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Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system (CNS), in which various immune cells contribute to disease progression, yet\u00a0the role of dendritic cells (DCs) remains incompletely understood. The RNA-binding protein Regnase-1 plays an important role in regulating immune cell function, but\u00a0its function\u00a0in DCs, particularly conventional type 1 DCs\u00a0(cDC1), has not been defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We investigated the\u00a0role\u00a0of Regnase-1 in cDC1 and its impact on experimental autoimmune encephalomyelitis (EAE)\u00a0on\n                      <jats:italic>Regnase-1<\/jats:italic>\n                      <jats:sup>fl\/+<\/jats:sup>\n                      \u00a0\n                      <jats:italic>Xcr1<\/jats:italic>\n                      <jats:sup>-Cre+<\/jats:sup>\n                      \u00a0and control mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Reduced Regnase-1\u00a0expression in cDC1 enhanced pro-inflammatory\u00a0gene expression and increased\u00a0their capacity to activate T cells. In the EAE model,\n                      <jats:italic>Regnase-1<\/jats:italic>\n                      <jats:sup>fl\/+<\/jats:sup>\n                      \u00a0\n                      <jats:italic>Xcr1<\/jats:italic>\n                      <jats:sup>-Cre+<\/jats:sup>\n                      \u00a0mice displayed accelerated inflammatory progression during the acute phase, accompanied\u00a0by increased infiltration of Th1 cells\u00a0and activated CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells in the CNS.\u00a0Subsequently,\n                      <jats:italic>Regnase-1<\/jats:italic>\n                      <jats:sup>fl\/+<\/jats:sup>\n                      \u00a0\n                      <jats:italic>Xcr1<\/jats:italic>\n                      <jats:sup>-Cre+<\/jats:sup>\n                      \u00a0mice\u00a0showed\u00a0accelerated recovery, together with increased frequencies of central memory CD8\n                      <jats:sup>+<\/jats:sup>\n                      \u00a0T (Tcm) cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our study reveals the complex role for cDC1 with reduced\u00a0Regnase-1 expression\u00a0in inflammatory regulation, exacerbating inflammatory responses during the acute phase, while\u00a0facilitate recovery. This dual role highlights Regnase-1 in cDC1 as a critical regulator that\u00a0balances\u00a0inflammation and immune memory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2025.1725702","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T06:36:33Z","timestamp":1767594993000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune 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