{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:24:23Z","timestamp":1770747863601,"version":"3.49.0"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The co-occurrence of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and hematological malignancies is infrequently described. We report a rare case of histopathologically confirmed MOGAD complicated by pancytopenia following corticosteroid therapy, which ultimately unveiled a concurrent systemic B-cell lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 76-year-old female presented with bilateral lower limb weakness and numbness persisting for two months. She was initially diagnosed with acute myelitis at an external institution and treated with intravenous methylprednisolone (IVMP). A relapse occurred one month after corticosteroid cessation. Upon admission, magnetic resonance imaging (MRI) demonstrated an enlarging spinal cord lesion and extensive enhancement of the cauda equina nerve roots. A spinal cord biopsy revealed necrosis, chronic inflammatory infiltration, and demyelination, without definitive evidence of tumor cells or atypical lymphoid cells. Immunohistochemical staining revealed a loss of MOG expression, while neurofilament (NF) staining confirmed relative axonal integrity with only focal loss within the affected area. The diagnosis of MOGAD was confirmed via cell-based assays, which showed MOG-IgG positivity in both serum (1:32) and cerebrospinal fluid (1:1). However, the patient was refractory to further IVMP treatment and subsequently developed fever and pancytopenia. Peripheral blood immunophenotyping and bone marrow biopsy eventually established a diagnosis of systemic B-cell lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The coexistence of MOGAD and systemic B-cell lymphoma is rare. This case suggests that MOGAD may serve as a sentinel paraneoplastic manifestation of an underlying lymphoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1675512","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:05:59Z","timestamp":1770707159000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic B-cell lymphoma with preceding myelin oligodendrocyte glycoprotein antibody-associated disease: a case report and literature review"],"prefix":"10.3389","volume":"17","author":[{"given":"Jing","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaokun","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shugang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00431-8","article-title":"Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria","volume":"22","author":"Banwell","year":"2023","journal-title":"Lancet Neurol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2022.577823","article-title":"A tumefactive anti-MOG antibody associated disorder heralding central nervous system B-cell lymphoma: Case report on diagnostic challenge","volume":"365","author":"Uzura","year":"2022","journal-title":"J Neuroimmunol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-023-06919-1","article-title":"Myelin oligodendrocyte glycoprotein antibody-associated disease preceding primary central nervous system lymphoma: causality or coincidence","volume":"44","author":"Cai","year":"2023","journal-title":"Neurol Sci"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.2.259","article-title":"Diagnosis of a multifocal B cell lymphoma with preceding demyelinating central nervous system lesions by single voxel proton MR spectroscopy","volume":"70","author":"Kuhlmann","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pediatrneurol.2023.03.002","article-title":"Two cases of juvenile myelomonocytic leukemia and myelin oligodendrocyte glycoprotein antibody-associated disease","volume":"144","author":"Yamamoto","year":"2023","journal-title":"Pediatr Neurol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102038","article-title":"A case of MOG encephalomyelitis with T- cell lymphoma","volume":"41","author":"Kwon","year":"2020","journal-title":"Mult Scler Relat Disord"},{"key":"B7","first-page":"48","volume-title":"Aids to the investigation of peripheral nerve injuries. Medical Research Council: Nerve Injuries Research Committee. His Majesty\u2019s Stationery Office","author":"Compston","year":"1942"},{"key":"B8","doi-asserted-by":"publisher","first-page":"342","DOI":"10.25259\/SNI_531_2020","article-title":"Histopathological variation in the demyelinating sentinel lesion of primary central nervous system lymphoma","volume":"11","author":"Bajagain","year":"2020","journal-title":"Surg Neurol Int"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e62","DOI":"10.1212\/NXI.0000000000000062","article-title":"Does MOG Ig-positive AQP4-seronegative opticospinal inflammatory disease justify a diagnosis of NMO spectrum disorder","volume":"2","author":"Zamvil","year":"2015","journal-title":"Neurol Neuroimmunol Neuroinflamm"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1675512\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:06:00Z","timestamp":1770707160000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1675512\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,10]]},"references-count":9,"alternative-id":["10.3389\/fimmu.2026.1675512"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1675512","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,10]]},"article-number":"1675512"}}