roles for lncRNAs in regulating and\/or participate in both innate immune responses and adaptive antibody production. Functional enrichment of lncRNA co-expressed protein-coding genes highlighted involvement in T-cell differentiation, interferon signaling, and leukocyte activation. Integrating global run-on sequencing data and comparative transcriptomic analysis across other vaccine studies suggests that\n                    <jats:italic>LEF1-AS1<\/jats:italic>\n                    modulation is distinctively associated with Ebola vaccination. Our findings demonstrate that lncRNAs are potential integral components of the human vaccine response and provide a foundation for future mechanistic studies targeting noncoding RNA regulation of immunity.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2025.1695514","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:16:01Z","timestamp":1770707761000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Long non-coding RNAs in response to Ebola virus vaccine-induced immunity"],"prefix":"10.3389","volume":"16","author":[{"given":"Izabela","family":"Mamede","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais","place":["Belo Horizonte, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomaz","family":"Lusch\u00ebr-Dias","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, Universidade de S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle Franco","family":"Moscardini","sequence":"additional","affiliation":[{"name":"Bios-Therapy, Physiological Systems for Health S.p.A.","place":["Sansepolcro, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"Gonzales-Dias","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford","place":["Oxford, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara","family":"Marinho","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais","place":["Belo Horizonte, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Marcon","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Molecular Cardiology (LGCM), InCor\/Clinical Hospital FMUSP (HCMUSP)","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago","family":"Dominguez Crespo Hirata","sequence":"additional","affiliation":[{"name":"Centre of Omics Technologies (CTO), School of Pharmaceutical Sciences, University of S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Eichberg","sequence":"additional","affiliation":[{"name":"Strategic Alliances at Merck Research Laboratories","place":["Boston, MA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donata","family":"Medaglini","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, Laboratory of Molecular Microbiology and Biotechnology, University of Siena","place":["Siena, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali M.","family":"Harandi","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg","place":["Gothenburg, Sweden"]},{"name":"Vaccine Evaluation Center, BC Children\u2019s Hospital Research Institute, University of British Columbia","place":["Vancouver, BC, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire-Anne","family":"Siegrist","sequence":"additional","affiliation":[{"name":"Center of Vaccinology, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva","place":["Geneva, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom H. M.","family":"Ottenhoff","sequence":"additional","affiliation":[{"name":"Leiden University Center of Infectious Diseases (LUCID)","place":["Leiden, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Santoro","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie Mediche, Universit\u00e0 di Siena","place":["Siena, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marylyn M.","family":"Addo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Indiana University School of Medicine","place":["Indianapolis, IN, United States"]},{"name":"INSPER Institute of Education and Research","place":["S\u00e3o Paulo, Brazil"]},{"name":"Hospital Israelita Albert Einstein","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford","place":["Oxford, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela M.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford","place":["Oxford, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Polidoro","sequence":"additional","affiliation":[{"name":"Institut Pasteur de S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gl\u00f3ria R.","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais","place":["Belo Horizonte, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo P.","family":"Amaral","sequence":"additional","affiliation":[{"name":"Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf","place":["Hamburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helder","family":"Nakaya","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, Universidade de S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]},{"name":"Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine","place":["Hamburg, Germany"]},{"name":"German Centre for Infection Research, partner site Hamburg-L\u00fcbeck-Borstel-Riems","place":["Hamburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00419-5","article-title":"Effectiveness of rVSV-ZEBOV vaccination during the 2018\u201320 Ebola virus disease epidemic in the Democratic Republic of the Congo: a retrospective test-negative study","volume":"24","author":"Meakin","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiad350","article-title":"Safety and immunogenicity of the heterologous 2-dose ad26.ZEBOV, MVA-BN-filo vaccine regimen in health care providers and frontliners of the democratic republic of the congo","volume":"229","author":"Larivi\u00e8re","year":"2024","journal-title":"J Infect Dis"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00410-2","article-title":"EBOVAC-3\/EBL2005 Study Team. Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in infants: a phase 2, randomised, double-blind, active-controlled trial in Guinea and Sierra Leone","volume":"11","author":"Choi","year":"2023","journal-title":"Lancet Glob. Health"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502924","article-title":"Phase 1 trials of rVSV ebola vaccine in africa and europe","volume":"374","author":"Agnandji","year":"2016","journal-title":"N. Engl J Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00154-1","article-title":"VSV-Ebola Consortium. The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1\/2 trial","volume":"15","author":"Huttner","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(21)00235-4","article-title":"Transcriptomic signatures induced by the Ebola virus vaccine rVSV\u0394G-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study","volume":"3","author":"Vianello","year":"2022","journal-title":"Lancet Microbe"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9020067","article-title":"Human transcriptomic response to the VSV-Vectored Ebola vaccine","volume":"9","author":"Santoro","year":"2021","journal-title":"Vaccines (Basel)"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"15670","DOI":"10.1038\/s41598-018-33722-2","article-title":"LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages","volume":"8","author":"Obaid","year":"2018","journal-title":"Sci Rep"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade0522","article-title":"The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9","volume":"381","author":"Wang","year":"2023","journal-title":"Science"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.813031","article-title":"A 9-lncRNA signature for predicting prognosis and immune response in diffuse large B-cell lymphoma","volume":"13","author":"Wang","year":"2022","journal-title":"Front Immunol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1313768111","article-title":"The long noncoding RNA THRIL regulates TNF\u03b1 expression through its interaction with hnRNPL","volume":"111","author":"Li","year":"2014","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00655","article-title":"Long non-coding RNA BST2\/BISPR is induced by IFN and regulates the expression of the antiviral factor tetherin","volume":"5","author":"Barriocanal","year":"2015","journal-title":"Front Immunol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201541763","article-title":"Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication","volume":"17","author":"Carnero","year":"2016","journal-title":"EMBO Rep"},{"key":"B15","doi-asserted-by":"publisher","first-page":"106471","DOI":"10.1016\/j.jinf.2025.106471","article-title":"Circulating lncRNAs as biomarkers for severe dengue using a machine learning approach","volume":"40","author":"Katz","year":"2025","journal-title":"J Infect"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20200072","article-title":"Long non-coding RNAs associated with infection and vaccine-induced immunity","volume":"65","author":"L\u00fcscher-Dias","year":"2021","journal-title":"Ess. Biochem"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/5313149","article-title":"Identification of Immune-Related Prognostic mRNA and lncRNA in Patients with Hepatocellular Carcinoma","volume":"2022","author":"Chen","year":"2022","journal-title":"J Oncol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1093\/jmcb\/mjy045","article-title":"IFN-stimulated P2Y13 protects mice from viral infection by suppressing the cAMP\/EPAC1 signaling pathway","volume":"11","author":"Zhang","year":"2019","journal-title":"J Mol Cell Biol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03589-x","article-title":"Shape of promoter antisense RNAs regulates ligand-induced transcription activation","volume":"595","author":"Yang","year":"2021","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.1.702-708.1999","article-title":"Sendai virus infection induces apoptosis through activation of caspase-8 (FLICE) and caspase-3 (CPP32)","volume":"73","author":"Bitzer","year":"1999","journal-title":"J Virol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S1074-7613(00)00004-2","article-title":"Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism","volume":"13","author":"Reya","year":"2000","journal-title":"Immunity"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-021-07051-w","article-title":"LncRNA LEF1-AS1\/LEF1\/FUT8 axis mediates colorectal cancer progression by regulating \u03b11, 6-fucosylationvia wnt\/\u03b2-catenin pathway","volume":"67","author":"Qi","year":"2022","journal-title":"Dig. Dis Sci"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202207","article-title":"The impact of physical frailty on the response to inactivated influenza vaccine in older adults","volume":"12","author":"Moehling","year":"2020","journal-title":"Aging"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110341","article-title":"Transcriptome-wide changes in gene expression, splicing, and