{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:15:59Z","timestamp":1792444559816,"version":"4.5.0"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute myocardial infarction (AMI) is one of the leading causes of mortality worldwide. Despite extensive research, only a limited number of genes have been identified as reliable biomarkers for the diagnosis and treatment of AMI. This study aims to identify novel biomarkers and therapeutic targets for AMI by integrating multi-omics data and machine learning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We obtained the GWAS dataset I9_MI_STRICT from the FinnGen database and the eQTL dataset of peripheral blood from the GTEx database. Using these datasets, we identified genes significantly associated with AMI through transcriptome-wide association studies (TWAS). Functional enrichment analysis was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Additionally, we downloaded three AMI peripheral blood gene expression microarray datasets (GSE66360, GSE48060, GSE60993) from the Gene Expression Omnibus (GEO) database. Key genes were further identified by combining the risk prediction model constructed by 12 machine learning methods(dataset GSE66360 as the training set, dataset GSE48060 and dataset GSE60993 as the validation set) and Bayesian colocalization analysis. To explore the potential mechanisms of these key genes in AMI, we conducted immunoinfiltration analysis, single-gene Gene Set Enrichment Analysis (GSEA), and Gene Set Variation Analysis (GSVA). Finally, the expression of key genes was validated using real-time quantitative PCR (RT-qPCR) and western blot.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified several key genes:\n                      <jats:italic>LIPA, PECAM1, SMARCA4, HP, RTN2, CFDP1, XPO6<\/jats:italic>\n                      , and\n                      <jats:italic>FES<\/jats:italic>\n                      . Receiver operating characteristic (ROC) analysis demonstrated that these genes exhibited excellent diagnostic performance. Enrichment analysis revealed their primary involvement in lipid metabolism, immune system processes, gene transcription regulation, and ion channel regulation. Furthermore, immunoinfiltration analysis showed that\n                      <jats:italic>PECAM1, HP, RTN2, CFDP1<\/jats:italic>\n                      , and\n                      <jats:italic>FES<\/jats:italic>\n                      were significantly correlated with various immune cell types. qRT-PCR and western blot analysis revealed that the mRNA expression of\n                      <jats:italic>LIPA, RTN2<\/jats:italic>\n                      , and\n                      <jats:italic>PECAM1<\/jats:italic>\n                      was upregulated in the AMI group, while\n                      <jats:italic>CFDP1<\/jats:italic>\n                      and\n                      <jats:italic>XPO6<\/jats:italic>\n                      showed downregulation compared to the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study identified nine key genes as potential novel targets for the diagnosis and treatment of AMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1711521","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:43:25Z","timestamp":1776059005000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of key biomarkers for myocardial infarction by multi-omics analysis and machine learning"],"prefix":"10.3389","volume":"17","author":[{"given":"Jiacheng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erha","family":"Lama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001123","article-title":"Heart disease and stroke statistics-2023 update: A report from the American Heart Association","volume":"147","author":"Tsao","year":"2023","journal-title":"Circulation"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa1096","article-title":"The year in cardiovascular medicine 2020: Interventional cardiology","volume":"42","author":"Alfonso","year":"2021","journal-title":"Eur Heart J"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4579806","article-title":"Microrna-155 promotes myocardial infarction-induced apoptosis by targeting rna-binding protein Qki","volume":"2019","author":"Guo","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232112906","article-title":"The role of inflammation in cardiovascular disease","volume":"23","author":"Henein","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318005","article-title":"Immune cells and immunotherapy for cardiac injury and repair","volume":"128","author":"Rurik","year":"2021","journal-title":"Circ Res"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz050","article-title":"Immune cells as targets for cardioprotection: New players and novel therapeutic opportunities","volume":"115","author":"Andreadou","year":"2019","journal-title":"Cardiovasc Res"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1059543","article-title":"Machine learning-based integration develops biomarkers initial the crosstalk between inflammation and immune in acute myocardial infarction patients","volume":"9","author":"Li","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/ng.2480","article-title":"Large-scale association analysis identifies new risk loci for coronary artery disease","volume":"45","author":"Deloukas","year":"2013","journal-title":"Nat Genet"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz1776","article-title":"Atlas of genetic regulatory effects across human tissues","volume":"369","year":"2020","journal-title":"Science"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1262110","article-title":"The genotype-tissue expression (Gtex) pilot analysis: Multitissue gene regulation in humans","volume":"348","year":"2015","journal-title":"Science"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3506","article-title":"Integrative approaches for large-scale transcriptome-wide association studies","volume":"48","author":"Gusev","year":"2016","journal-title":"Nat Genet"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104432","article-title":"Mitochondrial related genome-wide mendelian randomization identifies putatively causal genes for multiple cancer types","volume":"88","author":"Li","year":"2023","journal-title":"EBioMedicine"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PloS Genet"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky474","article-title":"Coloc-stats: A unified web interface to perform colocalization analysis of genomic features","volume":"46","author":"Simovski","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"B15","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1038\/s41467-018-03260-6","article-title":"A transcriptome-wide association study identifies Palmd as a susceptibility gene for calcific aortic valve stenosis","volume":"9","author":"Th\u00e9riault","year":"2018","journal-title":"Nat Commun"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1179","article-title":"Going forward","volume":"43","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1092","article-title":"Kegg: New perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1186\/s12967-023-04512-w","article-title":"DNA methylation regulator-mediated modification patterns and risk of intracranial aneurysm: A multi-omics and epigenome-wide association study integrating machine learning, mendelian randomization, eqtl and mqtl data","volume":"21","author":"Maimaiti","year":"2023","journal-title":"J Transl Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat