{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:52:47Z","timestamp":1777287167418,"version":"3.51.4"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Mitochondrial dysfunction has been increasingly implicated in the pathogenesis of multiple sclerosis (MS), contributing to oxidative stress, immune dysregulation, and neurodegeneration. Current therapies primarily target inflammation but do not adequately address mitochondrial impairment or progressive tissue damage. This study aimed to evaluate the therapeutic potential of mitochondrial transplantation in experimental autoimmune encephalomyelitis (EAE), a murine model of MS, by investigating its effects on immune modulation, mitochondrial function, and tissue integrity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>EAE was induced in mice using myelin oligodendrocyte glycoprotein. Isolated mitochondria were administered intravenously, and clinical progression, spinal cord histology, immune cell populations, mitochondrial activity, fibrosis, and gut microbiota composition were assessed. Additionally, human peripheral blood mononuclear cells (PBMCs) from MS patients were co-cultured with mitochondria to examine ATP production, reactive oxygen species levels, and T cell differentiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mitochondrial transplantation significantly reduced EAE severity, spinal cord inflammation, demyelination, and fibrosis. Treated mice showed increased regulatory T (Treg) cells, reduced T helper 17 (Th17) cells, improved mitochondrial biogenesis, and decreased oxidative stress. Gut microbiome analysis revealed beneficial compositional changes. In human PBMCs, mitochondrial transfer enhanced ATP synthesis, suppressed mitochondrial ROS, and promoted Treg differentiation while inhibiting pro-inflammatory cytokines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings suggest that mitochondrial transplantation restores mitochondrial function, rebalances immune responses, and mitigates neuroinflammation and fibrosis in EAE. This approach offers a novel therapeutic strategy for MS by addressing both metabolic and immunological drivers of disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1698136","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:23:32Z","timestamp":1773638612000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial transplantation ameliorates experimental autoimmune encephalomyelitis by modulating the Th17\/Treg balance and restoring metabolic homeostasis"],"prefix":"10.3389","volume":"17","author":[{"given":"A Ram","family":"Lee","sequence":"first","affiliation":[{"name":"Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea","place":["Seoul, Republic of Korea"]},{"name":"Department of Pathology, College of Medicine, The 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College of Medicine, The Catholic University of Korea","place":["Seoul, Republic of Korea"]},{"name":"Mitochondrial Immunomedicine center for Global Health Therapeutics (MIGHT), Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea","place":["Seoul, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Been","family":"Jeon","sequence":"additional","affiliation":[{"name":"Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea","place":["Seoul, Republic of Korea"]},{"name":"Department of Pathology, College of Medicine, The Catholic University of Korea","place":["Seoul, Republic of Korea"]},{"name":"Mitochondrial Immunomedicine center for Global Health Therapeutics (MIGHT), Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea","place":["Seoul, Republic of 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Korea","place":["Seoul, Republic of Korea"]},{"name":"Department of Pathology, College of Medicine, The Catholic University of Korea","place":["Seoul, Republic of Korea"]},{"name":"Mitochondrial Immunomedicine center for Global Health Therapeutics (MIGHT), Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea","place":["Seoul, Republic of Korea"]},{"name":"Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea","place":["Seoul, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Bin","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, College of Human Ecology, Kyung Hee University","place":["Seoul, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunju","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, College of Human Ecology, Kyung Hee University","place":["Seoul, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea","place":["Seoul, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woojun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea","place":["Seoul, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-La","family":"Cho","sequence":"additional","affiliation":[{"name":"Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea","place":["Seoul, Republic of Korea"]},{"name":"Department of Pathology, 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