lncRNAs in response to a live attenuated dengue virus vaccine","volume":"38","author":"Kim","year":"2022","journal-title":"Cell Rep"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1259197","article-title":"Baseline gene signatures of reactogenicity to Ebola vaccination: a machine learning approach across multiple cohorts","volume":"14","author":"Gonzalez Dias Carvalho","year":"2023","journal-title":"Front Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e0050224","DOI":"10.1128\/msphere.00502-24","article-title":"Predictive signatures of immune response to vaccination and implications of the immune setpoint remodeling","volume":"10","author":"Ramos","year":"2025","journal-title":"mSphere"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1822046116","article-title":"Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination","volume":"116","author":"De Lima","year":"2019","journal-title":"Proc Natl Acad Sci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.7150\/jca.94823","article-title":"Integration of single-cell and bulk RNA sequencing data reveals that CYTOR is a potential prognostic and immunotherapeutic response marker for skin cutaneous melanoma","volume":"15","author":"Zhang","year":"2024","journal-title":"J Cancer"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e1012172","DOI":"10.1371\/journal.ppat.1012172","article-title":"Direct and indirect effects of CYTOR lncRNA regulate HIV gene expression","volume":"20","author":"Kuzmina","year":"2024","journal-title":"PloS Pathog"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00226-19","article-title":"RNA sequencing analyses of gene expression during epstein-barr virus infection of primary B lymphocytes","volume":"93","author":"Wang","year":"2019","journal-title":"J Virol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s44319-024-00070-4","article-title":"A lncRNA Dleu2-encoded peptide relieves autoimmunity by facilitating Smad3-mediated Treg induction","volume":"25","author":"Tang","year":"2024","journal-title":"EMBO Rep"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S336428","article-title":"Prognostic value of long noncoding RNA DLEU2 and its relationship with immune infiltration in kidney renal clear cell carcinoma and liver hepatocellular carcinoma","volume":"14","author":"Fu","year":"2021","journal-title":"Int J Gen Med"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.718624","article-title":"Identification of a novel prognostic gene signature from the immune cell infiltration landscape of osteosarcoma","volume":"9","author":"Fan","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14164056","article-title":"The m6A-related long noncoding RNA signature predicts prognosis and indicates tumor immune infiltration in ovarian cancer","volume":"14","author":"Geng","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.2174\/0109298673311108240926062214","article-title":"FOXN3-AS1: A candidate prognostic marker and epigenetic target with immunotherapeutic implications in acute myeloid leukemia","volume":"32","author":"Ge","year":"2024","journal-title":"Curr Med Chem"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-023-10566-8","article-title":"Identification and validation of CXCL2 as a key gene for childhood obesity","volume":"62","author":"He","year":"2024","journal-title":"Biochem Genet"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3390\/biology12020319","article-title":"Identification of wnt\/\u03b2-catenin- and autophagy-related lncRNA signature for predicting immune efficacy in pancreatic adenocarcinoma","volume":"12","author":"Lyu","year":"2023","journal-title":"Biol (Basel)"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05418-5","article-title":"LncRNA SERPINB9P1 expression and polymorphisms are associated with ischemic stroke in a Chinese Han population","volume":"43","author":"Huang","year":"2022","journal-title":"Neurol Sci"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04646-y","article-title":"LncRNA SERPINB9P1 mitigates cerebral injury induced by oxygen\u2013Glucose deprivation\/reoxygenation by interacting with HSPA2","volume":"62","author":"Lv","year":"2025","journal-title":"Mol Neurobiol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.924409","article-title":"Use of long non-coding RNAs for the molecular diagnosis of papillary thyroid cancer","volume":"12","author":"Kim","year":"2022","journal-title":"Front Oncol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.add4874","article-title":"B cells require DOCK8 to elicit and integrate T cell help when antigen is limiting","volume":"9","author":"Deobagkar-Lele","year":"2024","journal-title":"Sci Immunol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.134508","article-title":"DOCK8 is essential for LFA-1\u2013dependent positioning of T follicular helper cells in germinal centers","volume":"5","author":"Janssen","year":"2020","journal-title":"JCI Insight"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-76","article-title":"The hyperimmunoglobulin E syndrome - clinical manifestation diversity in primary immune deficiency","volume":"6","author":"Szczawinska-Poplonyk","year":"2011","journal-title":"Orph. J R. Dis"},{"key":"B44","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.clim.2013.06.002","article-title":"Aberrant humoral immune reactivity in DOCK8 deficiency with follicular hyperplasia