{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:54:50Z","timestamp":1773320090780,"version":"3.50.1"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Central nervous system (CNS) involvement is recognized as a distinct manifestation of chronic GVHD (cGVHD). Myelin oligodendrocyte glycoprotein antibody\u2013associated disease (MOGAD) is an autoimmune disorder targeting the CNS. Therefore, the occasional detection of MOG antibodies in patients with CNS-cGVHD may represent a manifestation within the spectrum of CNS-GVHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 22-year-old female with severe aplastic anemia (AA) underwent maternal haploidentical hematopoietic stem cell transplantation (HSCT) in May 2021. During conditioning, she developed acute neurotoxicity. Subsequent complications included acute and chronic GVHD as well as posterior reversible encephalopathy syndrome (PRES). Three months after transplantation, she developed sensory deficits and ataxia, and cervical magnetic resonance imaging revealed inflammatory lesions consistent with cervical myelitis. Comprehensive neuroimmunological evaluation excluded alternative infectious, metabolic, or neoplastic etiologies. Anti\u2013myelin oligodendrocyte glycoprotein (MOG) antibodies were negative by cell-based assay (CBA) and tissue-based assay (TBA), but demonstrated weak, low-titer positivity on live-cell immunofluorescence. Neurological function recovered following treatment with intravenous immunoglobulin (IVIG) and methylprednisolone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case illustrates low-titer post-HSCT MOG seropositivity detected only by a live cell\u2013based assay in a patient who fulfilled diagnostic criteria for CNS-GVHD. Live cell\u2013based MOG testing may be considered in selected HSCT recipients with unexplained or atypical neuroinflammatory syndromes despite negative conventional assays, with results interpreted cautiously as hypothesis-generating for individualized immunosuppressive management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1684838","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T19:15:26Z","timestamp":1773256526000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurological graft-versus-host disease with MOG antibody positivity after allogeneic stem cell transplantation: a case report"],"prefix":"10.3389","volume":"17","author":[{"given":"Xin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Hematology, The Second Qilu Hospital of Shandong University","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningxia","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Second Qilu Hospital of Shandong University","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Qilu Hospital of Shandong University","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Second Qilu Hospital of Shandong University","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juandong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Second Qilu Hospital of Shandong University","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningning","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Second Qilu Hospital of Shandong University","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018021162","article-title":"Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment","volume":"2","author":"Georges","year":"2018","journal-title":"Blood Adv"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2020.35.e46","article-title":"Better failure-free survival and graft-versus-host disease-free\/failure free survival with fludarabine-based conditioning in stem cell transplantation for aplastic anemia in children","volume":"35","author":"Im","year":"2020","journal-title":"J Korean 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