{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T06:36:54Z","timestamp":1764139014985,"version":"3.46.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Acute pericarditis is a clinical syndrome characterized by acute inflammation of the pericardium, which may result from various infectious or non-infectious etiologies. The characteristic clinical manifestations primarily encompass chest pain, classic electrocardiographic changes, and new or worsening pericardial effusion. Acute pericarditis may manifest independently or as a component of systemic disease. Systemic lupus erythematosus (SLE)-associated pericarditis typically occurs during active disease phase. Ovarian stimulation promotes ovulation and alters sex hormone levels, potentially triggering or exacerbating SLE. We report a 34-year-old woman with stable SLE who developed a disease flare, predominantly manifesting as acute pericarditis, following ovarian stimulation. Significant clinical improvement was observed following treatment with glucocorticoids, colchicine, and immunosuppressive agents. A literature review identified eight additional cases of SLE flares following ovarian stimulation, presenting with arthritis, rash, pericarditis, nephritis, or thrombotic events. Consequently, a comprehensive recurrence risk assessment and close monitoring of disease activity are recommended for SLE patients undergoing this fertility treatment.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1715055","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T06:34:10Z","timestamp":1764138850000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute pericarditis after ovarian stimulation in a patient with systemic lupus erythematosus: a case report and literature 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