{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:22:39Z","timestamp":1767871359251,"version":"3.49.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kr\u00fcppel-like factor 5 (KLF5) is involved in various aspects of tumor development, metastasis, and drug resistance through their regulation of transcription and translation, yet its functions in a comprehensive cancer framework are still unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our research involved a detailed pan-cancer analysis using multi-omics data sourced from various public databases. We investigated the clinical characteristics, prognostic significance, mutations, and methylation patterns of KLF5 across various cancer types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We discovered that KLF5 is implicated in tumor progression and are prognostic markers across pan-cancer. KLF5 is significantly linked to various malignant pathways across different types of cancer. Additionally, KLF5 has associations with several immune-related features. Ultimately, experiments were carried out to investigate whether KLF5 could serve as a promising indicator for glioma and bladder cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>KLF5 may be utilized as a diagnostic tool for cancer, a predictor of its progression, and a guide for treatment., with particular promise as a therapeutic target for glioma and bladder cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2025.1730356","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:34:52Z","timestamp":1767854092000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dissecting the role of KLF5: from tumor progression to immune interactions with emphasis on glioma and bladder 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