{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:48:50Z","timestamp":1790261330327,"version":"4.1.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Mosquitoes rely exclusively on blood-derived sterols, transported by sterol carrier protein (SCP), for reproduction and metabolic regulation. SCP expression is strongly induced after blood feeding and dynamically modulated during\n                    <jats:italic>Plasmodium vivax<\/jats:italic>\n                    infection\u2014upregulated in the midgut and salivary glands but suppressed in hemocytes\u2014indicating that parasite infection modulates the host sterol transport and metabolism. RNAi-mediated knockdown of SCP significantly reduced mosquito fecundity, underscoring its vital role in reproductive physiology. These findings highlight SCP as a key metabolic regulator linking nutrient uptake to reproductive outcome, while its\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    infection-driven modulation may facilitate the parasite growth. While reproduction remains the primary physiological outcome, the metabolic modulation of SCP during infection also points to it as a possible transmission-blocking target in integrated malaria control strategies.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2025.1703479","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T06:30:42Z","timestamp":1765434642000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Plasmodium vivax infection-driven modulation of sterol carrier protein reveals a metabolic link to reproductive physiology in Anopheles 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