{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:35:54Z","timestamp":1787243754847,"version":"build-2736575974"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    The presence of non-neutralizing antibodies of any dengue serotype increases the severity of subsequent infection by other dengue serotypes. During the SARS-CoV-2 pandemic, the number of symptomatic dengue cases increased in India. We found that antibodies isolated from convalescent plasma from COVID-19 patients enhances DENV2 infection\n                    <jats:italic>in vitro<\/jats:italic>\n                    . CR3022, an antibody against the SARS-CoV-2 spike protein, also elevated DENV2 infection\n                    <jats:italic>in vitro<\/jats:italic>\n                    .\n                    <jats:italic>In silico<\/jats:italic>\n                    protein\u2013protein interactions between spike antibodies and the DENV2 E-protein revealed significant interactions. Likewise, few monoclonal\/polyclonal antibodies against SARS-CoV-2 have shown increased dengue infection\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Importantly, AG129 mice infected with SARS-CoV-2 three weeks prior to DENV2 infection showed elevated dengue pathogenesis. This highlights the possibility of elevated infection and symptomatic dengue disease in COVID-19 survivors.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2025.1724625","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:26:56Z","timestamp":1768458416000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infection in vitro and in vivo"],"prefix":"10.3389","volume":"16","author":[{"given":"Kamini","family":"Jakhar","sequence":"first","affiliation":[{"name":"Centre for Virus Research, Therapeutics and Vaccines, Translational Health Science and Technology Institute","place":["Faridabad, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudipta","family":"Sonar","sequence":"additional","affiliation":[{"name":"Centre for Virus Research, Therapeutics and Vaccines, Translational Health 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