Methods"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.0358","article-title":"Diagnosis and treatment of acute coronary syndromes: A review","volume":"327","author":"Bhatt","year":"2022","journal-title":"JAMA"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa1011","article-title":"Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: A Swedish nationwide cohort study","volume":"42","author":"Schubert","year":"2021","journal-title":"Eur Heart J"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.122.318884","article-title":"Elevated LDL cholesterol increases microvascular endothelial Vwf and thromboinflammation after myocardial infarction","volume":"43","author":"Ozawa","year":"2023","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126467","article-title":"Dynamic changes in ion channels during myocardial infarction and therapeutic challenges","volume":"25","author":"Song","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B24","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ebiom.2018.12.003","article-title":"Hdac inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction","volume":"39","author":"Tian","year":"2019","journal-title":"EBioMedicine"},{"key":"B25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1126\/science.3513311","article-title":"A receptor-mediated pathway for cholesterol homeostasis","volume":"232","author":"Brown","year":"1986","journal-title":"Science"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01069-0","article-title":"Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk","volume":"54","author":"Turner","year":"2022","journal-title":"Nat Genet"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf581","article-title":"Lipa, a risk locus for coronary artery disease: Decoding the variant-to-function relationship","volume":"46","author":"Li","year":"2025","journal-title":"Eur Heart J"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06090-9","article-title":"Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy","volume":"618","author":"Foronda","year":"2023","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae091","article-title":"Rtn2 deficiency results in an autosomal recessive distal motor neuropathy with lower limb spasticity","volume":"147","author":"Maroofian","year":"2024","journal-title":"Brain"},{"key":"B30","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41419-022-04757-1","article-title":"Reticulon 2 promotes gastric cancer metastasis via activating endoplasmic reticulum Ca2+ efflux-mediated Erk signalling","volume":"13","author":"Song","year":"2022","journal-title":"Cell Death Dis"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-023-01170-y","article-title":"Cardiac-specific deletion of Brg1 ameliorates ventricular arrhythmia in mice with myocardial infarction","volume":"45","author":"Li","year":"2024","journal-title":"Acta Pharmacol Sin"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.09.012","article-title":"Brg1 protects the heart from acute myocardial infarction by reducing oxidative damage through the activation of the Nrf2\/Ho1 signaling pathway","volume":"160","author":"Liu","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150617","article-title":"Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1\/Nrf2\/Stat3 signalling","volume":"130","author":"Wang","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104082","article-title":"Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease","volume":"9","author":"Sabater-Lleal","year":"2014","journal-title":"PloS One"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01233-6","article-title":"Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants","volume":"54","author":"Aragam","year":"2022","journal-title":"Nat Genet"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3390\/cells12151994","article-title":"Cfdp1 is essential for cardiac development and function","volume":"12","author":"Giardoglou","year":"2023","journal-title":"Cells"},{"key":"B37","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s12672-023-00700-8","article-title":"Targeting Xpo6 inhibits prostate cancer progression and enhances the suppressive efficacy of docetaxel","volume":"14","author":"Wang","year":"2023","journal-title":"Discov Oncol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112310","article-title":"Exportin Xpo6 upregulation activates the Tlr2\/Myd88\/Nf-Kb signaling by facilitating Tlr2 mRNA nuclear export in COPD pulmonary monocytes","volume":"135","author":"Wu","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/nrm783","article-title":"Closing in on the biological functions of Fps\/Fes and Fer","volume":"3","author":"Greer","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321146","article-title":"The Fes gene at the 15q26 coronary-artery-disease locus inhibits atherosclerosis","volume":"131","author":"Karamanavi","year":"2022","journal-title":"Circ Res"},{"key":"B41","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1186\/s12967-024-05178-8","article-title":"Comprehensive mendelian randomization analysis of plasma proteomics to identify new therapeutic targets for the treatment of coronary heart disease and myocardial infarction","volume":"22","author":"Sun","year":"2024","journal-title":"J Transl Med"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010097","article-title":"Fer and Fert govern mitochondrial susceptibility to metformin and hypoxic stress in colon and lung carcinoma cells","volume":"10","author":"Marciano","year":"2021","journal-title":"Cells"},{"key":"B43","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12933-019-0867-4","article-title":"Association of haptoglobin phenotype with incident acute myocardial infarction in Chinese patients with type 2 diabetes","volume":"18","author":"Gurung","year":"2019","journal-title":"Cardiovasc Diabetol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03948.x","article-title":"Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (Pecam-1) gene, Asn563ser and Gly670arg, associated with myocardial infarction in the Japanese","volume":"947","author":"Sasaoka","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1159\/000006876","article-title":"Soluble Pecam-1, but not P-selectin, nor osteonectin identify acute myocardial infarction in patients presenting with chest pain","volume":"91","author":"Serebruany","year":"1999","journal-title":"Cardiology"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020106113","article-title":"Pecam-1 supports leukocyte diapedesis by tension-dependent dephosphorylation of Ve-cadherin","volume":"40","author":"Arif","year":"2021","journal-title":"EMBO J"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.57.4.523","article-title":"The role of Pecam-1 (Cd31) in leukocyte emigration: Studies in vitro and in vivo","volume":"57","author":"Muller","year":"1995","journal-title":"J Leukoc Biol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41392-019-0081-6","article-title":"Integrative analysis of DNA methylation and gene expression identified cervical cancer-specific diagnostic biomarkers","volume":"4","author":"Xu","year":"2019","journal-title":"Signal Transduct Target Ther"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1711521\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:43:26Z","timestamp":1776059006000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1711521\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":48,"alternative-id":["10.3389\/fimmu.2026.1711521"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1711521","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,13]]},"article-number":"1711521"}}