{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T06:17:54Z","timestamp":1788675474747,"version":"build-2803163510"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that can rarely be complicated by systemic immune phenomena. We report a 41-year-old woman with severe HS refractory to adalimumab who developed fever, palpable purpura, and renal involvement. Skin biopsy confirmed IgA leukocytoclastic vasculitis, and renal biopsy revealed IgA nephritis. She was treated with corticosteroids, rituximab, and surgery, but proteinuria persisted. Initiation of bimekizumab led to marked improvement of HS lesions and a significant reduction in proteinuria. Over more than one year of follow-up, she achieved sustained HS control without recurrence of vasculitis or treatment-related adverse events. This case highlights the potential role of dual IL-17A\/F inhibition in managing refractory HS complicated by IgA vasculitis and nephritis.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1721038","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:19:48Z","timestamp":1767676788000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Refractory hidradenitis suppurativa complicated by IgA vasculitis with nephritis: successful long-term control with surgery and bimekizumab"],"prefix":"10.3389","volume":"16","author":[{"given":"Ayaka","family":"Yasuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuko","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.090","article-title":"Hidradenitis suppurativa: Epidemiology, clinical presentation, and pathogenesis","volume":"82","author":"Goldburg","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140","article-title":"Hidradenitis suppurativa","volume":"405","author":"Sabat","year":"2025","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13030502","article-title":"The development of systemic inflammatory diseases in hidradenitis suppurativa","volume":"13","author":"Saito-Sasaki","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2050313x19882852","DOI":"10.1177\/2050313X19882852","article-title":"Hidradenitis suppurativa and vasculitis: A case series and literature review of a rare association","volume":"7","author":"Alavi","year":"2019","journal-title":"SAGE Open Med Case Rep"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e30122","DOI":"10.7759\/cureus.30122","article-title":"IgA vasculitis with adalimumab therapy for hidradenitis suppurativa: A case report and review of literature","volume":"14","author":"Alsulami","year":"2022","journal-title":"Cureus"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v1.i5.119","article-title":"Henoch-Sch\u00f6nlein purpura complicating adalimumab therapy for Crohn\u2019s disease","volume":"1","author":"Rahman","year":"2010","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2812980","DOI":"10.1155\/2016\/2812980","article-title":"Henoch-sch\u00f6nlein purpura with adalimumab therapy for ulcerative colitis: A case report and review of the literature","volume":"2016","author":"LaConti","year":"2016","journal-title":"Case Rep Rheumatol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.07.010","article-title":"Expression of the IL-23\/Th17 pathway in lesions of hidradenitis suppurativa","volume":"65","author":"Schlapbach","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"4866","DOI":"10.1038\/s41598-024-55425-7","article-title":"Sequential administration of paricalcitol followed by IL-17 blockade for progressive refractory IgA nephropathy patients","volume":"14","author":"Uriol-Rivera","year":"2024","journal-title":"Sci Rep"},{"key":"B10","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s00403-025-03965-x","article-title":"IgA vasculitis induced by tumor necrosis factor-\u03b1 antagonists: clinical features, diagnosis and management","volume":"317","author":"Yan","year":"2025","journal-title":"Arch Dermatol Res"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1721038\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:19:49Z","timestamp":1767676789000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1721038\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":10,"alternative-id":["10.3389\/fimmu.2025.1721038"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1721038","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,6]]},"article-number":"1721038"}}