{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T21:24:07Z","timestamp":1768512247280,"version":"3.49.0"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Post-COVID-19 syndrome (PCS) is frequently associated with fatigue and cognitive dysfunction, while underlying mechanisms remain unclear. We report a 44-year-old male with persistent symptoms following SARS-CoV-2 infection, including severe cognitive and motor fatigue, word-finding difficulties, and impaired concentration. Neuropsychological testing revealed marked deficits in alertness, attention, fluency, and processing speed. Serum analysis demonstrated anti-VGLUT2 autoantibodies. IVIG therapy yielded subjective but no objective improvement. This appears to be the first PCS case associated with\u00a0VGLUT2 autoantibodies and raises the hypothesis of a potential pathophysiological link that requires confirmation in larger cohorts.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1731744","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:24:30Z","timestamp":1768458270000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti-VGLUT2 autoantibodies associated with post-COVID neurocognitive dysfunction: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Jeyanthan","family":"Charles James","sequence":"first","affiliation":[{"name":"Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum","place":["Bochum, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Teegen","sequence":"additional","affiliation":[{"name":"Clinical Immunological Laboratory Prof. 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