{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:32:41Z","timestamp":1792459961466,"version":"4.5.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recurrence triggered by immunological memory is a critical challenge in the treatment of psoriasis. Tissue-resident memory T (Trm) cells are the primary pacemakers in recurrent psoriasiform dermatitis following stimulation and infection by previous pathogens. However, the mechanisms underlying Trm cell activation remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, imiquimod-induced recurrent psoriatic mice were established to characterize the phenotypes of different Trm cell subsets. CD8\n                      <jats:sup>+<\/jats:sup>\n                      \/CD4\n                      <jats:sup>+<\/jats:sup>\n                      Tcm cell injection and NF-\u03baB inhibitor or agonist treatment were then used to investigate the role and mechanisms of Trm cells in recurrent psoriasis. Finally, CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells and keratinocyte co-culture systems were established to investigate the effects of activating NF-\u03baB activation in Trm cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mice displayed severe psoriatic dermatitis after repeated imiquimod treatment. The CD8\n                      <jats:sup>+<\/jats:sup>\n                      Trm cells, but not CD4\n                      <jats:sup>+<\/jats:sup>\n                      Trm cells, were elevated in the skin of recurrent psoriatic mice. Injection of CD8\n                      <jats:sup>+<\/jats:sup>\n                      Tcm cells injection elicited more severe psoriatic symptoms than imiquimod treatment alone, indicating that CD8\n                      <jats:sup>+<\/jats:sup>\n                      Trm cells are critical participants in psoriatic recurrence. Phosphorylation of NF-kB p65 (RELA), p-IKKa, p-RelB and NF-kB p100\/p52 was enhanced in the skin of imiquimod-induced recurrent psoriatic mice. NF-\u03baB inhibitor\/agonist treatment significantly suppressed or restored the dermatitis severity and CD8\n                      <jats:sup>+<\/jats:sup>\n                      Trm cell levels in recurrent psoriatic mice. Meanwhile, NF-\u03baB inhibition also restored the expression of DLAT in Trm cells. Finally, NF-\u03baB inhibitors directly suppressed Trm cell activation and inflammation of Trm cells\n                      <jats:italic>in vitro<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Together, these findings suggest that canonical and non-canonical NF-\u03baB signaling directly activates Trm cell differentiation, inhibits cellular cuproptosis, and promotes recurrent psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2025.1762269","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:34:57Z","timestamp":1770615297000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Activation of NF-\u03baB signaling in tissue-resident memory T cells promotes recurrent psoriasis in 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