{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:54:30Z","timestamp":1781844870913,"version":"3.54.5"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Orbital inflammation is the most common presentation of VEXAS, with any orbital structure potentially affected. Non-sight-threatening and uncomplicated anterior non-granulomatous uveitis and anterior diffuse scleritis follow in frequency, along with episcleritis. Ophthalmic involvement was significantly associated with relapsing polychondritis (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.014), with an increased chance of a fatal outcome (RR 5.87,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.016) and independently predicts a higher mortality rate (OR 3.72,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.026). Treatment of ophthalmic involvement showed full or partial response to glucocorticosteroids alone in 66.7% of cases. Ophthalmic involvement is common in VEXAS syndrome and signals a poorer prognosis in terms of mortality, highlighting the need for close monitoring.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1709085","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:30:06Z","timestamp":1781843406000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ophthalmic involvement in VEXAS syndrome and its influence on mortality: insights from the international AIDA network registry"],"prefix":"10.3389","volume":"17","author":[{"given":"Jurgen","family":"Sota","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center]","place":["Siena, 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