and nodal plasmacytosis","volume":"149","author":"Aan De Kerk","year":"2013","journal-title":"Clin Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.clim.2017.06.003","article-title":"DOCK8 deficiency: Insights into pathophysiology, clinical features and management","volume":"181","author":"Biggs","year":"2017","journal-title":"Clin Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.750084","article-title":"Current research progress of the role of lncRNA LEF1-AS1 in a variety of tumors","volume":"9","author":"Zheng","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmccpl.2024.100280","article-title":"Association of LEF1-AS1 with cardiovascular and neurological complications of COVID-19","volume":"11","author":"Vausort","year":"2025","journal-title":"J Mol Cell Cardiol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e16128","DOI":"10.7717\/peerj.16128","article-title":"Mechanism of LEF1-AS1 regulating HUVEC cells by targeting miR-489-3p\/S100A11 axis","volume":"11","author":"Zhang","year":"2023","journal-title":"PeerJ"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-018-00721-z","article-title":"LEF1-AS1 contributes to proliferation and invasion through regulating miR-544a\/FOXP1 axis in lung cancer","volume":"37","author":"Wang","year":"2019","journal-title":"Invest New Drugs"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S227652","article-title":"LncRNA LEF1-AS1 promotes ovarian cancer development through interacting with miR-1285-3p","volume":"12","author":"Zhang","year":"2020","journal-title":"Cancer Manag. Res"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V126.23.3586.3586","article-title":"Antisense long non-coding RNA in the LEF1 locus regulates sense LEF1 expression in leukemic cell line KG1","volume":"126","author":"Congrains","year":"2015","journal-title":"Blood"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2021.10.007","article-title":"Therapeutic vaccination strategies against EBOV by rVSV-EBOV-GP: the role of innate immunity","volume":"51","author":"Pinski","year":"2021","journal-title":"Curr Opin Virol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-025-00850-3","article-title":"An evolving landscape of PRC2\u2013RNA interactions in chromatin regulation","volume":"26","author":"Aguilar","year":"2025","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s41580-023-00694-9","article-title":"Transcription regulation by long non-coding RNAs: mechanisms and disease relevance","volume":"25","author":"Ferrer","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.10.024","article-title":"Small and long non-coding RNAs: Past, present, and future","volume":"187","author":"Chen","year":"2024","journal-title":"Cell"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1101\/gr.280431.125","article-title":"Widespread specific intron retention events in nuclear RNA complexes identified by sedimentation analysis of pluripotent cellular extracts","volume":"35","author":"Pereira","year":"2025","journal-title":"Genome Res"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.023","article-title":"Systems vaccinology identifies an early innate immune signature as a correlate of antibody responses to the ebola vaccine rVSV-ZEBOV","volume":"20","author":"Rechtien","year":"2017","journal-title":"Cell Rep"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414216","article-title":"A recombinant vesicular stomatitis virus ebola vaccine","volume":"376","author":"Regules","year":"2017","journal-title":"New Engl J Med"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf018","article-title":"dgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets","volume":"53","author":"Chen","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1087","article-title":"GENCODE 2021","volume":"49","author":"Frankish","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-024-02299-2","article-title":"The tidyomics ecosystem: enhancing omic data analyses","volume":"21","author":"Hutchison","year":"2024","journal-title":"Nat Methods"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J Stat Softw"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1028","article-title":"The reactome pathway knowledgebase 2022","volume":"50","author":"Gillespie","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"B64","doi-asserted-by":"publisher","first-page":"4385","DOI":"10.1038\/s41467-021-24584-w","article-title":"Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data","volume":"12","author":"Altman","year":"2021","journal-title":"Nat Commun"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-4035-6_10","article-title":"Computational approaches for mining GRO-seq data to identify and characterize active enhancers","volume":"1468","author":"Nagari","year":"2017","journal-title":"Methods Mol Biol"}],"updated-by":[{"DOI":"10.3389\/fimmu.2026.1809363","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000}}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1695514\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:20:26Z","timestamp":1772547626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1695514\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,10]]},"references-count":65,"alternative-id":["10.3389\/fimmu.2025.1695514"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1695514","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,10]]},"article-number":"1695514"}}