{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:43:51Z","timestamp":1793119431304,"version":"4.5.0"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Human papillomavirus (HPV) is a highly prevalent virus that primarily infects human epithelial cells, resulting in a significant health burden by causing conditions such as anogenital warts, cervical cancers, and head and neck squamous cell carcinoma. Although vaccination has been implemented for cancer prevention, a thorough understanding of anti-HPV immunity remains of critical importance for HPV-related disease management. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway forms a key signaling cascade within the innate immune system, which is activated by cytosolic DNA and functions through the production of type I interferon (IFN-I). Accumulating evidence indicates a correlation between the cGAS-STING pathway and HPV infection, as well as HPV-related malignancies, suggesting its potential as a promising therapeutic target. This review discusses the role of the cGAS-STING signaling pathway in HPV infection and HPV-related cancers, as well as potential therapeutic strategies that target this pathway.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1709613","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T05:28:54Z","timestamp":1759987734000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["The role of cGAS-STING signaling in HPV infection and HPV-related 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