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We employed next-generation sequencing (NGS) on patients with immunodeficiency and their immediate relatives to facilitate the diagnosis and genetic counseling of XLA, thereby improving our understanding of this rare disorder.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1704590","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:13:00Z","timestamp":1774930380000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Purulent meningitis in X-linked agammaglobulinemia: one case report"],"prefix":"10.3389","volume":"17","author":[{"given":"Anyi","family":"Ba","sequence":"first","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Henan Medical University","place":["Xinxiang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical 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