{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:18:11Z","timestamp":1788923891994,"version":"build-2803163510"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"\n Objective<\/jats:title>\n This study systematically characterized the key clinical features and influencing factors of patients with T-LGLL-PRCA, aiming to provide evidence to improve clinical diagnostic and therapeutic strategies.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Clinical characteristics were retrospectively compared between patients with T-LGLL-PRCA (n=15) and those without PRCA (T-LGLL\u2013Non-PRCA, n=25). Risk factors for the development of T-LGLL-PRCA were evaluated using univariate and multivariate logistic regression analyses.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n This study retrospectively included a total of 40 patients with T-LGLL, of whom 15 were classified into the T-LGLL\u2013PRCA group, accounting for one-third of the entire cohort. The median age of patients in the T-LGLL\u2013PRCA group was 68 years, with a relatively high proportion aged \u226565 years, and the majority were female. The most common symptoms included fatigue, dizziness, and palpitations. The major comorbidity was thrombocytopenia. Positivity for EBV and ANA was frequently observed. Mutations in TET2 exon 11 and exon 3 were the most frequently detected genetic variants. At the molecular level, clonal rearrangements of the TCR\u03b2 and TCR\u03b3 genes were most commonly observed. Moreover, a substantial proportion of patients displayed a TCR \u03b3\u03b4 immunophenotype. Significant differences between groups were observed in circulating T-LGL count, Hemoglobin (HB), Hematocrit (HCT), Reticulocyte Count (RNC), Erythropoietin (EPO) levels &gt;750 mIU\/mL, and Immature Reticulocyte Fraction (IRF) (\n P<\/jats:italic>\n \u00a0&lt;\u00a00.05). Univariate logistic regression suggested that HB (\n OR<\/jats:italic>\n :0.926;\n P<\/jats:italic>\n \u00a0=\u00a00.003), HCT (\n OR<\/jats:italic>\n :0.837;\n P<\/jats:italic>\n \u00a0=\u00a00.006), EPO levels&gt;750 mIU\/mL (\n OR<\/jats:italic>\n :7.071;\n P<\/jats:italic>\n \u00a0=\u00a00.008), RNC (\n OR<\/jats:italic>\n :0.682;\n P<\/jats:italic>\n \u00a0=\u00a00.027), and IRF (\n OR<\/jats:italic>\n :0.857;\n P<\/jats:italic>\n \u00a0=\u00a00.007) were associated with T-LGLL-PRCA(\n P<\/jats:italic>\n \u00a0&lt;\u00a00.05). Multivariate analysis identified RNC (\n OR<\/jats:italic>\n :0.590;\n P<\/jats:italic>\n \u00a0=\u00a00.048) as the sole independent influencing factor (\n P<\/jats:italic>\n \u00a0&lt;\u00a00.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n RNC is an independent influencing factor for the development of T-LGLL-PRCA.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fimmu.2025.1695742","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:37:09Z","timestamp":1768973829000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical features and influencing factors analysis of T-cell large granular lymphocytic leukemia complicated with pure red cell aplasia"],"prefix":"10.3389","volume":"16","author":[{"given":"Yiming","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Hematology, The Second Affiliated Hospital, Dalian Medical 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University","place":["Dalian, China"]},{"name":"Department of Hematology, Liaoning Medical Center Hematopoietic Stem Cell Transplantation, the Second Hospital of Dalian Medical University","place":["Dalian, China"]},{"name":"Department of Pediatric, Pediatric Oncology and Hematology Center, the Second Hospital of Dalian Medical University","place":["Dalian, China"]},{"name":"Liaoning Key Laboratory of Hematopoietic Stem Cell Transplantation and Translational Medicine, Blood Stem Cell Transplantation Institute, the Second Hospital of Dalian Medical University","place":["Dalian, China"]},{"name":"Dalian Key Laboratory of Hematology, Diamond Bay Institute of Hematology, the Second Hospital of Dalian Medical University","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-692590","article-title":"LGL leukemia: from 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