{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:22:59Z","timestamp":1772824979343,"version":"3.50.1"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470982, 82270983"],"award-info":[{"award-number":["82470982, 82270983"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral lichen planus (OLP) is a chronic T-cell-mediated inflammatory disorder of unknown etiology. Accumulating evidence has demonstrated elevated cholesterol levels in OLP, and its oxidation products --oxysterols have been implicated in T cell dysfunction. However, whether the oxysterol is involved in OLP pathogenesis remains to be fully elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Metabolomics was performed to profile oxysterols in the plasma of OLP patients, followed by functional enrichment analysis. Single-cell RNA sequencing was utilized to characterize gene expression dysregulation in tissue-resident T cells isolated from OLP lesions. Flow cytometry, immunofluorescence, and qRT-PCR were collectively used to quantify Ca\n                      <jats:sup>2+<\/jats:sup>\n                      concentration, cell apoptosis, protein expression, intracellular signaling, and gene transcription levels. Functional validation was conducted through a co-culture model and Transwell migration assays to assess the cytotoxic and migratory capacity of OLP T cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The oxysterol profiles were aberrant in OLP plasma, with marked accumulation of 7-ketocholesterol (7KC). Functional analysis identified significant enrichment of differential metabolites in androstenedione metabolism. 7KC upregulated the expression of cholesterol regulators (SREBP2\/LXR) in OLP T cells. Pro-7-ketocholesterogenic gene sets were dysregulated in OLP tissues, with localized T cells exhibiting enriched Ca\n                      <jats:sup>2+<\/jats:sup>\n                      -NFATc1 signaling and coordinated F-actin polymerization\/\n                      <jats:italic>ITGAL<\/jats:italic>\n                      (LFA-1\u03b1) upregulation, positively correlating with migration signatures. Peripheral OLP T cells showed elevated Ca\n                      <jats:sup>2+<\/jats:sup>\n                      , nuclear NFATc1, F-actin polymerization, and LFA-1\u03b1, all of which, along with\n                      <jats:italic>ITGAL\/IL1B\/CCL4\/IL6<\/jats:italic>\n                      levels, were further potentiated by 7KC treatment. 7KC was confirmed to enhance migrations of primary OLP T cells and OLP plasma-pretreated Jurkat T cells toward LPS-treated keratinocytes, without affecting keratinocyte apoptosis. Furthermore, CM4620-mediated blockade of Ca\n                      <jats:sup>2+<\/jats:sup>\n                      -NFATc1 pathway in OLP T cells inhibited 7KC-induced NFATc1 activation, reduced the expressions of F-actin and its modulators\n                      <jats:italic>ACTB\/DIAPH1<\/jats:italic>\n                      , and\n                      <jats:italic>IL1B\/CCL4\/IL6<\/jats:italic>\n                      gene expressions, with migration suppressions of both primary OLP T cells and OLP plasma-pretreated Jurkat T cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      7KC could promote T cell migration through Ca\n                      <jats:sup>2+<\/jats:sup>\n                      -NFATc1 pathway-mediated F-actin polymerization and expression of\n                      <jats:italic>IL1B\/CCL4\/IL6<\/jats:italic>\n                      in OLP.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1682589","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:36:15Z","timestamp":1770359775000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["7-Ketocholesterol promotes T cell migration through Ca2+-NFATc1 pathway-mediated F-actin polymerization and proinflammatory cytokine production in oral lichen planus"],"prefix":"10.3389","volume":"17","author":[{"given":"Qin","family":"Jiang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University","place":["Wuhan, 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